naive CD4 T cell

関

T細胞、late double-positive thymocyte<-->memory CD4 T cell

• TCRを備え、胸腺から出てた抗原刺激をまだ受けていないT細胞。

細胞表面マーカー=

• CD4
• CD62L
• CD45RA
• CD5

UpToDate Contents

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• 1. 細胞性免疫応答the adaptive cellular immune response t cells and cytokines [show details]
  …contact with an antigen-specific CD4+ T cell before it is capable of inducing a naive CD8+ cell to become a full-fledged effector (cytotoxic) T cell . Direct CD4+ T cell help may also be required for primary …
• 2. BおよびTリンパ球の正常な発生normal b and t lymphocyte development [show details]
  …distinction. Two principal categories of CD4 T cells have been defined: T cells that modulate the activity of B cells and other T cells, either by stimulating (helper T cells) or suppressing (regulatory T cells …
• 3. 自己免疫の概要overview of autoimmunity [show details]
  …reactions. In general, however, the cell-mediated responses are associated with the Th1 subset of CD4+ T cells . Antibody-mediated mechanisms in general associate with Th2 responses. Thus, sometimes an autoimmune…
• 4. サルコイドーシスの病理と発症機序pathology and pathogenesis of sarcoidosis [show details]
  …lymphocytic pleocytosis, with a predominance of CD4+ T cells relative to peripheral blood or lung lymphocytes obtained from healthy controls . These CD4+ T cells bear surface markers of previous activation …
• 5. 特発性CD4陽性リンパ球減少症idiopathic cd4 lymphocytopenia [show details]
  … Idiopathic CD4+ T cell lymphocytopenia (ICL) is defined by persistent CD4+ T cell lymphopenia in the absence of infection with HIV-1 or any other cause of immunodeficiency . CD4+ T cell counts should …

English Journal

• Effect of cinnamamides on atopic dermatitis through regulation of IL-4 in CD4 cells.

• Choi EJ, Ryu YB, Tang Y, Kim BR, Lee WS, Debnath T, Fan M, Kim EK, Lee HS.
• Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)613-619.
• This study aimed to evaluate the effects of cinnamamides on atopic dermatitis (AD) and the mechanisms underlying these effects. To this end, the actions of two cinnamamides, (E)-3-(4-hydroxyphenyl)-N-phenylethyl acrylamide (NCT) and N-trans-coumaroyltyramine (NCPA), were determined on AD by orally a
• PMID 30727775

• B cell depletion with ublituximab reshapes the T cell profile in multiple sclerosis patients.

• Lovett-Racke AE, Gormley M, Liu Y, Yang Y, Graham C, Wray S, Racke MK, Shubin R, Twyman C, Alvarez E, Bass A, Eubanks JL, Fox E.
• Journal of neuroimmunology. 2019 Jul;332()187-197.
• Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, thought to be mediated by myelin-specific CD4+ T cells. However, B cell depletion has proven to be an effective therapy for MS, but the mechanism is not well understood. This study was designed to determine how B cell
• PMID 31077854

• T lymphocyte phenotype of contact-allergic patients: experience with nickel and p-phenylenediamine.

• Wicks K, Stretton C, Popple A, Beresford L, Williams J, Maxwell G, Gosling JP, Kimber I, Dearman RJ.
• Contact dermatitis. 2019 Jul;81(1)43-53.
• There is considerable interest in understanding the immunological variables that have the greatest influence on the effectiveness of sensitization by contact allergens, particularly in the context of developing new paradigms for risk assessment of novel compounds. To examine the relationship between
• PMID 30779159

Japanese Journal

• Assessment of the 24th Week Success of Anti-Retroviral Therapy in the Action against HIV in Istanbul Database: Results from a Region with Increasing Incidence

• Bolukcu Sibel,Aslan Turan,Tabak Fehmi,Mete Bilgul,Gunduz Alper,Karaosmanoglu Hayat Kumbasar,Sargin Fatma,Durdu Bulent,Aydin Ozlem Altuntas,Yildiz Dilek,Dokmetas Ilyas
• Japanese Journal of Infectious Diseases 72(3), 173-178, 2019
• … <p>We aimed to assess the 24-week virological and immunological success of the treatment of treatment-naive and treatment-experienced patients included in the Action against HIV in Istanbul (ACTHIV-IST) database. … The data for these patients such as age, sex, treatment-naive or treatment-experienced status, date of diagnosis, date of commencing antiretroviral therapy, antiretroviral therapy regimen, CD4+ cell count, and viral load before and after therapy were analyzed. …
• NAID 130007652448

• Assessment of the 24^th week success of anti-retroviral therapy in ACTHIV-IST Database: Results from a region with increasing incidence

• Bolukcu Sibel,Aslan Turan,Tabak Fehmi,Mete Bilgul,Gunduz Alper,Karaosmanoglu Hayat Kumbasar,Sargin Fatma,Durdu Bulent,Aydin Ozlem Altuntas,Yildiz Dilek,Dokmetas Ilyas
• Japanese Journal of Infectious Diseases, 2019
• … <p>We aimed to assess 24-week virological and immunological success of treatment naive and experienced patients included in ACTHIV-IST database. … Data of these patients such as age, sex, being treatment naive or experienced, date of diagnosis, date of commencing antiretroviral therapy, antiretroviral therapy regimen, CD4+ cell count and viral load before and after therapy were analyzed. …
• NAID 130007585458

• Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations

• Fujii Sumie,Miura Yasuo,Fujishiro Aya,Shindo Takero,Shimazu Yutaka,Hirai Hideyo,Tahara Hidetoshi,Takaori-Kondo Akifumi,Ichinohe Tatsuo,Maekawa Taira
• Stem Cells 36(3), 434-445, 2018-02-22
• … A substantial proportion of patients with acute graft‐versus‐host disease (aGVHD) respond to cell therapy with culture‐expanded human bone marrow mesenchymal stromal/stem cells (BM‐MSCs). … In EV‐treated GVHD mice, CD4+ and CD8+ T cells were suppressed. … Importantly, the ratio of CD62L‐CD44+ to CD62L + CD44‐ T cells was decreased, suggesting that BM‐MSC‐derived EVs suppressed the functional differentiation of T cells from a naive to an effector phenotype. …
• NAID 120006454670

Related Links

• EasySep™ Human Naïve CD4+ T Cell Isolation Kit

The EasySep Human Naïve CD4+ T Cell Isolation Kit is designed to isolate naive CD4+ T cells from fresh or previously frozen peripheral blood mononuclear cells by negative selection. Unwanted cells are targeted for removal with ...

• Naive CD4+ T Cell Isolation Kit, mouse - T cells - MicroBeads ...

The Naive CD4+ T Cell Isolation Kit, mouse has been developed for the isolation of untouched naive CD4+ T helper cells from suspensions of mouse spleen cells or lymph node cells.

• Differentiation of Effector CD4 T Cell Populations *

Th17 Cells and iTregs That two major cell types differentiate from naive CD4 T cells dominated the field for more than a decade and a half. Other types of CD4 T cells were recognized, such as NKT cells and natural regulatory T cells ...

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★リンクテーブル★

リンク元	「CD5」
関連記事	「naive」「C」「CD」「T」「CD4」

「CD5」

　　[★]

同

Leucine-1

発現細胞

• 胸腺細胞、T細胞、B細胞のサブセット (IMM)
• 胸腺細胞、T細胞、NK細胞、B₁(B細胞のsubpopulation) (WCH.31)
• 成熟T細胞、胸腺細胞、一部のB細胞(CD5陽性B細胞(B-1細胞)。脾臓等、異所由来(骨髄非依存性)のB細胞) (資料1)
• B細胞性白血病・リンパ腫(資料1)

分子量

• 67kDa

別名

• T1, Ly1

機能

• CD5に対するモノクローナル抗体を作用させると、細胞内のチロシンのリン酸化が起こり、T細胞が活性化する。ただし、抑制的に作用する経路にも作用するかもしれない(WCH.31)

• T細胞はnaive CD4 T cellで発現しており、この細胞のマーカーとなる(IMM.315)

• CD5⁺ B細胞は自己抗体を産生する(WCH.31)
• CD72はCD5にたいするcounter-receptorである(WCH.31)

臨床関連

• B-CLLの多くの症例で発現している。 (WCH.31)
• 関節リウマチでCD5⁺ B細胞が増加する (WCH.31)
• 白血病/リンパ腫の中でCD5 positiveになるのは、慢性リンパ性白血病とマントル細胞リンパ腫だけ(HIM.693, 慢性リンパ性白血病#細胞表面マーカー WCH.2438)

参考

• 1. SRL

http://www.srl.info/srlinfo/kensa_ref_CD/KENSA/SRL5039.htm

• 2. beckman

http://www.bc-cytometry.com/Data/db_search/CD005.htm

• 3. wiki en

• http://en.wikipedia.org/wiki/CD5_(protein)

「naive」

　　[★]

• adj.

• 純真な、天真爛漫な、うぶな(artless)
• 愚直な、だまされやすい
• 未経験の。単純素朴な。(画家など)正規の訓練を受けていない、素朴な。特定の実験/投薬を受けたことがない。特定の麻薬をやったことがない

Sulfasalazine versus placebo in DMARD naive people with early rheumatoid arthritis.(DMARDを投薬されていない早期のRA患者において、プラセボに対するサルファサラジン)

関

intact, non-treated, nontreated, unchallenged, untreated

　 　 　

「C」

　　[★]

• 炭素 carbon
• シトシン cytosine
• システイン cysteine
• シチジン
• セルシウス度 摂氏 degrees Celsius degree C
• 産婦人科領域で「子宮外頚 子宮外頚部 exocervix」を表現するための略語

　 　 　 　

「CD」

　　[★]

• 表面抗原分類 cluster of differentiation
• 膠原病 collagen disease
• 集合管 collecting duct
• クローン病 Crohn's disease

　

「T」

　　[★]

• T波 T wave
• チミン thymine
• ツイスト数
• スレオニントレオニン threonine

　 　

「CD4」

　　[★]

同

T4, Leucine-SA, Leucine-3B

関

表面抗原分類