CD103

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/15 10:13:12」(JST)

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Integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
Identifiers
Symbols	ITGAE ; CD103; HUMINAE
External IDs	OMIM: 604682 MGI: 1298377 HomoloGene: 113560 IUPHAR: 2450 GeneCards: ITGAE Gene
Gene ontology Molecular function • metal ion binding Cellular component • plasma membrane • integrin complex • external side of plasma membrane Biological process • cell adhesion • integrin-mediated signaling pathway • extracellular matrix organization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3682	16407
Ensembl	ENSG00000083457	ENSMUSG00000005947
UniProt	P38570	Q60677
RefSeq (mRNA)	NM_002208	NM_008399
RefSeq (protein)	NP_002199	NP_032425
Location (UCSC)	Chr 17: 3.71 – 3.8 Mb	Chr 11: 73.09 – 73.15 Mb
PubMed search	[1]	[2]

Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene. CD103 binds integrin beta 7 (β7– ITGB7) to form the complete heterodimeric integrin molecule αEβ7, which has no distinct name. The αEβ7 complex is often referred to as "CD103" though this appellation strictly refers only to the αE chain. Note that the β7 subunit can bind with other integrin α chains, such as α4 (CD49d).

Tissue distribution

CD103 is expressed widely on intraepithelial lymphocyte (IEL) T cells (both αβ T cells and γδ T cells) and on some peripheral regulatory T cells (Tregs). It has also been reported on lamina propria T cells. A subset of dendritic cells in the gut mucosa and in mesenteric lymph nodes also expresses this marker and is known as CD103 DCs.

It is useful in identifying Hairy cell leukemia which is positive for this marker in contrast to most other hematologic malignancies which are negative for CD103 except Enteropathy associated T cell lymphoma.

Function

The chief ligand for αEβ7 is E-cadherin, an adhesion molecule (CAM) found on epithelial cells. It is probably important for T cell homing to the intestinal sites.

Tregs are important for decreasing the immune response and appear to play a crucial role in the prevention of autoimmune diseases. Tregs are defined as CD4⁺/CD25⁺/Foxp3⁺ cells. Some CD4⁺/FoxP3⁻ cells also express CD103 and have been attributed regulatory activity. It is unclear whether the presence of CD103 on Treg cells represents a specialized feature for Treg, or Treg differentiation of IEL T cells.

See also

• Cluster of differentiation

References

Further reading

• Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine.". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. 
• Tilburgs T, Scherjon SA, Roelen DL, Claas FH (2009). "Decidual CD8+CD28- T cells express CD103 but not perforin.". Hum. Immunol. 70 (2): 96–100. doi:10.1016/j.humimm.2008.12.006. PMID 19150377. 
• Schlickum S, Sennefelder H, Friedrich M, et al. (2008). "Integrin alpha E(CD103)beta 7 influences cellular shape and motility in a ligand-dependent fashion.". Blood 112 (3): 619–25. doi:10.1182/blood-2008-01-134833. PMID 18492951. 
• Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614. 
• Liu YH, Chen RH, Chen WC, et al. (2010). "Disease association of the CD103 polymorphisms in Taiwan Chinese Graves' ophthalmopathy patients". Ophthalmology 117 (8): 1645–51. doi:10.1016/j.ophtha.2009.12.037. PMID 20417566. 
• Lesch KP, Timmesfeld N, Renner TJ, et al. (2008). "Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies". J Neural Transm 115 (11): 1573–85. doi:10.1007/s00702-008-0119-3. PMID 18839057. 
• Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. doi:10.1161/ATVBAHA.107.153981. PMC 2636623. PMID 17975119. 
• Agace WW, Higgins JM, Sadasivan B, et al. (2000). "T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines". Curr. Opin. Cell Biol. 12 (5): 563–8. doi:10.1016/S0955-0674(00)00132-0. PMID 10978890. 
• Hadley G (2004). "Role of integrin CD103 in promoting destruction of renal allografts by CD8 T cells". Am. J. Transplant. 4 (7): 1026–32. doi:10.1111/j.1600-6143.2004.00465.x. PMID 15196058. 
• Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885. 
• Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene variants associated with ischemic stroke: the cardiovascular health study". Stroke 40 (2): 363–8. doi:10.1161/STROKEAHA.108.521328. PMC 2881155. PMID 19023099. 
• Silva LK, Blanton RE, Parrado AR, et al. (2010). "Dengue hemorrhagic fever is associated with polymorphisms in JAK1". Eur. J. Hum. Genet. 18 (11): 1221–7. doi:10.1038/ejhg.2010.98. PMC 2950898. PMID 20588308. 
• Annacker O, Coombes JL, Malmstrom V, et al. (2005). "Essential role for CD103 in the T cell-mediated regulation of experimental colitis". J. Exp. Med. 202 (8): 1051–61. doi:10.1084/jem.20040662. PMC 2213206. PMID 16216886. 
• Kilshaw PJ, Higgins JM (2002). "Alpha E: no more rejection?". J. Exp. Med. 196 (7): 873–5. doi:10.1084/jem.20021404. PMC 2194032. PMID 12370249. 
• Uss E, Rowshani AT, Hooibrink B, et al. (2006). "CD103 is a marker for alloantigen-induced regulatory CD8+ T cells". J. Immunol. 177 (5): 2775–83. doi:10.4049/jimmunol.177.5.2775. PMID 16920912. 
• Le Floc'h A, Jalil A, Vergnon I, et al. (2007). "Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis". J. Exp. Med. 204 (3): 559–70. doi:10.1084/jem.20061524. PMC 2137907. PMID 17325197. 
• Heron M, Grutters JC, Van Moorsel CH, et al. (2009). "Effect of variation in ITGAE on risk of sarcoidosis, CD103 expression, and chest radiography". Clin. Immunol. 133 (1): 117–25. doi:10.1016/j.clim.2009.06.007. PMID 19604725. 
• Shaw SK, Brenner MB (1995). "The beta 7 integrins in mucosal homing and retention". Semin. Immunol. 7 (5): 335–42. doi:10.1016/1044-5323(95)90014-4. PMID 8580465. 
• Dickeson SK, Santoro SA (1998). "Ligand recognition by the I domain-containing integrins". Cell. Mol. Life Sci. 54 (6): 556–66. doi:10.1007/s000180050184. PMID 9676575. 
• Heron M, Slieker WA, Zanen P, et al. (2008). "Evaluation of CD103 as a cellular marker for the diagnosis of pulmonary sarcoidosis". Clin. Immunol. 126 (3): 338–44. doi:10.1016/j.clim.2007.11.005. PMID 18182176. 

External links

• ITGAE protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• ITGAE Info with links in the Cell Migration Gateway

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 有毛細胞白血病の臨床的特徴および診断 clinical features and diagnosis of hairy cell leukemia
• 2. 腸症型T細胞性リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of enteropathy associated t cell lymphoma
• 3. B細胞前リンパ球性白血病 b cell prolymphocytic leukemia
• 4. リンパ形質細胞性リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of lymphoplasmacytic lymphoma
• 5. T細胞前リンパ球性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of t cell prolymphocytic leukemia

English Journal

• Reduced numbers of mucosal DR(int) macrophages and increased numbers of CD103(+) dendritic cells during anti-TNF-α treatment in patients with Crohn's disease.

• Dige A1, Magnusson MK2,3, Öhman L2,3, Hvas CL1, Kelsen J1, Wick MJ2, Agnholt J1.
• Scandinavian journal of gastroenterology.Scand J Gastroenterol.2016 Jun;51(6):692-9. doi: 10.3109/00365521.2015.1134649. Epub 2016 Jan 19.
• Objective Anti-TNF-α treatment constitutes a mainstay in the treatment of Crohn's disease (CD), but its mechanisms of action are not fully understood. We aimed to investigate the effects of adalimumab, a human monoclonal TNF-α antibody, on macrophage (MQ) and dendritic cell (DC) subsets in mucosal
• PMID 26784676

• IRF4 and IRF8 Act in CD11c+ Cells To Regulate Terminal Differentiation of Lung Tissue Dendritic Cells.

• Bajaña S1, Turner S1, Paul J1, Ainsua-Enrich E1, Kovats S2.
• Journal of immunology (Baltimore, Md. : 1950).J Immunol.2016 Feb 15;196(4):1666-77. doi: 10.4049/jimmunol.1501870. Epub 2016 Jan 8.
• Dendritic cells (DCs) initiate immune responses in barrier tissues including lung and skin. Conventional DC (cDC) subsets, CD11b(-) (cDC1s) or CD11b(+) (cDC2s), arise via distinct networks of transcription factors involving IFN regulatory factor 4 (IRF4) and IRF8, and are specialized for unique func
• PMID 26746189

Japanese Journal

• 腸管における自然免疫細胞サブセット (第1土曜特集 自然免疫Update : 研究最前線) -- (自然免疫に関わる細胞研究の最前線)

• 木下 允,竹田 潔
• 医学のあゆみ 243(1), 84-88, 2012-10-06
• NAID 40019429624

• Enteropathy-Associated T-Cell Lymphoma Type II Complicated by Autoimmune Hemolytic Anemia

• KATO Aiko,TAKIUCHI Yoko,AOKI Kazunari,ONO Yuichiro,ARIMA Hiroshi,NAGANO Seiji,TABATA Sumie,YANAGITA Soshi,MATSUSHITA Akiko,MARUOKA Hayato,WADA Masaya,IMAI Yukihiro,ISHIKAWA Takayuki,TAKAHASHI Takayuki
• Journal of clinical and experimental hematopathology 51(2), 119-123, 2011-11-01
• … Surface antigen analysis of abnormal cells in the ascites revealed positivity for CD3, CD8, CD56, and weak positivity for CD103. …
• NAID 10030207669

• Predominant donor CD103^+CD8^+ T cell infiltration into the gut epithelium during acute GvHD : a role of gut lymph nodes

• ZHOU Shu,UETA Hisashi,XU Xue-Dong,SHI Changde,MATSUNO Kenjiro
• International immunology 20(3), 385-394, 2008-03-01
• NAID 10021239949

Related Pictures

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★リンクテーブル★

リンク元	「慢性リンパ性白血病」
関連記事	「CD1」「CD10」

「慢性リンパ性白血病」

　　[★]

英

chronic lymphocytic leukemia, chronic lymphoid leukemia, CLL

関

白血病

• first aid step1 2006 p.300,302,303,304,309,310,427,430

概念

• the accumulation of nonproliferating mature-appearing lymphocytes in the blood, marrow, lymph nodes, and spleen.
• monoclonal B lymphocytes.
• CD5+ and CD23+CD5, CD23
• derived from memory B cell.

細胞表面マーカー WCH.2438

condition

smIg

CD5

CD10

CD11c

CD19

CD20

CD22

CD23

CD25

CD43

CD79b

CD103

FMC7

chronic lymphocytic leukemia

Dim

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prolymphocytic leukemia

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hairy cell leukemia

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hairy cell leukemia variant

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splenic lymphoma with villous lymphocytes

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marginal zone B-cell lymphoma

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mantle cell lymphoma

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follicular lymphoma

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臨床像

HIM.693

	年齢	子供における頻度	男性(%)	ステージI,II vs III,IV(%)	B症状(%)	骨髄浸潤(%)	消化管浸潤(%)	5年生存率(%)
B細胞CLL/小リンパ球性リンパ腫	65	まれ	53	9 vs 91	33	72	3	51

疫学

YN.G-49

• 全白血病の2-3%
• 60歳以上に多い。
• 男女比=2:1

病態

YN.G-49

• 正常な免疫グロブリンの産生が抑制されるばかりでなく、異常な自己抗体を産生　→　続発性免疫不全症、自己免疫性溶血性貧血

USMLE

• Q book p.246 42

参考

• 1. [charged] Epidemiology and clinical manifestations of chronic lymphocytic leukemia - uptodate [1]
• 2. [charged] Pathologic features, diagnosis, and differential diagnosis of chronic lymphocytic leukemia - uptodate [2]
• 3. [charged] Pathophysiology and cytogenetics of chronic lymphocytic leukemia - uptodate [3]

[show details]

慢性リンパ性白血病 : 約 28,600 件
慢性リンパ球性白血病 : 約 47,100 件

「CD1」

　　[★]

同

leucine-6, CD1A through E

種類

• CD1a, CD1b, CD1c, CD1d

発現組織

• 胸腺皮質、ランゲルハンス細胞、樹状細胞、B細胞(CD1c)、腸上皮、平滑筋、血管上皮(CD1d)

分子量

• 43-49

機能

• MHC class I-like molecule, associated with β2-microgloulin. Has specialized role in presentation of lipid antigens

「CD10」

　　[★]

同

common acute lymphoid leukemia antigen, nephrilysin

発現細胞

• B細胞やT細胞前駆体。骨髄間質細胞(bone marrow stromal cell)

分子量

• 100kDa

機能

• Zinc metalloproteinase, marker for pre-B acute lymphatic leukemia (ALL)

別名

• Neutral endopeptidase, common acute lymphocytic leukemia antigen(CALLA)