同: Integrin p3 subunit

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/02/21 06:19:15」(JST)

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Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene.^[5] CD61 is a cluster of differentiation found on thrombocytes.^[6]

Structure and function

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.^[7]

Role in endometriosis

Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition.^[8]

Interactions

CD61 has been shown to interact with PTK2,^[9]^[10] ITGB3BP,^[11]^[12] TLN1^[13]^[14] and CIB1.^[15]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000259207 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020689 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (August 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest. 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653 . PMID 2454952.
^ Heemskerk, J. W. M.; Mattheij, N. J. A.; Cosemans, J. M. E. M. (2013). "Platelet-based coagulation: different populations, different functions". Journal of Thrombosis and Haemostasis. 11 (1): 2–16. doi:10.1111/jth.12045. ISSN 1538-7933.
^ "Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)".
^ May, K. E.; Villar, J.; Kirtley, S.; Kennedy, S. H.; Becker, C. M. (2011). "Endometrial alterations in endometriosis: A systematic review of putative biomarkers". Human Reproduction Update. 17 (5): 637–653. doi:10.1093/humupd/dmr013. PMID 21672902.
^ Eliceiri, Brian P; Puente Xose S; Hood John D; Stupack Dwayne G; Schlaepfer David D; Huang Xiaozhu Z; Sheppard Dean; Cheresh David A (April 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. United States. 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263 . PMID 11927607.
^ Chung, J; Gao A G; Frazier W A (June 1997). "Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3". J. Biol. Chem. UNITED STATES. 272 (23): 14740–6. doi:10.1074/jbc.272.23.14740. ISSN 0021-9258. PMID 9169439.
^ Fujimoto, Tetsuro-Takahiro; Katsutani Shinya; Shimomura Takeshi; Fujimura Kingo (January 2002). "Novel alternatively spliced form of beta(3)-endonexin". Thromb. Res. United States. 105 (1): 63–70. doi:10.1016/S0049-3848(01)00405-4. ISSN 0049-3848. PMID 11864709.
^ Shattil, S J; O'Toole T; Eigenthaler M; Thon V; Williams M; Babior B M; Ginsberg M H (November 1995). "Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit". J. Cell Biol. UNITED STATES. 131 (3): 807–16. doi:10.1083/jcb.131.3.807. ISSN 0021-9525. PMC 2120613 . PMID 7593198.
^ Patil, S; Jedsadayanmata A; Wencel-Drake J D; Wang W; Knezevic I; Lam S C (October 1999). "Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail". J. Biol. Chem. UNITED STATES. 274 (40): 28575–83. doi:10.1074/jbc.274.40.28575. ISSN 0021-9258. PMID 10497223.
^ Calderwood, David A; Yan Boxu; de Pereda Jose M; Alvarez Begoña García; Fujioka Yosuke; Liddington Robert C; Ginsberg Mark H (June 2002). "The phosphotyrosine binding-like domain of talin activates integrins". J. Biol. Chem. United States. 277 (24): 21749–58. doi:10.1074/jbc.M111996200. ISSN 0021-9258. PMID 11932255.
^ Naik, U P; Patel P M; Parise L V (February 1997). "Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain". J. Biol. Chem. UNITED STATES. 272 (8): 4651–4. doi:10.1074/jbc.272.8.4651. ISSN 0021-9258. PMID 9030514.

External links

CD61 Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)
ITGB3 Info with links in the Cell Migration Gateway
Human ITGB3 genome location and ITGB3 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 自動血液分析装置 automated hematology instrumentation
2. Transient myeloproliferative disorder of Down syndrome
3. 血小板機能検査 platelet function testing
4. 急性骨髄性白血病の分類 classification of acute myeloid leukemia
5. 骨髄異形成症候群の臨床症状および診断 clinical manifestations and diagnosis of the myelodysplastic syndromes

English Journal

Functional Characterization of TPO-Expanded CD34(+) Cord Blood Cells Identifies CD34(-) CD61(-) Cells as Platelet-Producing Cells Early After Transplantation in NOD/SCID Mice and rCD34(+) Cells as CAFC Colony-Forming Cells.

Schipper LF, Brand A, Fibbe WE, Van Hensbergen Y.SourceSanquin Blood Supply Foundation, Division of Research, Department of Transfusion Medicine, Leiden, The Netherlands.
Stem cells (Dayton, Ohio).Stem Cells.2012 May;30(5):988-96. doi: 10.1002/stem.1071.
Transplantation of thrombopoietin (TPO)-expanded cord blood CD34(+) cells accelerates human platelet recovery in NOD/SCID mice. It is unknown which subpopulations of the TPO-expanded cells mediate accelerated platelet recovery and bone marrow (BM) engraftment. In this study, the contribution of the
PMID 22378601

PET imaging of angiogenesis after myocardial infarction/reperfusion using a one-step labeled integrin-targeted tracer (18)F-AlF-NOTA-PRGD2.

Gao H, Lang L, Guo N, Cao F, Quan Q, Hu S, Kiesewetter DO, Niu G, Chen X.SourceDepartment of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China, 710032.
European journal of nuclear medicine and molecular imaging.Eur J Nucl Med Mol Imaging.2012 Apr;39(4):683-92. Epub 2012 Jan 25.
PURPOSE: The α(v)β(3) integrin represents a potential target for noninvasive imaging of angiogenesis. The purpose of this study was to evaluate a novel one-step labeled integrin α(v)β(3)-targeting positron emission tomography (PET) probe, (18)F-AlF-NOTA-PRGD2, for angiogenesis imaging in a myoca
PMID 22274731

Japanese Journal

非血小板粒子・巨大血小板出現におけるセルダインサファイアを用いたCD61免疫学的血小板数測定の有用性

権藤和美
日本検査血液学会雑誌 8, 319-327, 2007
NAID 50006625351

Platelet Activation in Patients with Alcoholic Liver Disease

OGASAWARA Fusao,FUSEGAWA Hisae,HARUKI Yasuo,SHIRAISHI Koichi,WATANABE Norihito,MATSUZAKI Shohei
Tokai journal of experimental and clinical medicine 30(1), 41-48, 2005-04
… Methods: Platelet activation was evaluated by flow cytometry using monoclonal antibodies against P-selectin (CD62P) and the fibrinogen receptor (PAC-1), both specific for platelet activation, and anti-CD61 antibody for the presence of microparticles (PMP) in seven patients with Al-FL, thirteen patients with Al-LC and, as a non-alcoholic liver disease control, nine patients with C-LC. …
NAID 110005051990

Related Pictures

CD61 SAE Thread to Flange Head Adapters On Anchor Fluid Power CD61/CD62 NPTF 4-Bolt Stainless Steel Flanges On Anchor Fluid Power Mouse Monoclonal Anti-CD61 Platelet Glycoprotein Illa (Clone Y2/51) Anti-CD61 Antibody Products | Biocompare.com CD61 (2f2) CD61/CD62 Braze-On JIC Fittings On Anchor Fluid Power Anti-CD61 / Integrin beta-3 Antibody Clone ITGB3/1713 – enQuire BioReagents CD61 Antibody (Clone 2F2) - شرکت سما تشخیص آریا

★リンクテーブル★

リンク元	「血小板」「表面抗原分類」
関連記事	「CD」

「血小板」

ITGB3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4O02, 1JV2, 1KUP, 1KUZ, 1L5G, 1M1X, 1M8O, 1MIZ, 1MK7, 1MK9, 1S4X, 1TYE, 1U8C, 2K9J, 2KNC, 2KV9, 2L1C, 2L91, 2LJD, 2LJE, 2LJF, 2MTP, 2Q6W, 2RMZ, 2RN0, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3IJE, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 5HDB, 4Z7Q, 4Z7O, 4Z7N
Identifiers
Aliases	ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT, integrin subunit beta 3
External IDs	OMIM: 173470 MGI: 96612 HomoloGene: 55444 GeneCards: ITGB3
Gene location (Human)
Chr.	Chromosome 17 (human)
End	47,311,816 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	104,670,476 bp
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• vascular endothelial growth factor receptor 2 binding; • fibronectin binding; • virus receptor activity; • extracellular matrix binding; • protein disulfide isomerase activity; • protease binding; • platelet-derived growth factor receptor binding; • protein binding; • identical protein binding; • enzyme binding; • cell adhesion molecule binding; • receptor activity; • neuregulin binding; • coreceptor activity; • fibroblast growth factor binding; • insulin-like growth factor I binding; • C-X3-C chemokine binding;
Cellular component	• integral component of membrane; • cell projection; • alphav-beta3 integrin-vitronectin complex; • membrane; • focal adhesion; • melanosome; • receptor complex; • plasma membrane; • integral component of plasma membrane; • ruffle membrane; • cell surface; • cell junction; • integrin complex; • platelet alpha granule membrane; • integrin alphav-beta3 complex; • extracellular exosome; • lamellipodium membrane; • nucleus; • microvillus membrane; • filopodium membrane; • alphav-beta3 integrin-IGF-1-IGF1R complex;
Biological process	• negative regulation of lipoprotein metabolic process; • apolipoprotein A-I-mediated signaling pathway; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • positive regulation of protein phosphorylation; • regulation of cell migration; • negative chemotaxis; • positive regulation of endothelial cell proliferation; • tube development; • negative regulation of low-density lipoprotein particle receptor biosynthetic process; • heterotypic cell-cell adhesion; • angiogenesis involved in wound healing; • wound healing; • platelet degranulation; • blood coagulation; • extracellular matrix organization; • smooth muscle cell migration; • positive regulation of endothelial cell migration; • cell growth; • cell-substrate adhesion; • vascular endothelial growth factor receptor signaling pathway; • cell adhesion; • positive regulation of peptidyl-tyrosine phosphorylation; • mesodermal cell differentiation; • cell-substrate junction assembly; • integrin-mediated signaling pathway; • negative regulation of lipid storage; • substrate adhesion-dependent cell spreading; • negative regulation of lipid transport; • cell-matrix adhesion; • viral process; • regulation of bone resorption; • platelet aggregation; • cell migration; • negative regulation of macrophage derived foam cell differentiation; • activation of protein kinase activity; • leukocyte migration; • cell adhesion mediated by integrin; • platelet activation;
	Sources:Amigo / QuickGO
Orthologs
	3690
	16416
	ENSG00000259207
	ENSMUSG00000020689
	P05106
	O54890
	NM_000212
	NM_016780
	NP_000203
	NP_058060
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

英: platelet (Z), blood platelet (Z), PLT
同: 栓球 thrombocyte
関: 血小板血栓。血小板数 platelet count PLC

GOO. 1468(血小板凝集 platelet aggregation)
半減期:1週間(異常値の出るメカニズム第2版)。4日 (SP.505)。
寿命：10日
体積：5-10 fl
直径：2-5μm。
無核。

基準値

15万 - 40万 /μl (2007前期解剖学授業プリント, SP.505)
15万 - 35万 /μl (2007前期生理学授業プリント, PT.233)

新生児

10-28万/mm3 (SPE.74)

パニック値

出典不明

≦3万 /μl、≧100万 /ul

産生組織

骨髄の巨核球

トロンボポエチンにより巨核球の細胞質がちぎれて血流に放出される (SP.505)

貯蔵組織

約1/3が脾臓に存在

組織学

α顆粒 α-granule

P-セレクチンを膜上に持つ

フィブリノーゲン、フィブロネクチン、第V因子、第VIII因子、platelet factor 4、PDGF、TGF-α (BPT.89)

濃染顆粒　dense body

ADP、ATP、Ca2+、ヒスタミン、セロトニン、エピネフリン (BPT.89)

機能 (SAN.236-237)

1.一次止血

(1) 内皮が剥離した部位にvWFが結合
(2) 血小板のGpIb/GpIXを介してvWFに結合
(3) GpIIb/IpIIIa複合体を膜状に発現。血小板が変形し顆粒を放出(ADP, TXA₂,セロトニン)

TXA₂,セロトニンは血管収縮作用

ADP, TXA₂,セロトニンは血小板凝集

血小板のGpIIb/GpIIIa複合体がフィブリノゲンと結合し編み目を形成

2.血液凝固の促進

血小板表面のリン脂質がIX因子やX因子を結合し活性化する

3.毛細血管機能の維持

毛細血管内皮細胞に融合し血管内皮を補強している　→　血小板減少により点状出血を来すことになる。

膜タンパク

ファミリー	慣用名	CD分類	リガンド	機能	欠損症
インテグリン	GpIIb	CD41	フィブリノゲン	凝集	Glanzmann血小板無力症(GT)
	GpIIIa	CD61
LRG	GpIb	CD42bc	vWF	粘着	ベルナール・スリエ症候群(BSS)
	GpIX	CD42a
	GpV	CD42d

血小板減少による症状

5-10万　：症状なし-やや止血しにくい程度
2-3万　：下肢に点状出血 (→皮下出血)
1万以下：粘膜出血→臓器出血の危険あり

検査

抗凝固剤としてEDTAを用いた場合、EDTA依存性偽血小板減少をきたすことがある。

臨床関連

数の異常

増加：血小板増多症：真性多血症
減少：血小板減少症：肝硬変、多発性骨髄腫、巨赤芽球小生貧血、急性骨髄性白血病、播種性血管内凝固、溶血性尿毒症症候群、ITP、TTP
不変：→　グランツマン血小板無力症、血友病　　see also. 機能の異常

肝硬変(肝線維化のマーカーとして使われる。肝線維化が進むと血小板減少。肝線維化マーカー)　←　トロンボポエチンが肝臓で産生されることと関係していると考えて良い？

機能の異常

灰色血小板症候群

ストレージプール病の一つ。α顆粒の欠如

「表面抗原分類」

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「CD」

　　[★]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000259207 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020689 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid2454952-5] Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (August 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest. 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653 . PMID 2454952.

[HeemskerkMattheij2013-6] Heemskerk, J. W. M.; Mattheij, N. J. A.; Cosemans, J. M. E. M. (2013). "Platelet-based coagulation: different populations, different functions". Journal of Thrombosis and Haemostasis. 11 (1): 2–16. doi:10.1111/jth.12045. ISSN 1538-7933.

[7] "Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)".

[8] May, K. E.; Villar, J.; Kirtley, S.; Kennedy, S. H.; Becker, C. M. (2011). "Endometrial alterations in endometriosis: A systematic review of putative biomarkers". Human Reproduction Update. 17 (5): 637–653. doi:10.1093/humupd/dmr013. PMID 21672902.

[pmid11927607-9] Eliceiri, Brian P; Puente Xose S; Hood John D; Stupack Dwayne G; Schlaepfer David D; Huang Xiaozhu Z; Sheppard Dean; Cheresh David A (April 2002). "Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. Cell Biol. United States. 157 (1): 149–60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263 . PMID 11927607.

[pmid9169439-10] Chung, J; Gao A G; Frazier W A (June 1997). "Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3". J. Biol. Chem. UNITED STATES. 272 (23): 14740–6. doi:10.1074/jbc.272.23.14740. ISSN 0021-9258. PMID 9169439.

[pmid11864709-11] Fujimoto, Tetsuro-Takahiro; Katsutani Shinya; Shimomura Takeshi; Fujimura Kingo (January 2002). "Novel alternatively spliced form of beta(3)-endonexin". Thromb. Res. United States. 105 (1): 63–70. doi:10.1016/S0049-3848(01)00405-4. ISSN 0049-3848. PMID 11864709.

[pmid7593198-12] Shattil, S J; O'Toole T; Eigenthaler M; Thon V; Williams M; Babior B M; Ginsberg M H (November 1995). "Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit". J. Cell Biol. UNITED STATES. 131 (3): 807–16. doi:10.1083/jcb.131.3.807. ISSN 0021-9525. PMC 2120613 . PMID 7593198.

[pmid10497223-13] Patil, S; Jedsadayanmata A; Wencel-Drake J D; Wang W; Knezevic I; Lam S C (October 1999). "Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail". J. Biol. Chem. UNITED STATES. 274 (40): 28575–83. doi:10.1074/jbc.274.40.28575. ISSN 0021-9258. PMID 10497223.

[pmid11932255-14] Calderwood, David A; Yan Boxu; de Pereda Jose M; Alvarez Begoña García; Fujioka Yosuke; Liddington Robert C; Ginsberg Mark H (June 2002). "The phosphotyrosine binding-like domain of talin activates integrins". J. Biol. Chem. United States. 277 (24): 21749–58. doi:10.1074/jbc.M111996200. ISSN 0021-9258. PMID 11932255.

[pmid9030514-15] Naik, U P; Patel P M; Parise L V (February 1997). "Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain". J. Biol. Chem. UNITED STATES. 272 (8): 4651–4. doi:10.1074/jbc.272.8.4651. ISSN 0021-9258. PMID 9030514.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

匿名

検索

案内

CD61