同: B5,Leucine-14, sialic acid-binding Ig superfamily lectin-2
関: CD

発現細胞

成熟B細胞

分子量

α:130, β:140

機能

Binds sialoconjugates
CD22 is an adhesion molecule and prossesses lectin activity mediated by the first N-terminal Ig-like domain.(WCH.36)
CD22 binds to CD45RO and CDw75.(WCH.36)
CD22-deficident mice develop hight tires of high-affinity autoantibodies.(WCH.36)
CD22 is "masked" on resting B cells, unavailable for binding to its normal ligands. Release from this "masking" is necessary for CD22 to bind to its sialic acid ligands and exert the negative regulatory function on B-cell activation.(WCH.36)
免疫反応の抑制に関与している(IMM.244,631)

別名

BL-CAM

ファミリー

Immunoglobulin

臨床関連

CLLでは弱陽性

PrepTutorEJDIC

certificate of deposit / (また『C.D.』)Civil Defense民間防衛

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/27 07:20:53」(JST)

wiki en

[Wiki en表示]

CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins.^[1] It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.^[2]

CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.^[3]

An immunotoxin, BL22, that targets this receptor is being tested at the NIH.^[4]

External links

CD22 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

Interactions

CD22 has been shown to interact with Grb2,^[5]^[6] PTPN6,^[6]^[7]^[8]^[9]^[10] LYN,^[5]^[8] SHC1^[5] and INPP5D.^[5]

References

^ Crocker; et al. (1998). "Siglecs: a family of sialic-acid binding lectins". Glycobiology 8 (2): v. doi:10.1093/glycob/8.2.0. PMID 9498912.
^ Hatta; et al. (1999). "Identification of the gene variations in human CD22".
^ Lee; et al. (Oct 2014). "Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing". Nature Immunology 15 (10): 982–995. doi:10.1038/ni.2983. PMID 25173345.
^ "BL22 Immunotoxin in Treating Patients Previously Treated With Cladribine for Hairy Cell Leukemia". ClinicalTrials.gov - U.S. National Institutes of Health. Retrieved 2008-02-19.
^ ^a ^b ^c ^d Poe, J C; Fujimoto M; Jansen P J; Miller A S; Tedder T F (June 2000). "CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux". J. Biol. Chem. (UNITED STATES) 275 (23): 17420–7. doi:10.1074/jbc.M001892200. ISSN 0021-9258. PMID 10748054.
^ ^a ^b Otipoby, K L; Draves K E; Clark E A (November 2001). "CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1". J. Biol. Chem. (United States) 276 (47): 44315–22. doi:10.1074/jbc.M105446200. ISSN 0021-9258. PMID 11551923.
^ Blasioli, J; Paust S; Thomas M L (January 1999). "Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22". J. Biol. Chem. (UNITED STATES) 274 (4): 2303–7. doi:10.1074/jbc.274.4.2303. ISSN 0021-9258. PMID 9890995.
^ ^a ^b Greer, S F; Justement L B (May 1999). "CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein tyrosine phosphatase SHP-1". J. Immunol. (UNITED STATES) 162 (9): 5278–86. ISSN 0022-1767. PMID 10228003.
^ Law, C L; Sidorenko S P; Chandran K A; Zhao Z; Shen S H; Fischer E H; Clark E A (February 1996). "CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation". J. Exp. Med. (UNITED STATES) 183 (2): 547–60. doi:10.1084/jem.183.2.547. ISSN 0022-1007. PMC 2192439. PMID 8627166.
^ Adachi, T; Wienands J; Wakabayashi C; Yakura H; Reth M; Tsubata T (July 2001). "SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates". J. Biol. Chem. (United States) 276 (28): 26648–55. doi:10.1074/jbc.M100997200. ISSN 0021-9258. PMID 11356834.

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UpToDate Contents

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1. 有毛細胞白血病の治療 treatment of hairy cell leukemia
2. 有毛細胞白血病の臨床的特徴および診断 clinical features and diagnosis of hairy cell leukemia
3. B細胞前リンパ球性白血病 b cell prolymphocytic leukemia
4. リンパ形質細胞性リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of lymphoplasmacytic lymphoma
5. 節外（MALT）および節性濾胞辺縁帯リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of extranodal malt and nodal marginal zone lymphomas

English Journal

Systemic sclerosis: New evidence re-enforces the role of B cells.

Sakkas LI1, Bogdanos DP2.
Autoimmunity reviews.Autoimmun Rev.2016 Feb;15(2):155-61. doi: 10.1016/j.autrev.2015.10.005. Epub 2015 Oct 21.
Systemic sclerosis (SSc) is characterized by widespread fibrosis, microangiopathy (vasospasms and stenosis), and formation of autoantibodies. T cell activation has been shown to contribute to fibrosis and microvasculopathy in SSc. However, recent evidence suggests that B cells are also likely to con
PMID 26497107

MRI phenotypes with high neurodegeneration are associated with peripheral blood B-cell changes.

Comabella M1, Cantó E2, Nurtdinov R2, Río J2, Villar LM3, Picón C3, Castilló J2, Fissolo N2, Aymerich X4, Auger C4, Rovira A4, Montalban X2.
Human molecular genetics.Hum Mol Genet.2016 Jan 15;25(2):308-16. doi: 10.1093/hmg/ddv473. Epub 2015 Nov 24.
Little is known about the mechanisms leading to neurodegeneration in multiple sclerosis (MS) and the role of peripheral blood cells in this neurodegenerative component. We aimed to correlate brain radiological phenotypes defined by high and low neurodegeneration with gene expression profiling of per
PMID 26604134

Versatile strategy for controlling the specificity and activity of engineered T cells.

Ma JS1, Kim JY1, Kazane SA1, Choi SH2, Yun HY2, Kim MS1, Rodgers DT1, Pugh HM1, Singer O1, Sun SB1, Fonslow BR3, Kochenderfer JN4, Wright TM1, Schultz PG5, Young TS6, Kim CH6, Cao Y2.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2016 Jan 12. pii: 201524193. [Epub ahead of print]
The adoptive transfer of autologous T cells engineered to express a chimeric antigen receptor (CAR) has emerged as a promising cancer therapy. Despite impressive clinical efficacy, the general application of current CAR-T-cell therapy is limited by serious treatment-related toxicities. One approach
PMID 26759368

Agile CD22 nanoclusters run rings around fenced BCR.

Depoil D1, Dustin ML1.
The EMBO journal.EMBO J.2016 Jan 8. pii: e201593745. [Epub ahead of print]
PMID 26746852

Japanese Journal

新規抗体/薬物複合体によるリンパ系腫瘍の治療 : イノツズマブ・オゾガマイシンとブレンツキシマブ・ベドチン (特集新規ターゲットおよび医薬品による血液がん治療の新たな展開)

薄井紀子
血液内科 70(2), 186-191, 2015-02
NAID 40020385039

抗CD20抗体と抗CD22抗体の国内外の動向 (特集全身性エリテマトーデスにおけるターゲット治療の新しい動向)

中山田真吾,田中良哉
分子リウマチ治療 8(1), 4-8, 2015-02
NAID 40020338137

CD22,CD33を標的としたがん治療の展望 (特集注目すべき新標的と期待される次世代抗悪性腫瘍薬)

畠清彦
腫瘍内科 13(6), 782-785, 2014-06
NAID 40020137183

CD22とCD79bを標的とするmonomethyl auristatin E抱合ADCによるB細胞リンパ腫治療 (特集血液腫瘍に対する抗体医薬のさらなる進展)

棟方理
血液内科 68(4), 470-475, 2014-04
NAID 40020085498

Related Pictures

The Ligand-binding Domain of CD22 Is Needed for Inhibition of the B Cell Receptor PE - anti human CD22 - Clone HIB22 An extracatalytic function of CD45 in B cells is mediated by CD22 | PNAS CD22 Anti-MPO/CD22 Monoclonal Antibody (clone : 7,17, HIB22) - FITC/PE Human Siglec-2/CD22 Antibody MAB1968: R&D Systems ornisie • Blog Archive • Protein kinase b-cell activation pathway MPO/CD22 - IMMUNOSTEP. WE KNOW HOW

★リンクテーブル★

リンク元	「慢性リンパ性白血病」「抗原受容体」「表面抗原分類」
関連記事	「CD2」「CD」

「慢性リンパ性白血病」

CD22 molecule
Identifiers
Symbols	CD22 ; SIGLEC-2; SIGLEC2
External IDs	OMIM: 107266 MGI: 88322 HomoloGene: 31052 ChEMBL: 3218 GeneCards: CD22 Gene
Gene ontology
Molecular function	• protein binding; • carbohydrate binding;
Cellular component	• integral component of plasma membrane; • external side of plasma membrane; • extracellular exosome;
Biological process	• cell adhesion;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

　　[★]

英: chronic lymphocytic leukemia, chronic lymphoid leukemia, CLL
関: 白血病

first aid step1 2006 p.300,302,303,304,309,310,427,430

概念

the accumulation of nonproliferating mature-appearing lymphocytes in the blood, marrow, lymph nodes, and spleen.
monoclonal B lymphocytes.
CD5+ and CD23+CD5, CD23
derived from memory B cell.

細胞表面マーカー WCH.2438

condition

smIg

CD5

chronic lymphocytic leukemia

Dim

＋＋

－

－/＋

＋＋

Dim

－/＋

＋＋

＋/－

＋

－

－/＋

Waldenstrom macroglobulinemia

＋＋

－

－/＋

＋＋

＋

－

－/＋

＋/－

＋

－

＋

prolymphocytic leukemia

＋＋＋

－/＋

＋＋

＋＋＋

＋＋

－/＋

＋

＋＋

－

＋

hairy cell leukemia

＋＋＋

－

＋＋

＋＋＋

－

＋＋＋

＋

＋＋＋

hairy cell leukemia variant

＋＋＋

－

＋＋

＋＋＋

－

＋

＋＋＋

splenic lymphoma with villous lymphocytes

＋＋

－/＋

＋/－

＋＋

＋/－

－/＋

＋

＋＋

－/＋

＋＋

marginal zone B-cell lymphoma

＋＋

－

＋/－

＋＋

＋/－

－

－/＋

＋＋

－

＋

mantle cell lymphoma

＋＋

－/＋

－

＋＋

－

＋

＋＋

－

＋＋

follicular lymphoma

＋＋

－/＋

＋＋

－

＋＋

－/＋

－

＋＋

－

＋＋

臨床像

HIM.693

	年齢	子供における頻度	男性(%)	ステージI,II vs III,IV(%)	B症状(%)	骨髄浸潤(%)	消化管浸潤(%)	5年生存率(%)
B細胞CLL/小リンパ球性リンパ腫	65	まれ	53	9 vs 91	33	72	3	51

疫学

YN.G-49

全白血病の2-3%
60歳以上に多い。
男女比=2:1

病態

YN.G-49

正常な免疫グロブリンの産生が抑制されるばかりでなく、異常な自己抗体を産生　→　続発性免疫不全症、自己免疫性溶血性貧血

USMLE

Q book p.246 42

参考

1. [charged] Epidemiology and clinical manifestations of chronic lymphocytic leukemia - uptodate [1]
2. [charged] Pathologic features, diagnosis, and differential diagnosis of chronic lymphocytic leukemia - uptodate [2]
3. [charged] Pathophysiology and cytogenetics of chronic lymphocytic leukemia - uptodate [3]

[show details]

慢性リンパ性白血病 : 約 28,600 件
慢性リンパ球性白血病 : 約 47,100 件

「抗原受容体」

　　[★]

抗原受容体

TCR(T細胞受容体)
BCR(抗体)

シグナル伝達

	T細胞	B細胞
抗原受容体	TCR(β鎖, α鎖)	BCR(H鎖, L鎖)
受容体に付随するタンパク質	CD3δ	Igα
	CD3ε	Igβ
	CD3γ
	ζ
	CD5	CD19
	CD6	CD22
Src kinase	Lck, Fyn	Kyn, Blk, Fyn
Syc kinase ZAP-70 kinase	ZAP-70,Syk	Syk
Down stream enzymes	MAP kinase
	Vav
	PLCγ1	PLCγ1, PLCγ2
	GAP(+/-)	GAP
		PI3 kinase
Others	Ezrin
Others	Valosin-containing protein

「表面抗原分類」

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「CD2」

　　[★]

同: Leucine-5, SRBC receptor, LFA-2
関: CD

発現細胞

T細胞、胸腺細胞、NK細胞

分子量

45-58

機能

接着分子、CD58(LFA-3)に結合。細胞内部でLckに結合し、T細胞を活性化

リンパ球が抗原提示細胞と相互作用するのに重要 (IMM.343)

別名

LFA-2, T11

ファミリー

immunoglobulin

「CD」

　　[★]

[pmid9498912-1] Crocker; et al. (1998). "Siglecs: a family of sialic-acid binding lectins". Glycobiology 8 (2): v. doi:10.1093/glycob/8.2.0. PMID 9498912.

[Hatta1999-2] Hatta; et al. (1999). "Identification of the gene variations in human CD22".

[3] Lee; et al. (Oct 2014). "Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing". Nature Immunology 15 (10): 982–995. doi:10.1038/ni.2983. PMID 25173345.

[titleBL22_Immunotoxin_in_Treating_Patients_Previously_Treated_With_Cladribine_for_Hairy_Cell_Leukemia_-_Full_Text_View_-_ClinicalTrials.gov-4] "BL22 Immunotoxin in Treating Patients Previously Treated With Cladribine for Hairy Cell Leukemia". ClinicalTrials.gov - U.S. National Institutes of Health. Retrieved 2008-02-19.

[pmid10748054-5] Poe, J C; Fujimoto M; Jansen P J; Miller A S; Tedder T F (June 2000). "CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux". J. Biol. Chem. (UNITED STATES) 275 (23): 17420–7. doi:10.1074/jbc.M001892200. ISSN 0021-9258. PMID 10748054.

[pmid11551923-6] Otipoby, K L; Draves K E; Clark E A (November 2001). "CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1". J. Biol. Chem. (United States) 276 (47): 44315–22. doi:10.1074/jbc.M105446200. ISSN 0021-9258. PMID 11551923.

[pmid9890995-7] Blasioli, J; Paust S; Thomas M L (January 1999). "Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22". J. Biol. Chem. (UNITED STATES) 274 (4): 2303–7. doi:10.1074/jbc.274.4.2303. ISSN 0021-9258. PMID 9890995.

[pmid10228003-8] Greer, S F; Justement L B (May 1999). "CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein tyrosine phosphatase SHP-1". J. Immunol. (UNITED STATES) 162 (9): 5278–86. ISSN 0022-1767. PMID 10228003.

[pmid8627166-9] Law, C L; Sidorenko S P; Chandran K A; Zhao Z; Shen S H; Fischer E H; Clark E A (February 1996). "CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation". J. Exp. Med. (UNITED STATES) 183 (2): 547–60. doi:10.1084/jem.183.2.547. ISSN 0022-1007. PMC 2192439. PMID 8627166.

[pmid11356834-10] Adachi, T; Wienands J; Wakabayashi C; Yakura H; Reth M; Tsubata T (July 2001). "SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates". J. Biol. Chem. (United States) 276 (28): 26648–55. doi:10.1074/jbc.M100997200. ISSN 0021-9258. PMID 11356834.

匿名

検索

案内

CD22

発現細胞

分子量

機能

別名

ファミリー

臨床関連

PrepTutorEJDIC

Wikipedia preview

wiki en

External links

Interactions

References

UpToDate Contents

English Journal

Japanese Journal

Related Links

Related Pictures

★リンクテーブル★

「慢性リンパ性白血病」

概念

細胞表面マーカー WCH.2438

臨床像

疫学

病態

USMLE

参考

「抗原受容体」

抗原受容体

シグナル伝達

「表面抗原分類」

「CD2」

発現細胞

分子量

機能

別名

ファミリー

「CD」