• n.



  1. a soft thin (usually translucent) paper (同)tissue_paper
  2. part of an organism consisting of an aggregate of cells having a similar structure and function
  3. the act of organizing a business or an activity related to a business; "he was brought in to supervise the organization of a new department" (同)organisation
  4. the activity or result of distributing or disposing persons or things properly or methodically; "his organization of the work force was very efficient" (同)organisation
  5. an ordered manner; orderliness by virtue of being methodical and well organized; "his compulsive organization was not an endearing quality"; "we cant do it unless we establish some system around here" (同)organisation, system
  6. a group of people who work together (同)organisation
  7. of or relating to histology (同)histologic


  1. 〈U〉〈C〉(生物体の)『組織』 / 〈U〉〈C〉『薄織物』 / 〈U〉〈C〉水を吸収する柔らかな薄紙 / 〈C〉カーボンコピー用薄紙 / 〈C〉《a ~》(…を)織り交ぜて作ったもの《+of+名》 / =tissue paper

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/01 07:00:19」(JST)

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English Journal

  • Flaxseed Protects Against Diabetes-Induced Glucotoxicity by Modulating Pentose Phosphate Pathway and Glutathione-Dependent Enzyme Activities in Rats.
  • Gök M1, Ulusu NN2, Tarhan N3, Tufan C3, Ozansoy G3, Arı N3, Karasu Ç4.
  • Journal of dietary supplements.J Diet Suppl.2016 May 3;13(3):339-51. doi: 10.3109/19390211.2015.1036188. Epub 2015 Aug 28.
  • This study investigated the effects of flaxseed (Linum usitatissimum L.) intake on general metabolism, pentose phosphate pathway (PPP) and glutathione-dependent enzymes in diabetic rats. Diabetes was induced by streptozotocin injection (40 mg/kg, i.p.) and the enzyme activities were determined spec
  • PMID 26317558
  • Attenuation of Oxidative Damage by Boerhaavia diffusa L. Against Different Neurotoxic Agents in Rat Brain Homogenate.
  • Ayyappan P1, Palayyan SR1, Kozhiparambil Gopalan R1.
  • Journal of dietary supplements.J Diet Suppl.2016 May 3;13(3):300-12. doi: 10.3109/19390211.2015.1036186. Epub 2015 Aug 13.
  • Due to a high rate of oxidative metabolic activity in the brain, intense production of reactive oxygen metabolite occurs, and the subsequent generation of free radicals is implicated in the pathogenesis of traumatic brain injury, epilepsy, and ischemia as well as chronic neurodegenerative diseases.
  • PMID 26268727
  • Biotransformation effects on anti lipogenic activity of citrus extracts.
  • Nakajima VM1, Madeira JV Jr2, Macedo GA3, Macedo JA3.
  • Food chemistry.Food Chem.2016 Apr 15;197(Pt B):1046-1053. doi: 10.1016/j.foodchem.2015.11.109. Epub 2015 Nov 25.
  • Citrus peel is a good source of flavonoids, with higher content in relation to pulp. This study proposed to investigate the anti-lipogenic potential of a newly developed citrus flavonoids extract, obtained from citrus industrial residue, bioprocessed in order to generate a commercial source of some
  • PMID 26675840
  • Cranberries (Oxycoccus quadripetalus) inhibit pro-inflammatory cytokine and chemokine expression in 3T3-L1 adipocytes.
  • Kowalska K1, Olejnik A2.
  • Food chemistry.Food Chem.2016 Apr 1;196:1137-43. doi: 10.1016/j.foodchem.2015.10.069. Epub 2015 Oct 19.
  • Oxidative stress and inflammation are involved in the development of obesity, type 2 diabetes and vascular complications. Systemic inflammation, as seen in obesity, is associated with high plasmatic levels of pro-inflammatory, pro-atherogenic and pro-thrombotic adipokines. Here we studied the effect
  • PMID 26593599

Japanese Journal

  • The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
  • Kimura Ikuo,Ozawa Kentaro,Inoue Daisuke,Imamura Takeshi,Kimura Kumi,Maeda Takeshi,Terasawa Kazuya,Kashihara Daiji,Hirano Kanako,Tani Taeko,Takahashi Tomoyuki,Miyauchi Satoshi,Shioi Go,Inoue Hiroshi,Tsujimoto Gozoh
  • Nature communications 4, 2013-05-07
  • … We demonstrate that GPR43-deficient mice are obese on a normal diet, whereas mice overexpressing GPR43 specifically in adipose tissue remain lean even when fed a high-fat diet. … We further show that short-chain fatty acid-mediated activation of GPR43 suppresses insulin signalling in adipocytes, which inhibits fat accumulation in adipose tissue and promotes the metabolism of unincorporated lipids and glucose in other tissues. …
  • NAID 120005244704
  • Sox9 and programming of liver and pancreatic progenitors.
  • Kawaguchi Yoshiya
  • The Journal of clinical investigation 123(5), 1881-1886, 2013-05-01
  • … On the other hand, increasing evidence suggests that duct cells function as progenitors in the tissue restoration process after injury, during which embryonic programs are sometimes reactivated. …
  • NAID 120005244916
  • Non-woven PGA fabrics for the treatment of pancreatic juice leakage : a preliminary report
  • Kotani Yutaka,Wang Zhen,Tamura Atsushi,Kawasumi Akari,Tsuji Misaki,Hayashi Maho,Ikeda Junki,Orikasa Taichi,Takamori Hideki,Torii Hiroko,Ozamoto Yuki,Morita Shinichiro,Tsujimoto Hiroyuki,Urabe Mamoru,Hagiwara Akeo
  • 同志社大学理工学研究報告 54(1), 66-74, 2013-04-30
  • … We developed sheets of non-woven poly (glycolic acid) PGA fabric that can act as a scaffold to form smoothly dense granulation tissue for barrier walls to localize leakage of pancreatic juice. … Microscopically, granulation tissue was formed along the fabrics throughout the full thickness of the fabric scaffolds of fabric-0.9 and fabric-20. …
  • NAID 120005247513
  • New scaffolds for tissue engineering using adipose-derived stem cells
  • Kawasumi Akari,Wang Zhen,Kotani Yutaka,Tamura Atsushi,Tsuji Misaki,Hayashi Maho,Ikeda Junki,Orikasa Taichi,Takamori Hideki,Torii Hiroko,Ozamoto Yuki,Morita Shinichiro,Tsujimoto Hiroyuki,Urabe Mamoru,Hagiwara Akeo
  • 同志社大学理工学研究報告 54(1), 41-51, 2013-04-30
  • … Adipose-derived stem cells (ADSCs) have attracted attention as a useful cell source for tissue engineering, even in the clinical setting. … We isolated ADSCs from the inguinal adipose tissue of a rat and characterized the cells using flow cytometry with both CD29- and CD90-positive markers and CD11b- and CD45-negative markers. …
  • NAID 120005247511

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リンク元100Cases 33」「organization」「組織」「histologic」「histological
拡張検索connective and soft tissue neoplasm

100Cases 33」


☆case33 頭痛と混乱
slurred n. 不明瞭
強直間代痙攣 tonic-clonic convulsion
 意識消失とともに全身随意筋強直痙攣が生じ(強直痙攣tonic convulsion)、次いで全身の筋の強直弛緩とが律動的に繰り返される時期(間代痙攣clonic convulsion)を経て、発作後もうろう状態を呈する一連発作
28歳、女性 黒人 南アフリカ 手術室看護師 ロンドン住在
診察 examination
やせている。55kg。38.5℃。口腔カンジダ症(oral candidiasis)。リンパ節腫脹無し。心血管呼吸器系、消化器系正常。痙攣前における神経検査では時間場所、人の見当識無し。神経局所症状無し(no focal neurological sign)。眼底両側に乳頭浮腫有り。
検査 investigation
口腔カンジダ症(oral candidiasis)
口腔カンジダ症(oral candidiasis) → 細胞免疫低下状態(DM免疫抑制AIDSなど) or 常在細菌叢の攪乱(長期抗菌薬の使用)
 ・The occurrence of thrush in a young, otherwise healthy-appearing person should prompt an investigation for underlying HIV infection.(HIM.1254)
 ・More commonly, thrush is seen as a nonspecific manifestation of severe debilitating illness.(HIM.1254)
精神症状強直間代痙攣 → 一次的、あるいは二次的な脳の疾患がありそう
頭痛 → 漠然としていて絞れないが、他の症状からして機能性頭痛ではなく症候性頭痛っぽい。
・眼底両側に乳頭浮腫 → 脳圧亢進徴候 → 原因は・・・脳腫瘍、ことにテント下腫瘍側頭葉腫瘍クモ膜下出血、脳水腫など、そのほか、眼窩内病変、低眼圧などの局所的要因、悪性高血圧、血液疾患大量出血肺気腫などの全身的要因 (vindicate本のp342も参考になる)
 ・頭痛脳圧亢進 → 頭蓋内圧占拠性病変脳炎(IMD.274)
CT所見 → ringform病変脳浮腫脳圧亢進
・低ナトリウム血症 → 脳ヘルニア続発して起こることがあるらしい。実際には下垂体トキソプラズマによる病変形成されることにより起こりうる。
パターン認識HIV + 精神症状 + てんかん発作(強直間代痙攣) + 脳圧亢進 + CT所見 = 一番ありそうなのはToxoplasma gondiiによるトキソプラズマ脳症 cerebral toxoplasosis (トキソプラズマ脳炎 toxoplasmic encephalitis)
Toxoplasma gondii
 原虫 胞子原虫
(感染予防学 080521のプリント、CASES p,92、HIM p.1305-)
 ・終宿主ネコネコ小腸上皮細胞で有性・無性生殖 糞便オーシスト排泄
病原病因 phathogenesis
 1. オーシスト経口摂取
 2. 中間宿主の生肉中のシスト経口摂取
 3. 初感染妊婦からの経胎盤感染。既感染なら胎盤感染しないらしい(HIM.1306)
 (4)移植臓器、輸血確率は低い(at low rate)(HIM.1306)
 1. 先天性トキソプラズマ症 congenital toxoplasmosis
   ①網脈絡膜炎、 ②水頭症、 ③脳内石灰化、 ④精神運動障害
 2. 後天性トキソプラズマ症 acquired toxoplasmosis
  (1) 健常者
   ・(少数例)筋肉痛、暈疼痛、腹痛、斑状丘疹状皮疹(maculopapular rash)、脳脊髄炎、混乱(HIM.1308)
   ・急性感染症状は数週間で消失 筋肉中枢神経系緩増虫体残存
   AIDSでは、トキソプラズマ脳炎が指標疾患 AIDS-defineing illness(CASES)
 (日本)アセチルスピラマイシンファンシダール(感染予防学 080521)
トキソプラズマ脳炎 toxoplasmic encephalitisトキソプラズマ脳症 cerebral toxoplasosis
 (CT,MRI)多発性両側性ring-enhancing lesion、特に灰白質-白質境界、大脳基底核脳幹小脳が冒されやすい(CASES)
このCTcerebral toxoplasmosis特徴的かは不明
 AIDSWBC(leukocyte)の数はどうなるんだろう???AIDSの初診患者ではWBCが低い人が多いらしいし()、HIVCD4+ T cellmacrophage感染して殺すから、これによってB cellは減るだろうし、CD8+ T cellも若干減少するだろうからWBCは減るんじゃないか?!好中球AIDSとは関係ない?好中球は他の感染症に反応性増加している?ちなみに、好酸球寄生虫(原虫)の感染のために増える傾向にあるらしい(HIMのどこか)。
スルファメトキサゾールトリメトプリム合剤 sulfamethoxazole and trimethoprim mixture
A CD4+ T-cell count below 200 cells/μl (or a CD4+ T-cell percentage of total lymphocytes of less than 14%).
or he/she has one of the following defining illnesses:
People who are not infected with HIV may also develop these conditions; this does not mean they have AIDS. However, when an individual presents laboratory evidence against HIV infection, a diagnosis of AIDS is ruled out unless the patient has not:
HIM = Harrison's Principles of Internal Medicine 17th Edition
CASES = 100 Cases in Clinical Medicine Second edition
IMD = 内科診断学第2版



  • n.




  • 何種類かの決まった細胞が一定のパターンで集合した構造の単位のこと。
  • 全体としてひとつのまとまった役割をもつ。


  • 上皮組織
  • 支持組織
  • 筋組織
  • 神経組織



  • adj.
  • 組織学の、病理組織の、組織の



  • adj.
  • 組織学的な、組織学の、組織の


connective and soft tissue neoplasm」