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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/21 16:00:09」(JST)

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CD94 (Cluster of Differentiation 94), also known as killer cell lectin-like receptor subfamily D, member 1 (KLRD1) is a human gene.^[1]

The protein encoded by CD94 gene is a lectin, cluster of differentiation and a receptor that is involved in cell signaling and is expressed on the surface of natural killer cells in the innate immune system. CD94 pairs with the NKG2 molecule as a heterodimer. The CD94/NKG2 complex, on the surface of natural killer cells interacts with Human Leukocyte Antigen (HLA)-E on target cells.

Function

Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. KLRD1 has two alternatively spliced variants that differ in the presence or absence of exon 2 sequence.^[1]

Interactions

KLRD1 has been shown to interact with KLRC2.^[2]^[3]

References

^ ^a ^b "Entrez Gene: KLRD1 killer cell lectin-like receptor subfamily D, member 1".
^ Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH (Dec 1996). "Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits". Journal of Immunology 157 (11): 4741–5. PMID 8943374.
^ Ding Y, Sumitran S, Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scandinavian Journal of Immunology 49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. PMID 10320637.

External links

CD94 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

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English Journal

Diversification of both KIR and NKG2 natural killer cell receptor genes in macaques - implications for highly complex MHC-dependent regulation of natural killer cells.

Walter L1, Petersen B1.
Immunology.Immunology.2017 Feb;150(2):139-145. doi: 10.1111/imm.12666. Epub 2016 Oct 5.
The killer immunoglobulin-like receptors (KIR) as well as their MHC class I ligands display enormous genetic diversity and polymorphism in macaque species. Signals resulting from interaction between KIR or CD94/NKG2 receptors and their cognate MHC class I proteins essentially regulate the activity o
PMID 27565739

NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection.

Marshall NB1, Vong AM1, Devarajan P1, Brauner MD1, Kuang Y1, Nayar R1, Schutten EA1, Castonguay CH1, Berg LJ1, Nutt SL2,3, Swain SL4.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2017 Feb 1;198(3):1142-1155. doi: 10.4049/jimmunol.1601297. Epub 2016 Dec 28.
CD4 T cells can differentiate into multiple effector subsets, including ThCTL that mediate MHC class II-restricted cytotoxicity. Although CD4 T cell-mediated cytotoxicity has been reported in multiple viral infections, their characteristics and the factors regulating their generation are unclear, in
PMID 28031335

Differential pulmonic NK and NKT cell responses in Schistosoma japonicum-infected mice.

Cha H1, Qin W2,3, Yang Q1, Xie H1, Qu J1, Wang M1, Chen D1, Wang F4, Dong N5, Chen L6, Huang J7.
Parasitology research.Parasitol Res.2017 Feb;116(2):559-567. doi: 10.1007/s00436-016-5320-y. Epub 2016 Nov 30.
Natural killer cells (NK cells) and natural killer T cells (NKT cells) play a role in anti-infection, anti-tumor, transplantation immunity, and autoimmune regulation. However, the role of NK and NKT cells during Schistosoma japonicum (S. japonicum) infection has not been widely reported, especially
PMID 27904959

Japanese Journal

2)流産における免疫学的機序の解明 : 免疫グロブリン治療は流産抑止に有効か(シンポジウム1「流産の原因と対策」,第63回日本産科婦人科学会・学術講演会)

島田茂樹
日本産科婦人科學會雜誌 63(12), 2153-2166, 2011-12-01
… G: The expressions of inhibitory receptors, CD 158a and CD94, in the decicual NK cells of MSNK were significantly decreased as compared with those of MSAK or IA. … A positive correlation between CD94 and CD158a expressions on NK cells, negative correlations between CD94 on NK cells and perforin on NKcells/Tc cells, and between CD158a on NK cells and perforin on Tc cells were found. …
NAID 110008799035

Binding Affinities of NKG2D and CD94 to Sialyl Lewis X-Expressing N-Glycans and Heparin

Higai Koji,Suzuki Chiho,Imaizumi Yuzo,Xin Xin,Azuma Yutaro,Matsumoto Kojiro
Biological and Pharmaceutical Bulletin 34(1), 2011
… Lectin-like receptors natural killer group 2D (NKG2D) and CD94 on natural killer (NK) cells bind to α2,3-NeuAc-containing N-glycans and heparin/heparan sulfate (HS). …
NAID 130000402255

Related Pictures

★リンクテーブル★

リンク元	「表面抗原分類」
関連記事	「CD」

「表面抗原分類」

Killer cell lectin-like receptor subfamily D, member 1
	PDB rendering based on 1b6e.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1B6E, 3BDW, 3CDG, 3CII
Identifiers
Symbols	KLRD1 ; CD94
External IDs	OMIM: 602894 MGI: 1196275 HomoloGene: 1705 GeneCards: KLRD1 Gene
Gene ontology
Molecular function	• transmembrane signaling receptor activity; • protein binding; • MHC class I protein complex binding; • MHC class Ib protein binding, via antigen binding groove; • carbohydrate binding; • protein antigen binding;
Cellular component	• plasma membrane; • external side of plasma membrane; • integral component of membrane; • receptor complex;
Biological process	• natural killer cell mediated immunity; • cell surface receptor signaling pathway; • innate immune response; • regulation of immune response;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「CD」

　　[★]

[entrez-1] "Entrez Gene: KLRD1 killer cell lectin-like receptor subfamily D, member 1".

[pmid8943374-2] Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH (Dec 1996). "Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits". Journal of Immunology 157 (11): 4741–5. PMID 8943374.

[pmid10320637-3] Ding Y, Sumitran S, Holgersson J (May 1999). "Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells". Scandinavian Journal of Immunology 49 (5): 459–65. doi:10.1046/j.1365-3083.1999.00566.x. PMID 10320637.

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案内

CD94