histamine antagonists

抗ヒスタミン薬

WordNet

  1. a drug that neutralizes or counteracts the effects of another drug
  2. a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
  3. amine formed from histidine that stimulates gastric secretions and dilates blood vessels; released by the human immune system during allergic reactions

PrepTutorEJDIC

  1. 対立する人,敵対者,競争相手(opponent)
  2. ヒスタミン(子宮収縮・血圧降下の薬)

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/10/25 23:11:53」(JST)

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  • 5. 小児や青年の不眠症への薬物療法:エビデンスに基づいた治療法pharmacotherapy for insomnia in children and adolescents a rational approach [show details]

English Journal

  • 5-HT3 receptors as important mediators of nausea and vomiting due to chemotherapy.
  • Navari RM1.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2015 Oct;1848(10 Pt B):2738-46. doi: 10.1016/j.bbamem.2015.03.020. Epub 2015 Mar 30.
  • Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in quality of life. The emetogenicity of the chemotherapeutic agents, repeated chemotherapy cycles, and patient risk factors significantly influence CINV. The use of a combination of a 5-hydroxytryptamine-
  • PMID 25838122
  • The Role of Medication in Spontaneous Gastrocutaneous Fistula Closure.
  • Thomas PG1, Sharp NE1, Schnell K1, Snyder CL1, St Peter SD1.
  • European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie.Eur J Pediatr Surg.2015 Oct;25(5):405-8. doi: 10.1055/s-0034-1396417. Epub 2015 Feb 2.
  • Purpose Factors precipitating persistence of gastrocutaneous fistulas (GCFs) are not clearly understood. The role of proton pump inhibitors (PPIs) or histamine receptor antagonists in GCF closure is not yet studied. We aimed to identify whether these medications influence spontaneous GCF closure.
  • PMID 25643250
  • Inhibition of Ebola and Marburg Virus Entry by G Protein-Coupled Receptor Antagonists.
  • Cheng H1, Lear-Rooney CM2, Johansen L3, Varhegyi E1, Chen ZW1, Olinger GG2, Rong L4.
  • Journal of virology.J Virol.2015 Oct 1;89(19):9932-8. doi: 10.1128/JVI.01337-15. Epub 2015 Jul 22.
  • Filoviruses, consisting of Ebola virus (EBOV) and Marburg virus (MARV), are among the most lethal infectious threats to mankind. Infections by these viruses can cause severe hemorrhagic fevers in humans and nonhuman primates with high mortality rates. Since there is currently no vaccine or antiviral
  • PMID 26202243

Japanese Journal

  • <i>EGFR</i>遺伝子変異陽性肺腺癌におけるEGFR-TKIと制酸剤併用の検討
  • Histamine-Induced Dilation of Isolated Porcine Retinal Arterioles: Role of Endothelium-Derived Hyperpolarizing Factor.
  • Investigative ophthalmology and visual science 57(11), 4791-4798, 2016-09
  • NAID 120006325061
  • プロトンポンプ阻害薬,H2受容体拮抗薬 (特集 逆流性食道炎 : 最新の治療動向) -- (治療)

Related Links

Histamine H2-receptor antagonists, also known as H2-blockers, are used to treat duodenal ulcers and prevent their return. They are also used to treat gastric ulcers and for some conditions, such as Zollinger-Ellison disease, in ...
H2 antagonists block histamine-induced gastric acid secretion from the parietal cells of the gastric mucosa (lining of the stomach). H2 antagonists are used to treat gastroesophageal reflux disease (), gastrointestinal ...


Related Pictures

Receptors, Histamine H2; Histamine H2 Histamine AntagonistsHistamine receptor antagonistsHistamine. Causes, symptoms, treatment Histamine Agonists; Histamine H1 Agonists Histamine h3 antagonists; Antihistaminics



★リンクテーブル★
リンク元抗ヒスタミン薬

抗ヒスタミン薬」

  [★]

antihistamine antihistamines, histamine antagonist
ヒスタミン拮抗薬 histamine antagonistsヒスタミン遮断薬 histamine blocking agents
ヒスタミン受容体薬理学
ヒスタミンH1受容体拮抗薬 histamine H1 receptor antagonistH1拮抗薬 H1 blockerH2遮断薬
ヒスタミンH2受容体拮抗薬 histamine H2 receptor antagonistH2拮抗薬 H2 blockerH2遮断薬
  • 古典的抗ヒスタミン薬
  • エタノールアミン系
  • プロピルアミン系
  • ピペラジン系
  • ピペリジン系
  • 第二世代ヒスタミン薬
中枢作用↓、鎮静作用↓、抗コリン作用↓
  • ピペリジン系
  • アレルギー性抗ヒスタミン薬
ケミカルメディエーター放出を抑制
中枢作用:有。鎮静作用:有

薬理学的作用の比較

https://minds.jcqhc.or.jp/n/med/4/med0024/G0000065/0023 をより改変して引用
  受容体括抗作用 イオン電流阻害作用 血液脳関門透過性
H1 ACh NA 5-HT DA PAF LT Ca Na K
ジフェンヒドラミン ++         ++
プロメタジン ++ ++     ++
クロルフェニラミン ++         ++
ケトチフェン ++        
アゼラスチン ++        
オキサトミド ++      
テルフェナジン +++        
アステミゾール +++            
セチリジン +++                  

抗ヒスタミン薬の抗ヒスタミン受容体占拠率

https://www.jstage.jst.go.jp/article/jibiinkoka/112/3/112_3_99/_pdf