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1. 心血管疾患のない患者における心血管リスクの推定 estimation of cardiovascular risk in an individual patient without known cardiovascular disease
2. 成人における抗癌剤の投与 dosing of anticancer agents in adults
3. Myocardial ischemic conditioning: Pathogenesis
4. Uncommon congenital adrenal hyperplasias
5. 幼児の持続性高インスリン血症性低血糖症の病因、臨床的特徴、および診断 pathogenesis clinical features and diagnosis of persistent hyperinsulinemic hypoglycemia of infancy

Japanese Journal

Single-Molecule Analysis of the Rotation of F1-ATPase under High Hydrostatic Pressure

Okuno Daichi,Nishiyama Masayoshi,Noji Hiroyuki
Biophysical Journal 105(7), 1635-1642, 2013-10-01
… F1-ATPase is the water-soluble part of ATP synthase and is an ATP-driven rotary molecular motor that rotates the rotary shaft against the surrounding stator ring, hydrolyzing ATP. … However, high hydrostatic pressure induced a distinct intervening pause at the ATP-binding angles during continuous rotation. …
NAID 120005328380

Conferring the ability to utilize inorganic polyphosphate on ATP-specific NAD kinase

Nakamichi Yusuke,Yoshioka Aya,Kawai Shigeyuki,Murata Kousaku
Scientific reports 3, 2013-09-11
… ATP特異性の獲得メカニズムの解明 : 新薬と新しい物質生産系の開発に期待. … ATP-specific NADK prefers ATP to inorganic polyphosphate [poly(P)] as a phosphoryl donor, whereas poly(P)/ATP-NADK utilizes both ATP and poly(P), and is employed in industrial mass production of NADP(+). …
NAID 120005327028

Involvement of the phosphatidylinositol kinase pathway in augmentation of ATP-sensitive K+ channel currents by hypo-osmotic stress in rat ventricular myocytes

Mitsuyama Hirofumi,Yokoshiki Hisashi,Irie Yuki,Watanabe Masaya,Mizukami Kazuya,Tsutsui Hiroyuki
Canadian journal of physiology and pharmacology 91(9), 686-692, 2013-09-00
… The objective of this study was to investigate the mechanisms of increase in the efficacy of ATP-sensitive K+ channel (K-ATP) openings by hypo-osmotic stress. … The whole-cell K-ATP currents (I-K,I-ATP) stimulated by 100 mu mol/L pinacidil, a K+ channel opening drug, were significantly augmented during hypo-osmotic stress (189 mOsmol/L) compared with normal conditions (303 mOsmol/L). …
NAID 120005333605

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