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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/19 12:11:21」(JST)

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CD69 (Cluster of Differentiation 69) is a human transmembrane C-Type lectin protein encoded by the CD69 gene.

The activation of T lymphocytes, both in vivo and in vitro, induces expression of CD69. This molecule, which appears to be the earliest inducible cell surface glycoprotein acquired during lymphoid activation, is involved in lymphocyte proliferation and functions as a signal-transmitting receptor in lymphocytes, including natural killer (NK) cells, and platelets (Cambiaggi et al., 1992) [supplied by OMIM].^[1]

References

^ "Entrez Gene: CD69 CD69 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=969.

External links

CD69+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 免疫不全症を引き起こすCD3／T細胞受容体複合体疾患 cd3 t cell receptor complex disorders causing immunodeficiency
2. 若年性特発性関節炎：疫学と免疫病態学 juvenile idiopathic arthritis epidemiology and immunopathogenesis
3. ウイルス誘発性の喘鳴および喘息：概要 virus induced wheezing and asthma an overview
4. 高IgM症候群 hyperimmunoglobulin m syndromes
5. T細胞受容体シグナル伝達 t cell receptor signaling

English Journal

Measurement of Mucosal Biomarkers in a Phase 1 Trial of Intravaginal 3% StarPharma LTD 7013 Gel (VivaGel) to Assess Expanded Safety.

Moscicki AB, Kaul R, Ma Y, Scott ME, Daud II, Bukusi EA, Shiboski S, Rebbapragada A, Huibner S, Cohen CR.Source*Department of Pediatrics, University of California, San Francisco, CA †Departments of Medicine and Immunology, University of Toronto, Ontario, Canada ‡Center for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya §Department of Biostatistics, University of California, San Francisco, CA ‖Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA.
Journal of acquired immune deficiency syndromes (1999).J Acquir Immune Defic Syndr.2012 Feb 1;59(2):134-40.
OBJECTIVE: : The aim of this study was to examine the effect of the 3% StarPharma LTD 7013 gel (VivaGel) on mucosal immune markers hypothesized to be associated with HIV-1 acquisition.DESIGN: : Phase 1, placebo-controlled, randomized, double-blind clinical trial was performed in 54 young women in th
PMID 22067666

Human T Lymphotropic Virus Type 1 Increases T Lymphocyte Migration by Recruiting the Cytoskeleton Organizer CRMP2.

Varrin-Doyer M, Nicolle A, Marignier R, Cavagna S, Benetollo C, Wattel E, Giraudon P.SourceINSERM U1028, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5292, Centre de Recherche en Neuroscience de Lyon, Equipe Neurooncologie-Neuroinflammation, F-69000 Lyon, France;
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2012 Feb 1;188(3):1222-33. Epub 2012 Jan 6.
Recruitment of virus-infected T lymphocytes into the CNS is an essential step in the development of virus-associated neuroinflammatory diseases, notably myelopathy induced by retrovirus human T leukemia virus-1 (HTLV-1). We have recently shown the key role of collapsin response mediator protein 2 (C
PMID 22227566

Japanese Journal

ヘルパーT細胞サブセットの多様性と気道アレルギー性炎症の病態形成における役割 (AYUMI 花粉症 : 研究と治療の進展)

平原潔,中山俊憲
医学のあゆみ 247(12・13), 1203-1207, 2013-12-28
NAID 40019919170

P1-08 実験的自己免疫性脳脊髄炎（EAE）の寛解維持を担う'armoured Treg'の誘導：dominant epitopeによるペプチドワクチンへの可能性

林幼偉,三宅幸子,山村隆
日本臨床免疫学会会誌 36(5), 370b-370b, 2013
… 1つ目は炎症性細胞の惹起後に末梢リンパ節に誘導されるCD4+CD25+T細胞が高値で維持され，CD69CD103共陽性の分画を多く含むことである．この分画はTreg関連分子を最も高く発現し，複数のhybrid Tregを含むeffector細胞で，IL6Rの発現低下を維持して局所で抑制能を保持でき，'armoured Treg'と名付けることができる． …
NAID 130003383062

Related Pictures

Expression of activation marker CD69 by flow cytometry | Biocompare Antibody Review Fig. 1 | CD69: An Unexpected Regulator of TH17 Cell–Driven Inflammatory Responses CD69 is an immunoregulatory molecule induced following activation: Trends in Immunology Is CD69 an effective brake to control inflammatory diseases?: Trends in Molecular Medicine Frontiers | In vivo T Cell Activation in Lymphoid Tissues is Inhibited in the Oxygen Lmna-/- mice display an age-dependent defect in thymic T cell development. Human CD69 PE-conjugated Antibody FAB23591P: R&D Systems Paracrine Molecules of Mesenchymal Stem Cells for Hematopoietic Stem Cell Niche : Figure 1

★リンクテーブル★

リンク元	「表面抗原分類」
関連記事	「CD」

「表面抗原分類」

CD69 molecule
	; PDB rendering based on 1e87.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1E87, 1E8I, 1FM5, 3CCK, 3HUP
Identifiers
Symbols	CD69; AIM; BL-AC/P26; CLEC2C; EA1; GP32/28; MLR-3
External IDs	OMIM: 107273 MGI: 88343 HomoloGene: 128608 GeneCards: CD69 Gene
Gene Ontology
Molecular function	• transmembrane signaling receptor activity; • carbohydrate binding;
Cellular component	• integral to plasma membrane; • external side of plasma membrane;
Biological process	• cellular response to drug;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「CD」

　　[★]

[entrez-0] "Entrez Gene: CD69 CD69 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=969.

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案内

CD69