WordNet

the words of something written; "there were more than a thousand words of text"; "they handed out the printed text of the mayors speech"; "he wants to reconstruct the original text" (同)textual matter
a passage from the Bible that is used as the subject of a sermon; "the preacher chose a text from Psalms to introduce his sermon"
the main body of a written work (as distinct from illustrations or footnotes etc.); "pictures made the text easier to understand"

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〈U〉〈C〉(翻訳などに対し)『原文』 / 〈C〉〈U〉(題名・イラストなどに対する)『本文』 / 〈C〉(聖書の)一節 / 〈C〉(議論・演説などの)主題,題目 / =textbook

English Journal

Underexpressed CNDP2 Participates in Gastric Cancer Growth Inhibition through Activating the MAPK Signaling Pathway.

Zhang Z1, Miao L2, Xin X3, Zhang J4, Yang S4, Miao M4, Kong X5, Jiao B4.Author information 1Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China Key Laboratory of Liver Disease, Center of Infectious Diseases, Guangzhou 458 Hospital, Guangzhou, China.2Department of Pharmacology, School of Pharmacy and Institute of Biomedical Sciences, Fudan University, Shanghai, China.3Department of Pharmacology, School of Pharmacy and Institute of Biomedical Sciences, Fudan University, Shanghai, China Department of Pharmacology, Taishan Medical University, Shandong Province, China.4Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China.5Key Laboratory of Liver Disease, Center of Infectious Diseases, Guangzhou 458 Hospital, Guangzhou, China.AbstractIncreasing evidence suggests that cytosolic non-specific dipeptidase 2 (CNDP2) appears to do more than just perform an enzymatic activity; it is functionally important in cancers as well. Here, we show that the expression of CNDP2 is commonly down-regulated in gastric cancer tissues. The ectopic expression of CNDP2 resulted in significant inhibition of cell proliferation, induction of cell apoptosis and cell cycle arrest, and suppressed gastric tumor growth in nude mice. We further revealed that the reintroduction of CNDP2 transcriptionally upregulated p38 and activated c-Jun NH2-terminal kinase (JNK), whereas the loss of CNDP2 increased the phosphorylation of extracellular signal-related kinase (ERK). These results suggest that CNDP2 acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway.
Molecular medicine (Cambridge, Mass.).Mol Med.2014 Dec 24;20(1):17-28. doi: 10.2119/molmed.2013.00102.
Increasing evidence suggests that cytosolic non-specific dipeptidase 2 (CNDP2) appears to do more than just perform an enzymatic activity; it is functionally important in cancers as well. Here, we show that the expression of CNDP2 is commonly down-regulated in gastric cancer tissues. The ectopic exp
PMID 24395568

Resveratrol Restores Sirtuin 1 (SIRT1) Activity and Pyruvate Dehydrogenase Kinase 1 (PDK1) Expression after Hemorrhagic Injury in a Rat Model.

Jian B, Yang S, Chaudry IH, Raju R.Author information Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.AbstractSevere hemorrhage leads to decreased blood flow to tissues resulting in decreased oxygen and nutrient availability affecting mitochondrial function. A mitoscriptome profiling study demonstrated alteration in several genes related to mitochondria, consistent with the mitochondrial functional decline observed after trauma hemorrhage (T-H). Our experiments led to the identification of sirtuin 1 (SIRT1) as a potential target in T-H. Administration of resveratrol (a naturally occurring polyphenol and activator of SIRT1) after T-H improved left ventricular function and tissue ATP levels. Our hypothesis was that mitochondrial function after T-H depends on SIRT1 activity. In this study, we evaluated the activity of SIRT1, a mitochondrial functional modulator, and the mitochondrial-glycolytic balance after T-H. We determined the changes in protein levels of pyruvate dehydrogenase kinase (PDK)-1 and nuclear c-Myc, peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α and NF-E2-related factor (NRF)2 after T-H and after treatment with resveratrol or a combination of sirtinol (a SIRT1 inhibitor) and resveratrol. We have also tested the activity of mitochondrial complex 1. SIRT1 enzyme activity was significantly decreased after T-H, whereas resveratrol treatment restored the activity. We found elevated PDK1 and c-Myc levels and decreased PGC-1α, NRF2 and mitochondrial complex I activity after T-H. The reduced SIRT1 activity after T-H may be related to declining mitochondrial function, since resveratrol was able to reinstate SIRT1 activity and mitochondrial function. The elevated level of PDK1 (an inhibitor of pyruvate dehydrogenase complex) after T-H indicates a possible shift in cellular energetics from mitochondria to glycolysis. In conclusion, SIRT1 modulation alters left ventricular function after T-H through regulation of cellular energetics.
Molecular medicine (Cambridge, Mass.).Mol Med.2014 Dec 24;20(1):10-6. doi: 10.2119/molmed.2013.00077.
Severe hemorrhage leads to decreased blood flow to tissues resulting in decreased oxygen and nutrient availability affecting mitochondrial function. A mitoscriptome profiling study demonstrated alteration in several genes related to mitochondria, consistent with the mitochondrial functional decline
PMID 24395567

Fatty Acid synthase inhibitor c75 ameliorates experimental colitis.

Matsuo S1, Yang WL2, Aziz M2, Kameoka S3, Wang P2.Author information 1Department of Surgery, Hofstra North Shore-Long Island Jewish School of Medicine, and The Feinstein Institute for Medical Research, Manhasset, New York, United States of America Department of Surgery II, Tokyo Women's Medical University, Tokyo, Japan.2Department of Surgery, Hofstra North Shore-Long Island Jewish School of Medicine, and The Feinstein Institute for Medical Research, Manhasset, New York, United States of America.3Department of Surgery II, Tokyo Women's Medical University, Tokyo, Japan.AbstractAbnormalities of lipid metabolism through overexpression of fatty acid synthase (FASN), which catalyzes the formation of long-chain fatty acids, are associated with the development of inflammatory bowel disease (IBD). C75 is a synthetic α-methylene-γ-butyrolactone compound that inhibits FASN activity. We hypothesized that C75 treatment could effectively reduce the severity of experimental colitis. Male C57BL/6 mice were fed 4% dextran sodium sulfate (DSS) for 7 d. C75 (5 mg/kg body weight) or dimethyl sulfoxide (DMSO) (vehicle) was administered intraperitoneally from d 2 to 6. Clinical parameters were monitored daily. Mice were euthanized on d 8 for histological evaluation and measurements of colon length, chemokine, cytokine and inflammatory mediator expression. C75 significantly reduced body weight loss from 23% to 15% on d 8, compared with the vehicle group. The fecal bleeding, diarrhea and colon histological damage scores in the C75-treated group were significantly lower than scores in the vehicle animals. Colon shortening was significantly improved after C75 treatment. C75 protected colon tissues from DSS-induced apoptosis by inhibiting caspase-3 activity. Macrophage inflammatory protein 2, keratinocyte-derived chemokine, myeloperoxidase activity and proinflammatory cytokines (tumor necrosis factor-α, interleukin [IL]-1β and IL-6) in the colon were significantly downregulated in the C75-treated group, compared with the vehicle group. Treatment with C75 in colitis mice inhibited the elevation of FASN, cyclooxygenase-2 and inducible nitric oxide synthase expression as well as IκB degradation in colon tissues. C75 administration alleviates the severity of colon damage and inhibits the activation of inflammatory pathways in DSS-induced colitis. Thus, inhibition of FASN may represent an attractive therapeutic potential for treating IBD.
Molecular medicine (Cambridge, Mass.).Mol Med.2014 Dec 24;20(1):1-9. doi: 10.2119/molmed.2013.00113.
Abnormalities of lipid metabolism through overexpression of fatty acid synthase (FASN), which catalyzes the formation of long-chain fatty acids, are associated with the development of inflammatory bowel disease (IBD). C75 is a synthetic α-methylene-γ-butyrolactone compound that inhibits FASN activ
PMID 24306512

Japanese Journal

Textus Roffensisの構成 : 古文書学的視点から

鶴島博和
熊本大学教育学部紀要. 人文科学 41, 1-38, 1992-09-30
NAID 110000953700

『征服』直後におけるサクソン系住民の改名について : アングロ=ノルマン期における農村の社会的諸関係の解明に向けて

鶴島博和
史学 60(1), 1-30, 1991
… For this purpose I used Textus Roffensis as a main source and therefore set geographical and time limits for this study within Kent c. … The research into Textus Roffensis leads me to the following conclusions. … Rodberto Latimi, et 〓lfuuino frater ejus praeposito de Chetham (Textus Roffensis fo. … In the second place, (2) Under this condition, some used French names as common or additional name : quidam Uulfuuardus, cognomine henricus de Hou (Textus Roffensis, fo. …
NAID 110007410619

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TEXTUS HEAL Hyaluron Sprühverband 15 05:10 Textus Receptus (> NT, griechisch Textus Receptus and The Authorised Kings Textus Receptus - Scrivener Greek NT and El Textus Receptus Elzevir Textus Receptus (1624) with Textus Roffensis: Law, Language and