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English Journal

Curti BD1, Urba WJ2.
Molecular immunology.Mol Immunol.2015 Oct;67(2 Pt A):18-27. doi: 10.1016/j.molimm.2015.01.025. Epub 2015 Mar 6.
The concept of using immunotherapy to treat melanoma has existed for decades. The rationale comes from the knowledge that many patients with melanoma have endogenous immune responses against their tumor cells and clinically meaningful tumor regression can be achieved in a minority of patients using
PMID 25746916

Quantitative impact of immunomodulation versus oncolysis with cytokine-expressing virus therapeutics.

Kim PS1, Crivelli JJ, Choi IK, Yun CO, Wares JR.
Mathematical biosciences and engineering : MBE.Math Biosci Eng.2015 Aug;12(4):841-58. doi: 10.3934/mbe.2015.12.841.
The past century's description of oncolytic virotherapy as a cancer treatment involving specially-engineered viruses that exploit immune deficiencies to selectively lyse cancer cells is no longer adequate. Some of the most promising therapeutic candidates are now being engineered to produce immunost
PMID 25974336

Messenger RNA encoding constitutively active toll-like receptor 4 enhances effector functions of human T cells.

Pato A1,2, Eisenberg G2, Machlenkin A2, Margalit A1,3, Cafri G1,4, Frankenburg S2, Merims S2, Peretz T2, Lotem M2, Gross G1,3.
Clinical and experimental immunology.Clin Exp Immunol.2015 Jul 23. doi: 10.1111/cei.12688. [Epub ahead of print]
Adoptive T cell therapy of cancer employs a large number of ex-vivo-propagated T cells which recognize their targets either by virtue of their endogenous TCR or via genetic reprogramming. Yet, both cell-extrinsic and intrinsic mechanisms often diminish the in-vivo potency of these therapeutic T cell
PMID 26212048

P3-272 4-1BB ligandはLPS刺激によりマクロファージに誘導されTNF-α産生維持に関し重要な機能を持っている(Group109 生殖生理2,一般演題,第61回日本産科婦人科学会学術講演会)

Clinical association of serum CD137 (4-1BB) levels in patients with systemic sclerosis

HAMAGUCHI Yasuhito,HASEGAWA Minoru,MATSUSHITA Takashi,KOMURA Kazuhiro,TAKEHARA Kazuhiko,FUJIMOTO Manabu
Journal of dermatological science 53(2), 159-161, 2009-02-01
NAID 10025332542

Suppression of neointimal hyperplasia after vascular injury by blocking 4-1BB/4-1BB ligand pathway

Karube Akiyo,Suzuki Jun-ichi,Haraguchi Go,Maejima Yasuhiro,Saiki Hitoshi,Kosuge Hisanori,Isobe Mitsuaki,Uede Toshimitu
Journal of medical and dental sciences 55(2), 207-213, 2008-06
NAID 110006827395