同: MCP

WordNet

any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
a thin pliable sheet of material
a pliable sheet of tissue that covers or lines or connects the organs or cells of animals or plants (同)tissue layer
a substance (as a coenzyme) that must join with another to produce a given result

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蛋白(たんばく)質
(生物の)膜,皮膜

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/17 15:46:33」(JST)

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CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene.^[1] CD46 is an inhibitory complement receptor.^[2]

Gene

This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene.^[3]

Function

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system.

The encoded protein has cofactor activity for inactivation (through cleavage) of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement.^[4]

The protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization.^[5]

Clinical Significance

The encoded protein can act as a receptor for the Edmonston strain of measles virus,^[6] human herpesvirus-6 (HHV-6), and type IV pili of pathogenic Neisseria.^[7]

The extracellular region of CD46 contains four short consensus repeats (SCR) of about 60 amino acids that fold into a compact beta-barrel domain surrounded by flexible loops.^[8] As has been demonstrated for CD46 with other ligands, the CD46 protein structure is believed to linearize upon binding HHV-6. While their precise interaction has not yet been determined, the second and third SCR domains have been demonstrated to be required for HHV-6 receptor binding and cellular entry. The heterotetramer gH/gL/gQ1/gQ2 complex of HHV-6 has been identified as a CD46 ligand.^[9]

Established medulloblastoma (a malignant brain tumor common in childhood) specimens express CD46, and that medulloblastoma specimens removed from patients had a high level of CD46 expression. Therefore a vaccine made of the Edmonston strain of measles virus could treat the medulloblastoma. Such a vaccine has already been tested in a number of trials involving other tumor types which have a high expression of CD46, including one type of adult brain tumor.^[10]

Interactions

CD46 has been shown to interact with CD9,^[11] CD151^[11] and CD29.^[11]

References

^ Taylor CT, Biljan MM, Kingsland CR, Johnson PM (May 1994). "Inhibition of human spermatozoon-oocyte interaction in vitro by monoclonal antibodies to CD46 (membrane cofactor protein)". Hum. Reprod. 9 (5): 907–11. PMID 7929741.
^ Liszewski MK, Post TW, Atkinson JP (1991). "Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster". Annu. Rev. Immunol. 9 (1): 431–55. doi:10.1146/annurev.iy.09.040191.002243. PMID 1910685.
^ "Entrez Gene: CD46 CD46 molecule, complement regulatory protein".
^ Riley-Vargas RC, Gill DB, Kemper C, Liszewski MK, Atkinson JP (September 2004). "CD46: expanding beyond complement regulation". Trends Immunol. 25 (9): 496–503. doi:10.1016/j.it.2004.07.004. PMID 15324743.
^ Liszewski MK, Kemper C, Price JD, Atkinson JP (November 2005). "Emerging roles and new functions of CD46". Springer Semin. Immunopathol. 27 (3): 345–58. doi:10.1007/s00281-005-0002-3. PMID 16200405.
^ Dörig RE, Marcil A, Richardson CD (September 1994). "CD46, a primate-specific receptor for measles virus". Trends Microbiol. 2 (9): 312–8. doi:10.1016/0966-842X(94)90447-2. PMID 7529121.
^ Cattaneo R (May 2004). "Four viruses, two bacteria, and one receptor: membrane cofactor protein (CD46) as pathogens' magnet". J. Virol. 78 (9): 4385–8. doi:10.1128/JVI.78.9.4385-4388.2004. PMC 387720. PMID 15078919.
^ Arbuckle, Jesse. "The molecular biology of human herpesvirus-6 latency and telomere integration". Microbes and infection 13 (8-9). doi:10.1016/j.micinf.2011.03.006. PMC 3130849. PMID 21458587.
^ Mori (2009). "Recent topics related to human herpesvirus 6 cell tropism". Cell microbiology.
^ Studebaker AW, Kreofsky CR, Pierson CR, Russell SJ, Galanis E, Raffel C (May 2010). "Treatment of medulloblastoma with a modified measles virus". Neuro Oncol 12 (10): 1034–1042. doi:10.1093/neuonc/noq057. PMC 3018921. PMID 20494960.
^ ^a ^b ^c Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (March 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407.

External links

GeneReviews/NCBI/NIH/UW entry on Atypical Hemolytic-Uremic Syndrome
OMIM entries on Atypical Hemolytic-Uremic Syndrome
CD46 antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 補体介在性溶血性尿毒症症候群 complement mediated hemolytic uremic syndrome
2. 補体系の制御因子および受容体 regulators and receptors of the complement system
3. C3糸球体腎症：デンスデポジット病およびC3糸球体腎炎 c3 glomerulopathies dense deposit disease and c3 glomerulonephritis
4. 補体系の概要および臨床的評価 overview and clinical assessment of the complement system
5. ヒトヘルペスウイルス6型感染症のウイルス学、病因、および疫学 virology pathogenesis and epidemiology of human herpesvirus 6 infection

English Journal

Review: Progresses in understanding N-ethylmaleimide sensitive factor (NSF) mediated disassembly of SNARE complexes.

Ryu JK1, Jahn R2, Yoon TY3.
Biopolymers.Biopolymers.2016 Aug;105(8):518-31. doi: 10.1002/bip.22854.
N-ethylmaleimide sensitive factor (NSF) is a key protein of intracellular membrane traffic. NSF is a highly conserved protein belonging to the ATPases associated with other activities (AAA+ proteins). AAA+ share common domains and all transduce ATP hydrolysis into major conformational movements that
PMID 27062050

Selective effects of a fiber chimeric conditionally replicative adenovirus armed with hep27 gene on renal cancer cell.

Fang L1, Cheng Q1, Liu W1, Zhang J1, Ge Y1, Zhang Q1, Li L1,2, Liu J1, Zheng J1,2,3.
Cancer biology & therapy.Cancer Biol Ther.2016 May 19:0. [Epub ahead of print]
Adenoviruses mediated cancer gene therapies are widely investigated and show a promising effect on cancer treatment. However, efficient gene transfer varies among different cancer cell lines based on the expression of coxsakie adenovirus receptor (CAR). Hep27, a member of dehydrogenase/reductase (SD
PMID 27195521

Cytomegalovirus pUL50 is the multi-interacting determinant of the core nuclear egress complex (NEC) that recruits cellular accessory NEC components.

Sonntag E1, Hamilton ST2, Bahsi H3, Wagner S4, Jonjic S5, Rawlinson WD6, Marschall M7, Milbradt J8.
The Journal of general virology.J Gen Virol.2016 May 4. doi: 10.1099/jgv.0.000495. [Epub ahead of print]
Nuclear egress of herpesvirus capsids through the nuclear envelope is mediated by the multimeric nuclear egress complex (NEC). The human cytomegalovirus (HCMV) core NEC is defined by an interaction between the membrane-anchored pUL50 and its nuclear cofactor pUL53, tightly associated through heterod
PMID 27145986

Japanese Journal

The spatio-temporal distribution dynamics of Ebola virus proteins and RNA in infected cells

Nanbo Asuka,Watanabe Shinji,Halfmann Peter,Kawaoka Yoshihiro
Scientific Reports 3, 1206, 2013-02
… We found that viral nucleoprotein (NP), the polymerase cofactor VP35, the major matrix protein VP40, the transcription activator VP30, and the minor matrix protein VP24 were distributed in cytoplasmic inclusions. … These inclusions enlarged near the nucleus, became smaller pieces, and subsequently localized near the plasma membrane. … GP was distributed in the cytoplasm and transported to the plasma membrane independent of the other viral proteins. …
NAID 120005228271

Atypical HUS

吉田瑶子,松本雅則,早川正樹,藤村吉博
日本アフェレシス学会雑誌 31(1), 27-32, 2012-02-29
… Recent studies have revealed that aHUS is a disease of complement dysregulation with 50-60% of cases involving the complement regulatory genes, factor H (CFH), membrane cofactor protein (MCP;CD46) and factor I (FI) and so on. …
NAID 110009327450

テトラヒドロビオプテリンの細胞膜輸送体活性の測定 : アフリカツメガエル卵母細胞による輸送体遺伝子発現系の応用(<特集>ビタミン測定法の現状と課題[IV])

大橋晶子,菅原ゆうこ,真々田薫 [他],安西尚彦,相澤信,長谷川宏幸
ビタミン 85(9), 485-491, 2011-09-25
… Supplementation of tetrahydrobiopterin (BH_4), an essential cofactor in nitric oxide and monoamine production, is used in treating a systemic deficiency of BH_4 despite of high cost medication due to short retention of supplied BH_4. … Application of a membrane-protein expression system using Xenopus oocytes followed by a radioisotope assay has widely been employed in transporter research. …
NAID 110008723139

「MCP」

CD46 molecule, complement regulatory protein
	PDB rendering based on 1ckl.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1CKL, 1HR4, 2O39, 3INB, 3L89, 3O8E
Identifiers
Symbols	CD46 ; AHUS2; MCP; MIC10; TLX; TRA2.10
External IDs	OMIM: 120920 MGI: 1203290 HomoloGene: 7832 GeneCards: CD46 Gene
Gene ontology
Molecular function	• complement binding; • endopeptidase activity; • enzyme inhibitor activity; • receptor activity; • protein binding; • cadherin binding;
Cellular component	• inner acrosomal membrane; • Golgi apparatus; • plasma membrane; • integral component of plasma membrane; • focal adhesion; • cell surface; • basolateral plasma membrane; • extracellular exosome;
Biological process	• adaptive immune response; • T cell mediated immunity; • proteolysis; • complement activation, classical pathway; • single fertilization; • regulation of Notch signaling pathway; • positive regulation of gene expression; • negative regulation of gene expression; • viral process; • regulation of complement activation; • interleukin-10 production; • positive regulation of interleukin-10 production; • sequestering of extracellular ligand from receptor; • positive regulation of T cell proliferation; • negative regulation of catalytic activity; • positive regulation of memory T cell differentiation; • innate immune response; • positive regulation of regulatory T cell differentiation; • negative regulation of complement activation; • positive regulation of transforming growth factor beta production;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

　　[★]

monokine chemotactic protein
医療監督医師 medical control physician
中手指節の metacarpophalangeal　→　中手指節関節 metacarpophalangeal joint
membrane cofactor protein

「補体調節蛋白」

　　[★]

英: membrane cofactor protein
関: 補体調節タンパク質、メンブレンコファクタープロテイン

「complement control protein」

　　[★]

補体調節タンパク質、補体制御タンパク質

関: CCP、membrane cofactor protein

「CCP」

　　[★]

補体調節タンパク質

関: complement control protein、membrane cofactor protein

「メンブレンコファクタープロテイン」

　　[★]

英: membrane cofactor protein
関: 補体調節タンパク質、補体調節蛋白

「membrane」

　　[★]

n.

膜、メンブラン

[pmid7929741-1] Taylor CT, Biljan MM, Kingsland CR, Johnson PM (May 1994). "Inhibition of human spermatozoon-oocyte interaction in vitro by monoclonal antibodies to CD46 (membrane cofactor protein)". Hum. Reprod. 9 (5): 907–11. PMID 7929741.

[pmid1910685-2] Liszewski MK, Post TW, Atkinson JP (1991). "Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster". Annu. Rev. Immunol. 9 (1): 431–55. doi:10.1146/annurev.iy.09.040191.002243. PMID 1910685.

[3] "Entrez Gene: CD46 CD46 molecule, complement regulatory protein".

[pmid15324743-4] Riley-Vargas RC, Gill DB, Kemper C, Liszewski MK, Atkinson JP (September 2004). "CD46: expanding beyond complement regulation". Trends Immunol. 25 (9): 496–503. doi:10.1016/j.it.2004.07.004. PMID 15324743.

[pmid16200405-5] Liszewski MK, Kemper C, Price JD, Atkinson JP (November 2005). "Emerging roles and new functions of CD46". Springer Semin. Immunopathol. 27 (3): 345–58. doi:10.1007/s00281-005-0002-3. PMID 16200405.

[pmid7529121-6] Dörig RE, Marcil A, Richardson CD (September 1994). "CD46, a primate-specific receptor for measles virus". Trends Microbiol. 2 (9): 312–8. doi:10.1016/0966-842X(94)90447-2. PMID 7529121.

[pmid15078919-7] Cattaneo R (May 2004). "Four viruses, two bacteria, and one receptor: membrane cofactor protein (CD46) as pathogens' magnet". J. Virol. 78 (9): 4385–8. doi:10.1128/JVI.78.9.4385-4388.2004. PMC 387720. PMID 15078919.

[8] Arbuckle, Jesse. "The molecular biology of human herpesvirus-6 latency and telomere integration". Microbes and infection 13 (8-9). doi:10.1016/j.micinf.2011.03.006. PMC 3130849. PMID 21458587.

[9] Mori (2009). "Recent topics related to human herpesvirus 6 cell tropism". Cell microbiology.

[pmid20494960-10] Studebaker AW, Kreofsky CR, Pierson CR, Russell SJ, Galanis E, Raffel C (May 2010). "Treatment of medulloblastoma with a modified measles virus". Neuro Oncol 12 (10): 1034–1042. doi:10.1093/neuonc/noq057. PMC 3018921. PMID 20494960.

[pmid10741407-11] Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E (March 2000). "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. 30 (3): 900–7. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407.

リンク元	「MCP」「補体調節蛋白」「complement control protein」「CCP」「メンブレンコファクタープロテイン」
関連記事	「membrane」

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案内

membrane cofactor protein