関: ζ chain

同: CD32 antigen; ｣ polypeptide

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/04 23:49:05」(JST)

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T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a protein that in humans is encoded by the CD247 gene.^[1]

Genomics

The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand. The gene is 87,896 bases in length. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons.

Function

T-cell receptor zeta, together with T-cell receptor alpha/beta and gamma/delta heterodimers and CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[2]

Interactions

CD247 has been shown to interact with Janus kinase 3^[3] and Protein unc-119 homolog.^[4]

References

^ Weissman AM, Hou D, Orloff DG, Modi WS, Seuanez H, O'Brien SJ, Klausner RD (December 1988). "Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9709–13. doi:10.1073/pnas.85.24.9709. PMC 282845. PMID 2974162.
^ "Entrez Gene: CD247 CD247 molecule".
^ Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H, Ohno H, Shirasawa T, Kuriyama T, O'Shea JJ, Saito T (Jul 2001). "Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex". J. Biol. Chem. 276 (27): 25378–85. doi:10.1074/jbc.M011363200. PMID 11349123.
^ Gorska MM, Stafford SJ, Cen O, Sur S, Alam R (Feb 2004). "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation". J. Exp. Med. 199 (3): 369–79. doi:10.1084/jem.20030589. PMC 2211793. PMID 14757743.

External links

CD247 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

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Transcriptomic correlates of organ failure extent in sepsis.

Almansa R1, Heredia-Rodríguez M2, Gomez-Sanchez E3, Andaluz-Ojeda D4, Iglesias V5, Rico L6, Ortega A7, Gomez-Pesquera E8, Liu P9, Aragón M10, Eiros JM11, Jiménez-Sousa MÁ12, Resino S13, Gómez-Herreras I14, Bermejo-Martín JF15, Tamayo E16.
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Gene expression profiling analysis of patients with ankylosing spondylitis.

Shi Z1, Li Q, Cai B, Ran B, Li M.
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A novel thymoma-associated immunodeficiency with increased naive T cells and reduced CD247 expression.

Christopoulos P1, Dopfer EP2, Malkovsky M3, Esser PR4, Schaefer HE1, Marx A5, Kock S1, Rupp N1, Lorenz MR6, Schwarz K7, Harder J8, Martin SF4, Werner M1, Bogdan C9, Schamel WW2, Fisch P10.
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The mechanisms underlying thymoma-associated immunodeficiency are largely unknown, and the significance of increased blood γδ Τ cells often remains elusive. In this study we address these questions based on an index patient with thymoma, chronic visceral leishmaniasis, myasthenia gravis, and a ma
PMID 25732729

Related Pictures

Home / Spare Bulb For CD247. AA466 CD247 / CD3-ZETA Antibody, Rabbit PAb CD247 Crystal Goddess Swarovski Beaded by (écriture en option) Antic Line -CD247 PBB GE CD247 210031 at tn.png Protein CD247 PDB 2hac.png Jurkat cells were stained with 0.5ug CD247

★リンクテーブル★

「CD2」

CD247 molecule
	PDB rendering based on 2hac.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1TCE, 1YGR, 2HAC, 2OQ1, 3IK5, 3IOZ
Identifiers
Symbols	CD247 ; CD3-ZETA; CD3H; CD3Q; CD3Z; IMD25; T3Z; TCRZ
External IDs	OMIM: 186780 MGI: 88334 HomoloGene: 12818 GeneCards: CD247 Gene
Gene ontology
Molecular function	• transmembrane signaling receptor activity; • protein binding; • identical protein binding; • protein homodimerization activity;
Cellular component	• cytoplasm; • plasma membrane; • integral component of membrane; • T cell receptor complex; • alpha-beta T cell receptor complex;
Biological process	• viral process; • T cell costimulation; • Fc-gamma receptor signaling pathway involved in phagocytosis; • innate immune response; • regulation of defense response to virus by virus; • regulation of immune response; • T cell receptor signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

　　[★]

同: Leucine-5, SRBC receptor, LFA-2
関: CD

発現細胞

T細胞、胸腺細胞、NK細胞

分子量

45-58

機能

接着分子、CD58(LFA-3)に結合。細胞内部でLckに結合し、T細胞を活性化

リンパ球が抗原提示細胞と相互作用するのに重要 (IMM.343)

別名

LFA-2, T11

ファミリー

immunoglobulin

[pmid2974162-1] Weissman AM, Hou D, Orloff DG, Modi WS, Seuanez H, O'Brien SJ, Klausner RD (December 1988). "Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: distinction from the molecular CD3 complex". Proc. Natl. Acad. Sci. U.S.A. 85 (24): 9709–13. doi:10.1073/pnas.85.24.9709. PMC 282845. PMID 2974162.

[2] "Entrez Gene: CD247 CD247 molecule".

[pmid11349123-3] Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H, Ohno H, Shirasawa T, Kuriyama T, O'Shea JJ, Saito T (Jul 2001). "Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex". J. Biol. Chem. 276 (27): 25378–85. doi:10.1074/jbc.M011363200. PMID 11349123.

[pmid14757743-4] Gorska MM, Stafford SJ, Cen O, Sur S, Alam R (Feb 2004). "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation". J. Exp. Med. 199 (3): 369–79. doi:10.1084/jem.20030589. PMC 2211793. PMID 14757743.

匿名

検索

案内

案内

CD247