- 同
- pj Integrin chain, Very late antigen p- chain, Platelet glycoprotein IIA
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Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/28 16:44:09」(JST)
[Wiki en表示]
| Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) |
Rendering based on PDB 1K11. |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
|
3G9W, 3T9K, 3VI3, 3VI4, 4DX9
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| Identifiers |
| Symbols |
ITGB1; CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA; VLAB |
| External IDs |
OMIM: 135630 MGI: 96610 HomoloGene: 22999 ChEMBL: 1905 GeneCards: ITGB1 Gene |
| Gene Ontology |
| Molecular function |
• glycoprotein binding
• fibronectin binding
• protease binding
• actin binding
• receptor activity
• integrin binding
• protein binding
• collagen binding
• protein kinase binding
• protein domain specific binding
• peptide binding
• laminin binding
• metal ion binding
• protein heterodimerization activity
• alpha-actinin binding
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| Cellular component |
• acrosomal vesicle
• ruffle
• basement membrane
• cytoplasm
• plasma membrane
• focal adhesion
• integrin complex
• external side of plasma membrane
• cell surface
• intercalated disc
• hemidesmosome
• filopodium
• neuromuscular junction
• cleavage furrow
• ruffle membrane
• alpha3-beta1 integrin complex
• alpha8-beta1 integrin complex
• alpha9-beta1 integrin complex
• myelin sheath abaxonal region
• sarcolemma
• melanosome
• membrane raft
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| Biological process |
• G1/S transition of mitotic cell cycle
• in utero embryonic development
• cell fate specification
• tissue homeostasis
• cell migration involved in sprouting angiogenesis
• cellular calcium ion homeostasis
• cellular defense response
• homophilic cell adhesion
• leukocyte cell-cell adhesion
• cell-matrix adhesion
• calcium-independent cell-matrix adhesion
• integrin-mediated signaling pathway
• axon guidance
• blood coagulation
• regulation of G-protein coupled receptor protein signaling pathway
• positive regulation of cell proliferation
• negative regulation of cell proliferation
• germ cell migration
• positive regulation of cell-substrate adhesion
• positive regulation of neuron projection development
• response to activity
• cell migration
• virus-host interaction
• B cell differentiation
• positive regulation of cell migration
• negative regulation of cell projection organization
• protein transport within lipid bilayer
• cell-cell adhesion mediated by integrin
• cell junction assembly
• response to gonadotropin stimulus
• response to drug
• positive regulation of apoptotic process
• positive regulation of MAPK cascade
• sarcomere organization
• negative regulation of neuron differentiation
• positive regulation of neuron differentiation
• positive regulation of endocytosis
• positive regulation of peptidyl-tyrosine phosphorylation
• regulation of immune response
• leukocyte migration
• regulation of cell cycle
• cardiac muscle cell differentiation
• maternal process involved in female pregnancy
• tight junction assembly
• cellular response to mechanical stimulus
• cellular response to vitamin D
• cellular response to ionizing radiation
• response to transforming growth factor beta stimulus
• negative regulation of anoikis
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| Sources: Amigo / QuickGO |
|
| RNA expression pattern |
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| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
|
| Entrez |
3688 |
16412 |
|
| Ensembl |
ENSG00000150093 |
ENSMUSG00000025809 |
|
| UniProt |
P05556 |
P09055 |
|
| RefSeq (mRNA) |
NM_002211 |
NM_010578 |
|
| RefSeq (protein) |
NP_002202 |
NP_034708 |
|
| Location (UCSC) |
Chr 10:
33.19 – 33.29 Mb |
Chr 8:
128.69 – 128.73 Mb |
|
| PubMed search |
[1] |
[2] |
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Integrin beta-1 is a protein that in humans is encoded by the ITGB1 gene.[1] CD29 is an integrin unit associated with very late antigen receptors. It is known to conjoin with alpha-3 subunit to create α3β1 complex that reacts to such molecules as netrin-1 and reelin.
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. The protein encoded by this gene is a beta subunit. Six alternatively spliced variants have been found for this gene which encode five proteins with alternate carboxy termini.[2]
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Contents
- 1 Interactions
- 2 References
- 3 Further reading
- 4 External links
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Interactions
CD29 has been shown to interact with TSPAN4,[3] CD9,[4][5] Filamin,[6][7] FLNB,[6] CD81,[5][8] CD46,[9] MAP4K4,[10] FHL2,[11] NME1,[12] PKC alpha,[13][14] YWHAB,[15] ITGB1BP1,[16][17] LGALS8[18] and GNB2L1.[13][19] A neutralizing antibody for CD29 is AIIB2.
References
- ^ Goodfellow PJ, Nevanlinna HA, Gorman P, Sheer D, Lam G, Goodfellow PN (July 1989). "Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2". Ann Hum Genet 53 (Pt 1): 15–22. doi:10.1111/j.1469-1809.1989.tb01118.x. PMID 2524991.
- ^ "Entrez Gene: ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)".
- ^ Tachibana, I; Bodorova J, Berditchevski F, Zutter M M, Hemler M E (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. (UNITED STATES) 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. ISSN 0021-9258. PMID 9360996.
- ^ Radford, K J; Thorne R F, Hersey P (May. 1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma". Biochem. Biophys. Res. Commun. (UNITED STATES) 222 (1): 13–8. doi:10.1006/bbrc.1996.0690. ISSN 0006-291X. PMID 8630057.
- ^ a b Mazzocca, Antonio; Carloni Vinicio, Sciammetta Silvia, Cordella Claudia, Pantaleo Pietro, Caldini Anna, Gentilini Paolo, Pinzani Massimo (September 2002). "Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration". J. Hepatol. (England) 37 (3): 322–30. doi:10.1016/S0168-8278(02)00175-7. ISSN 0168-8278. PMID 12175627.
- ^ a b van der Flier, Arjan; Kuikman Ingrid, Kramer Duco, Geerts Dirk, Kreft Maaike, Takafuta Toshiro, Shapiro Sandor S, Sonnenberg Arnoud (January 2002). "Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin β subunits". J. Cell Biol. (United States) 156 (2): 361–76. doi:10.1083/jcb.200103037. ISSN 0021-9525. PMC 2199218. PMID 11807098.
- ^ Loo, D T; Kanner S B, Aruffo A (September 1998). "Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction". J. Biol. Chem. (UNITED STATES) 273 (36): 23304–12. doi:10.1074/jbc.273.36.23304. ISSN 0021-9258. PMID 9722563.
- ^ Serru, V; Le Naour F, Billard M, Azorsa D O, Lanza F, Boucheix C, Rubinstein E (May. 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. (ENGLAND) 340 (Pt 1): 103–11. doi:10.1042/0264-6021:3400103. ISSN 0264-6021. PMC 1220227. PMID 10229664.
- ^ Lozahic, S; Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (March 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. (GERMANY) 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. ISSN 0014-2980. PMID 10741407.
- ^ Poinat, Patrice; De Arcangelis Adèle, Sookhareea Satis, Zhu Xiaoping, Hedgecock Edward M, Labouesse Michel, Georges-Labouesse Elisabeth (April 2002). "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans". Curr. Biol. (England) 12 (8): 622–31. doi:10.1016/S0960-9822(02)00764-9. ISSN 0960-9822. PMID 11967148.
- ^ Wixler, V; Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. (UNITED STATES) 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324.
- ^ Fournier, Henri-Noël; Dupé-Manet Sandra, Bouvard Daniel, Lacombe Marie-Lise, Marie Christiane, Block Marc R, Albiges-Rizo Corinne (June 2002). "Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement". J. Biol. Chem. (United States) 277 (23): 20895–902. doi:10.1074/jbc.M200200200. ISSN 0021-9258. PMID 11919189.
- ^ a b Lee, H-S; Millward-Sadler S J, Wright M O, Nuki G, Al-Jamal R, Salter D M (November 2002). "Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction". Osteoarthr. Cartil. (England) 10 (11): 890–7. doi:10.1053/joca.2002.0842. ISSN 1063-4584. PMID 12435334.
- ^ Parsons, Maddy; Keppler Melanie D, Kline Adam, Messent Anthea, Humphries Martin J, Gilchrist Ruth, Hart Ian R, Quittau-Prevostel Corinne, Hughes William E, Parker Peter J, Ng Tony (August 2002). "Site-Directed Perturbation of Protein Kinase C- Integrin Interaction Blocks Carcinoma Cell Chemotaxis". Mol. Cell. Biol. (United States) 22 (16): 5897–911. doi:10.1128/MCB.22.16.5897-5911.2002. ISSN 0270-7306. PMC 133968. PMID 12138200.
- ^ Han, D C; Rodriguez L G, Guan J L (January 2001). "Identification of a novel interaction between integrin beta1 and 14-3-3beta". Oncogene (England) 20 (3): 346–57. doi:10.1038/sj.onc.1204068. ISSN 0950-9232. PMID 11313964.
- ^ Chang, D D; Wong C, Smith H, Liu J (September 1997). "ICAP-1, a Novel β1 Integrin Cytoplasmic Domain–associated Protein, Binds to a Conserved and Functionally Important NPXY Sequence Motif of β1 Integrin". J. Cell Biol. (UNITED STATES) 138 (5): 1149–57. doi:10.1083/jcb.138.5.1149. ISSN 0021-9525. PMC 2136751. PMID 9281591.
- ^ Chang, David D; Hoang Bao Q, Liu Jenny, Springer Timothy A (March 2002). "Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin". J. Biol. Chem. (United States) 277 (10): 8140–5. doi:10.1074/jbc.M109031200. ISSN 0021-9258. PMID 11741908.
- ^ Hadari, Y R; Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (July 2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell. Sci. (ENGLAND). 113 ( Pt 13): 2385–97. ISSN 0021-9533. PMID 10852818.
- ^ Liliental, J; Chang D D (January 1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol. Chem. (UNITED STATES) 273 (4): 2379–83. doi:10.1074/jbc.273.4.2379. ISSN 0021-9258. PMID 9442085.
Further reading
- Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". Bioessays 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216.
- Armulik A (2002). "Splice variants of human beta 1 integrins: origin, biosynthesis and functions". Front. Biosci. 7: d219–27. doi:10.2741/armulik. PMID 11779688.
- Brakebusch C, Fässler R (2006). "beta 1 integrin function in vivo: adhesion, migration and more". Cancer Metastasis Rev. 24 (3): 403–11. doi:10.1007/s10555-005-5132-5. PMID 16258728.
External links
- CD29 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
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Integrins
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| Alpha |
A1 · A2 · A3 · A4 · A5 · A6 · A7 · A8 · A9 · A10 · A11 · AD · AE · AL · AM · AV · AX
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| Beta |
B1 · B2 · B3 · B4 · B5 · B6 · B7 · B8
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| Dimers |
Cytoadhesin receptor: Integrin alpha6beta4 · Glycoprotein IIb/IIIa (ITGA2B+ITGB3)
Fibrinogen receptor: Macrophage-1 antigen (CD11b+CD18)
Fibronectin receptor: Integrin alpha2beta1 · Integrin alpha4beta1 · Integrin alpha5beta1
Leukocyte-adhesion receptor: LFA-1 (CD11a+CD18) · Macrophage-1 antigen (CD11b+CD18) · Integrin alphaXbeta2 (CD11c+CD18)
Very late antigen receptor: Integrin alpha1beta1 · Integrin alpha2beta1 · Integrin alpha3beta1 · VLA-4 (CD49d+CD29) · Alpha-5 beta-1 · Integrin alpha6beta1
Vitronectin receptor: Alpha-v beta-3 · Alpha-v beta-5
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see also cell surface receptor deficiencies
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
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English Journal
- Differentiation of human amniotic fluid-derived mesenchymal stem cells into type II alveolar epithelial cells in vitro.
- Li Y1, Xu W1, Yan J1, Xia Y2, Gu C1, Ma Y2, Tao H2.
- International journal of molecular medicine.Int J Mol Med.2014 Jun;33(6):1507-13. doi: 10.3892/ijmm.2014.1705. Epub 2014 Mar 19.
- Type II alveolar epithelial cells (AECII) play a key role in maintaining normal alveolar homeostasis and repair. AECII derived from exogenous stem cells may provide novel treatment options for distal lung diseases. In this study, to explore whether amniotic fluid-derived mesenchymal stem cells (AFMS
- PMID 24647685
- The effect of Arbas Cashmere goat bone marrow stromal cells on production of transgenic cloned embryos.
- Ren Y1, Wu H1, Wang H1, Wang X1, Liang H1, Liu D2.
- Theriogenology.Theriogenology.2014 Jun;81(9):1257-67. doi: 10.1016/j.theriogenology.2014.02.007. Epub 2014 Feb 13.
- The aim of this study was to develop a method for the in vitro separation and culture of Arbas Cashmere goat bone marrow stromal cells (gBMSCs). Arbas Cashmere gBMSCs were isolated and cultured in vitro, and cell surface markers were identified immunohistochemically. The gBMSCs were differentiated
- PMID 24679907
- Isolation, expansion and characterisation of mesenchymal stem cells from human bone marrow, adipose tissue, umbilical cord blood and matrix: a comparative study.
- Secunda R1, Vennila R, Mohanashankar AM, Rajasundari M, Jeswanth S, Surendran R.
- Cytotechnology.Cytotechnology.2014 May 6. [Epub ahead of print]
- The multipotent and immunosuppressive capacities of mesenchymal stem cells (MSCs) attract several scientists worldwide towards translational research focusing on treatment of diseases including liver failure. Though MSC's have been isolated from different sources, researchers do not concur on the be
- PMID 24798808
Japanese Journal
- Effects of the Dichloromethane Fraction of Dipsaci Radix on the Osteoblastic Differentiation of Human Alveolar Bone Marrow-Derived Mesenchymal Stem Cells
- KIM Beom-Su,KIM Yoon-Chul,ZADEH Homa,PARK Yoon-Jeong,PI Sung-Hee,SHIN Hyung-Shik,YOU Hyung-Keun
- Bioscience, Biotechnology, and Biochemistry 75(1), 13-19, 2011
- … They showed a fibroblast-like morphology and expressed CD29, CD44, CD73, and CD105, but not CD34. …
- NAID 130000406528
- Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages.
- TSUKUBA Takayuki,YANAGAWA Michiyo,OKAMOTO Kuniaki,OKAMOTO Yoshiko,YASUDA Yoshiyuki,NAKAYAMA Keiichi I.,KADOWAKI Tomoko,YAMAMOTO Kenji
- The journal of biochemistry 145(5), 565-573, 2009-05-01
- … Similar to the chemotactic receptors, the surface expressions of the adhesion receptors CD18 (integrin beta(2)) and CD 29 (integrin beta(1)) in CatE(-/-) macrophages were significantly decreased, thereby reducing cell attachment of CatE(-/-) macrophages. …
- NAID 10025588729
Related Links
- CD29抗原（血小板GPⅡa）は、130kDaのインテグリンβ1鎖で、インテグリンα1～α8とαVサブユニットと非共有結合的に結合したヘテロダイマーとして発現します。CD29複合体は、CD29に結合するα鎖に依存して、細胞間および細胞と細胞外 ...
- T細胞サブセットであるCD4+(CD4参照)細胞の中で,CD29+細胞は,ヘルパーインデュサーT細胞と称されます。抗体産生を促進するヘルパーT細胞に働きかけ,その働きを誘導する機能を有しています。機能的なカウンターパートナーとして,CD4 ...
Related Pictures
★リンクテーブル★
[★]
- 英
- adhesion molecule
- 同
- 接着因子
- 関
接着分子のファミリー
白血球の相互作用に関与している接着分子 (IMM.87)
白血球の相互作用に関与している免疫グロブリンスーパーファミリーの接着分子 (IMM.329)
-接着分子
-細胞接着分子
-カドヘリン
[★]
- 英
- cluster of differentiation, CD
- Bリンパ球 CD10,CD19,CD20
- Tリンパ球 CD2,CD3,CD5,CD7
- 幹細胞 CD34
- 顆粒球 CD13,CD33
- 単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。
- 巨核球 CD41(GpIIb),CD42(GpIb)
- NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)
[★]
- 英
- integrin, integrins
- 関
インテグリン IMM.87
[★]
- 英
- CD29 antigen
- 関
- β1インテグリン、インテグリンβ1
[★]
CD29抗原
- 関
- beta1 integrin、integrin beta1
[★]
- 同
- Leucine-5, SRBC receptor, LFA-2
- 関
- CD
発現細胞
分子量
機能
- リンパ球が抗原提示細胞と相互作用するのに重要 (IMM.343)
別名
ファミリー
[★]