- adj.
WordNet
- physically and mentally sound or healthy; "felt relaxed and fit after their holiday"; "keeps fit with diet and exercise"
- a display of bad temper; "he had a fit"; "she threw a tantrum"; "he made a scene" (同)tantrum, scene, conniption
- insert or adjust several objects or people; "Can you fit the toy into the box?"; "This man cant fit himself into our work environment"
- make fit; "fit a dress"; "He fitted other pieces of paper to his cut-out"
- the manner in which something fits; "I admired the fit of her coat"
- be the right size or shape; fit correctly or as desired; "This piece wont fit into the puzzle" (同)go
- (usually followed by `to or `for' (同)primed, set
- conform to some shape or size; "How does this shirt fit?"
- meeting adequate standards for a purpose; "a fit subject for discussion"; "it is fit and proper that you be there"; "water fit to drink"; "fit for duty"; "do as you see fit to"
- of, relating to, or representing an amount that is corrected for inflation; "real prices"; "real income"; "real wages"
- an old small silver Spanish coin
- the basic unit of money in Brazil; equal to 100 centavos
- being or occurring in fact or actuality; having verified existence; not illusory; "real objects"; "real people; not ghosts"; "a film based on real life"; "a real illness"; "real humility"; "Life is real! Life is earnest!"- Longfellow (同)existent
- capable of being treated as fact; "tangible evidence"; "his brief time as Prime Minister brought few real benefits to the poor" (同)tangible
- (of property) fixed or immovable; "real property consists of land and buildings"
- no less than what is stated; worthy of the name; "the real reason"; "real war"; "a real friend"; "a real woman"; "meat and potatoes--I call that a real meal"; "its time he had a real job"; "its no penny-ante job--hes making real money"
- not to be taken lightly; "statistics demonstrate that poverty and unemployment are very real problems"; "to the man sleeping regularly in doorways homelessness is real"
- refer (a word or name) to a person or thing; "He applied this racial slur to me!"
- be pertinent or relevant or applicable; "The same laws apply to you!"; "This theory holds for all irrational numbers"; "The same rules go for everyone" (同)hold, go for
- apply oneself to; "Please apply yourself to your homework"
- ask (for something); "He applied for a leave of absence"; "She applied for college"; "apply for a job"
- conformity to reality or actuality; "they debated the truth of the proposition"; "the situation brought home to us the blunt truth of the military threat"; "he was famous for the truth of his portraits"; "he turned to religion in his search for eternal verities" (同)the true, verity, trueness
- a true statement; "he told the truth"; "he thought of answering with the truth but he knew they wouldnt believe it" (同)true statement
- a fact that has been verified; "at last he knew the truth"; "the truth is that he didnt want to do it"
- one of the first seven ribs in a human being which attach to the sternum
- an indictment endorsed by a grand jury
- rightly so called; "true courage"; "a spirit which true men have always admired"; "a true friend"
- proper alignment; the property possessed by something that is in correct or proper alignment; "out of true"
- as acknowledged; "true, she is the smartest in her class" (同)admittedly, avowedly, confessedly
- accurately placed or thrown; "his aim was true"; "he was dead on target" (同)dead on target
- having a legally established claim; "the legitimate heir"; "the true and lawful king" (同)lawful, rightful
- accurately fitted; level; "the window frame isnt quite true" (同)straight
- make level, square, balanced, or concentric; "true up the cylinder of an engine" (同)true up
- conforming to definitive criteria; "the horseshoe crab is not a true crab"; "Pythagoras was the first true mathematician"
- consistent with fact or reality; not false; "the story is true"; "it is undesirable to believe a proposition when there is no ground whatever for supposing it true"- B. Russell; "the true meaning of the statement"
- determined with reference to the earths axis rather than the magnetic poles; "true north is geographic north"
- devoted (sometimes fanatically) to a cause or concept or truth; "true believers bonded together against all who disagreed with them"
PrepTutorEJDIC
- 『適した』,適切な,ぴったりの / 《補語にのみ用いて》よい調子で;健康で / 《be fit to do》いまにも…しそうである《explode,burst,fall,dropなど危険な意 / を含む動詞と共に用いる》 / 〈意図・目的など〉‘に'『合う』,ふさわしい / (…に)…‘を'『合わせる』,はめ込む,取り付ける《+『名』+『to』(『into,in,on』)+『名』》;(…を)…‘に'合わせる《+『名』+『with』+『名』》 / 〈人〉‘に'資格をつける,‘を'適させる / 適する,合う(服・靴などの)でき具合;体に合うもの / 〈U〉適合,対応
- (病気の)『発作』 / (感情などの)『一時的な爆発』《+『of』+『名』》
- (想像でなく)『現実の』,実際の,真実の / (まがいものでなく)『本物の』 / 不動産の / ほんとうに,とても(very)
- (…に)…'を'『適用する』,応用する《+『名』+『to』+『名』(do『ing』)》 / (…に)…'を'『当てる』,当てがう《+『名』+『to』+『名』》 / (…に)〈心・努力など〉'を'傾ける,注ぐ《+『名』+『to』+『名』(do『ing』)》 / …'を'作用させる,動かす / (…に)『適用される』,当てはまる《+『to』+『名』》 / 申し込む,出願する;(…に…を)申し込む《+『to』+『名』+『for』+『名』》
- 〈U〉(物事の)真実,事実,真相 / 〈U〉『真実性』,真実味,ほんとうのこと / 〈C〉『真理』,原理 / 〈U〉誠実さ,実直さ,正直
- 『ほんとうの』,真実の / 『本物の』,正真正銘の(real) / 『誠実な』,忠実な,忠誠な(faithful) / 心からの,うそ偽りのない / 寸分違わない,正確に一致する,適合する / 正当な,適正な,正しい(proper) / 間違いない,確実な / 〈機械・器具などが〉正確にできた,正しい位置にある;〈声などが〉正しい調子の / うそをつかないで,正直に / 寸分違わないように,確実に / 先祖の型どおりに / …‘を'正しく調整する《+up+名,+名+up》
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/02/26 17:03:21」(JST)
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- Cui J, Chong B, Rutherfurd SM, Wilkinson B, Singh H, Moughan PJ.SourceRiddet Institute, Massey University, Palmerston North, New Zealand. Electronic address: J.C.Cui@massey.ac.nz.
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Related Links
- 公式サイト。ストーリー、キャラクター紹介、キャストコメント。
- The new sound, light and dance performance, true is a stage performance piece that explores the relationship between the brain and the reality we face, and is, performed by two performers.
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★リンクテーブル★
| リンク元 | 「100Cases 14」「fit」「genuine」「あてはまる」「real」 |
| 拡張検索 | 「Struempell disease」「true keloid」 |
| 関連記事 | 「True」 |
「100Cases 14」
- ☆case14 複視
- ■glossary
- diplopia n. 複視
- 筋力低下、筋無力、筋脱力 muscle weakness, muscular weakness
- sunken
- vt. sinkのpp.
- adj.
- 沈没した、沈んだ、水中の
- 沈下した、一段低いところにある
- 落ち込んだ、くぼんだ
- 3,4-ジアミノピリジン 3,4-diaminopyridine 3,4-DAP K+チャネル阻害薬;ランバート・イートン筋無力症治療
- ■症例
- 43-year-old woman
- cheif complaint: diplopia
- present history: diplopia and holding her head up ; more marked in the evenings, for the last 3 months. difficulty of chewing. voice has become quieter. weight loss (3kg / 6months). non-smoker. drinks about 15 units/week. no regular medication.
- past history: no significant previous medical illnesses.
- family history: lives with her husband and three children.
- ・診察 examination
- looks well.
- organ systems: normal; cardiovascular, respiratory, and abdominal systems.
- muscle power; grossly normal. decrease after testing a movement repetitively.
- motor function: normal; tone, coordination, reflexes and sensation.
- bilateral ptosis. exacerbated by prolonged upward gaze
- eye: normal; pupillary reflexes, eye movements, and funduscopy
- ■答え
- diagnosis: myathenia gravis
- differential diagnoses:
- CASES
- 上位and/or下位運動ニューロン motor neurone disease 運動ニューロン疾患：線維束性攣縮。進行例では筋力低下
- 筋 muscular dystrophy 筋ジストロフィー：ある種の筋肉が選択的に筋力低下する。家族歴がある。
- 筋 dystrophia myotonica 強直性筋ジストロフィー：咬筋、側頭筋、胸鎖乳突筋の筋萎縮、四肢遠位端の筋萎縮。顔貌が特徴的(前頭部脱毛、無表情、窪んだ頬)。家族歴ある。筋電図が診断に有用(急降下爆撃音)。
- 筋 polymyositis 多発筋炎：普通は皮疹と関節痛が出現。CKが上昇。筋生検が診断に有用
- 筋 myopathy ミオパチー：甲状腺中毒性ミオパチー、甲状腺機能低下症によるミオパチー、クッシング症候群によるミオパチー、アルコール性のミオパチー
- 神経筋接合部？ non-metastatic associations of malignancy (paraneoplastic syndrome(傍腫瘍性症候群 = 腫瘍随伴症候群)のこと)：胸腺腫の症例の10%に重症筋無力症がみられる。ランバート・イートン筋無力症症候群は小細胞癌と関連がある。
- HIM.2674
- Treatment with penicillamine (used for scleroderma or rheumatoid arthritis) may result in true autoimmune MG, but the weakness is usually mild, and recovery occurs within weeks or months after discontinuing its use.
- 重症筋無力症の誘発：ペニシラミン(強皮症や関節リウマチの治療に用いられる)。
- mildだし、薬剤の中断で改善する。
- Aminoglycoside antibiotics or procainamide can cause exacerbation of weakness in myasthenic patients; very large doses can cause neuromuscular weakness in normal individuals.
- 重症筋無力症の悪化：アミドグリコシド系抗菌薬、プロカインアミド
- MGの患者の筋脱力が悪化する。
- 神経筋接合部 Lambert-Eaton myasthenic syndrome ランバート・イートン筋無力症症候群：全身の筋肉が冒されるが、特に下肢の近位筋が冒される。MGと同じように～70%の患者で脳神経所見(眼瞼下垂、複視など)が認められる。MGと違うのは(1)反射が消失・減弱すること、(2)自律神経系の変化(口渇、勃起不全)を生じる、(3)神経刺激検査で漸増(waxing)が見られることである。病因は神経筋接合部のP/Q type calcium channelsに対する抗体の出現であり、85%の患者で見いだされる。治療はMGのように血漿交換や免疫抑制薬が使われる。3,4-DAPやpyridostigmineは症状に対する治療のために用いる。前者は運動神経の終末部でカルシウムチャネルをブロックし活動電位を延長させる。後者はアセチルコリンエステラーゼを阻害してシナプスにおける神経伝達物質の濃度を上げる。
- 精神疾患 neurasthenia 神経衰弱症：歴史的な用語。器質的な障害を伴わない筋無力症のような脱力を伴う症候群。患者は筋脱力や疲労を訴えてやってくる。筋肉の検査では器質的変化は認めないが"jerky release"あるいは"give-away weakness"が認められる。患者の主訴は反復動作による筋力低下よりむしろ疲労や感情鈍麻である。
- 内分泌疾患 hyperthyroidism 甲状腺機能亢進症：MGが疑われる患者にはthyroid function testをルーチンにやる。甲状腺機能異常は筋無力症の筋力低下を大きくすることがある。
- 神経筋接合部 botulism ボツリヌス症：ボツリヌス毒素はシナプス前膜からの神経伝達物質の開口分泌を妨げる。症状はbulbar weakness (複視、構音障害、嚥下困難)。感覚障害はない。深部腱反射は初期には保たれている。進行すれば反射は見られなくなる。筋脱力は全身性。呼吸困難に陥ることがある。精神状態は正常。自律神経症状(麻痺性イレウス、便秘、urinary retention、瞳孔の散大、瞳孔の反応性低下、口渇)。確定診断は血清中の毒素の検出だけど、見つかることはまれ。神経伝導検査(nerve conduction studies)：compound muscle action potentials (CMAPs)の低下。高頻度の刺激で振幅が増加。治療：intubation for airway protection、呼吸補助、aggressive inpatient supportive care(e.g., nutrition, DVT prophylaxis)。馬の抗毒素を検査結果が帰ってくる前に投与する(？)。
- 上位運動ニューロン intracranial mass lesions 頭蓋内占拠病変：複視はintracranial mass lesionが外眼筋の神経を圧迫することにより生じる。
- 筋 progressive external ophthalmoplegia 進行性外眼筋麻痺：外眼筋の筋脱力を伴う。四肢の近位筋の筋力低下やそのほかの全身症状を伴うことがある。ミトコンドリアの異常を有する。
- ■参考文献
- HIM = Harrison's Principles of Internal Medicine 17th Edition
- CASES = 100 Cases in Clinical Medicine Second edition
- IMD = 内科診断学第2版
「fit」
- adj.
- 適当な、ふさわしい。至当な、穏当な。(任に)耐えうる、適任の
- (生物)(環境に対して)適応した、(生存)適者の
- 体調がよい、健康で
- (いつでも～する)用意ができて、今にも～しそうな
- vt.
- ～に適合する、合う、フィットする。～と調和/一致する、～に相応する
- vi.
- 合う、びったりする、フィットする。(～に)収まる(into)。調和/適合する(in, with)。
- n.
- 適合。(衣服などの)合いぐあい。体に合う衣服。(機械)(部品の)嵌め合い。(統計)適合度
- 関
- accord, accordance, adequate, adequately, adjust, agree, agreement, apply, apt, coincide, coincidence, concert, concerted, concordance, concur, concurrent, conform, conformity, congruence, congruent, consensus, consistent, consonant, correspond, correspondence, corresponding, instrument, match, matching, proper, suit, true, unanimous, unity, wear
- n.(病気の)発作。引きつけ、痙攣。(感情の)激発、一時的興奮、気まぐれ
「genuine」
- adj.
- 本物の、正真正銘の、純粋の、真の。(医)真性の。純血種の
- 誠実な、心からの、本当の
- She often puts on an overdramatized display of emotion but lacks genuine deep feelings.
「あてはまる」
「real」
- adj.
- 現実の、本当の、本物の