同: FcyRII

PrepTutorEJDIC

certificate of deposit / (また『C.D.』)Civil Defense民間防衛

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/11/13 22:37:14」(JST)

wiki en

CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling.

It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loop acts to lower the production of IgG by B cells when there is a surplus in the body.^[2]

Monoclonal antibodies can distinguish between CD32A and CD32B.^[3]

References

^ PDB 2FCB; Sondermann P, Huber R, Jacob U. (March 1999). "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution.". EMBO J. 18 (5): 1095–103. doi:10.1093/emboj/18.5.1095. PMC 1171201. PMID 10064577. ; rendered via PyMOL.
^ Coico, R., Sunshine, G., and Benjamin, E. (2003). "Immunology: A Short Course" p.97.
^ Veri MC, Gorlatov S, Li H, et al. (2007). "Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization". Immunology 121 (3): 392–404. doi:10.1111/j.1365-2567.2007.02588.x. PMC 2265948. PMID 17386079.

External links

CD32 Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

This immunology article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 幼児血管腫の疫学、病因、臨床的特徴、および合併症 epidemiology pathogenesis clinical features and complications of infantile hemangiomas
2. 体液性免疫応答 the humoral immune response
3. 全身性エリテマトーデスの疫学および病因 epidemiology and pathogenesis of systemic lupus erythematosus
4. 肥満細胞：表面受容体とシグナル伝達 mast cells surface receptors and signal transduction
5. 血清病および血清病様反応 serum sickness and serum sickness like reactions

English Journal

Systematic validation of specific phenotypic markers for in vitro polarized human macrophages.

Ambarus CA, Krausz S, van Eijk M, Hamann J, Radstake TR, Reedquist KA, Tak PP, Baeten DL.SourceDepartment of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, The Netherlands.
Journal of immunological methods.J Immunol Methods.2012 Jan 31;375(1-2):196-206. Epub 2011 Oct 29.
BACKGROUND: Polarization of macrophages by specific micro-environmental conditions impacts upon their function following subsequent activation. This study aimed to systematically validate robust phenotypic markers for in vitro polarized human macrophages in order to facilitate the study of macrophag
PMID 22075274

Targeted delivery of CpG ODN to CD32 on human and monkey plasmacytoid dendritic cells augments IFNα secretion.

Tel J, Beenhakker N, Koopman G, Hart B, Mudde GC, de Vries IJ.SourceDepartment of Tumor Immunology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.
Immunobiology.Immunobiology.2012 Jan 24. [Epub ahead of print]
Atopic diseases are characterized by the presence of Th2 cells. Recent studies, in mice and man, demonstrated that allergen-specific Th2 responses can be shifted to Th0/Th1 responses. Plasmacytoid dendritic cells (pDCs) produce large amounts of type I interferons (IFNs) after stimulation of Toll Lik
PMID 22349518

Japanese Journal

Capacity of Monocytes from Patients with Chronic Myelomonocytic Leukemia to Differentiate into Macrophages and Multinucleated Giant Cells

SHODA Eriko,KAWANO Eiji,AOKI Katsunori,AKAGAWA Kiyoko S.
Journal of clinical and experimental hematopathology 45(2), 89-92, 2005-12-01
… Macrophages (MΦ) generated from CMML-Mo expressed CD32, but not CD16. …
NAID 130000065659

T human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9

MEANS TK
J Clin Invest 115, 407-417, 2005
NAID 30023098452

急性冠症候群における末梢血単核球上FcγRII(CD32)発現の検討(平成15年度順天堂大学老人性疾患病態・治療研究センター研究発表会抄録)

住吉克彦,島田和典,宮崎哲朗,久米淳美,代田浩之,大澤俊也,大坂顯通
順天堂医学 50(4), 425, 2004-12-22
NAID 110004299120

Related Pictures

Amiga CD32 floppy drive into the back of the CD32 system cd32 welcome to the commodore cd32 What if? The Amiga CD32 Description Amiga CD32 console.jpg CD32 Boombox (Purple) Commodore Amiga CD32 CD32

★リンクテーブル★

リンク元	「食細胞」「表面抗原分類」
関連記事	「CD3」「CD」

「食細胞」

Fc fragment of IgG, low affinity IIc, receptor for (CD32)
Identifiers
Symbol	FCGR2C
Entrez	9103
HUGO	15626
RefSeq	NM_201563
UniProt	P31995
Other data
Locus	Chr. 1 q23

Fc fragment of IgG, low affinity IIb, receptor (CD32)
	Crystal structure of the human fcgamma-receptor IIb ectodomain (CD32).
Identifiers
Symbol	FCGR2B
Alt. symbols	FCG2, FCGR2
Entrez	2213
HUGO	3618
OMIM	604590
RefSeq	NM_004001
UniProt	P31994
Other data
Locus	Chr. 1 q23

Fc fragment of IgG, low affinity IIa, receptor (CD32)
Identifiers
Symbol	FCGR2A
Alt. symbols	FCG2, FCGR2A1, FCGR2
Entrez	2212
HUGO	3616
OMIM	146790
RefSeq	NM_021642
UniProt	P12318
Other data
Locus	Chr. 1 q23

　　[★]

英: phagocyte
同: 貪食細胞

[show details]

貪食細胞 : 約 24,500 件
食細胞 : 約 74,100 件
ファゴサイト : 約 1,660 件

貪食細胞 phagocyte : 約 2,200 件
食細胞 phagocyte : 約 13,000 件
ファゴサイト phagocyte : 34 件

食細胞表面レセプター (SMB.38)

リガンド種	受容体	CD	リガンド	発現
抗体	FcγRI	CD64	IgG3, IgG1, IgG4	マクロファージ
	FcγRII	CD32	IgG3, IgG1, IgG2	多核白血球
	FcγRIII	CD16	IgG1, IgG3
補体	CR1	CD35	C3b
	CR3	CD11b/CD18	iC3b
	CR4	CD11c/CD18	iC3b

「表面抗原分類」

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「CD3」

　　[★]

関: TCR, ζ

T細胞のマーカーとして使われる。

発現細胞

胸腺細胞、T細胞

機能

Associated with the T-cell antigen receptor(TCR)

ζと共にTCRで受容したシグナルを細胞内に伝達する

「CD」

　　[★]

[pmid10064577-1] PDB 2FCB; Sondermann P, Huber R, Jacob U. (March 1999). "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution.". EMBO J. 18 (5): 1095–103. doi:10.1093/emboj/18.5.1095. PMC 1171201. PMID 10064577. ; rendered via PyMOL.

[2] Coico, R., Sunshine, G., and Benjamin, E. (2003). "Immunology: A Short Course" p.97.

[pmid17386079-3] Veri MC, Gorlatov S, Li H, et al. (2007). "Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization". Immunology 121 (3): 392–404. doi:10.1111/j.1365-2567.2007.02588.x. PMC 2265948. PMID 17386079.

匿名

検索

案内

案内

CD32