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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/26 22:41:56」(JST)

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CD68 immunostaining demonstrating macrophages and giant cells in a case of xanthogranulomatous pyelonephritis

CD68 (Cluster of Differentiation 68) is a glycoprotein which binds to low density lipoprotein.

It is expressed on monocytes/macrophages.^[1]^[2]

The mouse equivalent is called "macrosialin".

Use in pathology

Immunohistochemistry can be used to identify the presence of CD68, which is found in the cytoplasmic granules of a range of different blood cells and myocytes. It is particularly useful as a marker for the various cells of the macrophage lineage, including monocytes, histiocytes, giant cells, Kupffer cells, and osteoclasts. This allows it to be used to distinguish diseases of otherwise similar appearance, such as the monocyte/macrophage and lymphoid forms of leukaemia (the latter being CD68 negative). Its presence in macrophages also makes it useful in diagnosing conditions related to proliferation or abnormality of these cells, such as malignant histiocytosis, histiocytic lymphoma, and Gaucher's disease.^[3]^[4]

References

^ Osterne R, Matos-Brito R, Alves AP et al. (February 2009). "Oral Granulocytic Sarcoma : A case report" (PDF). Med Oral Patol Oral Cir Bucal 14 (5): E232–5. PMID 19218902. ^{[dead link]}
^ Holness CL, Simmons DL (March 1993). "Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins". Blood 81 (6): 1607–13. PMID 7680921.
^ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. pp. 135–136. ISBN 1-84110-100-1.
^ Manduch M, Dexter DF, Jalink DW, Vanner SJ, Hurlbut DJ (January 2009). "Undifferentiated pancreatic carcinoma with osteoclast-like giant cells: Report of a case with osteochondroid differentiation". Pathol. Res. Pract. 205 (5): 353–9. doi:10.1016/j.prp.2008.11.006. PMID 19147301.

External links

CD68 antigen, human at the US National Library of Medicine Medical Subject Headings (MeSH)
CD68 protein, mouse at the US National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 血管内大細胞型リンパ腫 intravascular large cell lymphoma
2. 若年性黄色肉芽腫（JXG） juvenile xanthogranuloma jxg
3. エルドハイム・チェスター病 erdheim chester disease
4. 若年性特発性関節炎：疫学と免疫病態学 juvenile idiopathic arthritis epidemiology and immunopathogenesis
5. 古典型ホジキンリンパ腫の疫学、病理学的特徴、および診断 epidemiology pathologic features and diagnosis of classical hodgkin lymphoma

English Journal

SN79, a sigma receptor ligand, blocks methamphetamine-induced microglial activation and cytokine upregulation.

Robson MJ, Turner RC, Naser ZJ, McCurdy CR, Huber JD, Matsumoto RR.SourceDepartment of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, 1 Medical Center Dr., West Virginia University Health Sciences Center, Morgantown, WV 26506, USA.
Experimental neurology.Exp Neurol.2013 Sep;247:134-42. doi: 10.1016/j.expneurol.2013.04.009. Epub 2013 Apr 28.
Methamphetamine (METH) abuse is associated with several negative side effects including neurotoxicity in specific brain regions such as the striatum. The precise molecular mechanisms by which METH usage results in neurotoxicity remain to be fully elucidated, with recent evidence implicating the impo
PMID 23631864

Slowly progressive cholangiofibrosis induced in rats by α-naphthylisothiocyanate (ANIT), with particular references to characteristics of macrophages and myofibroblasts.

Golbar HM, Izawa T, Ichikawa C, Tanaka M, Juniantito V, Sawamoto O, Kuwamura M, Yamate J.SourceVeterinary Pathology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-ourai-kita, Izumisano City, Osaka 598-8531, Japan.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie.Exp Toxicol Pathol.2013 Sep;65(6):825-35. doi: 10.1016/j.etp.2012.12.001. Epub 2013 Jan 5.
A progressive cholangiofibrosis was developed as an animal model in 6-week-old male F344 rats by repeated intraperitoneal injections of α-naphthylisothiocyanate (ANIT) for 19 weeks; liver samples were examined at post-first injection (PFI) weeks 3, 7, 10, 13, 16 and 19, focusing on characteristics
PMID 23298557

Expressions of Iba1 and galectin-3 (Gal-3) in thioacetamide (TAA)-induced acute rat liver lesions.

Wijesundera KK, Juniantito V, Golbar HM, Fujisawa K, Tanaka M, Ichikawa C, Izawa T, Kuwamura M, Yamate J.SourceLaboratory of Veterinary Pathology, Division of Veterinary Sciences, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58, Rinku-ourai-kita, Izumisano City, Osaka 598-8531, Japan.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie.Exp Toxicol Pathol.2013 Sep;65(6):799-808. doi: 10.1016/j.etp.2012.11.006. Epub 2012 Dec 21.
Ionized calcium binding adaptor molecule 1 (Iba1) is associated with membrane ruffling and motility of cells. Galectin-3 (Gal-3) is a β-galactoside binding animal lectin, and regulates fibrogenesis probably through transforming growth factor-β1. To evaluate macrophage properties, expressions of Ib
PMID 23265716

Japanese Journal

IL-18頻回投与による熱傷後のマウスクッパー細胞の機能増強効果

宮崎裕美,木下学,小野聡,関修司,齋藤大蔵
Cytometry research : 日本サイトメトリー学会機関誌 21(2), 29-34, 2011-10-25
NAID 10029807503

症例報告疣状黄色腫の2例

信原桂子,上原慎司,石井正光 [他]
臨床皮膚科 65(11), 899-902, 2011-10
NAID 40019005559

Related Pictures

anti-CD68 antibody :: Rat anti-Mouse CD68 DETECTION OF CD68-POSITIVE MICROPARTICLES File:MS Demyelinisation CD68 10x.jpg CD68/SR-D1 Antibody (KP1) 0.5 ml Tonsil stained with Anti-CD68. cd68 cd68 antibody CD68 CD68 High power:

★リンクテーブル★

リンク元	「表面抗原分類」
関連記事	「CD」

「表面抗原分類」

CD68 molecule
Identifiers
Symbol	CD68
Entrez	968
HUGO	1693
OMIM	153634
RefSeq	NM_001251
UniProt	P34810
Other data
Locus	Chr. 17 p13

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「CD」

　　[★]

[pmid19218902-1] Osterne R, Matos-Brito R, Alves AP et al. (February 2009). "Oral Granulocytic Sarcoma : A case report" (PDF). Med Oral Patol Oral Cir Bucal 14 (5): E232–5. PMID 19218902. ^{[dead link]}

[pmid7680921-2] Holness CL, Simmons DL (March 1993). "Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins". Blood 81 (6): 1607–13. PMID 7680921.

[Leong-3] Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. pp. 135–136. ISBN 1-84110-100-1.

[pmid19147301-4] Manduch M, Dexter DF, Jalink DW, Vanner SJ, Hurlbut DJ (January 2009). "Undifferentiated pancreatic carcinoma with osteoclast-like giant cells: Report of a case with osteochondroid differentiation". Pathol. Res. Pract. 205 (5): 353–9. doi:10.1016/j.prp.2008.11.006. PMID 19147301.

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案内

CD68