Pegbelfermin (BMS-986036), a PEGylated human fibroblast growth factor 21 (FGF21) analogue, has previously been shown to improve markers of metabolism and liver fibrosis in obese patients with type 2 diabetes. In this phase 2a study, we aimed to evaluate the safety and efficacy of pegbelfermin in pat
A MetAP2 inhibitor blocks adipogenesis, yet improves glucose uptake in cells.
Siddik MAB, Das BC, Weiss L, Dhurandhar NV, Hegde V.
Adipocyte. 2019 Dec;8(1)240-253.
Adipose tissue expansion involves angiogenesis to remodel its capillary network. The enzymemethionine aminopeptidase 2(MetAP2) promotes angiogenesis.MetAP2 inhibitors suppress angiogenesis and have potential anti-obesity effect. However, impairment in adipose tissue expansion is also linked with imp
PNPLA3-I148M: a problem of plenty in non-alcoholic fatty liver disease.
, B B, S S, S S, .
Adipocyte. 2019 Dec;8(1)201-208.
Fatty liver disease (FLD) affects more than one-third of the population in the western world and an increasing number of children in the United States. It is a leading cause of obesity and liver transplantation. Mechanistic insights into the causes of FLD are urgently needed since no therapeutic int