同: av subunit of vitronectin receptor, Inte- grin av subunit

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/08 18:15:59」(JST)

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Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.^[1]

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.^[2]

References

^ Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS; et al. (Aug 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.
^ "Entrez Gene: ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)".

External links

CD51 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
ITGAV Info with links in the Cell Migration Gateway

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UpToDate Contents

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1. 夜間喘息 nocturnal asthma

English Journal

Systemic lupus erythematosus: disease activity may influence the release of endothelial microparticles?

Cicarini WB1, Ferreira KS1, Loures CMG1, Consoli RV2, Neiva CLS2, Pádua PM2, Nunes FFC1, Alves LCV1, Reis EA3, Toledo VPCP1, Lwaleed BA4, Carvalho MG1.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.Blood Coagul Fibrinolysis.2018 Mar;29(2):189-195. doi: 10.1097/MBC.0000000000000703.
PMID 29420454

Distorted leukocyte migration, angiogenesis, wound repair and metastasis in Tspan8 and Tspan8/CD151 double knockout mice indicate complementary activities of Tspan8 and CD51.

Zhao K1, Erb U1, Hackert T2, Zöller M3, Yue S4.
Biochimica et biophysica acta.Biochim Biophys Acta.2018 Feb;1865(2):379-391. doi: 10.1016/j.bbamcr.2017.11.007. Epub 2017 Nov 11.
PMID 29138006

Corrigendum to "Distorted leukocyte migration, angiogenesis, wound repair and metastasis in Tspan8 and Tspan8/CD151 double knockout mice indicate complementary activities of Tspan8 and CD51" [Biochim. Biophys. Acta 1865(2) (2018) 379-391].

Zhao K1, Erb U1, Hackert T1, Zöller M2, Yue S1.
Biochimica et biophysica acta.Biochim Biophys Acta.2018 Jan 20. pii: S0167-4889(18)30001-6. doi: 10.1016/j.bbamcr.2018.01.001. [Epub ahead of print]
PMID 29366556

Japanese Journal

P1-015　14-3-3ηが，ヒト破骨細胞分化へ及ぼす作用の検討

日本臨床免疫学会会誌 38(4), 316a-316a, 2015
NAID 130005104499

P2-007　　Rebamipideはヒト破骨細胞分化を抑制する

日本臨床免疫学会会誌 37(4), 339a-339a, 2014
NAID 130004694245

Endothelial Progenitor Cell Mobilization and Platelet Microparticle Release Are Influenced by Clopidogrel Plasma Levels in Stable Coronary Artery Disease

Circulation journal : official journal of the Japanese Circulation Society 76(3), 729-736, 2012-02-25
NAID 10030130404

Related Pictures

UHF Antennas : CD51-68-73 - Gencom Two Way BLAUPUNKT Casablanca CD51 Accueil RFI CD51-68-73 UHF Antenna item = cd51-0051 fans d2e146 cd51 23 model d2e146 cd51 23 Blaupunkt Casablanca CD51 face front panel 商品コード pcga cd51 pcga cd51

★リンクテーブル★

リンク元	「表面抗原分類」
関連記事	「CD5」「CD」

「表面抗原分類」

Integrin, alpha V
	Rendering of 1JV2
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1JV2, 1L5G, 1M1X, 1U8C, 3IJE, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 4O02, 4UM8, 4UM9
Identifiers
Symbols	ITGAV ; CD51; MSK8; VNRA; VTNR
External IDs	OMIM: 193210 MGI: 96608 HomoloGene: 20510 ChEMBL: 3660 GeneCards: ITGAV Gene
Gene ontology
Molecular function	• virus receptor activity; • opsonin binding; • fibronectin binding; • protease binding; • protein kinase C binding; • voltage-gated calcium channel activity; • protein binding; • insulin-like growth factor I binding; • metal ion binding; • transforming growth factor beta binding; • extracellular matrix binding; • extracellular matrix protein binding;
Cellular component	• plasma membrane; • integral component of plasma membrane; • focal adhesion; • integrin complex; • external side of plasma membrane; • cell surface; • membrane; • lamellipodium membrane; • filopodium membrane; • microvillus membrane; • ruffle membrane; • integrin alphav-beta3 complex; • integrin alphav-beta5 complex; • integrin alphav-beta8 complex; • alphav-beta3 integrin-IGF-1-IGF1R complex; • phagocytic vesicle; • extracellular exosome;
Biological process	• angiogenesis; • antigen processing and presentation of peptide antigen via MHC class I; • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; • cell adhesion; • cell-matrix adhesion; • integrin-mediated signaling pathway; • axon guidance; • blood coagulation; • positive regulation of cell proliferation; • negative regulation of macrophage derived foam cell differentiation; • negative regulation of lipid storage; • cell growth; • cell migration; • extracellular matrix organization; • positive regulation of cell migration; • cell-substrate adhesion; • negative regulation of lipid transport; • positive regulation of osteoblast proliferation; • heterotypic cell-cell adhesion; • substrate adhesion-dependent cell spreading; • endodermal cell differentiation; • apolipoprotein A-I-mediated signaling pathway; • antigen processing and presentation of exogenous peptide antigen via MHC class I; • apoptotic cell clearance; • negative regulation of low-density lipoprotein particle receptor biosynthetic process; • positive regulation of cell adhesion; • viral entry into host cell; • vascular endothelial growth factor receptor signaling pathway; • negative regulation of lipoprotein metabolic process; • regulation of phagocytosis; • leukocyte migration; • negative chemotaxis; • entry of symbiont into host cell by promotion of host phagocytosis; • ERK1 and ERK2 cascade; • calcium ion transmembrane transport; • extrinsic apoptotic signaling pathway in absence of ligand; • regulation of apoptotic cell clearance; • negative regulation of entry of bacterium into host cell; • negative regulation of extrinsic apoptotic signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「CD5」

　　[★]

同: Leucine-1

発現細胞

胸腺細胞、T細胞、B細胞のサブセット (IMM)
胸腺細胞、T細胞、NK細胞、B₁(B細胞のsubpopulation) (WCH.31)
成熟T細胞、胸腺細胞、一部のB細胞(CD5陽性B細胞(B-1細胞)。脾臓等、異所由来(骨髄非依存性)のB細胞) (資料1)
B細胞性白血病・リンパ腫(資料1)

分子量

67kDa

別名

T1, Ly1

機能

CD5に対するモノクローナル抗体を作用させると、細胞内のチロシンのリン酸化が起こり、T細胞が活性化する。ただし、抑制的に作用する経路にも作用するかもしれない(WCH.31)

T細胞はnaive CD4 T cellで発現しており、この細胞のマーカーとなる(IMM.315)

CD5⁺ B細胞は自己抗体を産生する(WCH.31)
CD72はCD5にたいするcounter-receptorである(WCH.31)

臨床関連

B-CLLの多くの症例で発現している。 (WCH.31)
関節リウマチでCD5⁺ B細胞が増加する (WCH.31)
白血病/リンパ腫の中でCD5 positiveになるのは、慢性リンパ性白血病とマントル細胞リンパ腫だけ(HIM.693, 慢性リンパ性白血病#細胞表面マーカー WCH.2438)

参考

1. SRL

http://www.srl.info/srlinfo/kensa_ref_CD/KENSA/SRL5039.htm

2. beckman

http://www.bc-cytometry.com/Data/db_search/CD005.htm

3. wiki en

http://en.wikipedia.org/wiki/CD5_(protein)

「CD」

　　[★]

[pmid2454952-1] Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS; et al. (Aug 1988). "Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa". J Clin Invest 81 (6): 1993–8. doi:10.1172/JCI113548. PMC 442653. PMID 2454952.

[2] "Entrez Gene: ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)".

匿名

検索

案内

案内

CD51