関: B7 molecules, CD80/CD86

同: B7-2, B70

関: B7 molecules, CD80/CD86

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/19 18:19:18」(JST)

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This article is about the molecule. For the compilation album, see CD86 (album).

Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.

The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily.^[1] Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.^[2]

Clinical significance

CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy.^[3]

References

^ Chen C, Gault A, Shen L, Nabavi N (May 1994). "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule". J. Immunol. 152 (10): 4929–36. PMID 7513726.
^ "Entrez Gene: CD86 CD86 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=942.
^ Steidl C, Lee T, Shah SP, Farinha P, Han G, Nayar T, Delaney A, Jones SJ, Iqbal J, Weisenburger DD, Bast MA, Rosenwald A, Muller-Hermelink HK, Rimsza LM, Campo E, Delabie J, Braziel RM, Cook JR, Tubbs RR, Jaffe ES, Lenz G, Connors JM, Staudt LM, Chan WC, Gascoyne RD (March 2010). "Tumor-associated macrophages and survival in classic Hodgkin's lymphoma". N. Engl. J. Med. 362 (10): 875–85. doi:10.1056/NEJMoa0905680. PMC 2897174. PMID 20220182. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2897174/.

UpToDate Contents

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1. BおよびTリンパ球の正常な発生 normal b and t lymphocyte development
2. 関節リウマチのT細胞標的療法 t cell targeted therapies for rheumatoid arthritis
3. 慢性関節リウマチにおける滑膜異常 synovial pathology in rheumatoid arthritis
4. 古典型ホジキンリンパ腫の疫学、病理学的特徴、および診断 epidemiology pathologic features and diagnosis of classical hodgkin lymphoma
5. 造血細胞移植後の移植片対腫瘍効果の生物学 biology of the graft versus tumor effect following hematopoietic cell transplantation

English Journal

Differences in B7 and CD28 family gene expression in the peripheral blood between newly diagnosed young-onset and adult-onset type 1 diabetes patients.

Pruul K1, Kisand K1, Alnek K1, Metsküla K1, Reimand K1, Heilman K2, Peet A3, Varik K4, Peetsalu M4, Einberg Ü5, Tillmann V3, Uibo R6.
Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 Sep 5;412:265-71. doi: 10.1016/j.mce.2015.05.012. Epub 2015 May 14.
Type-1 diabetes (T1D) is a heterogeneous autoimmune disease, and there are pathogenetic differences between young- and adult-onset T1D patients. We hypothesized that the expressions of genes involved in costimulatory immune system pathways in peripheral blood are differently regulated in young- and
PMID 25980680

Vascular endothelial growth factor affects dendritic cell activity in hypertensive disorders of pregnancy.

Wang J1, Tao YM2, Cheng XY3, Zhu TF3, Chen ZF4, Yao H1, Su LX1.
Molecular medicine reports.Mol Med Rep.2015 Sep;12(3):3781-6. doi: 10.3892/mmr.2015.3783. Epub 2015 May 14.
Vascular endothelial growth factor (VEGF) activity is involved in the growth and stability of the placenta, and its signaling has been implicated in the development of pregnancy‑induced hypertension (PIH). The present study sought to evaluate VEGF levels and dendritic cell (DC) profiles in patient
PMID 25975204

The infiltration and functional regulation of eosinophils induced by TSLP promote the proliferation of cervical cancer cell.

Xie F1, Liu LB2, Shang WQ3, Chang KK3, Meng YH3, Mei J3, Yu JJ3, Li DJ4, Li MQ5.
Cancer letters.Cancer Lett.2015 Aug 10;364(2):106-17. doi: 10.1016/j.canlet.2015.04.029. Epub 2015 May 12.
Cervical cancer is often associated with eosinophil (EOS) infiltration, but the source and the role of EOS are still largely unknown. Our previous work has established that thymic stromal lymphopoietin (TSLP) can stimulate the growth of cervical cancer cell in an autocrine manner. Here, we report th
PMID 25979231

Japanese Journal

JKCF1-2 Small interfering RNA against CD86 attenuates allergic airway inflammation(Inflammatory cells in allergic diseases,Free Paper Session 1,Japan-Korea-China Joint Symposium)

Asai Yukari
アレルギー 60(9・10), 1312, 2011-10-10
NAID 110008912137

The relationship between CD86 and CD54 protein expression and cytotoxicity following stimulation with contact allergen in THP-1 cells

NUKADA Yuko,ITO Yuichi,MIYAZAWA Masaaki,SAKAGUCHI Hitoshi,NISHIYAMA Naohiro
Journal of toxicological sciences 36(3), 313-324, 2011-06-01
Contact allergens induce the augmentation of cell surface molecules on and release of cytokines from Langerhans cells (LC) in skin sensitization. THP-1 and U937 cell lines, surrogates of LC, were used …
NAID 10029135868

Related Pictures

★リンクテーブル★

リンク元	「T細胞」「表面抗原分類」「CD80」
関連記事	「CD」

「T細胞」

CD86 molecule
	; PDB rendering based on 1i85.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1I85, 1NCN
Identifiers
Symbols	CD86; B7-2; B7.2; B70; CD28LG2; LAB72
External IDs	OMIM: 601020 MGI: 101773 HomoloGene: 10443 GeneCards: CD86 Gene
Gene Ontology
Molecular function	• receptor activity; • protein binding; • coreceptor activity;
Cellular component	• plasma membrane; • external side of plasma membrane; • integral to membrane; • intracellular membrane-bounded organelle;
Biological process	• toll-like receptor signaling pathway; • immune response; • cell-cell signaling; • positive regulation of cell proliferation; • virus-host interaction; • T cell costimulation; • T cell activation; • B cell activation; • positive regulation of lymphotoxin A biosynthetic process; • positive regulation of interleukin-2 biosynthetic process; • positive regulation of interleukin-4 biosynthetic process; • positive regulation of T-helper 2 cell differentiation; • positive regulation of transcription, DNA-dependent; • defense response to virus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

英: T cell
同: Tリンパ球、T lymphocyte
関: TCR、B細胞、MHC

図：IMM.315(T細胞の成熟)
胸腺で成熟したT細胞は血流によって移動し、リンパ節の傍皮質、白脾髄のリンパ性動脈周囲鞘、パイエル板の傍濾胞域に集まる(人間の正常構造と機能 VIIA血管・免疫 p.28)

種類

T細胞の抗原認識 (SP.248)

	CD	TCRが抗原と共に認識する分子	認識する細胞
Tc細胞	CD8	MHCクラスI	感染細胞
Th細胞	CD4	MHCクラスII	抗原提示細胞

CD4+ T細胞のサイトカイン放出とその原因

DCが認識する外来異物	DCが分泌する物質	DCに反応する細胞	この細胞が分泌するサイトカイン	NK系の細胞が放出したサイトカインに反応するTh細胞	Th細胞が分泌するサイトカイン
ウイルス、一部の細菌	IL-12	NK細胞(IL-12による)	INF-γ	Th1	IL-2, IFN-γ, TNF-β
原虫など		NKT細胞	IL-4	Th2	IL-4, IL-13, IL-5

Th細胞活性化と接着分子

	抗原提示細胞	Th細胞
主シグナル	MHC classII	TCR, CD3
主シグナル	MHC classII	CD4
副シグナル	B7{B7-1(CD80)/B7-2(CD86)}	CD28
	VCAM-1(CD106)	VLA-4
	ICAM-1	LFA-1
	LFA-3(CD58)	CD2

「表面抗原分類」

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「CD80」

　　[★]

関: B7 molecules, CD80/CD86

同: B7-1

「CD」

　　[★]

[pmid7513726-1] Chen C, Gault A, Shen L, Nabavi N (May 1994). "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule". J. Immunol. 152 (10): 4929–36. PMID 7513726.

[2] "Entrez Gene: CD86 CD86 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=942.

[pmid20220182-3] Steidl C, Lee T, Shah SP, Farinha P, Han G, Nayar T, Delaney A, Jones SJ, Iqbal J, Weisenburger DD, Bast MA, Rosenwald A, Muller-Hermelink HK, Rimsza LM, Campo E, Delabie J, Braziel RM, Cook JR, Tubbs RR, Jaffe ES, Lenz G, Connors JM, Staudt LM, Chan WC, Gascoyne RD (March 2010). "Tumor-associated macrophages and survival in classic Hodgkin's lymphoma". N. Engl. J. Med. 362 (10): 875–85. doi:10.1056/NEJMoa0905680. PMC 2897174. PMID 20220182. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2897174/.

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案内

案内

CD86