同: Campath-1

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/10 18:23:49」(JST)

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CAMPATH-1 antigen, also known as cluster of differentiation 52 (CD52), is a glycoprotein that in humans is encoded by the CD52 gene.

CD52 is present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes were derived. It also is found on monocytes^[1] and dendritic cells.^[2] Further, it is found within the male genital tract and is present on the surface of mature sperm cells. It is not found on resting T cells but is expressed on activated T cells.^[3]

CD52 is a peptide of 12 amino acids, anchored to glycosylphosphatidylinositol (GPI). Since it is highly negatively charged and present on sperm cells and lymphocytes, it has been conjectured that its function is anti-adhesion, allowing cells to freely move around.^[4]

CD52 binds the ITIM (Immunoreceptor tyrosine-based inhibitory motif)-bearing sialic acid-binding lectin SIGLEC10.

Clinical significance

It is associated with certain types of lymphoma.^[5]

It is the protein targeted by alemtuzumab, a monoclonal antibody used for the treatment of chronic lymphocytic leukemia. A phase III trial into treatment of relapsing-remitting Multiple Sclerosis showed a reduction in relapse rate, but no statistically significant reduction in accumulated disability, when used as a first-line therapy.^[6] However, a sister study looking at patients in whom relapses had occurred despite treatment with interferon beta or glatiramer demonstrated reduction in both relapse rate and accumulated disability. 20% patients randomised to interferon beta 1a had "sustained accumulation of disability" compared with 13% in the alemtuzumab group. .^[7]

References

^ Buggins AG, Mufti GJ, Salisbury J, Codd J, Westwood N, Arno M, Fishlock K, Pagliuca A, Devereux S (September 2002). "Peripheral blood but not tissue dendritic cells express CD52 and are depleted by treatment with alemtuzumab". Blood 100 (5): 1715–20. PMID 12176892.
^ Ratzinger G, Reagan JL, Heller G, Busam KJ, Young JW (February 2003). "Differential CD52 expression by distinct myeloid dendritic cell subsets: implications for alemtuzumab activity at the level of antigen presentation in allogeneic graft-host interactions in transplantation". Blood 101 (4): 1422–9. doi:10.1182/blood-2002-04-1093. PMID 12393688.
^ authors = Clark and Cook|date = 2013
^ Hale G, Waldmann H (2000). "From Laboratory to Clinic : The Story of CAM PA TH-1". Methods Mol. Med. 40: 243–66. doi:10.1385/1-59259-076-4:243. PMID 21337094.
^ Piccaluga PP, Agostinelli C, Righi S, Zinzani PL, Pileri SA (April 2007). "Expression of CD52 in peripheral T-cell lymphoma". Haematologica 92 (4): 566–7. doi:10.3324/haematol.10767. PMID 17488672.
^ Coles AJ, Twyman CL, Arnold DL, Cohen JA, Confavreux C, Fox EJ, Hartung HP, Havrdova E, Selmaj KW, Weiner HL, Miller T, Fisher E, Sandbrink R, Lake SL, Margolin DH, Oyuela P, Panzara MA, Compston DA (November 2012). "Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial". Lancet 380 (9856): 1829–39. doi:10.1016/S0140-6736(12)61768-1. PMID 23122650. ^{[unreliable medical source?]}
^ Cohen, Jeffrey; Coles A; Arnold D (24 November 2012). "Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial". The Lancet 380 (9856): 1819–1828. doi:10.1016/S0140-6736(12)61769-3. Retrieved 28 December 2012.

External links

CD52 antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

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1. 肺移植後の免疫抑制の導入induction immunosuppression following lung transplantation [show details]
…Alemtuzumab (Campath-1H) is a humanized preparation of monoclonal rat antibodies directed toward the CD52 antigen that is present on virtually all lymphocytes (both T and B cells). Alemtuzumab leads to depletion …
2. ナチュラルキラー（NK）細胞大顆粒リンパ球性白血病natural killer nk cell large granular lymphocyte leukemia [show details]
…limited. One patient with symptomatic chronic NK lymphocytosis responded to treatment with the anti-CD52 monoclonal antibody, alemtuzumab . The farnesyltransferase inhibitor tipifarnib achieved no objective…
3. 大顆粒リンパ球性白血病の治療treatment of large granular lymphocyte leukemia [show details]
…or allogeneic HCT (5 and 10 patients, respectively) . The monoclonal antibody alemtuzumab targets CD52 expressed on the surface of T cell LGL leukemia . Case reports and small case series have demonstrated…
4. 成人T細胞性白血病/リンパ腫の臨床症状、病理学的特徴、および診断clinical manifestations pathologic features and diagnosis of adult t cell leukemia lymphoma [show details]
…CD8- . Rare cases are CD4-/CD8+ or CD4+/CD8+. CD25 is expressed in a majority of the cases , as is CD52 . Anaplastic large cell variants react with CD30, but are negative for ALK protein and lack rearrangements…
5. 大顆粒T細胞リンパ球性白血病の臨床症状、病理学的特徴、および診断clinical manifestations pathologic features and diagnosis of t cell large granular lymphocyte leukemia [show details]
…phenotype is often associated with mutation of STAT5B . A CD4-/CD8- phenotype has been rarely described. CD52 is also expressed on these cells. Killer immunoglobulin-like receptor (KIR, CD158) expression has…

English Journal

Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies.

Poirot L1, Philip B2, Schiffer-Mannioui C1, Le Clerre D1, Chion-Sotinel I1, Derniame S1, Potrel P1, Bas C1, Lemaire L1, Galetto R1, Lebuhotel C1, Eyquem J1, Cheung GW2, Duclert A1, Gouble A1, Arnould S1, Peggs K2, Pule M2, Scharenberg AM3, Smith J4.
Cancer research.Cancer Res.2015 Sep 15;75(18):3853-64. doi: 10.1158/0008-5472.CAN-14-3321. Epub 2015 Jul 16.
Adoptive immunotherapy using autologous T cells endowed with chimeric antigen receptors (CAR) has emerged as a powerful means of treating cancer. However, a limitation of this approach is that autologous CAR T cells must be generated on a custom-made basis. Here we show that electroporation of trans
PMID 26183927

Outcomes Associated with Steroid Avoidance and Alemtuzumab among Kidney Transplant Recipients.

Serrano OK1, Friedmann P2, Ahsanuddin S3, Millan C1, Ben-Yaacov A4, Kayler LK5.
Clinical journal of the American Society of Nephrology : CJASN.Clin J Am Soc Nephrol.2015 Sep 4. pii: CJN.12161214. [Epub ahead of print]
BACKGROUND AND OBJECTIVES: Alemtuzumab is a humanized anti-CD52 monoclonal antibody used as induction in kidney transplantation (KTX) since 2003. Few studies have evaluated long-term outcomes of this agent or changes in outcomes over time.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A retrospe
PMID 26342042

Alemtuzumab treatment for Sézary syndrome: a single center experience.

Novelli S1, García-Muret P, Sierra J, Briones J.
The Journal of dermatological treatment.J Dermatolog Treat.2015 Sep 2:1-15. [Epub ahead of print]
INTRODUCTION: Sézary syndrome (SS) is characterized by rapidly progressive disease and poor survival. Although there is no standard treatment for SS, allogeneic stem cell transplantation (alloSCT) is the only treatment available that may offer a long survival. Alemtuzumab, a humanized monoclonal an
PMID 26329989

Japanese Journal

Evi-1高発現AMLに対する免疫療法のターゲットとしてのCD52分子

齋藤祐介,森下和広
血液内科 64(4), 467-473, 2012-04-00
NAID 40019312335

妊娠の成立とCD52 (特集生殖と免疫)

小森慎二,加藤徹,脇本裕
臨床免疫・アレルギー科 56(4), 386-390, 2011-10-00
NAID 40019053103

不妊と免疫--その基礎と臨床 (特集不妊診療のすべて)

細田容子,武信尚史,小森慎二
産婦人科治療 102(-), 439-444, 2011-04-00
NAID 40018836325

Related Pictures

CF-Blue™ - anti human CD52 - Clone HI186 PE - anti human CD52 - Clone HI186 Alemtuzumab is used to treat people with chronic lymphocytic leukemia. It works by Marantz CD52 MKII CD Player | 2ndhandhifi | Used Hifi Science子刊：皮肤T细胞淋巴瘤药物免疫新机制_皮肤T细胞淋巴瘤_抗 Marantz CD52 CD player with remote Photo #413958 - Canuck Audio Mart Immunosuppressive Drugs Alemtuzumab – Potential in Multiple Sclerosis (MS) - Drug Development Technology

★リンクテーブル★

リンク元	「表面抗原分類」
拡張検索	「anti-CD52 antibodies」「CD52P」
関連記事	「CD5」「CD」

「表面抗原分類」

CD52 molecule
Identifiers
Symbols	CD52 ; CDW52
External IDs	OMIM: 114280 HomoloGene: 88652 GeneCards: CD52 Gene
Gene ontology
Cellular component	• integral to plasma membrane; • membrane; • anchored to membrane;
Biological process	• elevation of cytosolic calcium ion concentration; • respiratory burst;
	Sources: Amigo / QuickGO
Orthologs
	This box: view; talk; edit;

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100