同: Transferrin receptor

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/11/28 12:34:22」(JST)

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Transferrin receptor protein 1 (TfR1) also known as (Cluster of Differentiation 71) (CD71) is a protein that in humans is encoded by the TFRC gene.^[1]^[2] TfR1 is required for iron delivery from transferrin to cells.^[3]^[4]

Structure and function

TfR1 is a transmembrane glycoprotein composed of two disulfide-linked monomers joined by two disulfide bonds. Each monomer binds one holo-transferrin molecule creating an iron-Tf-TfR complex which enters the cell by endocytosis.^[5]

Clinical significance

CD71 as a potential new target in cases of human leukemia & lymphoma. InatherYs, in Évry, France, developed a candidate drug, INA01 antibody (anti-CD71) that showed efficacy in pre-clinical studies in the therapy of two incurable orphan oncohematological diseases: the adult T cell leukemia (ATLL) caused by HTLV-1 and the Mantle cell lymphoma (MCL).^{[citation needed]}

Interactions

TFRC has been shown to interact with GABARAP^[6] and HFE.^[7]^[8]

References

^ Sutherland R, Delia D, Schneider C, Newman R, Kemshead J, Greaves M (July 1981). "Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin". Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4515–9. doi:10.1073/pnas.78.7.4515. PMC 319822. PMID 6270680.
^ Rabin M, McClelland A, Kühn L, Ruddle FH (November 1985). "Regional localization of the human transferrin receptor gene to 3q26.2----qter". Am. J. Hum. Genet. 37 (6): 1112–6. PMC 1684729. PMID 3002171.
^ Aisen P (November 2004). "Transferrin receptor 1". Int. J. Biochem. Cell Biol. 36 (11): 2137–43. doi:10.1016/j.biocel.2004.02.007. PMID 15313461.
^ Moos T (November 2002). "Brain iron homeostasis". Danish Medical Bulletin 49 (4): 279–301. PMID 12553165.
^ Speeckaert MM, Speeckaert R, Delanghe JR (December 2010). "Biological and clinical aspects of soluble transferrin receptor". Critical Reviews in Clinical Laboratory Sciences 47 (5-6): 213–228. doi:10.3109/10408363.2010.550461. PMID 21391831.
^ Green F, O'Hare T, Blackwell A, Enns CA (May 2002). "Association of human transferrin receptor with GABARAP". FEBS Lett. 518 (1–3): 101–6. doi:10.1016/S0014-5793(02)02655-8. PMID 11997026.
^ Feder JN, Penny DM, Irrinki A, Lee VK, Lebrón JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC (February 1998). "The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding". Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1472–7. doi:10.1073/pnas.95.4.1472. PMC 19050. PMID 9465039.
^ West AP, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ (December 2000). "Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE". J. Biol. Chem. 275 (49): 38135–8. doi:10.1074/jbc.C000664200. PMID 11027676.

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1. 成人における鉄欠乏性貧血の原因および診断 causes and diagnosis of iron deficiency anemia in the adult
2. 慢性疾患の貧血（［慢性］炎症時の貧血） anemia of chronic disease anemia of chronic inflammation
3. 鉄のバランス調節 regulation of iron balance
4. 遺伝性ヘモクロマトーシスの遺伝学 genetics of hereditary hemochromatosis
5. 高齢の成人における貧血 anemia in the older adult

English Journal

CD71 targeting boosts immunogenicity of sublingually delivered influenza haemagglutinin antigen and protects against viral challenge in mice.

Mann JF1, Tregoning JS1, Aldon Y1, Shattock RJ1, McKay PF2.
Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2016 Apr 16;232:75-82. doi: 10.1016/j.jconrel.2016.04.022. [Epub ahead of print]
The delivery of vaccines to the sublingual mucosa is an attractive prospect due to the ease and acceptability of such an approach. However, novel adjuvant and delivery approaches are required to optimally vaccinate at this site. We have previously shown that conjugation of protein antigen to the iro
PMID 27094605

The Form of Choline in the Maternal Diet Affects Immune Development in Suckled Rat Offspring.

Lewis ED1, Richard C1, Goruk S1, Dellschaft NS2, Curtis JM1, Jacobs RL1, Field CJ3.
The Journal of nutrition.J Nutr.2016 Apr;146(4):823-30. doi: 10.3945/jn.115.225888. Epub 2016 Mar 2.
BACKGROUND: Lipid-soluble phosphatidylcholine (PC) and aqueous free choline are absorbed and metabolized differently, but the metabolic effects of feeding these 2 forms of choline have not been thoroughly investigated.OBJECTIVE: We sought to compare the effects of PC and free choline in the maternal
PMID 26936140

Scanning Electron Microscopy Reveals Two Distinct Classes of Erythroblastic Island Isolated from Adult Mammalian Bone Marrow.

Yeo JH1, McAllan BM2, Fraser ST1.
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada.Microsc Microanal.2016 Apr;22(2):368-78. doi: 10.1017/S1431927616000155. Epub 2016 Feb 22.
Erythroblastic islands are multicellular clusters in which a central macrophage supports the development and maturation of red blood cell (erythroid) progenitors. These clusters play crucial roles in the pathogenesis observed in animal models of hematological disorders. The precise structure and fun
PMID 26898901

Japanese Journal

Dedifferentiation of Human Terminally Differentiating Keratinocytes into Their Precursor Cells Induced by Basic Fibroblast Growth Factor

Sun Xiaoyan,Fu Xiaobing,Han Weidong,Zhao Yali,Liu Huiling,Sheng Zhiyong
Biological & Pharmaceutical Bulletin 34(7), 1037-1045, 2011
… Moreover, these dedifferentiation-derived KSCs (dKSCs) showed an ability for high colony formation correlated with cell cycle analysis showing a marked accumulation in S phases, acquired a similar regional distribution of both α6-integrin and CD71 expression at the ultrastructural level, and had a increased proliferative capacity by releasing telomerase from nucleolar sites to nucleoplasmic distribution. …
NAID 130000738093

硫化水素によるヒト歯肉上皮幹細胞のアポトーシス誘導

落合真美
口腔衛生学会雑誌 60(3), 224-232, 2010-07-30
… は,H_2Sがヒト歯肉由来の上皮幹細胞でアポトーシスを誘導することを証明し,さらにアポトーシスシグナル伝達経路の活性化メカニズムを検討した.ヒト歯肉上皮幹細胞は,α_6β_4インテグリンと増殖関連マーカーCD71を用いて磁気分離した.分離した細胞は幹細胞マーカーのp63とサイトケラチン19,角化上皮細胞マーカーのサイトケラチン10とインボルクリンの発現を免疫染色にて観察した.ヒト歯肉上皮幹細胞は,H_2S濃度50ng/mLに …
NAID 110008513535

Related Pictures

Anti-CD71: Rabbit CD71 Antibody | Cell CD71 (D7G9X) XP® Rabbit mAb #13113 | CST CD71 Antibody (3B8 2A1) | Santa Cruz Mouse CD71 (Transferrin Receptor) Antibody CD71 Antibody Anti-CD71 - RI7217 AP Transferrin receptor/CD71 Antibody CD71 , based on their CD71/Ter119 expression Gene Therapy - Figure 3 for article: The

★リンクテーブル★

リンク元	「表面抗原分類」
関連記事	「CD」

「表面抗原分類」

Transferrin receptor
	; PDB rendering based on 1cx8.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1CX8, 1DE4, 1SUV, 2NSU, 3KAS, 3S9L, 3S9M, 3S9N
Identifiers
Symbols	TFRC ; CD71; T9; TFR; TFR1; TR; TRFR; p90
External IDs	OMIM: 190010 MGI: 98822 HomoloGene: 2429 GeneCards: TFRC Gene
Gene ontology
Molecular function	• double-stranded RNA binding; • transferrin receptor activity; • protein binding; • peptidase activity; • identical protein binding; • poly(A) RNA binding;
Cellular component	• extracellular region; • extracellular space; • endosome; • plasma membrane; • integral component of plasma membrane; • coated pit; • external side of plasma membrane; • cell surface; • membrane; • cytoplasmic membrane-bounded vesicle; • melanosome; • intracellular membrane-bounded organelle; • perinuclear region of cytoplasm; • extracellular vesicular exosome; • blood microparticle;
Biological process	• regulation of cell growth; • proteolysis; • cellular iron ion homeostasis; • receptor-mediated endocytosis; • viral process; • osteoclast differentiation; • transferrin transport; • regulation of cell proliferation; • positive regulation of bone resorption; • transmembrane transport; • iron ion import;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「CD」

　　[★]

[pmid6270680-1] Sutherland R, Delia D, Schneider C, Newman R, Kemshead J, Greaves M (July 1981). "Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin". Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4515–9. doi:10.1073/pnas.78.7.4515. PMC 319822. PMID 6270680.

[pmid3002171-2] Rabin M, McClelland A, Kühn L, Ruddle FH (November 1985). "Regional localization of the human transferrin receptor gene to 3q26.2----qter". Am. J. Hum. Genet. 37 (6): 1112–6. PMC 1684729. PMID 3002171.

[pmid15313461-3] Aisen P (November 2004). "Transferrin receptor 1". Int. J. Biochem. Cell Biol. 36 (11): 2137–43. doi:10.1016/j.biocel.2004.02.007. PMID 15313461.

[pmid12553165-4] Moos T (November 2002). "Brain iron homeostasis". Danish Medical Bulletin 49 (4): 279–301. PMID 12553165.

[5] Speeckaert MM, Speeckaert R, Delanghe JR (December 2010). "Biological and clinical aspects of soluble transferrin receptor". Critical Reviews in Clinical Laboratory Sciences 47 (5-6): 213–228. doi:10.3109/10408363.2010.550461. PMID 21391831.

[pmid11997026-6] Green F, O'Hare T, Blackwell A, Enns CA (May 2002). "Association of human transferrin receptor with GABARAP". FEBS Lett. 518 (1–3): 101–6. doi:10.1016/S0014-5793(02)02655-8. PMID 11997026.

[pmid9465039-7] Feder JN, Penny DM, Irrinki A, Lee VK, Lebrón JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC (February 1998). "The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding". Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1472–7. doi:10.1073/pnas.95.4.1472. PMC 19050. PMID 9465039.

[pmid11027676-8] West AP, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ (December 2000). "Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE". J. Biol. Chem. 275 (49): 38135–8. doi:10.1074/jbc.C000664200. PMID 11027676.

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案内

CD71