同: MY10, SGP90

血液幹細胞の細胞マーカー

発現細胞

hematopoietic precursors, capillary endothelium (IMM.785)
GIST

GISTではCD34とc-kit(CD117)が陽性

機能

ligand for CD62L(L-selectin) (IMM.785)

PrepTutorEJDIC

certificate of deposit / (また『C.D.』)Civil Defense民間防衛

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/15 15:25:07」(JST)

wiki en

[Wiki en表示]

CD34 molecule is a cluster of differentiation molecule present on certain cells within the human body. It is a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of stem cells to bone marrow extracellular matrix or directly to stromal cells. CD34 is also the name for the human gene that encodes the protein.^[1]^[2]^[3]

Function

The CD34 protein is a member of a family of single-pass transmembrane sialomucin proteins that show expression on early hematopoietic and vascular-associated tissue.^[4] However little is known about its exact function.^[5]

CD34 is also an important adhesion molecule and is required for T cells to enter lymph nodes. It is expressed on lymph node endothelia whereas the L-selectin to which it binds is on the T cell.^[6]^[7] Conversely, under other circumstances CD34 has been shown to act as molecular "Teflon" and block mast cell adhesion, or to facilitate opening of vascular lumens.^[8]^[9] Regardless of their mode of action, under all circumstances CD34 and its relatives, podocalyxin and endoglycan, have been shown to facilitate cell migration.^[10]^[11]

Tissue distribution

Cells expressing CD34 (CD34+ cell) are normally found in the umbilical cord and bone marrow as hematopoietic cells, a subset of mesenchymal stem cells, endothelial progenitor cells, endothelial cells of blood vessels but not lymphatics (except pleural lymphatics), mast cells, a sub-population dendritic cells (which are factor XIIIa negative) in the interstitium and around the adnexa of dermis of skin, as well as cells in soft tissue tumors like DFSP, GIST, SFT, HPC, and in to some degree also in MPNSTs etc.

Clinical applications

CD34+ cells may be isolated from blood samples using immunomagnetic or immunofluorescent methods.

Antibodies are used to quantify and purify hematopoietic progenitor stem cells for research and for clinical bone marrow transplantation. However, counting CD34+ mononuclear cells may overestimate myeloid blasts in bone marrow smears due to hematogones (B lymphocyte precursors) and CD34+ megakaryocytes.

Cells observed as CD34+ and CD38- are of an undifferentiated, primitive form; i.e. they are pluripotential hemopoietic stem cells. Thus, because of their CD34+ expression, such undifferentiated cells can be sorted out.

In tumors, CD34 is found in alveolar soft part sarcoma, preB-ALL (positive in 75%), AML (40%), AML-M7 (most), dermatofibrosarcoma protuberans, gastrointestinal stromal tumors, giant cell fibroblastoma, granulocytic sarcoma, Kaposi’s sarcoma, liposarcoma, malignant fibrous histiocytoma, malignant peripheral nerve sheath tumors, mengingeal hemangiopericytomas, meningiomas, neurofibromas, schwannomas, and papillary thyroid carcinoma.

A negative CD34 may exclude Ewing's sarcoma/PNET, myofibrosarcoma of the breast, and inflammatory myofibroblastic tumors of the stomach.

Injection of CD34+ hematopoietic Stem Cells has been clinically applied to treat various diseases including Spinal Cord Injury,^[12] Liver Cirrhosis^[13] and Peripheral Vascular disease.^[14] Research has shown that CD34+ cells are relatively more in men than in women in the reproductive age among Spinal Cord Injury victims.^[15]

Interactions

CD34 has been shown to interact with CRKL.^[16] It also interacts with L-selectin, important in inflammation.

References

^ "Entrez Gene: CD34 CD34 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=947.
^ Simmons DL, Satterthwaite AB, Tenen DG, Seed B (1 January 1992). "Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells". J. Immunol. 148 (1): 267–71. PMID 1370171. http://www.jimmunol.org/cgi/content/abstract/148/1/267.
^ Satterthwaite AB, Burn TC, Le Beau MM, Tenen DG (April 1992). "Structure of the gene encoding CD34, a human hematopoietic stem cell antigen". Genomics 12 (4): 788–94. doi:10.1016/0888-7543(92)90310-O. PMID 1374051.
^ Nielsen JS, McNagny KM (2008). "Novel functions of the CD34 family". J of Cell Science 121 (Pt 22): 3682–3692. doi:10.1242/jcs.037507. PMID 18987355.
^ Furness SG, McNagny K (2006). "Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis". Immunol. Res. 34 (1): 13–32. doi:10.1385/IR:34:1:13. PMID 16720896.
^ Berg EL, Mullowney AT, Andrew DP, Goldberg JE, Butcher EC (February 1998). "Complexity and differential expression of carbohydrate epitopes associated with L-selectin recognition of high endothelial venules". Am. J. Pathol. 152 (2): 469–77. PMC 1857953. PMID 9466573. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1857953/.
^ SSuzawa K, Kobayashi M, Sakai Y, Hoshino H, Watanabe M, Harada O, Ohtani H, Fukuda M, Nakayama J (July 2007). "Preferential induction of peripheral lymph node addressin on high endothelial venule-like vessels in the active phase of ulcerative colitis". Am. J. Gastroenterol. 102 (7): 1499–509. doi:10.1111/j.1572-0241.2007.01189.x. PMID 17459027.
^ Drew E, Merzaban JS, Seo W, Ziltener HJ, McNagny KM (2005). "CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution". Immunity 22 (1): 43–57. doi:10.1016/j.immuni.2004.11.014. PMID 15664158.
^ Strilić B, Kucera T, Eglinger J, Hughes MR, McNagny KM, Tsukita S, Dejana E, Ferrara N, Lammert E (2009). "The molecular basis of vascular lumen formation in the developing mouse aorta". Dev Cell 17 (4): 505–15. doi:10.1016/j.devcel.2009.08.011. PMID 19853564.
^ Blanchet MR, Maltby S, Haddon DJ, Merkens H, Zbytnuik L, McNagny KM (2007). "CD34 facilitates the development of allergic asthma". Blood 110 (6): 2005–12. doi:10.1182/blood-2006-12-062448. PMID 17557898.
^ Maltby S, Wohlfarth C, Gold M, Zbytnuik L, Hughes MR, McNagny KM (2010). "CD34 Is Required for Infiltration of Eosinophils into the Colon and Pathology Associated with DSS-Induced Ulcerative Colitis". Am J Path 177 (3): 1244–54. doi:10.2353/ajpath.2010.100191. PMC 2928958. PMID 20696776. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2928958/.
^ Srivastava A, Bapat M, Ranade S, Srinivasan V, Murugan P, Manjunath S, Thamaraikannan P, Abraham S (2010). "Autologous Multiple Injections of in Vitro Expanded Autologous Bone Marrow Stem Cells For Cervical Level Spinal Cord Injury - A Case Report". Journal of Stem Cells and Regenerative Medicine. http://www.pubstemcell.com/monthly/006030700113.htm.
^ Terai S, Ishikawa T, Omori K, Aoyama K, Marumoto Y, Urata Y, Yokoyama Y,Uchida K, Yamasaki T, Fujii Y, Okita K, Sakaida I (2006). "Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy". Stem Cells 24 (10): 2292–8. doi:10.1634/stemcells.2005-0542. PMID 16778155.
^ Subrammaniyan R, Amalorpavanathan J, Shankar R, Rajkumar M, Baskar S, Manjunath SR, Senthilkumar R, Murugan P, Srinivasan VR, Abraham S (September 2011). "Application of autologous bone marrow mononuclear cells in six patients with advanced chronic critical limb ischemia as a result of diabetes: our experience". Cytotherapy 13 (8): 993–9. doi:10.3109/14653249.2011.579961. PMID 21671823.
^ Dedeepiya V, Rao Y Y, Jayakrishnan G, Parthiban JKBC, Baskar S, Manjunath S, Senthilkumar R and Abraham S (2012). "Index of CD34+ cells and mononuclear cells in the bone marrow of Spinal cord Injury patients of different age groups- A comparative analysis". Bone Marrow Research. http://www.hindawi.com/journals/bmr/aip/787414/.
^ Felschow, D M; McVeigh M L, Hoehn G T, Civin C I, Fackler M J (Jun. 2001). "The adapter protein CrkL associates with CD34". Blood (United States) 97 (12): 3768–75. doi:10.1182/blood.V97.12.3768. ISSN 0006-4971. PMID 11389015.

External links

Antigens,+CD34 at the US National Library of Medicine Medical Subject Headings (MeSH)
Mouse CD Antigen Chart
Human CD Antigen Chart

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 造血および幹細胞の機能の概要 overview of hematopoiesis and stem cell function
2. GISTを含む消化管間葉系腫瘍の疫学、分類、臨床像、予後の特徴、および診断方法 epidemiology classification clinical presentation prognostic features and diagnostic work up of gastrointestinal mesenchymal neoplasms including gist
3. 急性骨髄性白血病の分類 classification of acute myeloid leukemia
4. HLAハプロタイプ適合造血細胞移植 hla haploidentical hematopoietic cell transplantation
5. 下肢末梢動脈疾患の症状を治療するための試験的治療 investigational therapies for treating symptoms of lower extremity peripheral artery disease

English Journal

Leptin receptor in childhood acute leukemias.

Gorska E, Popko K, Wasik M.SourceDepartment of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, 24 Marszalkowska St, 00-576, Warsaw, Poland, elgorska@litewska.edu.pl.
Advances in experimental medicine and biology.Adv Exp Med Biol.2013;756:155-61.
Ob-R receptor is encoded by db gene and belongs to class I cytokine receptors family. Its expression was observed in hematopoietic CD34+ stem cells, erythropoietic, myeloid and lymphoblastic lineages cell lines and in human leukemic blast cells in lymphomas, acute myeloid leukemia (AML), acute lymph
PMID 22836631

A distinct subpopulation within CD133 positive brain tumor cells shares characteristics with endothelial progenitor cells.

Choi SA, Wang KC, Phi JH, Lee JY, Park CK, Park SH, Kim SK.SourceDivision of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, College of Medicine, Seoul, Republic of Korea; Adolescent Cancer Center, Seoul National University Cancer Hospital, College of Medicine, Seoul, Republic of Korea; Department of Neurosurgery, Seoul National University Hospital, College of Medicine, Seoul, Republic of Korea.
Cancer letters.Cancer Lett.2012 Nov 28;324(2):221-30. Epub 2012 May 28.
The cell surface marker CD133 has been proposed as a brain tumor stem cell marker. However, there have been substantial controversies regarding the necessity and role of CD133 in tumorigenesis. This study aimed to characterize CD133(+) cells in brain tumors. Human brain tumor specimens and whole blo
PMID 22652175

Japanese Journal

Involvement of bone-marrow-derived cells in kidney fibrosis

Wada Takashi,Sakai Norihiko,Sakai Yoshio,Matsushima Kouji,Kaneko Shuichi,Furuichi Kengo
Clinical and Experimental Nephrology 15(1), 8-13, 2011-02
… Bone-marrow-derived cells positive for CD45 or CD34, and type 1 (pro)collagen dependent on the chemokine and renin-angiotensin systems migrate into diseased kidneys and enhance synthesis matrix protein, cytokines/chemokines, and profibrotic growth factors, which may promote and escalate chronic inflammatory processes and possible interaction with resident stromal cells, thereby perpetuating kidney fibrosis. …
NAID 120002851394

Extraskeletal Osteosarcoma with Pulmonary Metastasis in a Female F344 Rat

Nagaike Mika,Sakai Kimie,Tsuchiya Seiichiro,Shimada Fumi,Inui Kosei,Uratani Mamoru
Journal of Toxicologic Pathology 24(1), 75-79, 2011
A subcutaneous mass in the right femoral region of a female F344 Slc/N rat was examined histopathologically. At 83 weeks of age, the animal showed symptoms of severe anemia and nasal bleeding. Necrops …
NAID 130000675357

Related Pictures

★リンクテーブル★

リンク元	「白血球」「急性前骨髄球性白血病」「造血幹細胞」「表面抗原分類」「粘膜下腫瘍」
関連記事	「CD3」「CD」

「白血球」

CD34 molecule
Identifiers
Symbol	CD34
External IDs	OMIM: 142230 MGI: 88329 HomoloGene: 1343 GeneCards: CD34 Gene
Gene Ontology
Molecular function	• transcription factor binding; • carbohydrate binding; • sulfate binding;
Cellular component	• cytoplasm; • lysosome; • plasma membrane; • integral to plasma membrane; • external side of plasma membrane; • basal plasma membrane; • apical plasma membrane; • glomerular endothelium fenestra; • intercellular bridge; • perinuclear region of cytoplasm;
Biological process	• tissue homeostasis; • endothelial cell proliferation; • glomerular filtration; • endothelium development; • glutamate metabolic process; • signal transduction; • regulation of blood pressure; • cell proliferation; • positive regulation of gene expression; • negative regulation of gene expression; • cell-cell adhesion; • hemopoiesis; • negative regulation of blood coagulation; • negative regulation of tumor necrosis factor production; • positive regulation of interleukin-10 production; • mesangial cell-matrix adhesion; • paracrine signaling; • positive regulation of odontogenesis; • negative regulation of nitric oxide biosynthetic process; • positive regulation of angiogenesis; • cell motility; • regulation of immune response; • leukocyte migration; • transdifferentiation; • negative regulation of necrotic cell death; • vascular wound healing; • hemopoietic stem cell proliferation; • positive regulation of transforming growth factor beta production; • positive regulation of granulocyte colony-stimulating factor production; • extracellular vesicular exosome assembly; • glomerular endothelium development; • stem cell proliferation; • metanephric glomerular mesangial cell differentiation; • negative regulation of cellular response to heat; • negative regulation of cellular response to hypoxia; • negative regulation of interleukin-2 secretion; • positive regulation of glial cell line-derived neurotrophic factor secretion; • positive regulation of vasculogenesis;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

英: leukocyte, leucocyte (Z), white blood cell (Z), WBC, white corpuscle, white cell
関: 赤血球、血球、血液

白血球

顆粒球

基準値

4000-9000 (/μl)　(2007前期解剖学授業プリント)

異常値の出るメカニズム第5版

5000- 8400 (/μl) (健常者の2/3)
4500-11000 (/μl) (95%範囲)

年齢との関連

新生児期>幼児期>成人期(20歳までに成人値)
妊婦でも増加(妊娠#妊娠による変化)

生理的な変動

精神的ストレス↑　　→　交感神経の刺激により好中球の血管壁遊離が促進されるため
午前↓、午後↑

基準値

			07解	異メ	流マ		HIM.A-1
顆粒球	好中球	桿状核球	40～70	44～66	40～60	4～14	0～5
		分葉核球				43～59	40～70
	好酸球		2～4	0～ 4	2～4		0～6
	好塩基球		0～2	0～0.5	0～2		0～2
無顆粒球	リンパ球		25～40	30～38	26～40		20～50
	単球		3～6	0～ 5	3～6		4～8

07解: 2007前期解剖学授業プリント
異メ: 異常値の出るメカニズム第5版 p.91
流マ: 流れが分かる実践検査マニュアル上巻 p.10

血管外滲出 extravasation (SMB.37 BPT.37)

(margination)

1. 赤血球は軽く早く流れるので血管の中央をながれ、白血球は血管のへりを流れている

(rolling)

2. IL-1, TNFで血管内皮細胞が活性化し、血管内腔にE-selectinを発現する
3. P-selectinはヒスタミンやトロンビンの働きにより、血管内腔に発現する
4. 白血球と血管内皮細胞の接着分子で接着することで、白血球がrollingを始める
3. 次第にselectinによる接着はdown regulateされる

(adheresion & arrested)

4. 炎症部位から出されたケモカインが血管内皮細胞の表面ののペプチドグリカンに結合し、白血球に提示される
5. 白血球表面のインテグリンが活性化し、血管内皮細胞のICAM-1, VCAM-1と強く結合する

(transmigration)

6. 白血球と血管内皮細胞に発現しているPECAM-1(CD31)がお互い接着し、白血球が血管内皮細胞の間隙を通って細胞外マトリックスに入る

血管内皮細胞		白血球
Rolling
E-selectin	－	糖鎖(SLe^x)
P-selectin	－	糖鎖
糖鎖(GlyCAM-1)(=CD34)	－	L-selectin
Adhestion
ICAM-1	－	LFA-1 integlin(CD11a/CD18), Mac-1 integlin(CD11b/CD18)
VCAM-1	－	VLA-1 integlin
transmigration
PECAM-1(CD31)	－	PECAM-1(CD31)

白血球の染色

ギムザ染色

好酸性：赤く染まる→ヘモグロビン
好塩基性：青く染まる→リボソーム、核内のヒストン蛋白
好酸性でも好塩基性でもない：淡いピンクに染まる

MPO myeloperoxidase反応（染色）

MPOをもつ：顆粒球（前骨髄球～分葉核球）、単球（前単球～単球）
MPOをもたない：リンパ球系細胞

エステラーゼ esterase

好中球：長鎖エステルを分解
単球：短鎖エステルを分解

関節液

　　炎症感染
200 2000 20000
500 5000 50000

臨床関連

LAD(leukocyte adhesion deficiency)症候群 (SMB.37)

白血球のインテグリンが欠損または減少する先天性疾患

反復性の細菌皮膚感染

SIRSの診断基準：＜4,000/ul or ＞12,000/ul

「急性前骨髄球性白血病」

　　[★]

英: acute promyelocytic leukemia, APL
同: M3。急性前骨髄芽球性白血病？
関: 急性骨髄性白血病 AML、白血病。前骨髄球

概念

急性骨髄性白血病の一病型
白血病細胞が前骨髄球の段階で成熟停止を起こした型
FAB分類：M3
アウエル小体が多く認められる。アウエル小体が集積した細胞(鳥の巣細胞、ファゴット細胞)がみられる。
免疫組織化学：MPO陽性(*ミエロペルオキシダーゼ活性はほぼ100%陽性)
異型前骨髄球がみられる。
染色体異常

95%以上の症例：t(15;17)(q22;q21)
全症例：PML遺伝子(chr.15)とRAR-α遺伝子(chr.17)の融合遺伝子の存在

M3と他のAMLを区別するポイント

免疫表現型：CD13(+), CD33(+), HLA-DR(-)。(micro granular cariantの時は)CD34(+), CD2(+)

検査

急性白血病に特徴的：高尿酸血症、LDH上昇
染色体異常：全例にt(15;17)を認め、PML遺伝子とRAR-α遺伝子が誘導したPML-RARA遺伝子を認める。

[show details]

合併症

播種性血管内凝固症候群(DIC)

Auer顆粒を豊富に含み、この中にはトロンボプラスチン類似物質を含む。この物質の逸脱により凝固が亢進しDICにつながる
線溶亢進型DICを引きおこし、臓器障害より出血症状が前面にてくる。フィブリノゲン減少、Dダイマー・FDP増加が見られる。

治療

レチノイン酸(ATRA, all-trans retinoic acid)の経口投与で高い確率で寛解する
白血球や前骨髄球が多い場合には化学療法を併用する：レチノイン酸　＋　アントラサイクリン系抗悪性腫瘍薬(イダルビシン、ダウノルビシン, DNA二本鎖の間にintercalateしでDNA,RNAの合成を阻害)　＋　シタラビン(Ara-C, シトシンアナログ, 代謝拮抗薬)

国試

105D048

「造血幹細胞」

　　[★]

英: hematopoietic stem cell, HSC
関: 幹細胞

細胞表面マーカー

CD34
c-kit

分化

			血液中	組織
造血幹細胞 hematopoietic stem cell	リンパ球幹細胞 lymphoid stem cell	T細胞 T cell
		B細胞 B cell
		NK細胞 natuarl killer cell
	骨髄球幹細胞 myeloid stem cell	granulocyte/macrophage progenitor	好中球 neutrophil
			好酸球 eosinophil
			好塩基球 basophil
			unknown precursor of mast cell	肥満細胞 mast cell
			単球	マクロファージ macrophage
		赤芽球 erythroblast	赤血球 erythrocyte
		巨核球 megakaryocyte	血小板 platelet

「表面抗原分類」

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「粘膜下腫瘍」

　　[★]

英: submucosal tumor
関: 消化管粘膜下腫瘍、胃粘膜下腫瘍

概念

主病変が粘膜下層以下に存在する隆起病変の総称

分類

胃

非上皮病変

間葉系腫瘍 gastrointestinal mesenchymal tumor GIMT

GIST：CD34(+), c-Kit(+)　　　→　　　粘膜下腫瘍の中で最多である。
筋原性腫瘍：平滑筋腫、平滑筋肉腫、類上皮平滑筋肉腫：smooth muscle actin(+), desmin(+)
神経原性腫瘍：神経鞘腫、神経線維腫：S-100(+)

上皮性病変

迷入膵
嚢胞
カルチノイド

炎症性病変

好酸球性肉芽腫

形態的特徴

Delle デレ
なだらかな陰影の移行(造影、X線透視)、なだらかな隆起の移行(内視鏡)
bridging fold(ヒダが腫瘤をよけない)
粘膜表面に異常は認められない(圧排が強くなれば何らかの影響はある、と思う)

参考

1.

http://www.cancernetwork.com/gastrointestinal-stromal-tumor/content/article/10162/35555

「CD3」

　　[★]

関: TCR, ζ

T細胞のマーカーとして使われる。

発現細胞

胸腺細胞、T細胞

機能

Associated with the T-cell antigen receptor(TCR)

ζと共にTCRで受容したシグナルを細胞内に伝達する

「CD」

　　[★]

[0] "Entrez Gene: CD34 CD34 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=947.

[pmid1370171-1] Simmons DL, Satterthwaite AB, Tenen DG, Seed B (1 January 1992). "Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells". J. Immunol. 148 (1): 267–71. PMID 1370171. http://www.jimmunol.org/cgi/content/abstract/148/1/267.

[pmid1374051-2] Satterthwaite AB, Burn TC, Le Beau MM, Tenen DG (April 1992). "Structure of the gene encoding CD34, a human hematopoietic stem cell antigen". Genomics 12 (4): 788–94. doi:10.1016/0888-7543(92)90310-O. PMID 1374051.

[pmid18987355-3] Nielsen JS, McNagny KM (2008). "Novel functions of the CD34 family". J of Cell Science 121 (Pt 22): 3682–3692. doi:10.1242/jcs.037507. PMID 18987355.

[pmid16720896-4] Furness SG, McNagny K (2006). "Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis". Immunol. Res. 34 (1): 13–32. doi:10.1385/IR:34:1:13. PMID 16720896.

[pmid9466573-5] Berg EL, Mullowney AT, Andrew DP, Goldberg JE, Butcher EC (February 1998). "Complexity and differential expression of carbohydrate epitopes associated with L-selectin recognition of high endothelial venules". Am. J. Pathol. 152 (2): 469–77. PMC 1857953. PMID 9466573. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1857953/.

[pmid17459027-6] SSuzawa K, Kobayashi M, Sakai Y, Hoshino H, Watanabe M, Harada O, Ohtani H, Fukuda M, Nakayama J (July 2007). "Preferential induction of peripheral lymph node addressin on high endothelial venule-like vessels in the active phase of ulcerative colitis". Am. J. Gastroenterol. 102 (7): 1499–509. doi:10.1111/j.1572-0241.2007.01189.x. PMID 17459027.

[pmid15664158-7] Drew E, Merzaban JS, Seo W, Ziltener HJ, McNagny KM (2005). "CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution". Immunity 22 (1): 43–57. doi:10.1016/j.immuni.2004.11.014. PMID 15664158.

[pmid19853564-8] Strilić B, Kucera T, Eglinger J, Hughes MR, McNagny KM, Tsukita S, Dejana E, Ferrara N, Lammert E (2009). "The molecular basis of vascular lumen formation in the developing mouse aorta". Dev Cell 17 (4): 505–15. doi:10.1016/j.devcel.2009.08.011. PMID 19853564.

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[pmid11389015-15] Felschow, D M; McVeigh M L, Hoehn G T, Civin C I, Fackler M J (Jun. 2001). "The adapter protein CrkL associates with CD34". Blood (United States) 97 (12): 3768–75. doi:10.1182/blood.V97.12.3768. ISSN 0006-4971. PMID 11389015.

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CD34

発現細胞

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「白血球」

白血球

基準値

年齢との関連

生理的な変動

基準値

血管外滲出 extravasation (SMB.37 BPT.37)

白血球の染色

関節液

臨床関連

「急性前骨髄球性白血病」

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M3と他のAMLを区別するポイント

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合併症

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「造血幹細胞」

細胞表面マーカー

分化

「表面抗原分類」

「粘膜下腫瘍」

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胃

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「CD3」

発現細胞

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「CD」