同: CD80

WordNet

the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/19 20:32:04」(JST)

wiki en

Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4^[1]^[2] (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells.

References

^ Peach, R J; Bajorath J; Naemura J; Leytze G; Greene J; Aruffo A; Linsley P S (Sep 1995). "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28". J. Biol. Chem. (UNITED STATES) 270 (36): 21181–7. doi:10.1074/jbc.270.36.21181. ISSN 0021-9258. PMID 7545666.
^ Stamper, C C; Zhang Y; Tobin J F; Erbe D V; Ikemizu S; Davis S J; Stahl M L; Seehra J; Somers W S; Mosyak L (Mar 2001). "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses". Nature (England) 410 (6828): 608–11. doi:10.1038/35069118. ISSN 0028-0836. PMID 11279502.

UpToDate Contents

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English Journal

The β isoform of GSK3 mediates podocyte autonomous injury in proteinuric glomerulopathy.

Li C1,2, Ge Y2, Dworkin L2, Peng A1, Gong R2.
The Journal of pathology.J Pathol.2016 May;239(1):23-35. doi: 10.1002/path.4692. Epub 2016 Mar 16.
Converging evidence points to glycogen synthase kinase (GSK) 3 as a key player in the pathogenesis of podocytopathy and proteinuria. However, it remains unclear if GSK3 is involved in podocyte autonomous injury in glomerular disease. In normal kidneys, the β isoform of GSK3 was found to be the majo
PMID 26876299

ASP2408 and ASP2409, novel CTLA4-Ig variants with CD86-selective ligand binding activity and improved immunosuppressive potency, created by directed evolution.

Oshima S1, Karrer EE2, Paidhungat MM3, Neighbors M4, Chapin SJ4, Fan RA4, Reed MA4, Wu K4, Wong C4, Chen Y5, Whitlow M6, Anderson FA3, Bam RA3, Zhang Q3, Larsen BR5, Viswanathan S7, Devens BH4, Bass SH3, Higashi Y8.
Protein engineering, design & selection : PEDS.Protein Eng Des Sel.2016 May;29(5):159-67. doi: 10.1093/protein/gzw002. Epub 2016 Mar 10.
The CTLA4-Ig therapeutics abatacept and belatacept inhibit CD28-mediated T cell activation by binding CD80 (B7-1) and CD86 (B7-2) co-stimulatory ligands. Both compounds preferentially bind CD80, yet CD86 has been implicated as the dominant co-stimulatory ligand. Using directed evolution methods, nov
PMID 26968452

CD28 costimulatory signals in T lymphocyte activation: Emerging functions beyond a qualitative and quantitative support to TCR signalling.

Porciello N1, Tuosto L2.
Cytokine & growth factor reviews.Cytokine Growth Factor Rev.2016 Apr;28:11-9. doi: 10.1016/j.cytogfr.2016.02.004. Epub 2016 Mar 4.
CD28 is one of the most important co-stimulatory receptors necessary for full T lymphocyte activation. By binding its cognate ligands, B7.1/CD80 or B7.2/CD86, expressed on the surface of professional antigen presenting cells (APC), CD28 initiates several signalling cascades, which qualitatively and
PMID 26970725

Japanese Journal

The Influence of UGT2B7, UGT1A8, MDR1, ALDH, ADH, CYP3A4 and CYP3A5 Genetic Polymorphisms on the Pharmacokinetics of Silodosin in Healthy Chinese Volunteers

, , , ,
Drug Metabolism and Pharmacokinetics 28(3), 239-243, 2013
… Background: Silodosin (KMD-3213), a highly selective α1a-adrenergic receptor antagonist, was approved in Japan (2006), the United States of America (2008), and China (2011) for benign prostatic hyperplasia. … The relationship between plasma silodosin concentration, its pharmacokinetic parameters, polymorphic alleles (UGT2B7, UGT1A8, MDR1, ALDH, ADH, CYP3A4, and CYP3A5), and other enzymes related to silodosin metabolism were assessed for each subject. …
NAID 130004463307

UDP-グルクロン酸転移酵素によるシトクロムP450活性の調節：ヒト主要UGT分子種UGT2B7、1A1、1A6および1A9による、CYP3A4による酸化反応の促進

宮内優,石井祐次,山田英之
日本薬物動態学会年会講演要旨集 25(0), 202-202, 2010
NAID 130004639909

Genetic Impact of a Butyrophilin-like 2 (BTNL2) Gene Variation on Specific IgE Responsiveness to Dermatophagoides farinae (Der f) in Japanese

, , , , , , , ,
Allergology International 58(1), 29-35, 2009
… Butyrophilin-like 2 (BTNL2) is a member of the immunoglobulin superfamily and, on the basis of its homology to B7-1, has been implicated as a costimulatory molecule involved in T-cell activation. … Methods: Three single nucleotide polymorphisms (SNPs), including 2 coding SNPs and 1 intron SNP, were studied. … 1.55, p = 0.0060). …
NAID 130004477018

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★リンクテーブル★

リンク元	「T細胞」「CD80」
関連記事	「B」

「T細胞」

CD80
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DR9, 1I8L
Identifiers
Aliases	CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, CD80 molecule
External IDs	OMIM: 112203 MGI: 101775 HomoloGene: 3804 GeneCards: 941
Genetically Related Diseases
Disease Name	References
	[1]
Gene ontology
Molecular function	• coreceptor activity; • virus receptor activity; • protein binding;
Cellular component	• membrane; • cell surface; • external side of plasma membrane; • integral component of membrane; • plasma membrane; • intracellular;
Biological process	• T cell costimulation; • intracellular signal transduction; • phosphatidylinositol-mediated signaling; • positive regulation of interleukin-2 biosynthetic process; • epidermal growth factor receptor signaling pathway; • fibroblast growth factor receptor signaling pathway; • neurotrophin TRK receptor signaling pathway; • positive regulation of alpha-beta T cell proliferation; • cell-cell signaling; • positive regulation of signal transduction; • cellular response to lipopolysaccharide; • Fc-epsilon receptor signaling pathway; • positive regulation of T-helper 1 cell differentiation; • viral process; • viral entry into host cell; • positive regulation of T cell proliferation; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of transcription, DNA-templated; • positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; • innate immune response; • T cell activation;
	Sources:Amigo / QuickGO
Orthologs
	941
	12519
	ENSG00000121594
	ENSMUSG00000075122
	P33681
	Q00609
	NM_005191
	NM_009855
	NP_005182.1
	NP_033985.3
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

英: T cell
同: Tリンパ球、T lymphocyte
関: TCR、B細胞、MHC

図：IMM.315(T細胞の成熟)
胸腺で成熟したT細胞は血流によって移動し、リンパ節の傍皮質、白脾髄のリンパ性動脈周囲鞘、パイエル板の傍濾胞域に集まる(人間の正常構造と機能 VIIA血管・免疫 p.28)

種類

T細胞の抗原認識 (SP.248)

	CD	TCRが抗原と共に認識する分子	認識する細胞
Tc細胞	CD8	MHCクラスI	感染細胞
Th細胞	CD4	MHCクラスII	抗原提示細胞

CD4+ T細胞のサイトカイン放出とその原因

DCが認識する外来異物	DCが分泌する物質	DCに反応する細胞	この細胞が分泌するサイトカイン	NK系の細胞が放出したサイトカインに反応するTh細胞	Th細胞が分泌するサイトカイン
ウイルス、一部の細菌	IL-12	NK細胞(IL-12による)	INF-γ	Th1	IL-2, IFN-γ, TNF-β
原虫など		NKT細胞	IL-4	Th2	IL-4, IL-13, IL-5

Th細胞活性化と接着分子

	抗原提示細胞	Th細胞
主シグナル	MHC classII	TCR, CD3
主シグナル	MHC classII	CD4
副シグナル	B7{B7-1(CD80)/B7-2(CD86)}	CD28
	VCAM-1(CD106)	VLA-4
	ICAM-1	LFA-1
	LFA-3(CD58)	CD2

「CD80」

　　[★]

関: B7 molecules, CD80/CD86

同: B7-1

「B」

　　[★]

気管分岐部下緑
補体のalternative pathwayに関わる蛋白質

Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

[pmid7545666-1] Peach, R J; Bajorath J; Naemura J; Leytze G; Greene J; Aruffo A; Linsley P S (Sep 1995). "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28". J. Biol. Chem. (UNITED STATES) 270 (36): 21181–7. doi:10.1074/jbc.270.36.21181. ISSN 0021-9258. PMID 7545666.

[pmid11279502-2] Stamper, C C; Zhang Y; Tobin J F; Erbe D V; Ikemizu S; Davis S J; Stahl M L; Seehra J; Somers W S; Mosyak L (Mar 2001). "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses". Nature (England) 410 (6828): 608–11. doi:10.1038/35069118. ISSN 0028-0836. PMID 11279502.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

匿名

検索

案内

案内

B7-1