同: CD86

WordNet

the 2nd letter of the Roman alphabet (同)b
the blood group whose red cells carry the B antigen (同)type_B, group B

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/17 18:04:29」(JST)

wiki en

This article is about the molecule. For the compilation album, see CD86 (album).

Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.

The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily.^[1] Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.^[2]

Clinical significance[edit]

References[edit]

^ Chen C, Gault A, Shen L, Nabavi N (May 1994). "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule". J. Immunol. 152 (10): 4929–36. PMID 7513726. Cite uses deprecated parameters (help)
^ "Entrez Gene: CD86 CD86 molecule".

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 関節リウマチのT細胞標的療法 t cell targeted therapies for rheumatoid arthritis
2. リウマチ性疾患における生物学的製剤の概要 overview of biologic agents in the rheumatic diseases
3. 適応細胞性免疫応答 the adaptive cellular immune response
4. ウイルス誘発性の喘鳴および喘息：概要 virus induced wheezing and asthma an overview
5. 慢性関節リウマチにおける滑膜異常 synovial pathology in rheumatoid arthritis

English Journal

Toxoplasma gondii Induces B7-2 Expression through Activation of JNK Signal Transduction.

Morgado P, Ong YC, Boothroyd JC, Lodoen MB.SourceDepartment of Molecular Biology and Biochemistry, 3238 McGaugh Hall, University of California, Irvine, Irvine, CA 92697. mlodoen@uci.edu.
Infection and immunity.Infect Immun.2011 Nov;79(11):4401-12. Epub 2011 Sep 12.
Toxoplasma gondii is a globally distributed parasite pathogen that infects virtually all warm-blooded animals. A hallmark of immunity to acute infection is the production of gamma interferon (IFN-γ) and interleukin-12 (IL-12), followed by a protective T cell response that is critical for parasite c
PMID 21911468

Microglial Contribution to Secondary Injury Evaluated in a Large Animal Model of Human Spinal Cord Trauma.

Boekhoff TM, Ensinger EM, Carlson R, Bock P, Baumgartner W, Rohn K, Tipold A, Stein VM.Source1 Department of Small Animal Medicine and Surgery, University of Veterinary Medicine , Hannover, Germany .
Journal of neurotrauma.J Neurotrauma.2011 Sep 15. [Epub ahead of print]
Abstract Spinal cord injury (SCI) in dogs is a well recognized animal model to study pathogenesis and treatment modalities of the debilitating human disease. To define the contributing role of microglial cell activation to the secondary wave following SCI, microglia from 15 dogs with SCI confirmed b
PMID 21599492

Japanese Journal

B-7-2 画面転送によるモバイルシンクライアントの一検討(B-7.情報ネットワーク,一般セッション)

水野大輔,小澤一範,高田巡,仙田裕三,大塚壮一,佐保達也,木村司
電子情報通信学会総合大会講演論文集 2011年_通信(2), 166, 2011-02-28
NAID 110008577088

B-7-2 スケーラブルなアプリケーション・スイッチ実現方式の提案(B-7.情報ネットワーク,一般セッション)

高瀬正明,雨宮宏一郎,濱田圭,黒川康司,阿比留健一
電子情報通信学会ソサイエティ大会講演論文集 2010年_通信(2), 78, 2010-08-31
NAID 110008139213

Related Pictures

zu A4 B7 (8E) 2.0 TDI Edition : 4.0 von 5 File:VW Passat B7 2.0 TDI DSG Highline A4 B7/8E 3.2 FSI Avant quattro : 4.0 von 5 VW Passat 3C(B7) 2.0 TSI Variant B7 Highline Audi A4 B7 2,7 TDI Description BMW B7 2.JPG Polovni VW Passat B7 2.0TDi NAVI NEMAČKA

★リンクテーブル★

リンク元	「T細胞」
関連記事	「B」

「T細胞」

CD86 molecule
	; PDB rendering based on 1i85.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1I85, 1NCN
Identifiers
Symbols	CD86; B7-2; B7.2; B70; CD28LG2; LAB72
External IDs	OMIM: 601020 MGI: 101773 HomoloGene: 10443 GeneCards: CD86 Gene
Gene Ontology
Molecular function	• receptor activity; • protein binding; • coreceptor activity;
Cellular component	• plasma membrane; • external side of plasma membrane; • integral to membrane; • intracellular membrane-bounded organelle;
Biological process	• toll-like receptor signaling pathway; • immune response; • epidermal growth factor receptor signaling pathway; • cell-cell signaling; • positive regulation of cell proliferation; • fibroblast growth factor receptor signaling pathway; • virus-host interaction; • T cell costimulation; • T cell activation; • B cell activation; • positive regulation of lymphotoxin A biosynthetic process; • positive regulation of interleukin-2 biosynthetic process; • innate immune response; • positive regulation of interleukin-4 biosynthetic process; • positive regulation of T-helper 2 cell differentiation; • positive regulation of transcription, DNA-dependent; • neurotrophin TRK receptor signaling pathway; • phosphatidylinositol-mediated signaling; • defense response to virus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

英: T cell
同: Tリンパ球、T lymphocyte
関: TCR、B細胞、MHC

図：IMM.315(T細胞の成熟)
胸腺で成熟したT細胞は血流によって移動し、リンパ節の傍皮質、白脾髄のリンパ性動脈周囲鞘、パイエル板の傍濾胞域に集まる(人間の正常構造と機能 VIIA血管・免疫 p.28)

種類

T細胞の抗原認識 (SP.248)

	CD	TCRが抗原と共に認識する分子	認識する細胞
Tc細胞	CD8	MHCクラスI	感染細胞
Th細胞	CD4	MHCクラスII	抗原提示細胞

CD4+ T細胞のサイトカイン放出とその原因

DCが認識する外来異物	DCが分泌する物質	DCに反応する細胞	この細胞が分泌するサイトカイン	NK系の細胞が放出したサイトカインに反応するTh細胞	Th細胞が分泌するサイトカイン
ウイルス、一部の細菌	IL-12	NK細胞(IL-12による)	INF-γ	Th1	IL-2, IFN-γ, TNF-β
原虫など		NKT細胞	IL-4	Th2	IL-4, IL-13, IL-5

Th細胞活性化と接着分子

	抗原提示細胞	Th細胞
主シグナル	MHC classII	TCR, CD3
主シグナル	MHC classII	CD4
副シグナル	B7{B7-1(CD80)/B7-2(CD86)}	CD28
	VCAM-1(CD106)	VLA-4
	ICAM-1	LFA-1
	LFA-3(CD58)	CD2

「B」

　　[★]

気管分岐部下緑
補体のalternative pathwayに関わる蛋白質

Mg2+存在下でC3, B, Dが反応してC3bBbとなり、これがC3転換酵素(C3bBb)あるいはC5転換酵素(C3bBb3b)を形成する。これらはP(properdin)と結合して活性化し、それぞれC3、C5を活性化する

[pmid7513726-1] Chen C, Gault A, Shen L, Nabavi N (May 1994). "Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule". J. Immunol. 152 (10): 4929–36. PMID 7513726. Cite uses deprecated parameters (help)

[2] "Entrez Gene: CD86 CD86 molecule".

匿名

検索

案内

案内

B7-2