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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/04/22 11:00:35」(JST)
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| CD37 molecule |
| Identifiers |
| Symbols |
CD37 ; GP52-40; TSPAN26 |
| External IDs |
OMIM: 151523 MGI: 88330 HomoloGene: 20422 GeneCards: CD37 Gene |
| Gene ontology |
| Molecular function |
• protein binding
|
| Cellular component |
• immunological synapse
• integral to membrane
|
| Biological process |
• positive regulation of immunoglobulin production
• regulation of humoral immune response
|
| Sources: Amigo / QuickGO |
|
| RNA expression pattern |
|
| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
|
| Entrez |
951 |
12493 |
|
| Ensembl |
ENSG00000104894 |
ENSMUSG00000030798 |
|
| UniProt |
P11049 |
Q61470 |
|
| RefSeq (mRNA) |
NM_001040031 |
NM_007645 |
|
| RefSeq (protein) |
NP_001035120 |
NP_031671 |
|
| Location (UCSC) |
Chr 19:
49.84 – 49.85 Mb |
Chr 7:
45.23 – 45.24 Mb |
|
| PubMed search |
[1] |
[2] |
|
|
|
Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.[1][2]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.[2]
Contents
- 1 See also
- 2 References
- 3 Further reading
- 4 External links
See also
- Cluster of differentiation
References
- ^ Virtaneva KI, Angelisova P, Baumruker T, Horejsi V, Nevanlinna H, Schroder J (Mar 1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics 37 (6): 461–465. doi:10.1007/BF00222471. PMID 8436422.
- ^ a b "Entrez Gene: CD37 CD37 molecule".
Further reading
- Horejsí V, Vlcek C (1991). "Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63". FEBS Lett. 288 (1–2): 1–4. doi:10.1016/0014-5793(91)80988-F. PMID 1879540.
- Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell. Sci. 114 (Pt 23): 4143–51. PMID 11739647.
- Classon BJ, Williams AF, Willis AC et al. (1990). "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". J. Exp. Med. 172 (3): 1007–1007. doi:10.1084/jem.172.3.1007. PMC 2188538. PMID 2388030.
- Classon BJ, Williams AF, Willis AC et al. (1989). "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". J. Exp. Med. 169 (4): 1497–1502. doi:10.1084/jem.169.4.1497. PMC 2189247. PMID 2466944.
- Schwartz-Albiez R, Dörken B, Hofmann W, Moldenhauer G (1988). "The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein". J. Immunol. 140 (3): 905–14. PMID 3257508.
- Angelisová P, Hilgert I, Horejsí V (1994). "Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins". Immunogenetics 39 (4): 249–56. doi:10.1007/BF00188787. PMID 8119731.
- Wright MD, Rochelle JM, Tomlinson MG et al. (1993). "Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication". Int. Immunol. 5 (2): 209–216. doi:10.1093/intimm/5.2.209. PMID 8452817.
- Serru V, Le Naour F, Billard M et al. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
- Okochi H, Mine T, Nashiro K et al. (1999). "Expression of tetraspans transmembrane family in the epithelium of the gastrointestinal tract". J. Clin. Gastroenterol. 29 (1): 63–67. doi:10.1097/00004836-199907000-00016. PMID 10405235.
- Matsumoto K, Bochner BS, Wakiguchi H, Kurashige T (1999). "Functional expression of transmembrane 4 superfamily molecules on human eosinophils". Int. Arch. Allergy Immunol. 120 Suppl 1: 38–44. doi:10.1159/000053592. PMID 10529602.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- van Spriel AB, Puls KL, Sofi M et al. (2004). "A regulatory role for CD37 in T cell proliferation". J. Immunol. 172 (5): 2953–61. PMID 14978098.
- Suzuki Y, Yamashita R, Shirota M et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–1718. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Meyer-Wentrup F, Figdor CG, Ansems M et al. (2007). "Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production". J. Immunol. 178 (1): 154–62. PMID 17182550.
- Zhao X, Lapalombella R, Joshi T et al. (2007). "Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical". Blood 110 (7): 2569–2577. doi:10.1182/blood-2006-12-062927. PMC 1988922. PMID 17440052.
External links
- CD37 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
|
Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
|
|
| Arrestin |
|
|
| Membrane-spanning 4A |
- MS4A1
- MS4A2
- MS4A3
- MS4A4A
- MS4A4E
- MS4A5
- MS4A6A
- MS4A6E
- MS4A7
- MS4A8B
- MS4A9
- MS4A10
- MS4A12
- MS4A13
- MS4A14
- MS4A15
- MS4A18
|
|
| Myelin |
- Myelin basic protein
- Myelin proteolipid protein
- Myelin oligodendrocyte glycoprotein
- Myelin-associated glycoprotein
- Myelin protein zero
|
|
| Pulmonary surfactant |
- Pulmonary surfactant-associated protein B
- Pulmonary surfactant-associated protein C
|
|
| Tetraspanin |
- TSPAN1
- TSPAN2
- TSPAN3
- TSPAN4
- TSPAN5
- TSPAN6
- TSPAN7
- TSPAN8
- TSPAN9
- TSPAN10
- TSPAN11
- TSPAN12
- TSPAN13
- TSPAN14
- TSPAN15
- TSPAN16
- TSPAN17
- TSPAN18
- TSPAN19
- TSPAN20
- TSPAN21
- TSPAN22
- TSPAN23
- TSPAN24
- TSPAN25
- TSPAN26
- TSPAN27
- TSPAN28
- TSPAN29
- TSPAN30
- TSPAN31
- TSPAN32
- TSPAN33
- TSPAN34
|
|
| Other/ungrouped |
- Calnexin
- LDL-receptor-related protein-associated protein
- Neurofibromin 2
- Presenilin
- HFE
- Phospholipid transfer proteins
- Dysferlin
- STRC
- OTOF
|
|
|
see also other cell membrane protein disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), other
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English Journal
- Transcriptional response of Atlantic salmon (Salmo salar) after primary versus secondary exposure to infectious salmon anemia virus (ISAV).
- Leblanc F, Arseneau JR, Leadbeater S, Glebe B, Laflamme M, Gagné N.SourceDepartment of Fisheries & Oceans Canada, Gulf Fisheries Center, Moncton, NB, Canada.
- Molecular immunology.Mol Immunol.2012 Jun;51(2):197-209. Epub 2012 Apr 3.
- Following an infection with a specific pathogen, the acquired immune system of many teleostean fish, including salmonids, is known to retain a specific memory of the infectious agent, which protects the host against subsequent infections. For example, Atlantic salmon (Salmo salar) that have survived
- PMID 22475434
- Draft genome sequence of the nontoxigenic Clostridium difficile strain CD37.
- Brouwer MS, Allan E, Mullany P, Roberts AP.SourceUCL Eastman Dental Institute, London, UK.
- Journal of bacteriology.J Bacteriol.2012 Apr;194(8):2125-6.
- Here we report the draft genome sequence of Clostridium difficile strain CD37, the first nontoxigenic strain sequenced. Every sequenced strain of Clostridium difficile has been shown to contain multiple different mobile genetic elements. The draft genome sequence of strain CD37 reveals the presence
- PMID 22461557
Japanese Journal
- Expression and Function of Transmembrane-4 Superfamily (Tetraspanin) Proteins in Osteoclasts: Reciprocal Roles of Tspan-5 and NET-6 during Osteoclastogenesis
- Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal co-stimulatory conditions
- Expression of tetra-spans transmembrane family ( CD9, CD37, CD53, CD63, CD81 and CD82 ) in normal and neoplastic human keratinocytes : an association of CD9 with α3β1 integrin
Related Links
- フローサイトメトリー入門 サイトメトリーとは FCMの歴史 FCMの原理入門講座 フローサイトメトリー用語辞典 フローサイトメトリー用蛍光色素 初心者のためのFCM入門(PPT) 初めてFCMを使う方のために 臨床検査のフローサイトメトリー
- 【発明の詳細な説明】 【技術分野】 【0001】 本発明は、B細胞枯渇を基礎とする免疫療法に関する。特に本発明は、そのような療法、例えばB細胞悪性疾患及び自己免疫症状の治療で使用される抗CD37抗体分子に関する。
Related Pictures
★リンクテーブル★
[★]
- 英
- cluster of differentiation, CD
- Bリンパ球 CD10,CD19,CD20
- Tリンパ球 CD2,CD3,CD5,CD7
- 幹細胞 CD34
- 顆粒球 CD13,CD33
- 単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。
- 巨核球 CD41(GpIIb),CD42(GpIb)
- NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)
[★]
- 関
- TCR, ζ
発現細胞
機能
- Associated with the T-cell antigen receptor(TCR)
- ζと共にTCRで受容したシグナルを細胞内に伝達する
[★]