histamine antagonist

WordNet

  1. a drug that neutralizes or counteracts the effects of another drug
  2. a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
  3. amine formed from histidine that stimulates gastric secretions and dilates blood vessels; released by the human immune system during allergic reactions

PrepTutorEJDIC

  1. 対立する人,敵対者,競争相手(opponent)
  2. ヒスタミン(子宮収縮・血圧降下の薬)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2019/01/02 19:09:41」(JST)

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English Journal

  • The critical role of mast cell-derived hypoxia-inducible factor-1α in human and mice melanoma growth.
  • Jeong HJ, Oh HA, Nam SY, Han NR, Kim YS, Kim JH, Lee SJ, Kim MH, Moon PD, Kim HM, Oh HA.SourceBiochip Research Center, Hoseo University, 165, Sechul-ri, Baebang-myun, Asan, Chungnam 336-795, Republic of Korea.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2013 Jun 1;132(11):2492-501. doi: 10.1002/ijc.27937. Epub 2012 Dec 3.
  • Mast cells play an important role in tumorigenesis. Histamine released from mast cells stimulates new vessel formation by acting through the histamine1 (H1) receptor. Despite the evidence of the role of mast cells in tumor growth and angiogenesis, the potential mechanism remains to be elucidated. Th
  • PMID 23161568
  • A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787.
  • Andaloussi M, Lim HD, van der Meer T, Sijm M, Poulie CB, de Esch IJ, Leurs R, Smits RA.SourceGriffin Discoveries BV, Department of Medicinal Chemistry, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
  • Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2013 May 1;23(9):2663-70. doi: 10.1016/j.bmcl.2013.02.091. Epub 2013 Mar 1.
  • In this work we describe the optimization of a lead compound based on the quinazoline template to give a new series of potent pyrido[3,2-d]pyrimidines as histamine H4 receptor antagonists. The pyrido[3,2-d]pyrimidine ligands have significantly reduced hERG binding compared to clinical stage compound
  • PMID 23558237
  • Novel and highly potent histamine H3 receptor ligands. Part 3: An alcohol function to improve the pharmacokinetic profile.
  • Labeeuw O, Levoin N, Poupardin-Olivier O, Calmels T, Ligneau X, Berrebi-Bertrand I, Robert P, Lecomte JM, Schwartz JC, Capet M.SourceBioprojet-Biotech, 4 rue du Chesnay Beauregard, BP 96205, 35762 Saint-Grégoire, France. Electronic address: o.labeeuw@bioprojet.com.
  • Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2013 May 1;23(9):2548-54. doi: 10.1016/j.bmcl.2013.02.118. Epub 2013 Mar 14.
  • Synthesis and biological evaluation of potent histamine H3 receptor antagonists incorporating a hydroxyl function are described. Compounds in this series exhibited nanomolar binding affinities for human receptor, illustrating a new possible component for the H3 pharmacophore. As demonstrated with co
  • PMID 23535326

Japanese Journal

  • アレルギー性結膜炎における自覚症状評価を目的としたFacial Imaging Scale (FISA)の検討
  • ラテックスアレルギー 病態生理と診断・治療
  • The Role of Histamine H1 and H4 Receptors in Atopic Dermatitis: From Basic Research to Clinical Study

Related Links

Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds. ... ChEBI Name histamine antagonist ChEBI ID CHEBI:37956 Definition Histamine ...
Pdf Ebooks PDF Word Power Point Ebook Histamine antagonist Histamine H2 Antagonist Drug Class Review Book 6.39 MB | Ebook Pages: 80 histamine H2-receptor antagonists in the treatment heartburn/GERD, erosive ...



★リンクテーブル★
リンク元抗ヒスタミン薬

抗ヒスタミン薬」

  [★]

antihistamine antihistamines, histamine antagonist
ヒスタミン拮抗薬 histamine antagonistsヒスタミン遮断薬 histamine blocking agents
ヒスタミン受容体薬理学
ヒスタミンH1受容体拮抗薬 histamine H1 receptor antagonistH1拮抗薬 H1 blockerH2遮断薬
ヒスタミンH2受容体拮抗薬 histamine H2 receptor antagonistH2拮抗薬 H2 blockerH2遮断薬
  • 古典的抗ヒスタミン薬
  • エタノールアミン系
  • プロピルアミン系
  • ピペラジン系
  • ピペリジン系
  • 第二世代ヒスタミン薬
中枢作用↓、鎮静作用↓、抗コリン作用↓
  • ピペリジン系
  • アレルギー性抗ヒスタミン薬
ケミカルメディエーター放出を抑制
中枢作用:有。鎮静作用:有

薬理学的作用の比較

https://minds.jcqhc.or.jp/n/med/4/med0024/G0000065/0023 をより改変して引用
  受容体括抗作用 イオン電流阻害作用 血液脳関門透過性
H1 ACh NA 5-HT DA PAF LT Ca Na K
ジフェンヒドラミン ++         ++
プロメタジン ++ ++     ++
クロルフェニラミン ++         ++
ケトチフェン ++        
アゼラスチン ++        
オキサトミド ++      
テルフェナジン +++        
アステミゾール +++            
セチリジン +++                  

抗ヒスタミン薬の抗ヒスタミン受容体占拠率

https://www.jstage.jst.go.jp/article/jibiinkoka/112/3/112_3_99/_pdf