同: Human natural killer cell-1 antigen; Leucine-7 antigen

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/08/15 13:26:52」(JST)

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Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 is an enzyme that in humans is encoded by the B3GAT1 gene.^[1]

The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized.^[1]

In immunology, the CD57 antigen (CD stands for cluster of differentiation) is a carbohydrate which is also called HNK1 (human natural killer-1) or LEU7. It is expressed as a carbohydrate epitope that contains a sulfoglucuronyl residue in several adhesion molecules of the nervous system.^[2]

Immunohistochemistry[edit source | edit]

In anatomical pathology, CD57 (immunostaining) is similar to CD56 for use in differentiating neuroendocrine tumors from others.^[3] Using immunohistochemistry, CD57 molecule can be demonstrated in around 10 to 20% of lymphocytes, as well as in some epithelial, neural, and chromaffin cells. Among lymphocytes, CD57 positive cells are typically either T cells or NK cells, and are most commonly found within the germinal centres of lymph nodes, tonsils, and the spleen.^[4]

There is an increase in the number of circulating CD57 positive cells in the blood of patients who have recently undergone organ or tissue transplants, especially of the bone marrow, and in patients with HIV. Increased CD57+ counts have also been reported in rheumatoid arthritis and Felty's syndrome, among other conditions.^[4]

Neoplastic CD57 positive cells are seen in conditions as varied as large granular lymphocytic leukaemia, small-cell carcinoma, thyroid carcinoma, and neural and carcinoid tumours. Although the antigen is particularly common in carcinoid tumours, it is found in such a wide range of other conditions that it is of less use in distinguishing these tumours from others than more specific markers such as chromogranin and NSE.^[4]

References[edit source | edit]

^ ^a ^b "Entrez Gene: B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)".
^ Mitsumoto Y, Oka S, Sakuma H, Inazawa J, Kawasaki T (2000). "Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope". Genomics 65 (2): 166–73. doi:10.1006/geno.2000.6152. PMID 10783264.
^ Dabbs, D. editor, Diagnostic Immunohistochemistry, 3rd ed, 2010, Ch 11, pp. 345-346.
^ ^a ^b ^c Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. pp. 131–134. ISBN 1-84110-100-1.

External links[edit source | edit]

CD57 Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

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UpToDate Contents

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1. ナチュラルキラー（NK）細胞大顆粒リンパ球性白血病 natural killer nk cell large granular lymphocyte leukemia
2. 自己免疫性リンパ増殖症候群(ALPS)：臨床的特徴および診断 autoimmune lymphoproliferative syndrome alps clinical features and diagnosis
3. Principles of cancer immunotherapy
4. 結節性リンパ球優位型ホジキンリンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of nodular lymphocyte predominant hodgkin lymphoma
5. 過敏性肺臓炎（外因性アレルギー性肺胞炎）の診断 diagnosis of hypersensitivity pneumonitis extrinsic allergic alveolitis

English Journal

Specific patterns of CD4-associated immunosenescence in vertically HIV-infected subjects.

Méndez-Lagares G, Díaz L, Correa-Rocha R, León Leal JA, Ferrando-Martínez S, Ruiz-Mateos E, Pozo-Balado MM, Gurbindo MD, de José MI, Muñoz-Fernández MA, Leal M, Pacheco YM.Source Laboratory of Immunovivology, Clinic Unit of Infectious Diseases, Microbiology and preventive Medicine of Seville, IBiS, Virgen del Rocion University Hospital/CSiC/University of Seville, Seville 41013, Spain Laboratorio InmunoBiología Molecular, Hospital General Universitario Gregorio Marañón.C/Doctor Esquerdo, 46, Madrid, Spain Paediatric Infectious Diseases Unit, Virgen del Rocío University Hospital, Sevilla, Spain Paediatric Infectious Diseases Unit, Gregorio Marañón General University Hospital.C/Doctor Esquerdo, 46, Madrid, Spain Paediatric Infectious Diseases Unit, La Paz University Hospital, Pº de la Castellana, 261, Madrid, Spain Department of Clinical Biochemistry, IBIS/CSIC/University of Seville, Virgen del Rocío University Hospital, Seville, Spain.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.Clin Microbiol Infect.2013 Jun;19(6):558-565. doi: 10.1111/j.1469-0691.2012.03934.x. Epub 2012 Jun 27.
Clin Microbiol Infect ABSTRACT: Vertical transmission of human immunodeficiency virus (HIV) represents an important world-wide health problem although the incidence in developed countries has been drastically reduced by the extensive use of highly active antiretroviral therapy. Vertically HIV-infect
PMID 22735071

Immunophenotyping of selected hematologic disorders - focus on lymphoproliferative disorders with more than one malignant cell population.

Porwit A.SourceDepartment of Pathobiology and Laboratory Medicine, University of Toronto, University Health Network, Toronto, ON, Canada.
International journal of laboratory hematology.Int J Lab Hematol.2013 Jun;35(3):275-82. doi: 10.1111/ijlh.12080.
Currently, clinical laboratories face increasing demand for flow cytometry testing combined with limited funding. Therefore, many laboratories search for panels that would provide sufficient immunophenotyping information and meet economical requirements. At the Flow Cytometry Laboratory, University
PMID 23590655

Analysis of metallothionein and vimentin immunoreactivity in pharyngeal squamous cell carcinoma and its microenvironment.

Dutsch-Wicherek M, Lazar A, Tomaszewska R, Kazmierczak W, Wicherek L.SourceOutpatient Unit of Otolaryngology, Lukaszczyk Oncological Center, Bydgoszcz, Poland, mowicher@gmail.com.
Cell and tissue research.Cell Tissue Res.2013 May;352(2):341-9. doi: 10.1007/s00441-013-1566-1. Epub 2013 Feb 9.
Metallothionein (MT) has been shown to have pro-proliferative anti-apoptotic activity and to be involved in microenvironment remodeling. The aim of this study has been to determine whether the changes in MT and vimentin immunoreactivity observed in cancer and its microenvironment are related to the
PMID 23397427

Japanese Journal

The comprehensive assessment of local immune status of ovarian cancer by the clustering of multiple immune factors.

Hamanishi Junzo,Mandai Masaki,Abiko Kaoru,Matsumura Noriomi,Baba Tsukasa,Yoshioka Yumiko,Kosaka Kenzo,Konishi Ikuo
Clinical immunology 141(3), 338-347, 2011-12
… The numbers of CD1α+, CD4+, CD8+, CD57+, forkhead box P3+ and programmed cell death-1+ cells were counted, and the intensity of immunosuppressive factors, such as programmed cell death-1 ligand (PD-L)1, PD-L2, cyclooxygenase (COX)-1, COX-2 and transforming growth factor β1, were evaluated in 70 ovarian cancer specimens stained by immunohistochemistry. …
NAID 120003610113

SF-109-4 進行大腸癌の予後予測因子 : CD57NKT/CD56NKT ratio(サージカルフォーラム(109)大腸:化学療法-1,第111回日本外科学会定期学術集会)

赤木純児,久留須裕治,馬場秀夫
日本外科学会雑誌 112(臨時増刊号_1・2), 472, 2011-05-25
NAID 110008684199

Related Pictures

Sarar Elata CD57 Kısa Kol Turkuaz Gömlek Info about CD57 CD57 (NK-1), tonsil, 200x cromodora cd57 CD57 d'Athlétisme Mouse Anti-Human CD57 , Hagelin CD57 Cryptographer Tonsil stained with CD57 antibody

★リンクテーブル★

リンク元	「ナチュラルキラー細胞」「表面抗原分類」
関連記事	「CD5」「CD」

「ナチュラルキラー細胞」

Beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
	; PDB rendering based on 1v82.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1V82, 1V83, 1V84
Identifiers
Symbols	B3GAT1; CD57; GLCATP; GLCUATP; HNK1; LEU7; NK-1; NK1
External IDs	OMIM: 151290 MGI: 1924148 HomoloGene: 49551 ChEMBL: 4067 GeneCards: B3GAT1 Gene
EC number	2.4.1.135
Gene Ontology
Molecular function	• UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; • galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity; • metal ion binding;
Cellular component	• Golgi membrane; • integral to membrane;
Biological process	• carbohydrate metabolic process; • protein glycosylation; • glycosaminoglycan metabolic process; • chondroitin sulfate metabolic process; • small molecule metabolic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

英: natural killer cell, NK cell
同: NK細胞
関: 単球、自然免疫、LAK細胞、ナチュラルキラー細胞活性、natural killer

概念

自然免疫

リンパ球の5-10%を占めるらしい。

Large granular lymphocytes(LGLs) or NK cells account for 5-10% of periphral blood plymphocytes.(HAR.2024)

大型のアズール好性顆粒を有する(SMB.41)

単球と共に自然免疫に関与
ウイルス感染細胞やガン細胞を傷害する細胞で、T細胞に特異的なマーカをもたずに直接標的細胞を攻撃する (人間の正常構造と機能 VIIA血管・免疫 p.29)

抗体依存性細胞毒性(ADCC)

II型アレルギーにかかわる

分子細胞学的な定義

大顆粒リンパ球の形状(15μm以上の大リンパ球。アズール顆粒を3つ以上有する)
CD56(+), sCD3(-), TCR再構成(-), 胚細胞型
MHC非拘束性のキラー活性を有する

機能

自然免疫

activation signalにより、IFN-γの放出や顆粒(パーフォリン、グランザイム)を放出する(IMM.96)

ADCC

IgGのFc部を結合し、顆粒を放出する(IMM.96)

分子マーカー

CD16：IgGのFc部に対するレセプター
CD56：NCAM-I
NK1.1(NKRP-1 = CD161)

~

CD8：IL-2に反応してNK細胞が増殖
CD57：多くの細胞表面で発現

ケモカイン

リガンド	作用	産生
IL-12	NK細胞活性化	INF-γ
IL-18	Th1分化促進	INF-γ

IL-12,IL-18により活性化され、IFN-γを産生

IL-2により活性化し、細胞障害能が高まる (SPU.65)

受容体

NIR

MHC class Iを認識して攻撃を抑制。MHC class Iが少ないと抑制が外れる(IMM.96)

NKR

「表面抗原分類」

　　[★]

英: cluster of differentiation, CD

細胞の表面抗原を認識する抗体を整理した分類

Bリンパ球 CD10,CD19,CD20

Tリンパ球 CD2,CD3,CD5,CD7

幹細胞 CD34

顆粒球 CD13,CD33

単球 CD14：LPSをリガンドとし、Toll-like receptorと共役して細胞内シグナルを伝達する分子。

巨核球 CD41(GpIIb),CD42(GpIb)

NK細胞：CD16(IgGのFc部に対する受容体)、CD56(NCAM-I)

CD1	CD21	CD41	CD61	CD81
CD2	CD22	CD42	CD62	CD82
CD3	CD23	CD43	CD63	CD83
CD4	CD24	CD44	CD64	CD84
CD5	CD25	CD45	CD65	CD85
CD6	CD26	CD46	CD66	CD86
CD7	CD27	CD47	CD67	CD87
CD8	CD28	CD48	CD68	CD88
CD9	CD29	CD49	CD69	CD89
CD10	CD30	CD50	CD70	CD90
CD11	CD31	CD51	CD71	CD91
CD12	CD32	CD52	CD72	CD92
CD13	CD33	CD53	CD73	CD93
CD14	CD34	CD54	CD74	CD94
CD15	CD35	CD55	CD75	CD95
CD16	CD36	CD56	CD76	CD96
CD17	CD37	CD57	CD77	CD97
CD18	CD38	CD58	CD78	CD98
CD19	CD39	CD59	CD79	CD99
CD20	CD40	CD60	CD80	CD100

「CD5」

　　[★]

同: Leucine-1

発現細胞

胸腺細胞、T細胞、B細胞のサブセット (IMM)
胸腺細胞、T細胞、NK細胞、B₁(B細胞のsubpopulation) (WCH.31)
成熟T細胞、胸腺細胞、一部のB細胞(CD5陽性B細胞(B-1細胞)。脾臓等、異所由来(骨髄非依存性)のB細胞) (資料1)
B細胞性白血病・リンパ腫(資料1)

分子量

67kDa

別名

T1, Ly1

機能

CD5に対するモノクローナル抗体を作用させると、細胞内のチロシンのリン酸化が起こり、T細胞が活性化する。ただし、抑制的に作用する経路にも作用するかもしれない(WCH.31)

T細胞はnaive CD4 T cellで発現しており、この細胞のマーカーとなる(IMM.315)

CD5⁺ B細胞は自己抗体を産生する(WCH.31)
CD72はCD5にたいするcounter-receptorである(WCH.31)

臨床関連

B-CLLの多くの症例で発現している。 (WCH.31)
関節リウマチでCD5⁺ B細胞が増加する (WCH.31)
白血病/リンパ腫の中でCD5 positiveになるのは、慢性リンパ性白血病とマントル細胞リンパ腫だけ(HIM.693, 慢性リンパ性白血病#細胞表面マーカー WCH.2438)

参考

1. SRL

http://www.srl.info/srlinfo/kensa_ref_CD/KENSA/SRL5039.htm

2. beckman

http://www.bc-cytometry.com/Data/db_search/CD005.htm

3. wiki en

http://en.wikipedia.org/wiki/CD5_(protein)

「CD」

　　[★]

[entrez-1] "Entrez Gene: B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)".

[pmid10783264-2] Mitsumoto Y, Oka S, Sakuma H, Inazawa J, Kawasaki T (2000). "Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope". Genomics 65 (2): 166–73. doi:10.1006/geno.2000.6152. PMID 10783264.

[3] Dabbs, D. editor, Diagnostic Immunohistochemistry, 3rd ed, 2010, Ch 11, pp. 345-346.

[Leong-4] Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. pp. 131–134. ISBN 1-84110-100-1.

匿名

検索

案内

案内

CD57