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English Journal

Chemical constituents and sources of ambient particulate air pollution and biomarkers of endothelial function in a panel of healthy adults in Beijing, China.

Wu S1, Yang D1, Pan L1, Shan J1, Li H1, Wei H1, Wang B2, Huang J1, Baccarelli AA3, Shima M4, Deng F5, Guo X6.
The Science of the total environment.Sci Total Environ.2016 Aug 1;560-561:141-9. doi: 10.1016/j.scitotenv.2016.03.228. Epub 2016 Apr 18.
BACKGROUND: Exposure to ambient air pollution has been associated with endothelial dysfunction as reflected by short-term alterations in circulating biomarkers, but the chemical constituents and pollution sources behind the association has been unclear.METHODS: We investigated the associations betwe
PMID 27101449

Hypoxia inhibits pulmonary artery endothelial cell apoptosis via the e-selectin/biliverdin reductase pathway.

Song S1, Yi Z1, Zhang M1, Mao M1, Fu L1, Zhao X1, Liu Z1, Gao J2, Cao W1, Liu Y1, Shi H1, Zhu D3.
Microvascular research.Microvasc Res.2016 Jul;106:44-56. doi: 10.1016/j.mvr.2016.03.009. Epub 2016 Mar 28.
Hypoxia-induced inhibition of apoptosis in pulmonary artery endothelial cells (PAECs) has an important role in pulmonary arterial remodeling leading to aggravated hypoxic pulmonary arterial hypertension. However, the mechanisms involved in the hypoxia-induced inhibition of PAEC apoptosis have not be
PMID 27033411

A semisynthetic diterpenoid lactone inhibits NF-κB signalling to ameliorate inflammation and airway hyperresponsiveness in a mouse asthma model.

Lim JC1, Goh FY2, Sagineedu SR3, Yong AC4, Sidik SM5, Lajis NH3, Wong WS6, Stanslas J7.
Toxicology and applied pharmacology.Toxicol Appl Pharmacol.2016 Jul 1;302:10-22. doi: 10.1016/j.taap.2016.04.004. Epub 2016 Apr 27.
Andrographolide (AGP) and 14-deoxy-11,12-didehydroandrographolide (DDAG), two main diterpenoid constituents of Andrographis paniculata were previously shown to ameliorate asthmatic symptoms in a mouse model. However, due to inadequacies of both compounds in terms of drug-likeness, DDAG analogues wer
PMID 27089844

Reduction of Ischemia-reperfusion Injury to Skin Flap by Treatment with Monoclonal Antibody to Endothelial Leukocyte Adhesion Molecule-1

Study of interleukin-6 in the spread of colorectal cancer: the diagnostic significance of IL-6.

リンク元

白血球の相互作用に関与している接着分子 (IMM.87)

グループ名	機能	名称	別名		組織分布	リガンド
セレクチン	炭化水素鎖に結合。白血球-内皮細胞の反応を開始	P-selectin	PADGEN	CD62P	活性化した内皮細胞、活性化した血小板	PSGL-1, sialyl-Lewisx
セレクチン	炭化水素鎖に結合。白血球-内皮細胞の反応を開始	E-selectin	ELAM-1	CD62E	活性化した内皮細胞	sialyl-Lewisx
インテグリン	CAMや細胞外マトリックスに結合。強い結合	LFA-1	αL:β2	CD11a:CD18	単球、T細胞、マクロファージ、好中球、樹状細胞	ICAMs
		CR3, Mac-1	αM:β2	CD11b:CD18	好中球、単球、マクロファージ	ICAM-1, iC3b, fibrinogen
		CR4, p150.95	αX:β2	CD11c:CD18	樹状細胞、マクロファージ、好中球	iC3b
		VLA-5	α5:β1	CD49d:CD29	単球、マクロファージ	fibronectin
免疫グロブリンスーパーファミリー	細胞結合で様々に働く。インテグリンの基質	ICAM-1		CD54	活性化した内皮細胞	LFA-1, MAC1
		ICAM-2		CD102	非活性化状態の内皮細胞、樹状細胞	LFA-1
		VCAM-1		CD106	活性化した内皮細胞	VLA-4
		PECAM		CD31	活性化した白血球、内皮細胞間の結合	CD31

-接着分子

-細胞接着分子

-カドヘリン