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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/12 22:03:55」(JST)

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Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24 gene.^[1] CD24 is a cell adhesion molecule.

Function

CD24 is a glycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and in many B cells. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 1p36, 3p26, 15q21.3, 20q11.2 and Yq11.222. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined (source: NCBI).

References

^ Hough MR, Rosten PM, Sexton TL, Kay R, Humphries RK (July 1994). "Mapping of CD24 and homologous sequences to multiple chromosomal loci". Genomics 22 (1): 154–61. doi:10.1006/geno.1994.1356. PMID 7959762.

External links

CD24 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
Mouse CD Antigen Chart
Human CD Antigen Chart
www.copewithcytokines.de: description of CD24 expression
CD24 human gene location in the UCSC Genome Browser.
CD24 human gene details in the UCSC Genome Browser.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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English Journal

Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer.

Arima Y, Hayashi N, Hayashi H, Sasaki M, Kai K, Sugihara E, Abe E, Yoshida A, Mikami S, Nakamura S, Saya H.SourceDivision of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, Tokyo 160-8582, Japan; Japan Science and Technology Agency, CREST, Tokyo 102-0075, Japan.
International journal of cancer. Journal international du cancer.Int J Cancer.2012 Jun 1;130(11):2568-79. doi: 10.1002/ijc.26271. Epub 2011 Aug 24.
Triple-negative breast cancer [TNBC, which is negative for the estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2] is a high-risk form of the disease without a specific therapy. DNA microarray and immunohistochemical analyses have shown that most TNBCs fall w
PMID 21717460

Raf-1 oncogenic signaling is linked to activation of mesenchymal to epithelial transition pathway in metastatic breast cancer cells.

Leontovich AA, Zhang S, Quatraro C, Iankov I, Veroux PF, Gambino MW, Degnim A, McCubrey J, Ingle J, Galanis E, D'Assoro AB.SourceDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN, USA.
International journal of oncology.Int J Oncol.2012 Jun;40(6):1858-64. doi: 10.3892/ijo.2012.1407. Epub 2012 Mar 19.
Aberrant activation of the Raf/MEK/MAPK pathway plays a key role in breast cancer development and progression. Dysregulation of Raf/MEK/MAPK oncogenic signaling often results from overexpression of the HER-2/Neu tyrosine kinase receptor leading to chemoendocrine r
PMID 22447278

Japanese Journal

SF-044-4 原発部位と再発転移部位における乳癌幹細胞[CD44(+),CD24(-/low)cells]発現比率の変化と,ER,PgR,Her-2発現を基礎とした悪性度分類との相関性(SF-044 サージカルフォーラム(44)乳腺:基礎-1,第111回日本外科学会定期学術集会)

武山浩,木下智樹,京田茂也,岡本友好,福永真治,神尾麻紀子,加藤久美子,野木裕子,川瀬和美,鳥海弥寿雄,内田賢,森川利昭,大木隆生
日本外科学会雑誌 112(臨時増刊号_1・2), 390, 2011-05-25
NAID 110008683875

SF-009-1 Transforming growth factor-β1によるCD24発現調節を介した膵癌細胞浸潤能亢進(SF-009 サージカルフォーラム(9)膵臓:基礎-2,第111回日本外科学会定期学術集会)

北浦良樹,大西秀哉,田坂健彦,宗崎正恵,岩崎寛智,荻野利達,甲斐昌也,鈴木宏往,近沢信人,田中雅夫,片野光男
日本外科学会雑誌 112(臨時増刊号_1・2), 346, 2011-05-25
NAID 110008683698

Related Pictures

★リンクテーブル★

リンク元	「表面抗原分類」
拡張検索	「CD247」
関連記事	「CD2」「CD」

「表面抗原分類」

CD24 molecule
Identifiers
Symbols	CD24 ; CD24A
External IDs	OMIM: 600074 HomoloGene: 122183 GeneCards: CD24 Gene
Gene ontology
Molecular function	• signal transducer activity; • protein binding; • protein kinase binding; • protein tyrosine kinase activator activity;
Cellular component	• intracellular; • cytosol; • plasma membrane; • cell surface; • membrane; • anchored component of membrane; • membrane raft;
Biological process	• response to hypoxia; • cell activation; • regulation of cytokine-mediated signaling pathway; • response to molecule of bacterial origin; • immune response-regulating cell surface receptor signaling pathway; • positive regulation of cytosolic calcium ion concentration; • axon guidance; • Wnt signaling pathway; • single organismal cell-cell adhesion; • cell migration; • regulation of epithelial cell differentiation; • T cell costimulation; • B cell receptor transport into membrane raft; • chemokine receptor transport out of membrane raft; • negative regulation of transforming growth factor beta3 production; • positive regulation of activated T cell proliferation; • regulation of phosphorylation; • cholesterol homeostasis; • positive regulation of MAP kinase activity; • regulation of MAPK cascade; • response to estrogen; • respiratory burst; • positive regulation of protein tyrosine kinase activity; • glomerular visceral epithelial cell differentiation; • glomerular parietal epithelial cell differentiation; • intrinsic apoptotic signaling pathway; • positive regulation of nephron tubule epithelial cell differentiation;
	Sources: Amigo / QuickGO
Orthologs
	v; t; e;

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100