同: Semaphorin 4D

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/24 08:43:06」(JST)

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Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene.^[1]

Function

Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system.^[2]

In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still under investigation.^[3]^[4]

During skin damage repairs, SEMA4D interacts with Plexin B2 on gamma delta t cells to play a role in the healing process.^[5]

References

^ "Entrez Gene: SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D".
^ Ito Y, Oinuma I, Katoh H, Kaibuchi K, Negishi M (July 2006). "Sema4D/plexin-B1 activates GSK-3β through R-Ras GAP activity, inducing growth cone collapse". EMBO Reports 7 (7): 704–9. doi:10.1038/sj.embor.7400737. PMC 1500830. PMID 16799460.
^ Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T, Matsumoto M, Yoshida K, Yakura H, Pan C, Parnes JR, Kikutani H (November 2000). "Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling". Immunity 13 (5): 621–31. doi:10.1016/S1074-7613(00)00062-5. PMID 11114375.
^ Ishida I, Kumanogoh A, Suzuki K, Akahani S, Noda K, Kikutani H (August 2003). "Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses". Int. Immunol. 15 (8): 1027–34. doi:10.1093/intimm/dxg098. PMID 12882840.
^ Deborah A. Witherden, Megumi Watanabe, Olivia Garijo, Stephanie E. Rieder, Gor Sarkisyan, Shane J.F. Cronin, Petra Verdino, Ian A. Wilson, Atsushi Kumanogoh, Hitoshi Kikutani, Luc Teyton, Wolfgang H. Fischer, Wendy L. Havran (August 2012). "The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function". Immunity 37 (2): 314–25. doi:10.1016/j.immuni.2012.05.026.

External links

SEMA4D protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

English Journal

Semaphorins: New Cues for Skin Healing by γδ T Cells.

Bonneville M.SourceCentre de Recherche en Cancérologie Nantes-Angers, Université de Nantes, 44007, Nantes, France; INSERM UMR892, 44007 Nantes, France; CNRS UMR6299, 44007 Nantes, France.
Immunity.Immunity.2012 Aug 24;37(2):194-6.
In this issue of Immunity, Witherden et al. (2012) demonstrate a crucial role for CD100-plexin B2 interactions in the wound healing response mediated by murine γδ T cells and in the T cell morphological changes associated with this process.Copyright © 2012 Elsevier Inc. All rights reserved.
PMID 22921116

The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function.

Witherden DA, Watanabe M, Garijo O, Rieder SE, Sarkisyan G, Cronin SJ, Verdino P, Wilson IA, Kumanogoh A, Kikutani H, Teyton L, Fischer WH, Havran WL.SourceDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Immunity.Immunity.2012 Aug 24;37(2):314-25. Epub 2012 Aug 16.
γδ T cells respond rapidly to keratinocyte damage, providing essential contributions to the skin wound healing process. The molecular interactions regulating their response are unknown. Here, we identify a role for interaction of plexin B2 with the CD100 receptor in epithelial repair. In vitro b
PMID 22902232

Japanese Journal

マスト細胞機能のCD72による制御 (特集マスト細胞活性化の関与因子)

臨床免疫・アレルギー科 55(6), 623-628, 2011-06
NAID 40018904441

知っておかなければならないアレルギー疾患の基礎的知識(7)CD72とマスト細胞活性化制御

アレルギ-・免疫 17(9), 1586-1591, 2010-09
NAID 40017271229

「日本叩き」でCD100枚プレゼントという「韓国テレビ局」 (ワイドこんな話を聞いた)

週刊新潮 52(32), 144-145, 2007-08-30
NAID 40015529153

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★リンクテーブル★

リンク元	「表面抗原分類」
関連記事	「CD1」「CD10」

「表面抗原分類」

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
	PDB rendering based on 1olz.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1OLZ, 3OL2
Identifiers
Symbols	SEMA4D ; C9orf164; CD100; M-sema-G; SEMAJ; coll-4
External IDs	OMIM: 601866 MGI: 109244 HomoloGene: 21282 GeneCards: SEMA4D Gene
Gene ontology
Molecular function	• receptor activity; • transmembrane signaling receptor activity; • receptor binding; • protein binding; • semaphorin receptor binding;
Cellular component	• extracellular space; • plasma membrane; • integral component of plasma membrane;
Biological process	• negative regulation of transcription from RNA polymerase II promoter; • positive regulation of protein phosphorylation; • immune response; • cell adhesion; • negative regulation of cell adhesion; • axon guidance; • regulation of cell shape; • negative regulation of alkaline phosphatase activity; • positive regulation of phosphatidylinositol 3-kinase signaling; • positive regulation of cell migration; • regulation of cell projection organization; • negative regulation of apoptotic process; • positive regulation of GTPase activity; • ossification involved in bone maturation; • negative regulation of osteoblast differentiation; • positive regulation of collateral sprouting; • regulation of dendrite morphogenesis; • positive regulation of peptidyl-tyrosine phosphorylation; • negative regulation of peptidyl-tyrosine phosphorylation; • leukocyte aggregation; • semaphorin-plexin signaling pathway; • semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「CD1」

　　[★]

同: leucine-6, CD1A through E

種類

CD1a, CD1b, CD1c, CD1d

発現組織

胸腺皮質、ランゲルハンス細胞、樹状細胞、B細胞(CD1c)、腸上皮、平滑筋、血管上皮(CD1d)

分子量

43-49

機能

MHC class I-like molecule, associated with β2-microgloulin. Has specialized role in presentation of lipid antigens

「CD10」

　　[★]

同: common acute lymphoid leukemia antigen, nephrilysin

発現細胞

B細胞やT細胞前駆体。骨髄間質細胞(bone marrow stromal cell)

分子量

100kDa

機能

Zinc metalloproteinase, marker for pre-B acute lymphatic leukemia (ALL)

別名

Neutral endopeptidase, common acute lymphocytic leukemia antigen(CALLA)

[entrez-1] "Entrez Gene: SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D".

[pmid16799460-2] Ito Y, Oinuma I, Katoh H, Kaibuchi K, Negishi M (July 2006). "Sema4D/plexin-B1 activates GSK-3β through R-Ras GAP activity, inducing growth cone collapse". EMBO Reports 7 (7): 704–9. doi:10.1038/sj.embor.7400737. PMC 1500830. PMID 16799460.

[pmid11114375-3] Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T, Matsumoto M, Yoshida K, Yakura H, Pan C, Parnes JR, Kikutani H (November 2000). "Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling". Immunity 13 (5): 621–31. doi:10.1016/S1074-7613(00)00062-5. PMID 11114375.

[pmid12882840-4] Ishida I, Kumanogoh A, Suzuki K, Akahani S, Noda K, Kikutani H (August 2003). "Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses". Int. Immunol. 15 (8): 1027–34. doi:10.1093/intimm/dxg098. PMID 12882840.

[Witherden-5] Deborah A. Witherden, Megumi Watanabe, Olivia Garijo, Stephanie E. Rieder, Gor Sarkisyan, Shane J.F. Cronin, Petra Verdino, Ian A. Wilson, Atsushi Kumanogoh, Hitoshi Kikutani, Luc Teyton, Wolfgang H. Fischer, Wendy L. Havran (August 2012). "The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function". Immunity 37 (2): 314–25. doi:10.1016/j.immuni.2012.05.026.

匿名

検索

案内

案内

CD100