同: Integrin-associated protein, RH-associ- ated protein, Neurophilin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/02/27 10:10:12」(JST)

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CD47 (Cluster of Differentiation 47) is a protein that in humans is encoded by the CD47 gene.^[1]

Function

CD47 is a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution, and is reduced in expression on Rh erythrocytes.

Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[1] Isoform 2 and 4 are the most abundant. Other than thrombospondin, CD47 also binds CD172a. CD47 deficient mice have been generated. Their reported phenotype is a defect in cellular migration of the CD172a expressing cells, suggesting that CD47 to CD172a interactions are necessary for the proper distribution of these cell types.

Interactions

CD47 has been shown to interact with BNIP3.^[2]

Clinical significance

CD47 is used by bladder cancer cells to hide from normal scavenging by macrophages.^[3]

References

^ ^a ^b "Entrez Gene: CD47 CD47 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=961.
^ Lamy, Laurence; Ticchioni Michel, Rouquette-Jazdanian Alexandre K, Samson Michel, Deckert Marcel, Greenberg Arnold H, Bernard Alain (Jun. 2003). "CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis". J. Biol. Chem. (United States) 278 (26): 23915–21. doi:10.1074/jbc.M301869200. ISSN 0021-9258. PMID 12690108.
^ Chan KS, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, Gill H, Presti J, Chang HY, van de Rijn M, Shortliffe L, Weissman IL (August 2009). "Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells". Proc. Natl. Acad. Sci. U.S.A. 106 (33): 14016–21. doi:10.1073/pnas.0906549106. PMC 2720852. PMID 19666525. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2720852. Lay summary – Reuters.

External links

MeSH CD47+protein,+human

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UpToDate Contents

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1. 好中球運動の決定要因 determinants of neutrophil movement
2. 自己免疫性溶血性貧血の病因：温暖凝集素と薬剤 pathogenesis of autoimmune hemolytic anemia warm agglutinins and drugs
3. 赤血球細胞の生存：正常値と測定値 red blood cell survival normal values and measurement

English Journal

Osteoclast Fusion is Based on Heterogeneity Between Fusion Partners.

Hobolt-Pedersen AS1, Delaissé JM, Søe K.
Calcified tissue international.Calcif Tissue Int.2014 Jul;95(1):73-82. doi: 10.1007/s00223-014-9864-5. Epub 2014 May 27.
Bone-resorbing osteoclasts are formed through fusion of mononucleated precursors. Their choice of partners during the fusion process remains unclear. We hypothesized that osteoclasts are selective in their choice of fusion partner and that this selectivity is based on heterogeneity among the cells w
PMID 24862648

Efficacy of anti-CD47 antibody-mediated phagocytosis with macrophages against primary effusion lymphoma.

Goto H1, Kojima Y2, Matsuda K1, Kariya R1, Taura M1, Kuwahara K3, Nagai H2, Katano H4, Okada S5.
European journal of cancer (Oxford, England : 1990).Eur J Cancer.2014 Jul;50(10):1836-46. doi: 10.1016/j.ejca.2014.03.004. Epub 2014 Apr 9.
BACKGROUND: Recently, the critical role of CD47 on the surface of resistant cancer cells has been proposed in their evasion of immunosurveillance. Primary effusion lymphoma (PEL) is a subtype of aggressive non-Hodgkin lymphoma that shows serous lymphomatous effusion in body cavities, especially in a
PMID 24726056

Ligation of CD47 Induces G1 Arrest in EBV-transformed B Cells Through ROS Generation, p38 MAPK/JNK Activation, and Tap73 Upregulation.

Park GB1, Bang SR, Lee HK, Kim D, Kim S, Kim JK, Kim YS, Hur DY.
Journal of immunotherapy (Hagerstown, Md. : 1997).J Immunother.2014 Jul-Aug;37(6):309-20. doi: 10.1097/CJI.0000000000000042.
CD47 is expressed in normal activated cells as well as in several tumors. It also has been implicated as having antiangiogenic and antimetastatic properties, but its roles in Epstein-Barr virus (EBV)-transformed B cells are still not fully understood. Herein, we report that EBV infection induced CD4
PMID 24911792

Japanese Journal

SHPチロシンホスファターゼおよびその関連分子と癌 (特集ホスファターゼ研究新章--創薬につながる新機能と第四の脱リン酸化酵素の発見)

岡澤秀樹,大西浩史
細胞工学 30(6), 619-623, 2011
NAID 40018863896

CD47 regulates the TGF-β signaling pathway in osteoblasts and is distributed in Meckels cartilage

Shimada Koichi,Nakajima Akira,Ikeda Kyoko,Ishibashi Kazuya,Shimizu Noriyoshi,Ito Koichi
Journal of Oral Science 53(2), 169-175, 2011
… Previously, CD47 gene expression has been shown to increase during mandible development using a micro array technique. … To determine the function of CD47 in osteoblasts, CD47 was silenced using siRNA in vitro. … The TGF-β1 and phosphorylated-Smad2 levels and transcription factor genes related to bone metabolism increased dose-dependently with CD47 silencing. …
NAID 130000834356

Related Pictures

figure 10 phagocytic synapse and cd47 s Protein CD47 PDB 2JJS.png Poels LG, Peters D, van Megen Y, Vooijs GP PBB GE CD47 213857 s at tn.png the physiological functions of the CD47 fig 1 trans endocytosis of cd47 on cd47 So far, these studies have been performed Anti-CD47 Antibody Synergizes with

★リンクテーブル★

リンク元	「表面抗原分類」
関連記事	「CD」「CD4」

「表面抗原分類」

CD47 molecule
	; Rendering based on PDB 2JJS.
Available structures
PDB	2JJS, 2JJT, 2VSC
Identifiers
Symbols	CD47; IAP; MER6; OA3
External IDs	OMIM: 601028 MGI: 96617 HomoloGene: 1346 GeneCards: CD47 Gene
Gene Ontology
Molecular function	• protein binding; • thrombospondin receptor activity;
Cellular component	• plasma membrane; • plasma membrane; • integral to plasma membrane; • extracellular vesicular exosome;
Biological process	• cell adhesion; • integrin-mediated signaling pathway; • blood coagulation; • opsonization; • positive regulation of cell proliferation; • response to bacterium; • positive regulation of cell-cell adhesion; • cell junction assembly; • positive regulation of inflammatory response; • positive regulation of phagocytosis; • positive regulation of T cell activation; • leukocyte migration;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「CD」

　　[★]

「CD4」

　　[★]

同: T4, Leucine-SA, Leucine-3B
関: 表面抗原分類

[entrez-0] "Entrez Gene: CD47 CD47 molecule". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=961.

[pmid12690108-1] Lamy, Laurence; Ticchioni Michel, Rouquette-Jazdanian Alexandre K, Samson Michel, Deckert Marcel, Greenberg Arnold H, Bernard Alain (Jun. 2003). "CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis". J. Biol. Chem. (United States) 278 (26): 23915–21. doi:10.1074/jbc.M301869200. ISSN 0021-9258. PMID 12690108.

[pmid19666525-2] Chan KS, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, Gill H, Presti J, Chang HY, van de Rijn M, Shortliffe L, Weissman IL (August 2009). "Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells". Proc. Natl. Acad. Sci. U.S.A. 106 (33): 14016–21. doi:10.1073/pnas.0906549106. PMC 2720852. PMID 19666525. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2720852. Lay summary – Reuters.

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案内

案内

CD47