Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/28 19:27:13」(JST)

wiki en

Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome 17.^[1]^[2]^[3]^[4] PECAM-1 plays a key role in removing aged neutrophils from the body.

Function

PECAM-1 is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte transmigration, angiogenesis, and integrin activation.^[1]

Tissue distribution

CD31 is normally found on endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, T / NK cells, lymphocytes, megakaryocytes, osteoclasts, neutrophils.

CD31 is also expressed in certain tumors, including epithelioid hemangioendothelioma, epithelioid sarcoma-like hemangioendothelioma, other vascular tumors, histiocytic malignancies, and plasmacytomas. It is rarely found in some sarcomas, such as Kaposi's sarcoma,^[5]^[6] and carcinomas.

Immunohistochemistry

Micrograph of an angiosarcoma stained with a CD31 immunostain.

In immunohistochemistry, CD31 is used primarily to demonstrate the presence of endothelial cells in histological tissue sections. This can help to evaluate the degree of tumour angiogenesis, which can imply a rapidly growing tumour. Malignant endothelial cells also commonly retain the antigen, so that CD31 immunohistochemistry can also be used to demonstrate both angiomas and angiosarcomas. It can also be demonstrated in small lymphocytic and lymphoblastic lymphomas, although more specific markers are available for these conditions.^[7]

References

^ ^a ^b "Entrez Gene: platelet/endothelial cell adhesion molecule".
^ Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA (March 1990). "PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily". Science 247 (4947): 1219–22. doi:10.1126/science.1690453. PMID 1690453.
^ Gumina RJ, Kirschbaum NE, Rao PN, vanTuinen P, Newman PJ (June 1996). "The human PECAM1 gene maps to 17q23". Genomics 34 (2): 229–32. doi:10.1006/geno.1996.0272. PMID 8661055.
^ Xie Y, Muller WA (October 1996). "Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1". Genomics 37 (2): 226–8. doi:10.1006/geno.1996.0546. PMID 8921400.
^ Ganjei-Azar, Parvin (2007). Color Atlas of Immunocytochemistry in Diagnostic Cytology. [New York]: Springer Science+Business Media, LLC. p. 47. ISBN 978-0387-32121-9.
^ Paolo Gattuso, ed. (2010). Differential diagnosis in surgical pathology (2nd ed.). Philadelphia, PA: Saunders/Elsevier. p. 108. ISBN 978-1-4160-4580-9.
^ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. p. 103. ISBN 1-84110-100-1.

External links

Mouse CD Antigen Chart
Human CD Antigen Chart

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 薬剤性血小板減少症 drug induced thrombocytopenia
2. 移植片対宿主病の病因 pathogenesis of graft versus host disease
3. 炎症の病因における白血球内皮細胞接着 leukocyte endothelial adhesion in the pathogenesis of inflammation
4. 移植免疫 transplantation immunobiology
5. 鎌状細胞貧血における臨床的ばらつき clinical variability in sickle cell anemia

English Journal

Bioluminescent and micro-computed tomography imaging of bone repair induced by fibrin-binding growth factors.

Vila OF1, Martino MM2, Nebuloni L3, Kuhn G3, Pérez-Amodio S4, Müller R3, Hubbell JA2, Rubio N1, Blanco J5.
Acta biomaterialia.Acta Biomater.2014 Oct;10(10):4377-89. doi: 10.1016/j.actbio.2014.05.028. Epub 2014 Jun 4.
In this work we have evaluated the capacity of bone morphogenetic protein-2 (BMP-2) and fibrin-binding platelet-derived growth factor-BB (PDGF-BB) to support cell growth and induce bone regeneration using two different imaging technologies to improve the understanding of structural and organizationa
PMID 24905933

Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice.

Imeri F1, Fallegger D1, Zivkovic A2, Schwalm S3, Enzmann G4, Blankenbach K3, Meyer zu Heringdorf D3, Homann T5, Kleuser B5, Pfeilschifter J3, Engelhardt B4, Stark H2, Huwiler A6.
Neuropharmacology.Neuropharmacology.2014 Oct;85:314-27. doi: 10.1016/j.neuropharm.2014.05.012. Epub 2014 May 23.
The immunomodulatory FTY720 (fingolimod) is presently approved for the treatment of relapsing-remitting multiple sclerosis. It is a prodrug that acts by modulating sphingosine 1-phosphate (S1P) receptor signaling. In this study, we have developed and characterized two novel oxazolo-oxazole derivativ
PMID 24863045

Sweet Role of Platelet Endothelial Cell Adhesion Molecule (PECAM) in Understanding Angiogenesis.

Kitazume S, Imamaki R, Ogawa K, Taniguchi N.
Glycobiology.Glycobiology.2014 Sep 11. pii: cwu094. [Epub ahead of print]
The vascular endothelial glycocalyx contains several anionic sugars, one of which is a sialic acid attached to both N- and O-glycans. Platelet endothelial cell adhesion molecule (PECAM), a member of the Ig superfamily that plays multiple roles in cell adhesion, mechanical stress sensing, antiapoptos
PMID 25214153

Japanese Journal

9J-03 血管内皮細胞の流れ負荷に伴う変形の量子ドットを用いた局所計測の試み(OS-11(3) 細胞・生体分子のバイオメカニクス(1))

大脇靖史,長山和亮,松本明郎,松本健郎
バイオエンジニアリング講演会講演論文集 2010(23), 483-484, 2011-01-07
NAID 110008744233

皮膚の炎症における細胞接着分子の役割

門野岳史
日本臨床免疫学会会誌 = Japanese journal of clinical immunology 33(5), 242-248, 2010-10-31
… グリンファミリーが重要であり，その主なものとしてβ2 integrinとそのリガンドであるICAM-1およびα4 integrinとそのリガンドであるVCAM-1がある．これらの分子の阻害によっても皮膚の炎症は減弱する．Transmigrationおよびdiapedesisに関与する分子に関しても，PECAM-1, CD99, JAMの阻害により皮膚の炎症が改善した報告がみられている．今後，これら様々な細胞接着因子を抑えることにより，皮膚の炎症を制御することが期待される． …
NAID 10027753863

Related Pictures

★リンクテーブル★

リンク元	「接着分子」「CD31」
拡張検索	「PECAM-1」
関連記事	「PEC」

「接着分子」

Platelet/endothelial cell adhesion molecule 1
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	2KY5
Identifiers
Symbols	PECAM1 ; CD31; CD31/EndoCAM; GPIIA'; PECA1; PECAM-1; endoCAM
External IDs	OMIM: 173445 MGI: 97537 HomoloGene: 47925 GeneCards: PECAM1 Gene
Gene ontology
Molecular function	• protein binding;
Cellular component	• extracellular space; • plasma membrane; • integral component of membrane; • cell junction; • platelet alpha granule membrane; • extracellular exosome;
Biological process	• platelet degranulation; • phagocytosis; • cell adhesion; • signal transduction; • blood coagulation; • cell recognition; • platelet activation; • extracellular matrix organization; • leukocyte migration; • diapedesis; • glomerular endothelium development;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

　　[★]

英: adhesion molecule
同: 接着因子
関

接着分子のファミリー

インテグリンファミリー
Igスーパーファミリー
セレクチンファミリー
CD44ファミリー
カドヘリンファミリー

白血球の相互作用に関与している接着分子 (IMM.87)

グループ名	機能	名称	別名		組織分布	リガンド
セレクチン	炭化水素鎖に結合。白血球-内皮細胞の反応を開始	P-selectin	PADGEN	CD62P	活性化した内皮細胞、活性化した血小板	PSGL-1, sialyl-Lewisx
セレクチン	炭化水素鎖に結合。白血球-内皮細胞の反応を開始	E-selectin	ELAM-1	CD62E	活性化した内皮細胞	sialyl-Lewisx
インテグリン	CAMや細胞外マトリックスに結合。強い結合	LFA-1	αL:β2	CD11a:CD18	単球、T細胞、マクロファージ、好中球、樹状細胞	ICAMs
		CR3, Mac-1	αM:β2	CD11b:CD18	好中球、単球、マクロファージ	ICAM-1, iC3b, fibrinogen
		CR4, p150.95	αX:β2	CD11c:CD18	樹状細胞、マクロファージ、好中球	iC3b
		VLA-5	α5:β1	CD49d:CD29	単球、マクロファージ	fibronectin
免疫グロブリンスーパーファミリー	細胞結合で様々に働く。インテグリンの基質	ICAM-1		CD54	活性化した内皮細胞	LFA-1, MAC1
		ICAM-2		CD102	非活性化状態の内皮細胞、樹状細胞	LFA-1
		VCAM-1		CD106	活性化した内皮細胞	VLA-4
		PECAM		CD31	活性化した白血球、内皮細胞間の結合	CD31

白血球の相互作用に関与している免疫グロブリンスーパーファミリーの接着分子 (IMM.329)

名称		分布組織	リガンド
CD2	LFA-2	T細胞	LFA-1	CD53
ICAM-1	CD54	活性化した血管、リンパ球、樹状細胞	LFA-1, Mac-1
ICAM-2	CD102	非活性化状態の血管	LFA-1
ICAM-3	CD50	Naive T cells	DC-SIGN, LFA-1
LFA-3	CD58	リンパ球、APC	CD2
VCAM-1	CD106	活性化した内皮細胞	VLA-4

-接着分子

-細胞接着分子

-カドヘリン

「CD31」

　　[★]

同: PECAM, platelet endothelial cell adhesion molecule-1

「PECAM-1」

　　[★]

血小板内皮細胞接着分子-1、血小板内皮細胞接着分子1

同: CD31
関: CD31 antigen、platelet endothelial cell adhesion molecule-1、platelet endothelial cell adhesion molecule 1

「PEC」

　　[★] 腹腔滲出細胞 peritoneal exudate cell

[entrez-1] "Entrez Gene: platelet/endothelial cell adhesion molecule".

[pmid1690453-2] Newman PJ, Berndt MC, Gorski J, White GC, Lyman S, Paddock C, Muller WA (March 1990). "PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily". Science 247 (4947): 1219–22. doi:10.1126/science.1690453. PMID 1690453.

[pmid8661055-3] Gumina RJ, Kirschbaum NE, Rao PN, vanTuinen P, Newman PJ (June 1996). "The human PECAM1 gene maps to 17q23". Genomics 34 (2): 229–32. doi:10.1006/geno.1996.0272. PMID 8661055.

[pmid8921400-4] Xie Y, Muller WA (October 1996). "Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1". Genomics 37 (2): 226–8. doi:10.1006/geno.1996.0546. PMID 8921400.

[5] Ganjei-Azar, Parvin (2007). Color Atlas of Immunocytochemistry in Diagnostic Cytology. [New York]: Springer Science+Business Media, LLC. p. 47. ISBN 978-0387-32121-9.

[6] Paolo Gattuso, ed. (2010). Differential diagnosis in surgical pathology (2nd ed.). Philadelphia, PA: Saunders/Elsevier. p. 108. ISBN 978-1-4160-4580-9.

[Leong-7] Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. p. 103. ISBN 1-84110-100-1.

匿名

検索

案内

案内

PECAM