同: CD27L

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/08 15:58:31」(JST)

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CD70 (Cluster of Differentiation 70) is a ligand for CD27.

Clinical significance

The CD70 protein is expressed on highly activated lymphocytes (like in T- and B-cell lymphomas). It is therefore suggested that anti-CD70 antibodies might be a possible treatment for CD70 positive lymphomas as normal lymphocytes do not express a lot of CD70.^[1]

Drug development

ARGX-110 is a CD70-specific antibody that is currently under investigation for the treatment of hematological malignancies. It is being developed by the Belgian company arGEN-X. In December 2013 a first part of a phase 1b trial was completed. In January 2014 a safety and efficacy phase of the study started.^[2]

Vorsetuzumab mafodotin is a CD70-targeted antibody-drug conjugate that started clinical trials for renal cell carcinoma.^[3]

References

^ Israel BF, Gulley M, Elmore S, Ferrini S, Feng WH, Kenney SC (2005). "Anti-CD70 antibodies: a potential treatment for EBV+ CD70-expressing lymphomas". Mol. Cancer Ther. 4 (12): 2037–44. doi:10.1158/1535-7163.MCT-05-0253. PMID 16373719.
^ "ARGX-110: first-in-class CD70-targeting antibody with unique mode of therapeutic action". arGEN-X. Retrieved 28 February 2015.
^ Seattle Genetics Third Quarter 2013 Financial Report

External links

CD70 Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. エプスタインバーウイルス（EBウイルス）感染の臨床的特徴および治療 clinical manifestations and treatment of epstein barr virus infection
2. BおよびTリンパ球の正常な発生 normal b and t lymphocyte development
3. 複合免疫不全 combined immunodeficiencies

English Journal

Increased expressions of DNA methyltransferases contribute to CD70 promoter hypomethylation and over expression of CD70 in ITP.

Ma L, Zhou Z, Wang H, Zhou H, Zhang D, Li H, Qi A, Yang R.SourceState Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, PR China.
Molecular immunology.2011 Jul;48(12-13):1525-31. Epub 2011 May 6.
CD70 (TNFSF7), as a methylation susceptive immune gene, was hypomethylated in some autoimmune diseases. To investigate the status of CD70 methylation and the expressions of genes that regulated methylation in immune thrombocytopenia (ITP) patients, the expressions of CD70 mRNA and protein in CD4(+)
PMID 21550117

Therapeutic vaccination with an autologous mRNA electroporated dendritic cell vaccine in patients with advanced melanoma.

Wilgenhof S, Van Nuffel AM, Corthals J, Heirman C, Tuyaerts S, Benteyn D, De Coninck A, Van Riet I, Verfaillie G, Vandeloo J, Bonehill A, Thielemans K, Neyns B.SourceDepartments of *Medical Oncology ‡Dermatology §Clinical Hematology ∥Surgery ¶Blood Transfusion Center of the Universitair Ziekenhuis †Laboratory of Molecular and Cellular Therapy, Department of Physiology-Immunology, Brussels, Belgium.
Journal of immunotherapy (Hagerstown, Md. : 1997).2011 Jun;34(5):448-56.
The immunostimulatory capacity of dendritic cells is improved by co-electroporation with mRNA encoding CD40 ligand, constitutively active toll-like receptor 4, and CD70 (TriMix-DC). This pilot clinical trial evaluated the feasibility, safety, and immunogenicity of a therapeutic vaccination containin
PMID 21577140

Japanese Journal

抗CD70抗体はマウス角膜移植拒絶反応を抑制する

服部貴明,本橋良祐,臼井嘉彦,熊倉重人,後藤浩,秋葉久弥
東京医科大学雑誌 72(4), 398, 2014-10-30
NAID 120005619171

MS5-10 抗CD70抗体投与によるOVA誘発性喘息マウスの発症抑制とそのメカニズムの解析(MS5 気管支喘息動物モデル,ミニシンポジウム,第61回日本アレルギー学会秋季学術大会)

牧野文彦,伊藤潤,原田紀宏,蒲池史卓,安倍能之,高橋和久,秋葉久弥
アレルギー 60(9・10), 1330, 2011-10-10
NAID 110008912186

CD70と自己免疫疾患

安達貴弘
臨床免疫・アレルギー科 56(2), 213-218, 2011-08
NAID 40018972288

Related Pictures

Das CD70 Navi Verkaufe CD70 Navi für Opel Astra H bzw Das opel astra gtc cd70 navi ist in einen Part: Opel/Vauxhall CD70 NAVI Mapy navi cd70 OPEL cd70-vectra Panasonic RX-CD70 CD70+CID+RGB+GPS Antenne+Kabelsatz

★リンクテーブル★

リンク元	「表面抗原分類」「CD27」
関連記事	「CD」

「表面抗原分類」

CD70 molecule
Identifiers
Symbol	CD70
Alt. symbols	CD27LG, TNFSF7
Entrez	970
HUGO	11937
OMIM	602840
RefSeq	NM_001252
UniProt	P32970
Other data
Locus	Chr. 19 p13

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「CD27」

　　[★]

発現細胞

髄質胸腺細胞
T細胞
NK細胞
ある種のB細胞

メモリーB細胞はIgD陰性、CD27がマーカーとなる

分子量

55kDa

機能

CD70に結合する。T細胞とB細胞のco-stimulatorとして機能

ファミリー

TNF family

抗原提示細胞がnaive T細胞を活性化する際、MHC class II ⇔ TCR+CD4が第一のシグナルとして入力される。
第2のシグナルは幾つかあるが、APCがもつCD27がリガンド、naive T細胞のCD70が受容体となりco-stimulatorとして働くものがある (IMM.346)

「CD」

　　[★]

[1] Israel BF, Gulley M, Elmore S, Ferrini S, Feng WH, Kenney SC (2005). "Anti-CD70 antibodies: a potential treatment for EBV+ CD70-expressing lymphomas". Mol. Cancer Ther. 4 (12): 2037–44. doi:10.1158/1535-7163.MCT-05-0253. PMID 16373719.

[2] "ARGX-110: first-in-class CD70-targeting antibody with unique mode of therapeutic action". arGEN-X. Retrieved 28 February 2015.

[SG3Q2013-3] Seattle Genetics Third Quarter 2013 Financial Report

匿名

検索

案内

案内

CD70