- 同
- Ecto-nucleoside triphosphate diphos- phohydrolase, Apyrase, Ecto-aden- osine triphosphatase
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/27 06:03:31」(JST)
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| Ectonucleoside triphosphate diphosphohydrolase 1 |
| Identifiers |
| Symbols |
ENTPD1 ; ATPDase; CD39; NTPDase-1; SPG64 |
| External IDs |
OMIM: 601752 MGI: 102805 HomoloGene: 20423 ChEMBL: 5722 GeneCards: ENTPD1 Gene |
| EC number |
3.6.1.5 |
| Gene ontology |
| Molecular function |
• protein binding
• ATP binding
• nucleoside-diphosphatase activity
• nucleoside-triphosphatase activity
|
| Cellular component |
• basal lamina
• plasma membrane
• integral component of plasma membrane
• membrane
• extracellular exosome
|
| Biological process |
• cell adhesion
• G-protein coupled receptor signaling pathway
• blood coagulation
• purine ribonucleoside diphosphate catabolic process
• platelet activation
|
| Sources: Amigo / QuickGO |
|
| RNA expression pattern |
|
|
|
| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
953 |
12495 |
| Ensembl |
ENSG00000138185 |
ENSMUSG00000048120 |
| UniProt |
P49961 |
P55772 |
| RefSeq (mRNA) |
NM_001098175 |
NM_001304721 |
| RefSeq (protein) |
NP_001091645 |
NP_001291650 |
| Location (UCSC) |
Chr 10:
95.71 – 95.88 Mb |
Chr 19:
40.61 – 40.74 Mb |
| PubMed search |
[1] |
[2] |
|
|
Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1) also known as CD39 (Cluster of Differentiation 39), is a human membrane-bound protein.[1] CD39, an ectonucleotidase like CD73, hydrolyzes ATP and ADP to AMP.[2]
Contents
- 1 See also
- 2 References
- 3 Further reading
- 4 External links
See also
- Cluster of differentiation
References
- ^ "Entrez Gene: ENTPD1 Ectonucleoside triphosphate diphosphohydrolase 1".
- ^ Yegutkin, GG (May 2008). "Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade.". Biochimica et biophysica acta 1783 (5): 673–94. doi:10.1016/j.bbamcr.2008.01.024. PMID 18302942.
Further reading
- Maliszewski CR, Delespesse GJ, Schoenborn MA, et al. (1994). "The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization". J. Immunol. 153 (8): 3574–83. PMID 7930580.
- Christoforidis S, Papamarcaki T, Galaris D, et al. (1996). "Purification and properties of human placental ATP diphosphohydrolase". Eur. J. Biochem. 234 (1): 66–74. doi:10.1111/j.1432-1033.1995.066_c.x. PMID 8529670.
- Wang TF, Guidotti G (1996). "CD39 is an ecto-(Ca2+,Mg2+)-apyrase". J. Biol. Chem. 271 (17): 9898–901. doi:10.1074/jbc.271.17.9898. PMID 8626624.
- Kaczmarek E, Koziak K, Sévigny J, et al. (1997). "Identification and characterization of CD39/vascular ATP diphosphohydrolase". J. Biol. Chem. 271 (51): 33116–22. doi:10.1074/jbc.271.51.33116. PMID 8955160.
- Robson SC, Kaczmarek E, Siegel JB, et al. (1997). "Loss of ATP Diphosphohydrolase Activity with Endothelial Cell Activation". J. Exp. Med. 185 (1): 153–63. doi:10.1084/jem.185.1.153. PMC 2196106. PMID 8996251.
- Gray IC, Fallowfield J, Ford S, et al. (1997). "An integrated physical and genetic map spanning chromosome band 10q24". Genomics 43 (1): 85–8. doi:10.1006/geno.1997.4809. PMID 9226376.
- Makita K, Shimoyama T, Sakurai Y, et al. (1999). "Placental ecto-ATP diphosphohydrolase: its structural feature distinct from CD39, localization and inhibition on shear-induced platelet aggregation". Int. J. Hematol. 68 (3): 297–310. doi:10.1016/S0925-5710(98)00080-2. PMID 9846014.
- Matsumoto M, Sakurai Y, Kokubo T, et al. (1999). "The cDNA cloning of human placental ecto-ATP diphosphohydrolases I and II". FEBS Lett. 453 (3): 335–40. doi:10.1016/S0014-5793(99)00751-6. PMID 10405171.
- Kittel A, Kaczmarek E, Sevigny J, et al. (1999). "CD39 as a caveolar-associated ectonucleotidase". Biochem. Biophys. Res. Commun. 262 (3): 596–9. doi:10.1006/bbrc.1999.1254. PMID 10471369.
- Koziak K, Kaczmarek E, Kittel A, et al. (2000). "Palmitoylation targets CD39/endothelial ATP diphosphohydrolase to caveolae". J. Biol. Chem. 275 (3): 2057–62. doi:10.1074/jbc.275.3.2057. PMID 10636909.
- Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
- Goepfert C, Imai M, Brouard S, et al. (2001). "CD39 modulates endothelial cell activation and apoptosis". Mol. Med. 6 (7): 591–603. PMC 1949966. PMID 10997340.
- Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochim. Biophys. Acta 1492 (1): 127–38. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484.
- Kittel A, Garrido M, Varga G (2002). "Localization of NTPDase1/CD39 in normal and transformed human pancreas". J. Histochem. Cytochem. 50 (4): 549–56. doi:10.1177/002215540205000412. PMID 11897808.
- Kaneider NC, Egger P, Dunzendorfer S, et al. (2002). "Reversal of thrombin-induced deactivation of CD39/ATPDase in endothelial cells by HMG-CoA reductase inhibition: effects on Rho-GTPase and adenosine nucleotide metabolism". Arterioscler. Thromb. Vasc. Biol. 22 (6): 894–900. doi:10.1161/01.ATV.0000018305.95943.F7. PMID 12067895.
- Drosopoulos JH (2002). "Roles of Asp54 and Asp213 in Ca2+ utilization by soluble human CD39/ecto-nucleotidase". Arch. Biochem. Biophys. 406 (1): 85–95. doi:10.1016/S0003-9861(02)00414-9. PMID 12234494.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Krötz F, Sohn HY, Keller M, et al. (2002). "Depolarization of endothelial cells enhances platelet aggregation through oxidative inactivation of endothelial NTPDase". Arterioscler. Thromb. Vasc. Biol. 22 (12): 2003–9. doi:10.1161/01.ATV.0000043454.08172.51. PMID 12482826.
- Rossatto ER, da Silva LB, Pereira GS, et al. (2003). "ATP diphosphohydrolase in human platelets from patients with coronary arteries heart disease". Platelets 14 (1): 47–52. doi:10.1080/0953710021000062923. PMID 12623446.
- Sørensen CE, Amstrup J, Rasmussen HN, et al. (2004). "Rat pancreas secretes particulate ecto-nucleotidase CD39". J. Physiol. (Lond.) 551 (Pt 3): 881–92. doi:10.1113/jphysiol.2003.049411. PMC 2343304. PMID 12832497.
External links
- ENTPD1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- Hydroxycarbamide modulates components involved in the regulation of adenosine levels in blood cells from sickle-cell anemia patients.
- Silva-Pinto AC1, Dias-Carlos C, Saldanha-Araujo F, Ferreira FI, Palma PV, Araujo AG, Queiroz RH, Elion J, Covas DT, Zago MA, Panepucci RA.
- Annals of hematology.Ann Hematol.2014 Sep;93(9):1457-65. doi: 10.1007/s00277-014-2066-4. Epub 2014 Apr 3.
- Recent studies have demonstrated the role of adenosine (ADO) in sickle-cell anemia (SCA). ADO is produced by CD39 and CD73 and converted to inosine by adenosine deaminase (ADA). We evaluated the effects of hydroxycarbamide (HU) treatment on the modulation of adenosine levels in SCA patients. The exp
- PMID 24696091
- Cell exhaustion in HIV-1 infection: role of suppressor cells.
- Seddiki N1, Brezar V, Draenert R.
- Current opinion in HIV and AIDS.Curr Opin HIV AIDS.2014 Sep;9(5):452-8. doi: 10.1097/COH.0000000000000087.
- PURPOSE OF REVIEW: Suppressor cells regulate immune responses during chronic viral infection by limiting immunopathology associated with inflammation and immune activation. This dampening of adaptive immune responses can be harmful in HIV-1 infection as it also prevents the immune system from cleari
- PMID 25010895
- Extracellular Adenosine Triphosphate Affects the Response of Human Macrophages Infected With Mycobacterium tuberculosis.
- Dubois-Colas N1, Petit-Jentreau L1, Barreiro LB2, Durand S3, Soubigou G4, Lecointe C5, Klibi J5, Rezaï K3, Lokiec F3, Coppée JY4, Gicquel B5, Tailleux L5.
- The Journal of infectious diseases.J Infect Dis.2014 Sep 1;210(5):824-33. doi: 10.1093/infdis/jiu135. Epub 2014 Mar 5.
- Granulomas are the hallmark of Mycobacterium tuberculosis infection. As the host fails to control the bacteria, the center of the granuloma exhibits necrosis resulting from the dying of infected macrophages. The release of the intracellular pool of nucleotides into the surrounding medium may modulat
- PMID 24604822
Japanese Journal
- Relation of CD39 to Plaque Instability and Thrombus Formation in Directional Atherectomy Specimens from Patients with Stable and Unstable Angina(Acute Coronary Syndrome, Basic/Clinical 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Hatakeyama Kinta,Hao Hiroyuki,Imamura Takuroh,Ishikawa Tetsunori,Shibata Yoshisato,Asada Yujiro
- Circulation journal : official journal of the Japanese Circulation Society 69(Supplemnt_I), 492, 2005-03-01
- NAID 110004053465
- CD39/NTPDase-1 Modifies Acute Injury after Myocardial Infarction(Acute Myocardial Infarction, Basic 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Ogawa Mika,Ogawa Norihiko,Nakayama Masaharu,Enjyoji Keiichi,Kohzuki Masahiro,Robson Simon C.
- Circulation journal : official journal of the Japanese Circulation Society 69(Supplemnt_I), 203, 2005-03-01
- NAID 110004052304
Related Links
- CD39 is responsible for the inhibition of ADP-induced platelet aggregation (Kaczmarek et al, 1996; Marcus et al, 1997). Studies with knock-out mice lacking expression of CD39 have indicated that CD39 participates in the in ...
- 性状 eBioA1モノクローナル抗体は、ENTPD1(ectonucleoside triphosphate diphosphohydrolase 1)やNTPDaseとして知られるヒトCD39に反応します。CD39は、2つの膜貫通ドメインを持つ内在性膜タンパクで、ホモ四量体として存在しま す。また ...
- The CD39 antibody specifically recognizes the membrane-bound human CD39 antigen, which is expressed on an effector/memory-like subset of FoxP3+ regulatory T cells1. CD39 is an ec ... Antigen CD39 Clone MZ18-23C8 Isotype
Related Pictures
★リンクテーブル★
[★]
- 英
- cluster of differentiation, CD
- Bリンパ球 CD10,CD19,CD20
- Tリンパ球 CD2,CD3,CD5,CD7
- 幹細胞 CD34
- 顆粒球 CD13,CD33
- 単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。
- 巨核球 CD41(GpIIb),CD42(GpIb)
- NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)
[★]
アピラーゼ
- 同
- CD39
[★]
- 関
- TCR, ζ
発現細胞
機能
- Associated with the T-cell antigen receptor(TCR)
- ζと共にTCRで受容したシグナルを細胞内に伝達する
[★]