H1 blocker


antihistaminehistamine H1 antagonisthistamine H1 receptor antagonist


  1. a medicine used to treat allergies and hypersensitive reactions and colds; works by counteracting the effects of histamine on a receptor site
  2. a three-dimensional shape with six square or rectangular sides (同)cube
  3. (computer science) a sector or group of sectors that function as the smallest data unit permitted; "since blocks are often defined as a single sector, the terms `block and `sector are sometimes used interchangeably"
  4. support, secure, or raise with a block; "block a plate for printing"; "block the wheels of a car"
  5. a solid piece of something (usually having flat rectangular sides); "the pyramids were built with large stone blocks"
  6. housing in a large building that is divided into separate units; "there is a block of classrooms in the west wing"
  7. a rectangular area in a city surrounded by streets and usually containing several buildings; "he lives in the next block" (同)city block
  8. an inability to remember or think of something you normally can do; often caused by emotional tension; "I knew his name perfectly well but I had a temporary block" (同)mental_block
  9. a number or quantity of related things dealt with as a unit; "he reserved a large block of seats"; "he held a large block of the companys stock"
  10. interrupt the normal function of by means of anesthesia; "block a nerve"; "block a muscle"
  11. run on a block system; "block trains"
  12. shape by using a block; "Block a hat"; "block a garment"
  13. shape into a block or blocks; "block the graphs so one can see the results clearly"
  14. stamp or emboss a title or design on a book with a block; "block the book cover"
  15. a class of drugs that inhibit (block) some biological process (同)blocking_agent
  16. a football player whose responsibility is to block players attempting to stop an offensive play
  17. the 8th letter of the Roman alphabet (同)h


  1. 抗ヒスタミン剤(各種のアレルギー症・風邪の治療に用いる)
  2. (木・石などの,通例平らな面のある)『かたまり』 / 《米》(四団を街路に囲まれた)『区画』,街区 / 街区の1辺の距離(一般に40メートル前後) / 《英》ブロック(アパート・事務所・商店などに区切られている大きな建物) / 『妨害物』,障害物(obstacle);(障害によって生じた)停滞,渋滞 / 台木,台(まないた・肉切り台・まき割り台・せり売り台・帽子の木型など);《the~》炭頭台 / (特にアメリカンフットボールで)ブロック(相手の選手の突進を阻止する) / 滑車(pulley) / (座席券・株券などの)一組《+『of』+『名』》 / 〈通路など〉'を'『ふさぐ』,〈通行・進行など〉'を'妨げる / 〈帽子など〉の型取りをする / (特にアメリカンフットボールで)〈相手選手の突進〉'を'ブロックする;(ボクシングで)〈相手のパンチ〉'を'ブロックする
  3. hydrogenの化学記号
  4. 鉛筆の硬度 / 《俗》heroin

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/08/28 23:17:51」(JST)

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English Journal

  • Proton pump inhibitor use and fracture risk - effect modification by histamine H1 receptor blockade. Observational case-control study using National Prescription Data.
  • Abrahamsen B, Vestergaard P.SourceDepartment of Medicine F, Gentofte Hospital, Copenhagen, Denmark; OPEN, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark. Electronic address: b.abrahamsen@physician.dk.
  • Bone.Bone.2013 Nov;57(1):269-71. doi: 10.1016/j.bone.2013.08.013. Epub 2013 Aug 22.
  • It remains unknown why proton pump inhibitor (PPI) use may be associated with risk of osteoporotic fractures; evidence of direct effects on calcium absorption or on the osteoclast in humans is weak or absent. However, the ensuing increased gastrin levels may cause histamine production through hypert
  • PMID 23973557
  • Pharmacological Profile of 2-Bromoterguride at Human Dopamine D2, Porcine Serotonin 5-Hydroxytryptamine 2A, and α2C-Adrenergic Receptors, and Its Antipsychotic-Like Effects in Rats.
  • Jantschak F, Brosda J, Franke RT, Fink H, Möller D, Hübner H, Gmeiner P, Pertz HH.SourceInstitute of Pharmacy, Free University of Berlin, Berlin, Germany (F.J., H.H.P.); Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Free University of Berlin, Berlin, Germany (J.B., R.T.F., H.F.); and Department of Chemistry and Pharmacy, Emil Fischer Center, Friedrich Alexander University, Erlangen, Germany (D.M., H.H., P.G.).
  • The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2013 Oct;347(1):57-68. doi: 10.1124/jpet.113.205997. Epub 2013 Jul 17.
  • Dopaminergic, serotonergic, and adrenergic receptors are targets for therapeutic actions in schizophrenia. Dopamine D2 receptor partial agonists such as aripiprazole represent a treatment option for patients with this severe disorder. The ineffectiveness of terguride, another D2 receptor partial ago
  • PMID 23863695
  • Differential mechanisms underlie the regulation of serotonergic transmission in the dorsal and median raphe nuclei by mirtazapine: a dual probe microdialysis study.
  • Fukuyama K, Tanahashi S, Hamaguchi T, Nakagawa M, Shiroyama T, Motomura E, Okada M.SourceDepartment of Neuropsychiatry, Division of Neuroscience, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
  • Psychopharmacology.Psychopharmacology (Berl).2013 Oct;229(4):617-26. doi: 10.1007/s00213-013-3122-9. Epub 2013 May 9.
  • RATIONALE: Blockade of α2 adrenoceptors and histamine H1 receptors plays important roles in the antidepressant and hypnotic effects of mirtazapine.OBJECTIVES: However, it remains unclear how mirtazapine's actions at these receptors interact to affect serotonergic transmission in the dorsal (DRN) an
  • PMID 23657423

Japanese Journal

  • 気管支喘息の病態におけるヒスタミンの役割と抗ヒスタミン薬の臨床的有用性の再検証
  • 山内 広平,鹿内 俊樹,中村 豊,小林 仁,小笠原 正人,前山 一隆
  • YAKUGAKU ZASSHI 131(2), 185-191, 2011
  • … However, H1-blockers are not recommended as the first drug for asthma therapy in the guidelines. … Histamine may play various roles in allergic airway inflammation through the H1 receptor (H1R), H2R, and H4R in immune cells including T lymphocytes and dendritic cells. … H1-blockers are recommended as first-line drugs to treat allergic rhinitis in the guidelines. …
  • NAID 130000451448
  • R-(?)-α-Methylhistamine, a Histamine H3 Receptor Agonist, Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries
  • Sun Pengyuan,Jin Xin,Koyama Toshihiro,Li Simin,Kitamura Yoshihisa,Kawasaki Hiromu
  • Biological & Pharmaceutical Bulletin 33(1), 58-63, 2010
  • … This vasodilation was abolished by endothelium removal and attenuated by histamine H3 receptor antagonists, thioperamide and clobenpropit, but not by chlorpheniramine (histamine H1 receptor antagonist) and cimetidine (histamine H2 receptor antagonist). …
  • NAID 130000140192

Related Links

←→ヒスタミン/受容体/神経系/炎症メディエーター/血管作動物質 →抗ヒスタミン薬 →H2ブロッカー 抗ヒスタミン薬 H1 antihistamine =H1ブロッカー H1 antagonist ←→ H1受容体 抗ヒスタミン薬は、受容体の部位でヒスタミンと競合的に拮抗 ...
ヒスタミンH1受容体 拮抗薬、H1-receptor antagonist,H1ブロッカー,H1拮抗薬 ヒスタミンによる血管透過性亢進、気管支平滑筋収縮作用、掻痒感を遮断する。I型アレルギー性疾患(じんま疹、アレルギー性鼻炎、結膜炎)に用いられる。




antihistamine antihistamines, histamine antagonist
ヒスタミン拮抗薬 histamine antagonistsヒスタミン遮断薬 histamine blocking agents
ヒスタミンH1受容体拮抗薬 histamine H1 receptor antagonistH1拮抗薬 H1 blockerH2遮断薬
ヒスタミンH2受容体拮抗薬 histamine H2 receptor antagonistH2拮抗薬 H2 blockerH2遮断薬
  • 古典的抗ヒスタミン薬
  • エタノールアミン系
  • プロピルアミン系
  • ピペラジン系
  • ピペリジン系
  • 第二世代ヒスタミン薬
  • ピペリジン系
  • アレルギー性抗ヒスタミン薬


https://minds.jcqhc.or.jp/n/med/4/med0024/G0000065/0023 をより改変して引用
  受容体括抗作用 イオン電流阻害作用 血液脳関門透過性
ジフェンヒドラミン ++         ++
プロメタジン ++ ++     ++
クロルフェニラミン ++         ++
ケトチフェン ++        
アゼラスチン ++        
オキサトミド ++      
テルフェナジン +++        
アステミゾール +++            
セチリジン +++                  





H1 blocker



H1 blocker



H1 blocker



H1 blocker



  • n.
  • v.
  • 遮断する、ブロックする、封鎖する、阻止する
blockadeblockagedeterinhibitinhibitionlumppreventpreventionrepressrepressionsealturn off




H, H0, HX
  • 胃癌の病期分類に用いられている。
  • 肝転移の有無を示す。
  • 肝転移を認める。



  • n.
antagonistblocking agentinhibitor