同: leucine-6, CD1A through E

種類

CD1a, CD1b, CD1c, CD1d

発現組織

胸腺皮質、ランゲルハンス細胞、樹状細胞、B細胞(CD1c)、腸上皮、平滑筋、血管上皮(CD1d)

分子量

43-49

機能

MHC class I-like molecule, associated with β2-microgloulin. Has specialized role in presentation of lipid antigens

WordNet

the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system

PrepTutorEJDIC

carbonの化学記号
certificate of deposit / (また『C.D.』)Civil Defense民間防衛

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/18 11:54:45」(JST)

wiki ja

[Wiki ja表示]

CD1は種々の抗原提示細胞の表面に発現している糖タンパク質、細胞表面抗原の1つである。この分子は1型の主要組織適合抗原 (MHC-1) と深く関連し、T細胞への脂質抗原の提示に関わる。しかしながら、詳しい機能は知られていない^[1]。

分類[編集]

CD1は脂質固着における違いにより、大きく2つのグループに分類できる^[2]。

CD1a、CD1b、CD1c（グループ1 CD1分子）は抗原提示細胞に特異的に発現している^[3]。
CD1d（グループ2 CD1分子）は普遍的に様々な細胞、組織に発現している。

CD1eは中間型であり、細胞内に発現しているが、役割は不確かである^[4]。

ヒトのCD1[編集]

グループ1[編集]

このグループのCD1分子は外来性の脂質（特に抗酸菌の細胞壁など）をCD1特異的T細胞に提示することが示されている。

グループ2[編集]

CD1dの自然抗原ははっきりとした特徴を持たないが、海綿から発見された混合物より単離された合成糖脂質であるαガラクトシルセラミドが強い活性を持つ。

CD1dはCD161などのナチュラルキラー細胞マーカーを持つためにナチュラルキラーT細胞（NKT細胞）と名付けられたT細胞の一群を活性化する。NKT細胞はCD1dにより提示される抗原により活性化し、それぞれIFN-γ、IL-4に代表されるTh1系、及びTh2系のサイトカインを迅速に産生する。

診断との関連[編集]

CD1分子は胸腺皮質の細胞で発現が見られるが、成熟したT細胞はCD1を発現していない。このことはこれらの細胞を起源とする腫瘍細胞でもいえるため、免疫組織化学的診断においてCD1分子の発現を、胸腺細胞やT細胞の前駆細胞に由来する腫瘍の同定に応用することができる。特にCD1aはランゲルハンス細胞の特異的マーカーであり、それ故にランゲルハンス細胞組織球症の診断に用いることができる。また、骨髄性白血病や一部のB細胞リンパ腫でもCD1分子が陽性になりうる^[5]。

ウシ及びマウスのCD1[編集]

マウスはグループ1のCD1分子を欠き、代わりに2コピーのCD1dを持つ。このため、マウスは様々な疾患モデルにおけるCD1dとCD1d依存性NKT細胞の役割を調べるために利用されている。

最近の研究でウシがグループ2のCD1を欠き、グループ2 CD1のタイプがヒトより多いことがわかった^[6]。この発見と、ウシがウシ型結核菌（Mycobacterium bovis、ヒトにも感染しうる）の自然宿主であることから、ウシでの研究がグループ1 CD1分子の抗原提示に関する知見を得ることにつながると期待されている。

脚注[編集]

^ Porcelli S, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA (1989). “Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes”. Nature 341 (6241): 447–50. doi:10.1038/341447a0. PMID 2477705.
^ Zajonc DM, Wilson IA (2007). “Architecture of CD1 proteins”. Curr. Top. Microbiol. Immunol. 314: 27–50. doi:10.1007/978-3-540-69511-0_2. PMID 17593656.
^ Sköld M, Behar SM (2005). “The role of group 1 and group 2 CD1-restricted T cells in microbial immunity”. Microbes Infect. 7 (3): 544–51. doi:10.1016/j.micinf.2004.12.012. PMID 15777730.
^ Angenieux C, Salamero J, Fricker D, Cazenave JP, Goud B, Hanau D, de La Salle H (2000). “Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells”. J. Biol. Chem. 275 (48): 37757–64. doi:10.1074/jbc.M007082200. PMID 10948205.
^ Kumarasen C, Anthony S-Y L (2003). Manual of diagnostic antibodies for immunohistology. London: Greenwich Medical Media. pp. 59–60. ISBN 1-84110-100-1.
^ Van Rhijn I, Koets AP, Im JS, Piebes D, Reddington F, Besra GS, Porcelli SA, van Eden W, Rutten VP (2006). “The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d”. J. Immunol. 176 (8): 4888–93. PMID 16585584.

wiki en

[Wiki en表示]

For the album by Throbbing Gristle, see CD1 (album).

CD1d molecule
Identifiers
Symbol	CD1D
Entrez	912
HUGO	1637
OMIM	188410
RefSeq	NM_001766
UniProt	P15813
Other data
Locus	Chr. 1 q22-q23

CD1e molecule
Identifiers
Symbol	CD1E
Entrez	913
HUGO	1638
OMIM	188411
RefSeq	NM_030893
UniProt	P15812
Other data
Locus	Chr. 1 q22-q23

CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T cells. However their precise function is unknown.^[1]

Types[edit]

CD1 glycoproteins can be classified primarily into two groups which differ in their lipid anchoring.^[2]

CD1a, CD1b and CD1c (group 1 CD1 molecules) are expressed on cells specialized for antigen presentation.^[3]

CD1d (group 2 CD1) is expressed in a wider variety of cells.

CD1e is an intermediate form, expressed intracellularly, the role of which is currently unclear.^[4]

In humans[edit]

Group 1[edit]

Group 1 CD1 molecules have been shown to present foreign lipid antigens, and specifically a number of mycobacterial cell wall components, to CD1-specific T cells.

Group 2[edit]

The natural antigens of group 2 CD1 are not well-characterized, but a synthetic glycolipid, alpha-galactosylceramide, originally isolated from a compound found in a marine sponge, has strong biologic activity.

Group 2 CD1 molecules activate a group of T cells, known as Natural killer T cells because of their expression of NK surface markers such as CD161. Natural Killer T (NKT) cells are activated by CD1d-presented antigens, and rapidly produce Th1 and Th2 cytokines, typically represented by interferon-gamma and IL-4 production.

The group 2 (CD1d) ligand alpha-galactosylceramide is currently in phase I clinical trials for the treatment of advanced non-hematologic cancers.

Diagnostic relevance[edit]

CD1 antigens are expressed on cortical thymocytes, but not on mature T cells. This often remains true in neoplastic cells from these populations, so that the presence of CD1 antigens can be used in diagnostic immunohistochemistry to identify some thymomas and malignancies arising from T cell precursors. CD1a, in particular, is a specific marker for Langerhans cells, and can therefore also be used in the diagnosis of Langerhans cell histiocytosis. Other conditions that may show CD1 positivity include myeloid leukaemia and some B cell lymphomas.^[5]

In cows and mice[edit]

Mice lack the group 1 CD1 molecules, and instead have 2 copies of CD1d. Thus, mice have been used extensively to characterize the role of CD1d and CD1d-dependent NKT cells in a variety of disease models.

It has recently been shown that cows lack the group 2 CD1 molecules, and have an expanded set of group 1 CD1 molecules.^[6] Because of this and the fact that cows are a natural host of Mycobacterium bovis, a pathogen in humans as well, it is hoped that studying cows will yield insights into the group 1 CD1 antigen-presenting system.

References[edit]

^ Porcelli S, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA (1989). "Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes". Nature 341 (6241): 447–50. doi:10.1038/341447a0. PMID 2477705.
^ Zajonc DM, Wilson IA (2007). "Architecture of CD1 proteins". Curr. Top. Microbiol. Immunol. 314: 27–50. doi:10.1007/978-3-540-69511-0_2. PMID 17593656.
^ Sköld M, Behar SM (2005). "The role of group 1 and group 2 CD1-restricted T cells in microbial immunity". Microbes Infect. 7 (3): 544–51. doi:10.1016/j.micinf.2004.12.012. PMID 15777730.
^ Angenieux C, Salamero J, Fricker D, Cazenave JP, Goud B, Hanau D, de La Salle H (2000). "Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells". J. Biol. Chem. 275 (48): 37757–64. doi:10.1074/jbc.M007082200. PMID 10948205.
^ Kumarasen C, Anthony S-Y L (2003). Manual of diagnostic antibodies for immunohistology. London: Greenwich Medical Media. pp. 59–60. ISBN 1-84110-100-1.
^ Van Rhijn I, Koets AP, Im JS, Piebes D, Reddington F, Besra GS, Porcelli SA, van Eden W, Rutten VP (2006). "The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d". J. Immunol. 176 (8): 4888–93. PMID 16585584.

External links[edit]

CD1 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
Mouse CD Antigen Chart
Human CD Antigen Chart

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 抗原提示細胞 antigen presenting cells
2. 肺ランゲルハンス細胞組織球症 pulmonary langerhans cell histiocytosis
3. 間質性肺疾患における肺生検結果の解釈 interpretation of lung biopsy results in interstitial lung disease
4. ランゲルハンス細胞組織球症の治療 treatment of langerhans cell histiocytosis
5. 類乾癬（小局面型および大局面型） parapsoriasis small plaque and large plaque parapsoriasis

English Journal

Adverse effect of tetracycline and doxycycline on testicular tissue and sperm parameters in CD1 outbred mice.

Elzeinová F, Pěknicová J, Děd L, Kubátová A, Margaryan H, Dorosh A, Makovický P, Rajmon R.SourceLaboratory of Reproductive Biology, Institute of Biotechnology, Academy of Sciences of the Czech Republic v.v.i., Prague, Czech Republic.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie.Exp Toxicol Pathol.2013 Sep;65(6):911-7. doi: 10.1016/j.etp.2013.01.004. Epub 2013 Feb 4.
Tetracycline and doxycycline are commonly used antibiotics in acne treatment during puberty in humans. The long-term effect of these antibiotics on male reproductive tract development has not been fully elucidated. For this reason we tested the effect of antibiotics on the reproductive parameters of
PMID 23384891

Diverse antigen presentation by the Group 1 CD1 molecule, CD1c.

Adams EJ.SourceDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, United States. ejadams@uchicago.edu
Molecular immunology.Mol Immunol.2013 Sep;55(2):182-5. doi: 10.1016/j.molimm.2012.10.019. Epub 2012 Nov 3.
CD1 molecules are Major Histocompatibility Complex (MHC) class I-like proteins that present diverse lipid antigens to T cells. Most of our understanding of CD1 lipid presentation and T cell recognition has come from study of the invariant Natural Killer T cell recognition of CD1d. However, in additi
PMID 23127489

Chronic social stress during adolescence: Interplay of paroxetine treatment and ageing.

Scharf SH, Sterlemann V, Liebl C, Müller MB, Schmidt MV.SourceRG Molecular Stress Physiology, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804 Munich, Germany. Electronic address: sscharf@mpipsykl.mpg.de.
Neuropharmacology.Neuropharmacology.2013 Sep;72:38-46. doi: 10.1016/j.neuropharm.2013.03.035. Epub 2013 Apr 16.
Exposure to chronic stress during developmental periods is a risk factor for a number of psychiatric disorders. While the direct effects of stress exposure have been studied extensively, little is known about the long-lasting effects and the interaction with ageing. The same holds true for the treat
PMID 23602985

Japanese Journal

The immunosenescence-related gene Zizimin2 is associated with early bone marrow B cell development and marginal zone B cell formation

Matsuda Takenori,Yanase Shougo,Takaoka Akinori,Maruyama Mitsuo
Immunity & Ageing 12, 1, 2015-02-22
… We finally demonstrated that CD1d-positive MZ B cell region outside CD169-positive marginal metallophilic macrophages (MMM) was narrowed in Ziz2 KO mice. …
NAID 120005593441

Effect of ovarian hormones on maturation of dendritic cells from peripheral blood monocytes in dogs

WIJEWARDANA Viskam,SUGIURA Kikuya,WIJESEKERA Daluthgamage Patsy H.,HATOYA Shingo,NISHIMURA Toshiya,KANEGI Ryoji,USHIGUSA Takahiro,INABA Toshio
Journal of Veterinary Medical Science 77(7), 771-775, 2015
… When various ovarian hormones were added to the culture for the DC differentiation, progesterone significantly decreased the expression of DC maturation markers, such as CD1a, CD80 and CD86, on mature DCs. …
NAID 130005089954

Discovery of NKT cells and development of NKT cell-targeted anti-tumor immunotherapy

TANIGUCHI Masaru,HARADA Michishige,DASHTSOODOL Nyambayar,KOJO Satoshi
Proceedings of the Japan Academy, Series B 91(7), 292-304, 2015
… Natural Killer T (NKT) cells are unique lymphocytes characterized by their expression of a single invariant antigen receptor encoded by Vα14Jα18 in mice and Vα24Jα18 in humans, which recognizes glycolipid antigens in association with the monomorphic CD1d molecule. …
NAID 130005088948

Related Pictures

★リンクテーブル★

リンク元	「免疫グロブリンスーパーファミリー」「表面抗原分類」
関連記事	「C」「CD」

「免疫グロブリンスーパーファミリー」

CD1c molecule
Identifiers
Symbol	CD1C
Alt. symbols	CD1
Entrez	911
HUGO	1636
OMIM	188340
RefSeq	NM_001765
UniProt	P29017
Other data
Locus	Chr. 1 q22-q23

CD1b molecule
Identifiers
Symbol	CD1B
Alt. symbols	CD1
Entrez	910
HUGO	1635
OMIM	188360
RefSeq	NM_001764
UniProt	P29016
Other data
Locus	Chr. 1 q22-q23

CD1a molecule
Identifiers
Symbol	CD1A
Alt. symbols	CD1
Entrez	909
HUGO	1634
OMIM	188370
RefSeq	NM_001763
UniProt	P06126
Other data
Locus	Chr. 1 q22-q23

　　[★]

英: immunoglobulin superfamily
同: 免疫グロブリン遺伝子スーパーファミリー　←？; immunoglobulin gene superfamily　←？
関: 免疫グロブリン

Igドメイン	サブユニット	多形性	遺伝子再構成	局在
単一	単量体	無し	無し	細胞表面	Thy1, CD1のサブユニット, CD3のサブユニット
多	単量体	無し	無し	細胞表面	N-CAM, PDGF-R, poly Ig receptor, CEA, MAG, CD2
多	多量体	無し	無し	細胞表面	CD4, CD8
多	多量体	有り	無し	細胞表面	MHC
多	多量体	有り	有り	細胞表面	TCR
多	多量体	有り	有り	液性因子	Ig

「表面抗原分類」

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「C」

　　[★]

炭素 carbon
シトシン cytosine
システイン cysteine
シチジン
セルシウス度摂氏 degrees Celsius degree C
産婦人科領域で「子宮外頚子宮外頚部 exocervix」を表現するための略語

「CD」

　　[★]

[pmid2477705-1] Porcelli S, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA (1989). “Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes”. Nature 341 (6241): 447–50. doi:10.1038/341447a0. PMID 2477705.

[pmid17593656-2] Zajonc DM, Wilson IA (2007). “Architecture of CD1 proteins”. Curr. Top. Microbiol. Immunol. 314: 27–50. doi:10.1007/978-3-540-69511-0_2. PMID 17593656.

[pmid15777730-3] Sköld M, Behar SM (2005). “The role of group 1 and group 2 CD1-restricted T cells in microbial immunity”. Microbes Infect. 7 (3): 544–51. doi:10.1016/j.micinf.2004.12.012. PMID 15777730.

[pmid10948205-4] Angenieux C, Salamero J, Fricker D, Cazenave JP, Goud B, Hanau D, de La Salle H (2000). “Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells”. J. Biol. Chem. 275 (48): 37757–64. doi:10.1074/jbc.M007082200. PMID 10948205.

[isbn1-84110-100-1-5] Kumarasen C, Anthony S-Y L (2003). Manual of diagnostic antibodies for immunohistology. London: Greenwich Medical Media. pp. 59–60. ISBN 1-84110-100-1.

[pmid16585584-6] Van Rhijn I, Koets AP, Im JS, Piebes D, Reddington F, Besra GS, Porcelli SA, van Eden W, Rutten VP (2006). “The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d”. J. Immunol. 176 (8): 4888–93. PMID 16585584.

[pmid2477705-1] Porcelli S, Brenner MB, Greenstein JL, Balk SP, Terhorst C, Bleicher PA (1989). "Recognition of cluster of differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes". Nature 341 (6241): 447–50. doi:10.1038/341447a0. PMID 2477705.

[pmid17593656-2] Zajonc DM, Wilson IA (2007). "Architecture of CD1 proteins". Curr. Top. Microbiol. Immunol. 314: 27–50. doi:10.1007/978-3-540-69511-0_2. PMID 17593656.

[pmid15777730-3] Sköld M, Behar SM (2005). "The role of group 1 and group 2 CD1-restricted T cells in microbial immunity". Microbes Infect. 7 (3): 544–51. doi:10.1016/j.micinf.2004.12.012. PMID 15777730.

[pmid10948205-4] Angenieux C, Salamero J, Fricker D, Cazenave JP, Goud B, Hanau D, de La Salle H (2000). "Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells". J. Biol. Chem. 275 (48): 37757–64. doi:10.1074/jbc.M007082200. PMID 10948205.

[isbn1-84110-100-1-5] Kumarasen C, Anthony S-Y L (2003). Manual of diagnostic antibodies for immunohistology. London: Greenwich Medical Media. pp. 59–60. ISBN 1-84110-100-1.

[pmid16585584-6] Van Rhijn I, Koets AP, Im JS, Piebes D, Reddington F, Besra GS, Porcelli SA, van Eden W, Rutten VP (2006). "The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d". J. Immunol. 176 (8): 4888–93. PMID 16585584.

匿名

検索

案内

CD1

種類