発現細胞

髄質胸腺細胞
T細胞
NK細胞
ある種のB細胞

メモリーB細胞はIgD陰性、CD27がマーカーとなる

分子量

55kDa

機能

CD70に結合する。T細胞とB細胞のco-stimulatorとして機能

ファミリー

TNF family

抗原提示細胞がnaive T細胞を活性化する際、MHC class II ⇔ TCR+CD4が第一のシグナルとして入力される。
第2のシグナルは幾つかあるが、APCがもつCD27がリガンド、naive T細胞のCD70が受容体となりco-stimulatorとして働くものがある (IMM.346)

PrepTutorEJDIC

certificate of deposit / (また『C.D.』)Civil Defense民間防衛

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/06 09:53:02」(JST)

wiki en

[Wiki en表示]

CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.^[1]

Interactions

CD27 has been shown to interact with SIVA1,^[2] TRAF2^[3]^[4] and TRAF3.^[3]^[4]

References

^ "Entrez Gene: CD27 CD27 molecule".
^ Prasad, K V; Ao Z; Yoon Y; Wu M X; Rizk M; Jacquot S; Schlossman S F (Jun 1997). "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (12): 6346–51. doi:10.1073/pnas.94.12.6346. ISSN 0027-8424. PMC 21052. PMID 9177220.
^ ^a ^b Yamamoto, H; Kishimoto T; Minamoto S (Nov 1998). "NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27". J. Immunol. (UNITED STATES) 161 (9): 4753–9. ISSN 0022-1767. PMID 9794406.
^ ^a ^b Akiba, H; Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware C F, Malinin N L, Wallach D, Yagita H, Okumura K (May 1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". J. Biol. Chem. (UNITED STATES) 273 (21): 13353–8. doi:10.1074/jbc.273.21.13353. ISSN 0021-9258. PMID 9582383.

External links

CD27 Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 複合免疫不全 combined immunodeficiencies
2. 分類不能型低ガンマグロブリン血症の病因 pathogenesis of common variable immunodeficiency
3. 体液性免疫応答 the humoral immune response
4. アレルギー疾患の皮下免疫療法：治療メカニズム subcutaneous immunotherapy for allergic disease therapeutic mechanisms
5. BおよびTリンパ球の正常な発生 normal b and t lymphocyte development

English Journal

Monocytoid B cells: An Enigmatic B cell Subset Showing Evidence of Extrafollicular Immunoglobulin gene Somatic Hypermutation.

Warsame A, Delabie J, Malecka A, Wang J, Trøen G, Tierens A.SourceDepartment of Pathology, the Norwegian Radiumhospital, University of Oslo, Oslo, Norway.
Scandinavian journal of immunology.Scand J Immunol.2012 May;75(5):500-9. doi: 10.1111/j.1365-3083.2012.02688.x.
Monocytoid B cells are IgM(+) , IgD(-/+) , CD27(-) B cells, localized in the perisinusoidal area of the lymph node. These cells are especially prominent in infections such as those caused by toxoplasma and HIV. The ontogeny of monocytoid B cells with respect to B cell maturation is incompletely kno
PMID 22486786

Division-linked generation of death-intermediates regulates the numerical stability of memory CD8 T cells.

Nolz JC, Rai D, Badovinac VP, Harty JT.SourceDepartments of Microbiology and Pathology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2012 Apr 17;109(16):6199-204. Epub 2012 Apr 2.
Infection or successful vaccination results in the formation of long-lived memory CD8 T-cell populations. Despite their numerical stability, memory CD8 T-cell populations are thought to completely turn over through proliferation within a 2- to 3-mo period. Therefore, steady-state memory cell prolife
PMID 22474367

Vigorous Response of Human Innate Functioning IgM Memory B Cells upon Infection by Neisseria gonorrhoeae.

So NS, Ostrowski MA, Gray-Owen SD.SourceDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2012 Apr 15;188(8):4008-22. Epub 2012 Mar 16.
Neisseria gonorrhoeae, the cause of the sexually transmitted infection gonorrhea, elicits low levels of specific Ig that decline rapidly after the bacteria are cleared. Reinfection with the same serovar can occur, and prior gonococcal infection does not alter the Ig response upon subsequent exposure
PMID 22427638

Japanese Journal

Multiparameter Flow Cytometry for the Identification of Neoplastic Plasma Cells in POEMS Syndrome with IgG-kappa Gammopathy: Successful Treatment Using Lenalidomide and Dexamethasone

Ikeda Sho,Kobayashi Takahiro,Saito Masaya,Komatsuda Atsushi,Ubukawa Kumi,Kameoka Yoshihiro,Takahashi Naoto
Internal Medicine, 2020
… CD19-, CD27-, and lambda-negative) in the bone marrow leading to POEMS syndrome. …
NAID 130007688025

舌下免疫療法におけるTh2細胞サブセットの解析

伊原史英,櫻井大樹,岡本美孝
日本薬理学雑誌 154(1), 12-16, 2019
… 群の治療後に減少したが，これに加えて新たにST2＋細胞，IL-5，IL-13産生型CD27－CD161＋細胞（CD27－CD161＋細胞）が治療に関連して変動することを見いだした．さらにこのST2＋細胞およびCD27－CD161＋細胞は，実薬群の有効例において無効例と比較 …
NAID 130007678406

CD27発現B細胞腫瘍に対するCD70を介したNK細胞の監視機構

磯部泰司
血液内科 = Hematology 76(3), 382-385, 2018-03
NAID 40021511594

Related Pictures

CD27 Pathway The price of the CD27–CD70 costimulatory Plan C125 CD27 » Photos » distri fiesta » cd27 Carlsson C-Tronic CD27 W210, W203, W209

★リンクテーブル★

リンク元	「表面抗原分類」
関連記事	「CD2」「CD」

「表面抗原分類」

CD27 molecule
Identifiers
Symbols	CD27 ; S152; S152. LPFS2; T14; TNFRSF7; Tp55
External IDs	OMIM: 186711 MGI: 88326 HomoloGene: 74386 IUPHAR: 1876 GeneCards: CD27 Gene
Gene ontology
Molecular function	• transmembrane signaling receptor activity; • protein binding; • cysteine-type endopeptidase inhibitor activity involved in apoptotic process;
Cellular component	• extracellular region; • integral component of plasma membrane; • external side of plasma membrane; • extracellular vesicular exosome;
Biological process	• cell surface receptor signaling pathway; • release of cytoplasmic sequestered NF-kappaB; • immunoglobulin mediated immune response; • negative regulation of apoptotic process; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • response to ethanol; • positive regulation of B cell differentiation; • positive regulation of JNK cascade; • negative regulation of T cell apoptotic process; • extrinsic apoptotic signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「CD2」

　　[★]

同: Leucine-5, SRBC receptor, LFA-2
関: CD

発現細胞

T細胞、胸腺細胞、NK細胞

分子量

45-58

機能

接着分子、CD58(LFA-3)に結合。細胞内部でLckに結合し、T細胞を活性化

リンパ球が抗原提示細胞と相互作用するのに重要 (IMM.343)

別名

LFA-2, T11

ファミリー

immunoglobulin

「CD」

　　[★]

[1] "Entrez Gene: CD27 CD27 molecule".

[pmid9177220-2] Prasad, K V; Ao Z; Yoon Y; Wu M X; Rizk M; Jacquot S; Schlossman S F (Jun 1997). "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (12): 6346–51. doi:10.1073/pnas.94.12.6346. ISSN 0027-8424. PMC 21052. PMID 9177220.

[pmid9794406-3] Yamamoto, H; Kishimoto T; Minamoto S (Nov 1998). "NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27". J. Immunol. (UNITED STATES) 161 (9): 4753–9. ISSN 0022-1767. PMID 9794406.

[pmid9582383-4] Akiba, H; Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware C F, Malinin N L, Wallach D, Yagita H, Okumura K (May 1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". J. Biol. Chem. (UNITED STATES) 273 (21): 13353–8. doi:10.1074/jbc.273.21.13353. ISSN 0021-9258. PMID 9582383.

匿名

検索

案内

案内

CD27

発現細胞

分子量

機能

ファミリー

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Wikipedia preview

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Contents

Interactions

References

Further reading

External links

UpToDate Contents

English Journal

Japanese Journal

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Related Pictures

★リンクテーブル★

「表面抗原分類」

「CD2」

発現細胞

分子量

機能

別名

ファミリー

「CD」