WordNet

a medicine used to treat allergies and hypersensitive reactions and colds; works by counteracting the effects of histamine on a receptor site
a drug that neutralizes or counteracts the effects of another drug
a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
the 8th letter of the Roman alphabet (同)h
amine formed from histidine that stimulates gastric secretions and dilates blood vessels; released by the human immune system during allergic reactions
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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1. 制吐剤の特性 characteristics of antiemetic drugs
2. 肥満細胞由来のメディエーター mast cell derived mediators
3. 慢性蕁麻疹：標準的なマネージメントおよび患者教育 chronic urticaria standard management and patient education
4. 癌治療に用いられる治療用モノクローナル抗体に対する輸注反応 infusion reactions to therapeutic monoclonal antibodies used for cancer therapy
5. アレルギーのin vitro検査の概要 overview of in vitro allergy tests

Histamine reverses a memory deficit induced in rats by early postnatal maternal deprivation.

Benetti F, Silveira CK, Silva WC, Cammarota M, Izquierdo I.SourceCentro de Memória, Instituto do Cérebro, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga 6690, 2° andar, Porto Alegre, RS 90610-000, Brazil; Instituto Nacional de Neurociência Translacional, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Avenida Ipiranga 6690, 2° andar, Porto Alegre, RS 90610-000, Brazil.
Neurobiology of learning and memory.Neurobiol Learn Mem.2012 Jan;97(1):54-8. Epub 2011 Sep 28.
Early partial maternal deprivation causes long-lasting neurochemical, behavioral and brain structural effects. In rats, it causes a deficit in memory consolidation visible in adult life. Some of these deficits can be reversed by donepezil and galantamine, which suggests that they may result from an
PMID 21979429

Potential role of store-operated Ca(2+) entry in Th(2) response induced by histamine in human monocyte-derived dendritic cells.

Geng S, Gao YD, Yang J, Zou JJ, Guo W.SourceDepartment of Respiratory Medicine, Zhongnan Hospital, Wuhan, Donghu Road 169, 430071 Wuhan, China; Department of Respiratory Medicine, Renmin Hospital, Wuhan, Donghu Road 169, 430071 Wuhan, China.
International immunopharmacology.Int Immunopharmacol.2011 Dec 30. [Epub ahead of print]
Store-operated calcium entry (SOCE) is proved to be the main Ca(2+) influx pathway of dendritic cells (DCs). DCs primed with histamine facilitate Th(2) immune response via different types of histamine receptors. Histamine induces DCs to release Ca(2+) from internal store. Therefore, it is rational t
PMID 22212353

Electrophysiological Analysis of the Mechanism of Autonomic Action by Lactobacilli

Tanida Mamoru,Nagai Katsuya
Bioscience and Microflora 30(4), 99-109, 2011
… Interestingly, we found that the hypothalamic suprachiasmatic nucleus (SCN), a master circadian clock, and histamine receptors in histaminergic neurons play important roles in peripheral autonomic control. … To investigate the possible role of SCN and histamine receptors in lactobacilli-mediated pathology, we created an SCN-lesion model and experimented with histaminergic blocker injections. …
NAID 130001253242

Prophylactic Effects of the Histamine H1 Receptor Antagonist Epinastine and the Dual Thromboxane A2 Receptor and Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Antagonist Ramatroban on Allergic Rhinitis Model in Mice

Suzuki Yuh,Inoue Toshio,Yamamoto Atsuki,Sugimoto Yukio
Biological & Pharmaceutical Bulletin 34(4), 507-510, 2011
… However, there is little information regarding the prophylactic effect of thromboxane A2 (TXA2) receptor antagonist on allergic rhinitis. … Recent studies revealed that a TXA2 receptor antagonist ramatroban could block the prostaglandin D2 (PGD2) receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). …
NAID 130000657839

リンク元	「抗ヒスタミン薬」「H1 blocker」「histamine H1 antagonist」
関連記事	「H1」「H」

英: antihistamine antihistamines, histamine antagonist
同: ヒスタミン拮抗薬 histamine antagonists、ヒスタミン遮断薬 histamine blocking agents
関: ヒスタミン受容体。薬理学; ヒスタミンH1受容体拮抗薬 histamine H1 receptor antagonist、H1拮抗薬 H1 blocker、H2遮断薬; ヒスタミンH2受容体拮抗薬 histamine H2 receptor antagonist、H2拮抗薬 H2 blocker、H2遮断薬

中枢作用↓、鎮静作用↓、抗コリン作用↓

ケミカルメディエーター放出を抑制

中枢作用：有。鎮静作用：有