- 同
- Complement membrane co factor pro- tein
PrepTutorEJDIC
- certificate of deposit / (また『C.D.』)Civil Defense民間防衛
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/07 04:10:37」(JST)
[Wiki en表示]
| CD46 molecule, complement regulatory protein |
|
PDB rendering based on 1ckl.
|
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
|
1CKL, 1HR4, 2O39, 3INB, 3L89, 3O8E
|
|
|
| Identifiers |
| Symbols |
CD46 ; AHUS2; MCP; MIC10; TLX; TRA2.10 |
| External IDs |
OMIM: 120920 MGI: 1203290 HomoloGene: 7832 GeneCards: CD46 Gene |
| Gene ontology |
| Molecular function |
• complement binding
• endopeptidase activity
• enzyme inhibitor activity
• receptor activity
• protein binding
• cadherin binding
|
| Cellular component |
• inner acrosomal membrane
• Golgi apparatus
• plasma membrane
• integral component of plasma membrane
• focal adhesion
• cell surface
• basolateral plasma membrane
• extracellular exosome
|
| Biological process |
• adaptive immune response
• T cell mediated immunity
• proteolysis
• complement activation, classical pathway
• single fertilization
• regulation of Notch signaling pathway
• positive regulation of gene expression
• negative regulation of gene expression
• viral process
• regulation of complement activation
• interleukin-10 production
• positive regulation of interleukin-10 production
• sequestering of extracellular ligand from receptor
• positive regulation of T cell proliferation
• negative regulation of catalytic activity
• positive regulation of memory T cell differentiation
• innate immune response
• positive regulation of regulatory T cell differentiation
• negative regulation of complement activation
• positive regulation of transforming growth factor beta production
|
| Sources: Amigo / QuickGO |
|
| RNA expression pattern |
|
|
|
| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
4179 |
17221 |
| Ensembl |
ENSG00000117335 |
ENSMUSG00000016493 |
| UniProt |
P15529 |
O88174 |
| RefSeq (mRNA) |
NM_002389 |
NM_010778 |
| RefSeq (protein) |
NP_002380 |
NP_034908 |
| Location (UCSC) |
Chr 1:
207.75 – 207.8 Mb |
Chr 1:
195.04 – 195.09 Mb |
| PubMed search |
[1] |
[2] |
|
|
CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene.[1] CD46 is an inhibitory complement receptor.[2]
Contents
- 1 Gene
- 2 Function
- 3 Clinical Significance
- 4 Interactions
- 5 References
- 6 External links
Gene
This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene.[3]
Function
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system.
The encoded protein has cofactor activity for inactivation (through cleavage) of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement.[4]
The protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization.[5]
Clinical Significance
The encoded protein can act as a receptor for the Edmonston strain of measles virus,[6] human herpesvirus-6 (HHV-6), and type IV pili of pathogenic Neisseria.[7]
The extracellular region of CD46 contains four short consensus repeats (SCR) of about 60 amino acids that fold into a compact beta-barrel domain surrounded by flexible loops.[8] As has been demonstrated for CD46 with other ligands, the CD46 protein structure is believed to linearize upon binding HHV-6. While their precise interaction has not yet been determined, the second and third SCR domains have been demonstrated to be required for HHV-6 receptor binding and cellular entry. The heterotetramer gH/gL/gQ1/gQ2 complex of HHV-6 has been identified as a CD46 ligand.[9]
Established medulloblastoma (a malignant brain tumor common in childhood) specimens express CD46, and that medulloblastoma specimens removed from patients had a high level of CD46 expression. Therefore a vaccine made of the Edmonston strain of measles virus could treat the medulloblastoma. Such a vaccine has already been tested in a number of trials involving other tumor types which have a high expression of CD46, including one type of adult brain tumor.[10]
Interactions
CD46 has been shown to interact with CD9,[11] CD151[11] and CD29.[11]
References
- ^ Taylor CT, Biljan MM, Kingsland CR, Johnson PM (May 1994). "Inhibition of human spermatozoon-oocyte interaction in vitro by monoclonal antibodies to CD46 (membrane cofactor protein)". Hum. Reprod. 9 (5): 907–11. PMID 7929741.
- ^ Liszewski MK, Post TW, Atkinson JP (1991). "Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster". Annu. Rev. Immunol. 9 (1): 431–55. doi:10.1146/annurev.iy.09.040191.002243. PMID 1910685.
- ^ "Entrez Gene: CD46 CD46 molecule, complement regulatory protein".
- ^ Riley-Vargas RC, Gill DB, Kemper C, Liszewski MK, Atkinson JP (September 2004). "CD46: expanding beyond complement regulation". Trends Immunol. 25 (9): 496–503. doi:10.1016/j.it.2004.07.004. PMID 15324743.
- ^ Liszewski MK, Kemper C, Price JD, Atkinson JP (November 2005). "Emerging roles and new functions of CD46". Springer Semin. Immunopathol. 27 (3): 345–58. doi:10.1007/s00281-005-0002-3. PMID 16200405.
- ^ Dörig RE, Marcil A, Richardson CD (September 1994). "CD46, a primate-specific receptor for measles virus". Trends Microbiol. 2 (9): 312–8. doi:10.1016/0966-842X(94)90447-2. PMID 7529121.
- ^ Cattaneo R (May 2004). "Four viruses, two bacteria, and one receptor: membrane cofactor protein (CD46) as pathogens' magnet". J. Virol. 78 (9): 4385–8. doi:10.1128/JVI.78.9.4385-4388.2004. PMC 387720. PMID 15078919.
- ^ Arbuckle, Jesse. "The molecular biology of human herpesvirus-6 latency and telomere integration". Microbes and infection 13 (8-9). doi:10.1016/j.micinf.2011.03.006. PMC 3130849. PMID 21458587.
- ^ Mori (2009). "Recent topics related to human herpesvirus 6 cell tropism". Cell microbiology.
- ^ Studebaker AW, Kreofsky CR, Pierson CR, Russell SJ, Galanis E, Raffel C (May 2010). "Treatment of medulloblastoma with a modified measles virus". Neuro Oncol 12 (10): 1034–1042. doi:10.1093/neuonc/noq057. PMC 3018921. PMID 20494960.
- ^ a b c Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (March 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407.
External links
- GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
- OMIM entries on Atypical Hemolytic-Uremic Syndrome
- CD46 antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Proteins: complement system (C, L, A)
|
|
| Activators/enzymes |
| Early |
- A: Factor B
- Factor D
- Factor P/Properdin
|
|
| Middle |
- C3-convertase
- C5-convertase
|
|
| Late |
|
|
|
| Inhibitors |
- CLA: C1-inhibitor
- Decay-accelerating factor/CD59
- Factor I
|
|
| Complement receptors |
- CR1
- CR2
- CR3
- CR4
- CD11b/CD11c/CD18
- Anaphylatoxin
|
|
|
Index of the immune system
|
|
| Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
|
|
| Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
|
|
| Treatment |
- Procedures
- Drugs
- antihistamines
- immunostimulants
- immunosuppressants
- monoclonal antibodies
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.
- Martínez-Barricarte R1, Heurich M2, López-Perrote A3, Tortajada A1, Pinto S1, López-Trascasa M4, Sánchez-Corral P5, Morgan BP2, Llorca O3, Harris CL2, Rodríguez de Córdoba S6.
- Molecular immunology.Mol Immunol.2015 Aug;66(2):263-73. doi: 10.1016/j.molimm.2015.03.248. Epub 2015 Apr 11.
- Atypical hemolytic uremic syndrome (aHUS) associates with complement dysregulation caused by mutations and polymorphisms in complement activators and regulators. However, the reasons why some mutations in complement proteins predispose to aHUS are poorly understood. Here, we have investigated the fu
- PMID 25879158
- Oncolytic measles virus as a novel therapy for malignant peripheral nerve sheath tumors.
- Deyle DR1, Escobar DZ2, Peng KW2, Babovic-Vuksanovic D3.
- Gene.Gene.2015 Jul 1;565(1):140-5. doi: 10.1016/j.gene.2015.04.001. Epub 2015 Apr 2.
- Malignant peripheral nerve sheath tumors (MPNSTs) are devastating soft tissue sarcomas that can arise sporadically or in association with neurofibromatosis type I, have a poor prognosis, and have limited treatment options. Oncolytic measles virus therapy has been demonstrated to have significant ant
- PMID 25843626
- Complement regulator CD46: genetic variants and disease associations.
- Liszewski MK1, Atkinson JP2.
- Human genomics.Hum Genomics.2015 Jun 10;9(1):7. [Epub ahead of print]
- Membrane cofactor protein (MCP; CD46) is an ubiquitously expressed complement regulatory protein that protects host cells from injury by complement. This type-I membrane glycoprotein serves as a cofactor for the serine protease factor I to mediate inactivation of C3b and C4b deposited on host cells.
- PMID 26054645
Japanese Journal
- Dendritic cell subsets involved in type I IFN induction in mouse measles virus infection models
- Takaki Hiromi,Oshiumi Hiroyuki,Matsumoto Misako,Seya Tsukasa
- International Journal of Biochemistry & Cell Biology 53, 329-333, 2014-08
- … Although the natural host of MV is human, mouse models expressing MV entry receptors (human CD46, CD150) and disrupting the interferon (IFN) pathways work for investigating immune responses during early MV infection in vivo. …
- NAID 120005476101
- Human herpesvirus-6A gQ1 and gQ2 are critical for human CD46 usage
- Jasirwan Chyntia,Furusawa Yoshikazu,Tang Huamin [他]
- Microbiology and immunology 58(1), 22-30, 2014-01
- NAID 40019971058
- 次世代型制限増殖アデノウイルスを利用した血中循環がん細胞検出法の開発 (ウイルスを利用した医療・創薬研究の新展開 : ウイルスは貴重なバイオマテリアル)
- 櫻井 文教,藤原 俊義,水口 裕之
- YAKUGAKU ZASSHI 133(3), 291-296, 2013
- … The next-generation conditionally replicating Ad possesses the fiber protein derived from Ad serotype 35, leading to efficient infection in both CAR-positive and -negative tumor cells, because the fiber protein of Ad serotype 35 binds to CD46, which is expressed on almost all human cells. …
- NAID 130003361913
Related Links
- CD46, CD55 の構造的特徴はともにアミノ酸60余個から成るshort consensus repeat (SCR, or Sushi domain) を構成モチーフとすることである。補体関連のSCR蛋白はその遺伝子が1q32 に gene cluster を形成し、 Regulator of 補体の ...
- Philipsリニアトラッキング・メカCDM-12を使用したデジタル・サーボ構成のCDプレイヤー。 DA変換部には、新型CC DAC（TDA1545）を搭載しています。 フェードイン・アウト機能を搭載しています。 オートミュージックスキャン機能を搭載して ...
Related Pictures
★リンクテーブル★
[★]
- 英
- cluster of differentiation, CD
- Bリンパ球 CD10,CD19,CD20
- Tリンパ球 CD2,CD3,CD5,CD7
- 幹細胞 CD34
- 顆粒球 CD13,CD33
- 単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。
- 巨核球 CD41(GpIIb),CD42(GpIb)
- NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)
[★]
- 英
- CD46 antigen
- 関
- 補体調節タンパク質
[★]
CD46抗原
- 関
- membrane cofactor protein
[★]
[★]
- 同
- T4, Leucine-SA, Leucine-3B
- 関
- 表面抗原分類