n.

阻害剤、阻害薬、抑制薬、抑制剤、(内在性物質について)インヒビター、抑制物質

関: blocker、depressant、suppressant

WordNet

a substance that retards or stops an activity
the 9th letter of the Roman alphabet (同)i
a class of drugs that inhibit (block) some biological process (同)blocking_agent
a football player whose responsibility is to block players attempting to stop an offensive play
capable of depressing physiological or psychological activity or response by a chemical agent
a drug that suppresses appetite (同)appetite_suppressant
limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
limit the range or extent of; "Contact between the young was inhibited by strict social customs"

PrepTutorEJDIC

抑制する人(物) / 化学反応抑制剤
『私は』私が
iodineの化学記号
機能低下剤,鎮静剤,抑制剤 / 鎮静効果のある / 意気消沈させる / 物価を抑制する
抑制剤
〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/22 19:53:46」(JST)

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UpToDate Contents

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1. 後天性の凝固因子阻害物質 acquired inhibitors of coagulation
2. 最新の診療アップデート practice changing updates
3. 後天性C1インヒビター欠損症：管理および予後 acquired c1 inhibitor deficiency management and prognosis
4. 後天性C1インヒビター欠損症：臨床症状、疫学、病因、および診断 acquired c1 inhibitor deficiency clinical manifestations epidemiology pathogenesis and diagnosis
5. C1阻害剤正常を示す遺伝性血管性浮腫（III型HAE） hereditary angioedema with normal c1 inhibitor type iii hae

English Journal

HIV takes double hit before entry.

Sanders RW.SourceLaboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands. r.w.sanders@amc.uva.nl
BMC biology.BMC Biol.2013 Dec 7;10:99. doi: 10.1186/1741-7007-10-99.
In the absence of a vaccine or a cure, identification of novel HIV-1 inhibitors remains important. A paper in Retrovirology describes a rationally designed bi-specific protein that irreversibly damages the viral envelope glycoprotein complex via a two-punch mechanism. In contrast to traditional drug
PMID 23216951

Conformational analysis and parallel QM/MM X-ray refinement of protein bound anti-Alzheimer drug donepezil.

Fu Z, Li X, Miao Y, Merz KM Jr.SourceDepartment of Chemistry and the Quantum Theory Project, 2328 New Physics Building, P.O. Box 118435, University of Florida, Gainesville, Florida, 32611-8435.
Journal of chemical theory and computation.J Chem Theory Comput.2013 Dec 3;9(3):1686-1693. Epub 2013 Feb 18.
The recognition and association of donepezil with acetylcholinesterase (AChE) has been extensively studied in the past several decades because of the former's use as a palliative treatment for mild Alzheimer disease. Herein we examine the conformational properties of donepezil and we re-examine the
PMID 23526889

Deficiencies in immunoassay methods used to monitor serum Estradiol levels during aromatase inhibitor treatment in postmenopausal breast cancer patients.

Jaque J, Macdonald H, Brueggmann D, Patel SK, Azen C, Clarke N, Stanczyk FZ.SourceDepartment of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, CA USA.
SpringerPlus.Springerplus.2013 Dec;2(1):5. Epub 2013 Jan 11.
Optimal care for breast cancer patients undergoing aromatase inhibitor (AI) treatment is ensured when estradiol (E2) levels are adequately suppressed. To assess treatment efficacy accurately, it is important to measure the serum E2 levels using a well validated assay method with high sensitivity and
PMID 23520572

Human follicular dendritic cells promote germinal center B cell survival by providing prostaglandins.

Kim J, Lee S, Kim YM, Jeoung DI, Choe J.SourceDepartment of Microbiology and Immunology, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, Republic of Korea.
Molecular immunology.Mol Immunol.2013 Oct;55(3-4):418-23. doi: 10.1016/j.molimm.2013.03.019. Epub 2013 Apr 11.
Evidence for the immunoregulatory function of lipid molecules in addition to proteins is accumulating. Based on our previous reports on the production of prostaglandin E2 (PGE2) and prostacyclin by human follicular dendritic cells (FDCs), we hypothesized that these prostaglandins (PGs) have a regula
PMID 23583086

Japanese Journal

Thromboxane A2 synthase inhibitors prevent production of infectious hepatitis C virus in mice with humanized livers.

Abe Yuichi,Aly Hussein Hassan,Hiraga Nobuhiko,Imamura Michio,Wakita Takaji,Shimotohno Kunitada,Chayama Kazuaki,Hijikata Makoto
Gastroenterology 145(3), 658-667.e11, 2013-09-00
… Small interfering RNA–mediated knockdown of thromboxane A2 synthase (TXAS) and incubation of hepatocytes with a TXAS inhibitor showed that this enzyme is required for production of infectious HCV, but does not affect replication of the HCV genome or particle release. … The TXAS inhibitor and a prostaglandin I2 receptor agonist, which has effects that are opposite those of thromboxane A2, reduced serum levels of HCV and inhibited the infection of human hepatocytes by blood-borne HCV in mice. …
NAID 120005324909

Nrf2-ARE経路活性化を介したドパミン神経保護作用の機序解析及びその活性化物質の探索

泉安彦
YAKUGAKU ZASSHI (藥學雜誌) 133(9), 983-988, 2013-09-00
… Treatment with lactacystin, a proteasome inhibitor, significantly suppressed 6-hydroxydopamine (6-OHDA)-induced toxicity and oxidative stress in PC12 cells. …
NAID 120005323877

Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response

Haniu Hisao,Saito Naoto,Matsuda Yoshikazu,Tsukahara Tamotsu,Maruyama Kayo,Usui Yuki,Aoki Kaoru,Takanashi Seiji,Kobayashi Shinsuke,Nomura Hiroki,Okamoto Masanori,Shimizu Masayuki,Kato Hiroyuki
Toxicology in Vitro 27(6), 1679-1685, 2013-09-00
… MWCNT uptake was suppressed by a clathrin-mediated endocytosis inhibitor and a caveolae-mediated endocytosis inhibitor in BEAS-2B cells cultured in Ham's F12 and HBEpCs cultured in SFGM. …
NAID 120005248282

Management of postoperative hemorrhage associated with factor VIII inhibitor: report of a case

Onishi Ichiro,Kayahara Masato,Munemoto Masayoshi,Sakai Seisyo,Makino Isamu,Hayashi Hironori,Nakagawara Hisatoshi,Tajima Hidehiro,Takamura Hiroyuki,Kitagawa Hirohisa,Tani Takashi,Ohta Tetsuo
Surgery Today 43(9), 1058-1061, 2013-09-00
… This report presents a case that was successfully treated for acquired factor VIII inhibitor after extensive visceral surgery. … An extensive coagulation work-up revealed factor VIII deficiency (1 %), and a diagnosis of an acquired factor VIII deficiency was established when a factor VIII inhibitor of 8 Bethesda units was demonstrated. … Inhibitor elimination was started using prednisolone on POD 20; …
NAID 120004754695

Related Pictures

★リンクテーブル★

リンク元	「100Cases 16」「I」「blocker」「depressant」「阻害剤」
拡張検索	「Bowman-Birk soybean trypsin inhibitor」「cyclin-dependent kinase inhibitors」「inhibitor of differentiation protein 3」「leukocyte migration-inhibitory factor」
関連記事	「inhibit」

「100Cases 16」

　　[★]

☆case16　膝の痛み

■glossary

indigestion 消化障害、消化不良

■症例

80歳　男性

主訴：左膝の痛みと腫脹

現病歴：左膝の痛みを2日前から認めた。膝は発熱・腫脹しており、動かすと疼痛を生じる。時々胸焼けと消化不良が見られる。6ヶ月前のhealth checkで、高血圧(172/102mmHg)と血中クレアチニンが高い(正常高値)こと以外は正常といわれた。その4週間数回血圧を測定したが、高値が継続したため、2.5mg bendrofluamethizide(UK)/ベンドロフルメチアジド bendroflumethiazide(US)で治療を開始した。最近の血圧は138/84 mmHgであった。

喫煙歴：なし。

飲酒歴：一週間に平均4unit。

既往歴：股関節に中程度(mild)の変形性関節症

家族歴：特記なし

服薬歴：アセトアミノフェン(股関節の疼痛に対して)

身体所見 examination

　血圧 142/86mmHg。体温37.5℃。脈拍88/分。grade 2 hypertensive retinopathy(高血圧症性網膜症)。心血管系、呼吸器系に検査場異常なし。手にDIPにヘバーデン結節なし。

　左膝が発熱し腫脹している。関節内に液、patellar tap陽性。90℃以上膝関節を屈曲させると痛みを生じる。右の膝関節は正常に見える。

検査　 investigation

　生化学：白血球増多、ESR 上昇、尿素高値、グルコース高値

　単純X線：関節間隙やや狭小。それ以外に異常は認めない。

■problem list

　#1 左膝の痛み

　#2 胸焼け

　#3 消化不良

　#4 高血圧

　#5 クレアチニン正常高値

　#6 股関節の変形性リウマチ

　#7 高血圧性網膜症

■考え方

　・関節痛の鑑別診断を考える。

　・VINDICATEで考えてみてもよいでしょう。

　・関節痛の頻度としては　外傷＞慢性疾患(OAなど)＞膠原病＞脊椎疾患＞悪性腫瘍

■関節痛の鑑別疾患

DIF 282

V Vascular 血友病 hemophilia, 壊血病 scurvy, 無菌性骨壊死 aseptic bone necrosis (Osgood-Schlatter diseaseとか)

I Inflammatory 淋疾 gonorrhea, ライム病 lyme disease, 黄色ブドウ球菌 Staphylococcus, 連鎖球菌 Streptococcus, 結核 tuberculosis, 梅毒 syphilis, 風疹 rubella, 単純ヘルペス herpes simplex, HIV human immunodeficiency virus, サイトメガロウイルス cytomegalovirus

N Neoplastic disorders 骨原性肉腫 osteogenic sarcoma, 巨細胞腫 giant cell tumors

D Degenerative disorders degenerative joint disease or 変形性関節症 osteoarthritis

I Intoxication 痛風 gout (uric acid), 偽痛風 pseudogout (calcium pyrophosphate), ループス症候群 lupus syndrome of hydralazine (Apresoline) and procainamide, gout syndrome of diuretics

C Congenital and acquired malformations bring to mind the joint deformities of tabes dorsalis and syringomyelia and congenital dislocation of the hip. Alkaptonuria is also considered here.