histamine H1 receptor antagonist

  • ヒスタミンH1受容体遮断薬、ヒスタミンH1受容体拮抗薬
antihistamineH1 blockerhistamine H1 antagonist


  1. a medicine used to treat allergies and hypersensitive reactions and colds; works by counteracting the effects of histamine on a receptor site
  2. a drug that neutralizes or counteracts the effects of another drug
  3. a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
  4. the 8th letter of the Roman alphabet (同)h
  5. amine formed from histidine that stimulates gastric secretions and dilates blood vessels; released by the human immune system during allergic reactions
  6. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response


  1. 抗ヒスタミン剤(各種のアレルギー症・風邪の治療に用いる)
  2. 対立する人,敵対者,競争相手(opponent)
  3. hydrogenの化学記号
  4. 鉛筆の硬度 / 《俗》heroin
  5. ヒスタミン(子宮収縮・血圧降下の薬)
  6. =sense organ / 受信装置

UpToDate Contents

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English Journal

  • Histamine reverses a memory deficit induced in rats by early postnatal maternal deprivation.
  • Benetti F, Silveira CK, Silva WC, Cammarota M, Izquierdo I.SourceCentro de Memória, Instituto do Cérebro, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga 6690, 2° andar, Porto Alegre, RS 90610-000, Brazil; Instituto Nacional de Neurociência Translacional, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Avenida Ipiranga 6690, 2° andar, Porto Alegre, RS 90610-000, Brazil.
  • Neurobiology of learning and memory.Neurobiol Learn Mem.2012 Jan;97(1):54-8. Epub 2011 Sep 28.
  • Early partial maternal deprivation causes long-lasting neurochemical, behavioral and brain structural effects. In rats, it causes a deficit in memory consolidation visible in adult life. Some of these deficits can be reversed by donepezil and galantamine, which suggests that they may result from an
  • PMID 21979429
  • Potential role of store-operated Ca(2+) entry in Th(2) response induced by histamine in human monocyte-derived dendritic cells.
  • Geng S, Gao YD, Yang J, Zou JJ, Guo W.SourceDepartment of Respiratory Medicine, Zhongnan Hospital, Wuhan, Donghu Road 169, 430071 Wuhan, China; Department of Respiratory Medicine, Renmin Hospital, Wuhan, Donghu Road 169, 430071 Wuhan, China.
  • International immunopharmacology.Int Immunopharmacol.2011 Dec 30. [Epub ahead of print]
  • Store-operated calcium entry (SOCE) is proved to be the main Ca(2+) influx pathway of dendritic cells (DCs). DCs primed with histamine facilitate Th(2) immune response via different types of histamine receptors. Histamine induces DCs to release Ca(2+) from internal store. Therefore, it is rational t
  • PMID 22212353

Japanese Journal

  • Electrophysiological Analysis of the Mechanism of Autonomic Action by Lactobacilli
  • Tanida Mamoru,Nagai Katsuya
  • Bioscience and Microflora 30(4), 99-109, 2011
  • … Interestingly, we found that the hypothalamic suprachiasmatic nucleus (SCN), a master circadian clock, and histamine receptors in histaminergic neurons play important roles in peripheral autonomic control. … To investigate the possible role of SCN and histamine receptors in lactobacilli-mediated pathology, we created an SCN-lesion model and experimented with histaminergic blocker injections. …
  • NAID 130001253242
  • Prophylactic Effects of the Histamine H1 Receptor Antagonist Epinastine and the Dual Thromboxane A2 Receptor and Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Antagonist Ramatroban on Allergic Rhinitis Model in Mice
  • Suzuki Yuh,Inoue Toshio,Yamamoto Atsuki,Sugimoto Yukio
  • Biological & Pharmaceutical Bulletin 34(4), 507-510, 2011
  • … However, there is little information regarding the prophylactic effect of thromboxane A2 (TXA2) receptor antagonist on allergic rhinitis. … Recent studies revealed that a TXA2 receptor antagonist ramatroban could block the prostaglandin D2 (PGD2) receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). …
  • NAID 130000657839

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Related Pictures

Pharmacology of Histamine H2-Receptor  of a Histamine H1-Receptor AntagonistHistamine Antagonists (Antihistamines)Antihistaminics, H1; Histamine H1 Receptor Histamine. Causes, symptoms, treatment Animation on histamine release and

リンク元抗ヒスタミン薬」「H1 blocker」「histamine H1 antagonist



antihistamine antihistamines, histamine antagonist
ヒスタミン拮抗薬 histamine antagonistsヒスタミン遮断薬 histamine blocking agents
ヒスタミンH1受容体拮抗薬 histamine H1 receptor antagonistH1拮抗薬 H1 blockerH2遮断薬
ヒスタミンH2受容体拮抗薬 histamine H2 receptor antagonistH2拮抗薬 H2 blockerH2遮断薬
  • 古典的抗ヒスタミン薬
  • エタノールアミン系
  • プロピルアミン系
  • ピペラジン系
  • ピペリジン系
  • 第二世代ヒスタミン薬
  • ピペリジン系
  • アレルギー性抗ヒスタミン薬


https://minds.jcqhc.or.jp/n/med/4/med0024/G0000065/0023 をより改変して引用
  受容体括抗作用 イオン電流阻害作用 血液脳関門透過性
ジフェンヒドラミン ++         ++
プロメタジン ++ ++     ++
クロルフェニラミン ++         ++
ケトチフェン ++        
アゼラスチン ++        
オキサトミド ++      
テルフェナジン +++        
アステミゾール +++            
セチリジン +++                  



H1 blocker」



antihistaminehistamine H1 antagonisthistamine H1 receptor antagonist

histamine H1 antagonist」


antihistamineH1 blockerhistamine H1 receptor antagonist



H, H0, HX
  • 胃癌の病期分類に用いられている。
  • 肝転移の有無を示す。
  • 肝転移を認める。