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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/22 20:50:16」(JST)
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| CD7 molecule |
| Identifiers |
| Symbols |
CD7 ; GP40; LEU-9; TP41; Tp40 |
| External IDs |
OMIM: 186820 MGI: 88344 HomoloGene: 4471 GeneCards: CD7 Gene |
| Gene ontology |
| Molecular function |
• receptor activity
|
| Cellular component |
• plasma membrane
• membrane
• integral component of membrane
• extracellular vesicular exosome
|
| Biological process |
• immune response
• transmembrane receptor protein tyrosine kinase signaling pathway
• T cell activation
• homeostasis of number of cells within a tissue
|
| Sources: Amigo / QuickGO |
|
| RNA expression pattern |
|
|
| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
|
| Entrez |
924 |
12516 |
|
| Ensembl |
ENSG00000173762 |
ENSMUSG00000025163 |
|
| UniProt |
P09564 |
P50283 |
|
| RefSeq (mRNA) |
NM_006137 |
NM_009854 |
|
| RefSeq (protein) |
NP_006128 |
NP_033984 |
|
| Location (UCSC) |
Chr 17:
80.27 – 80.28 Mb |
Chr 11:
121.04 – 121.04 Mb |
|
| PubMed search |
[1] |
[2] |
|
|
|
CD7 (Cluster of Differentiation 7) is a protein that in humans is encoded by the CD7 gene.[1]
Contents
- 1 Function
- 2 See also
- 3 Interactions
- 4 Clinical significance
- 5 References
- 6 Further reading
- 7 External links
Function
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.[1]
See also
- Cluster of differentiation
Interactions
CD7 has been shown to interact with PIK3R1.[2][3]
Clinical significance
CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis.[4] Also, a lack of CD7 expression could insinuate mycosis fungoides (MF) or Sezary syndrome (SS).[5]
References
- ^ a b "Entrez Gene: CD7 CD7 molecule".
- ^ Lee DM, Patel DD, Pendergast AM, Haynes BF (Aug 1996). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif". Int. Immunol. 8 (8): 1195–203. doi:10.1093/intimm/8.8.1195. PMID 8918688.
- ^ Subrahmanyam G, Rudd CE, Schneider H (Jan 2003). "Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover". Eur. J. Immunol. 33 (1): 46–52. doi:10.1002/immu.200390006. PMID 12594831.
- ^ Yasuko H, Hideto T, Mariko I, Namiko O, Asaka K, Keiichi M et al. (2013). "CD7 Expression On Blasts Of Myelodysplastic Syndromes Is Associated With Apoptosis Resistance With Decreased Expression Of The Proapoptotic Protein Bad and An Independent Unfavorable Prognostic Factor Together With The Revised IPSS Score In Patients". Blood 122 (21): 2799.
- ^ Stevens SR, Baron ED, Masten S, Cooper KD (2002). "Circulating CD4+CD7- lymphocyte burden and rapidity of response: predictors of outcome in the treatment of Sézary syndrome and erythrodermic mycosis fungoides with extracorporeal photopheresis". Arch Dermatol 138 (10): 1347–50. doi:10.1001/archderm.138.10.1347. PMID 12374541.
Further reading
- Stillwell R, Bierer BE (2002). "T cell signal transduction and the role of CD7 in costimulation.". Immunol. Res. 24 (1): 31–52. doi:10.1385/IR:24:1:31. PMID 11485208.
- Baker E, Sandrin MS, Garson OM, Sutherland GR, McKenzie IF, Webber LM (1990). "Localization of the cell surface antigen CD7 by chromosomal in situ hybridization.". Immunogenetics 31 (5-6): 412–3. doi:10.1007/BF02115022. PMID 1695199.
- Schanberg LE, Fleenor DE, Kurtzberg J, Haynes BF, Kaufman RE (1991). "Isolation and characterization of the genomic human CD7 gene: structural similarity with the murine Thy-1 gene.". Proc. Natl. Acad. Sci. U.S.A. 88 (2): 603–7. doi:10.1073/pnas.88.2.603. PMC 50860. PMID 1703303.
- Yoshikawa K, Seto M, Ueda R, Obata Y, Notake K, Yokochi T et al. (1991). "Molecular cloning of the gene coding for the human T cell differentiation antigen CD7.". Immunogenetics 33 (5-6): 352–60. doi:10.1007/BF00216694. PMID 1711009.
- Ware RE, Scearce RM, Dietz MA, Starmer CF, Palker TJ, Haynes BF (1990). "Characterization of the surface topography and putative tertiary structure of the human CD7 molecule.". J. Immunol. 143 (11): 3632–40. PMID 2479685.
- Osada S, Utsumi KR, Ueda R, Akao Y, Tsuge I, Nishida K et al. (1988). "Assignment of a gene coding for a human T-cell antigen with a molecular weight of 40,000 daltons to chromosome 17.". Cytogenet. Cell Genet. 47 (1-2): 8–10. doi:10.1159/000132494. PMID 3258561.
- Aruffo A, Seed B (1988). "Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system.". EMBO J. 6 (11): 3313–6. PMC 553785. PMID 3501369.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Lee DM, Schanberg LE, Fleenor DE, Seldin MF, Haynes BF, Kaufman RE (1996). "The mouse CD7 gene: identification of a new element common to the human CD7 and mouse Thy-1 promoters.". Immunogenetics 44 (2): 108–14. doi:10.1007/s002510050097. PMID 8662072.
- Bevec T, Stoka V, Pungercic G, Dolenc I, Turk V (1996). "Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L.". J. Exp. Med. 183 (4): 1331–8. doi:10.1084/jem.183.4.1331. PMC 2192513. PMID 8666891.
- Leta E, Hou Z, Lederman L, Jung LK (1996). "Interaction between the extracellular domain of CD7 and concanavalin A: a clue to the identity of the ligand for CD7.". Cell. Immunol. 173 (1): 15–21. doi:10.1006/cimm.1996.0247. PMID 8871597.
- Lee DM, Patel DD, Pendergast AM, Haynes BF (1997). "Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif.". Int. Immunol. 8 (8): 1195–203. doi:10.1093/intimm/8.8.1195. PMID 8918688.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Slentz-Kesler KA, Hale LP, Kaufman RE (1998). "Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms.". Genomics 47 (3): 327–40. doi:10.1006/geno.1997.5151. PMID 9480746.
- Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S et al. (1999). "Three novel proteins of the syntaxin/SNAP-25 family.". J. Biol. Chem. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
- Pace KE, Lee C, Stewart PL, Baum LG (1999). "Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1.". J. Immunol. 163 (7): 3801–11. PMID 10490978.
- Lyman SD, Escobar S, Rousseau AM, Armstrong A, Fanslow WC (2000). "Identification of CD7 as a cognate of the human K12 (SECTM1) protein.". J. Biol. Chem. 275 (5): 3431–7. doi:10.1074/jbc.275.5.3431. PMID 10652336.
- Rotem-Yehudar R, Galperin E, Horowitz M (2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29.". J. Biol. Chem. 276 (35): 33054–60. doi:10.1074/jbc.M009913200. PMID 11423532.
- Rossi MI, Yokota T, Medina KL, Garrett KP, Comp PC, Schipul AH et al. (2003). "B lymphopoiesis is active throughout human life, but there are developmental age-related changes.". Blood 101 (2): 576–84. doi:10.1182/blood-2002-03-0896. PMID 12393702.
External links
- CD7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Cluster of differentiation by lineage
|
|
| Lymphoid |
| B cell |
- Pre-B cell: CD10/CALLA
- CD79A
- mature: CD19
- CD20
- CD21/CR2
- CD23/FcεRII
- CD127
- CD40
|
|
| T/NK |
| T cell |
- CD1
- CD4
- CD8
- CD13
- CD18
- CD26
- CD27
- CD28
|
|
| NK cell |
|
|
| All |
|
|
|
| All |
|
|
|
| Myeloid |
CFU-GM/
Myelomonocyte |
- CD11c
- CD14
- CD15
- CD31
- CD64
- CD68
|
|
| MEP |
|
|
| All (pan-myeloid) |
|
|
|
| Stem cell |
|
|
|
Index of cells from bone marrow
|
|
| Description |
- Immune system
- Cells
- Physiology
- coagulation
- proteins
- granule contents
- colony-stimulating
- heme and porphyrin
|
|
| Disease |
- Red blood cell
- Monocyte and granulocyte
- Neoplasms and cancer
- Histiocytosis
- Symptoms and signs
- Blood tests
|
|
| Treatment |
- Transfusion
- Drugs
- thrombosis
- bleeding
- other
|
|
Index of the immune system
|
|
| Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
|
|
| Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
|
|
| Treatment |
- Procedures
- Drugs
- antihistamines
- immunostimulants
- immunosuppressants
- monoclonal antibodies
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Heterogeneity of Abnormal RUNX1 Leading to Clinicopathologic Variations in Childhood B-Lymphoblastic Leukemia.
- Knez VM1, Carstens BJ2, Swisshelm KL2, McGranahan AN3, Liang X4.
- American journal of clinical pathology.Am J Clin Pathol.2015 Aug;144(2):305-14. doi: 10.1309/AJCPVY5E5OMMYBFJ.
- OBJECTIVES: Abnormalities of the RUNX1 gene in childhood B-acute lymphoblastic leukemia (B-ALL) are manifested by ETV6-RUNX1 or RUNX1 amplification. A detailed comparison between the two regarding clinicopathologic features with genetic analysis has not been performed previously. This parallel study
- PMID 26185316
- Extranodal NK/T cell lymphoma and aggressive NK cell leukaemia: evidence for their origin on CD56+bright CD16-/+dim NK cells.
- Lima M1.
- Pathology.Pathology.2015 Jul 10. [Epub ahead of print]
- Mature natural killer (NK) cell neoplasms are classified by the World Health Organization into extranodal NK/T cell lymphoma, nasal type (ENKTL) and aggressive NK cell leukaemia (ANKL). In order to propose their normal NK cell counterparts, we reviewed the literature on the phenotype of the neoplast
- PMID 26166665
- Acute megakaryoblastic leukemia associated with trisomy 21 demonstrates a distinct immunophenotype.
- Wang L1, Peters JM1,2, Fuda F1, Li L1, Karandikar NJ1,3, Koduru P1, Wang HY1,4, Chen W1.
- Cytometry. Part B, Clinical cytometry.Cytometry B Clin Cytom.2015 Jul 8;88(4):244-52. doi: 10.1002/cyto.b.21198. Epub 2014 Oct 31.
- BACKGROUND: Acute megakaryoblastic leukemia (AMKL) is a rare form of acute myeloid leukemia that encompasses three distinct subgroups: children with Down syndrome (DS-AMKL), children without DS (non-DS-AMKL), and adults (adult-AMKL). We hypothesize that the biological differences in the subtypes of
- PMID 25361478
Japanese Journal
- Leukemic T cells are specifically enriched in a unique CD3^<dim>CD7^<low> subpopulation of CD4^+ T cells in acute-type adult T-cell leukemia
- TIAN Yamin,KOBAYASHI Seiichro,OHNO Nobuhiro,ISOBE Masamichi,TSUDA Mayuko,ZAIKE Yuji,WATANABE Nobukazu,TANI Kenzaburo,TOJO Arinobu,UCHIMARU Kaoru
- Cancer science 102(3), 569-577, 2011-03-10
- NAID 10029291148
Related Links
- CD7抗原は分子量40kDaの単鎖タンパクです。胸腺移入前のTリンパ球前駆細胞に 発現します。CD7は胸腺細胞や、大半の末梢血T細胞球にみられます。ほとんどのNK 細胞、pre-Bリンパ球にも発現し、単球にも弱く発現します。成熟Bリンパ球および顆粒球 は ...
- ラパラのCD7販売。ルアー通販ショップのソルトベイト。シーバスルアーを格安販売。 ヒラメルアー、メバルルアー、青物ルアーも充実.
Related Pictures
★リンクテーブル★
[★]
- 英
- cluster of differentiation, CD
- Bリンパ球 CD10,CD19,CD20
- Tリンパ球 CD2,CD3,CD5,CD7
- 幹細胞 CD34
- 顆粒球 CD13,CD33
- 単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。
- 巨核球 CD41(GpIIb),CD42(GpIb)
- NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)
[★]
- 同
- MB1, immunoglobulin a
[★]
[★]