Not to be confused with Enalapril.
Allopurinol
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| Systematic (IUPAC) name |
| 1H-pyrazolo[3,4-d]pyrimidin-4(2H)-one |
| Clinical data |
| Trade names |
Lopurin, Zyloprim |
| AHFS/Drugs.com |
monograph |
| MedlinePlus |
a682673 |
| Pregnancy cat. |
C(USA) |
| Legal status |
℞-only (US) |
| Routes |
tablet (100, 300 mg) |
| Pharmacokinetic data |
| Bioavailability |
78±20% |
| Protein binding |
Negligible |
| Metabolism |
hepatic (80% oxypurinol, 10% allopurinol ribosides) |
| Half-life |
2 h (oxypurinol 18-30 h) |
| Identifiers |
| CAS number |
315-30-0 Y |
| ATC code |
M04AA01 |
| PubChem |
CID 2094 |
| DrugBank |
DB00437 |
| ChemSpider |
2010 Y |
| UNII |
63CZ7GJN5I Y |
| KEGG |
D00224 Y |
| ChEBI |
CHEBI:40279 Y |
| ChEMBL |
CHEMBL1467 Y |
| Chemical data |
| Formula |
C5H4N4O |
| Mol. mass |
136.112 g/mol |
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InChI
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InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10) Y
Key:OFCNXPDARWKPPY-UHFFFAOYSA-N Y
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Y (what is this?) (verify)
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Allopurinol (Zyloprim, and generics) is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout.[1]
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Contents
- 1 Mechanism of action
- 2 Uses
- 2.1 Gout and hyperuricemia
- 2.2 Tumor lysis syndrome
- 2.3 Thiopurine co-therapy
- 2.4 Reperfusion injury
- 2.5 Renal disease, Heart failure and Angina
- 2.6 Epilepsy
- 2.7 Blood pressure
- 3 Metabolism
- 4 Side-effects
- 5 Brand names
- 6 References
- 7 Further reading
- 8 External links
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Mechanism of action
Allopurinol is a purine analog; it is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and is an inhibitor of the enzyme xanthine oxidase.[1] Xanthine oxidase is responsible for the successive oxidation of hypoxanthine and xanthine, resulting in the production of uric acid, the product of human purine metabolism.[1] In addition to blocking uric acid production, inhibition of xanthine oxidase causes an increase in hypoxanthine and xanthine. While xanthine cannot be converted to purine ribotides, hypoxanthine can be salvaged to the purine ribotides adenosine and guanosine monophosphates. Increased levels of these ribotides may cause feedback inhibition of amidophosphoribosyl transferase, the first and rate-limiting enzyme of purine biosynthesis. Allopurinol, therefore, decreases uric acid formation and may also inhibit purine synthesis.[2]
Uses
Allopurinol inhibits the breakdown (catabolism) of the thiopurine drug mercaptopurine, and it was specifically invented by Gertrude Elion to enhance the action of mercaptopurine in the treatment of acute lymphoblastic leukemia.[3] However, no improvement in leukemia response was noted with mercaptopurine-allopurinol co-therapy, and this use of the drug was abandoned.
Gout and hyperuricemia
Subsequently the uric acid lowering capacity of allopurinol was noted, and the drug went on to be developed for its more famous use: to treat hyperuricemia (excess uric acid in blood plasma) and its complications.[3] Allopurinol does not alleviate acute attacks of gout (and can actually make them worse initially), but is useful in chronic gout to prevent future attacks.
Tumor lysis syndrome
Allopurinol was also commonly used in chemotherapeutic treatments to treat 'tumor lysis syndrome' (as these regimes can rapidly produce severe acute hyperuricemia) although it has gradually been replaced by urate oxidase therapy.[4]
Thiopurine co-therapy
Allopurinol can cause severe pancytopenia if given with full-dose mercaptopurine or its pro-drug azathioprine, due to the inhibition of xanthine oxidase that metabolizes mercaptopurine.[5] For this reason, allopurinol has usually been contraindicated for thiopurine therapy. However, in recent years the use of allopurinol in combination with azathioprine or mercaptopurine has been revived. First, it was shown that an azathioprine/allopurinol combination significantly improved renal transplant graft survival.[6] More recently, it was discovered that this co-therapy greatly improves the outcome for patients that do not respond to thiopurine monotherapy when treating inflammatory bowel disease (IBD), specifically Crohn's disease.[7] Co-therapy has also been shown to greatly improve hepatoxicity side effects in treatment of IBD.[8] Co-therapy invariably requires dose reduction of the thiopurine, usually to 1/3 of the standard dose depending upon the patient's genetic status for thiopurine methyltransferase (TPMT).[9]
Reperfusion injury
Other established indications for allopurinol therapy include ischemic reperfusion injury, kidney stones with a uric acid component (uric acid nephrolithiasis), and protozoal infections (Leishmaniasis).
Renal disease, Heart failure and Angina
Allopurinol can be used in patients with poor kidney function, but it may also help them. A study of allopurinol use in patients with chronic kidney disease suggested that "Allopurinol decreases C-reactive protein and slows down the progression of renal disease in patients with chronic kidney disease. In addition, allopurinol reduces cardiovascular and hospitalization risk in these subjects."[10]
A mechanistic study in patients with chronic heart failure has shown that the actions of allopurinol may be due to its inhibition of xanthine oxidase rather than a urate-lowering effect. This study also showed for the first time that a high dose (600 mg) is significantly better at improving endothelial function compared to standard doses.[11]
A recent study has suggested that allopurinol may help reduce the effects of angina in ischaemic heart disease by reducing the workload on the heart.[12]
Epilepsy
Allopurinol is used as an add-on drug for refractory epilepsy, because it is an adenosine agonist, which inhibits glutamine release from excitatory neurons, but does not change the plasma concentration of other epilepsy drugs.[13]
Blood pressure
Allopurinol can lower blood pressure in mild hypertension.[14]
Metabolism
A common misconception is that allopurinol is metabolized by its target, xanthine oxidase, but this action is principally carried out by Aldehyde oxidase.[15] The active metabolite of allopurinol is oxypurinol, which is also an inhibitor of xanthine oxidase. Allopurinol is almost completely metabolized to oxypurinol within two hours of oral administration, whereas oxypurinol is slowly excreted by the kidneys over 18–30 hours. For this reason, oxypurinol is believed responsible for the majority of allopurinol's effect.[16]
Side-effects
Because allopurinol is not a uricosuric, it can be used in patients with poor kidney function. However, allopurinol has two important disadvantages.
First, its dosing is complex,.[17] Second, some patients are hypersensitive to the drug,[18] therefore its use requires careful monitoring. Allopurinol has rare but potentially fatal adverse effects involving the skin. The most serious adverse effect is a hypersensitivity syndrome consisting of fever, skin rash, eosinophilia, hepatitis, worsened renal function, and, in some cases, allopurinol hypersensitivity syndrome.[18] Allopurinol is one of the drugs commonly known to cause Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TENS), two life-threatening dermatological conditions.[19] More common is a less-serious rash that leads to discontinuing this drug. Studies have found HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions that include Steven Johnson Syndrome and toxic epidermal necrosis caused by allopurinol.[20]
More rarely, allopurinol can also result in the depression of bone marrow elements, leading to cytopenias, as well as aplastic anemia. Moreover, allopurinol can also cause peripheral neuritis in some patients, although this is a rare side effect. Another side effect of allopurinol is interstitial nephritis.[21]
It is suspected to cause congenital malformations when used during pregnancy, and should be avoided whenever possible by women trying to conceive.[22]
Brand names
Pure Allopurinol is a white powder
Allopurinol has been marketed in the United States since August 19, 1966, when it was first approved by FDA under the trade name of Zyloprim.[23] Allopurinol was marketed at the time by Burroughs-Wellcome. Allopurinol is now a generic drug sold under a variety of brand names including Allohexal, Allosig, Milurit, Alloril, Progout, Zyloprim, Zyloric, Zyrik and Aluron.[24]
References
- ^ a b c Pacher, P.; Nivorozhkin, A; Szabó, C (2006). "Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol". Pharmacological Reviews 58 (1): 87–114. doi:10.1124/pr.58.1.6. PMC 2233605. PMID 16507884. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2233605/.
- ^ Cameron JS, Moro F, Simmonds HA. (1993). "Gout, uric acid and purine metabolism in paediatric nephrology.". Pediatr Nephrol. 7 (1): 105–118. PMID 8439471.
- ^ a b Elion GB. (1989). "The purine path to chemotherapy (Nobel lecture in physiology or medicine - 1988).". Science 244 (4900): 41–47. PMID 2649979.
- ^ Jeha S. (2001). "Tumor lysis syndrome.". Semin Hematol. 38 (4 Suppl 10): 4–8. PMID 11694945.
- ^ Evans WE. (2004). "Pharmacogenetics of thiopurine S-methyltransferase and thiopurine therapy.". Ther Drug Monit. 26 (2): 186–91. PMID 12891528.
- ^ Chocair PR, Duley JA, Simmonds HA et al. (1993). "Low dose allopurinol, plus azathioprine/ cyclosporin/ prednisolone, a novel immunosuppressive regimen.". Lancet 342 (8863): 83–84. PMID 8100914.
- ^ Sparrow MP, Hande SA, Friedman S et al. (2007). "Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine.". Clin Gastroenterol Hepatol. 5 (2): 209–214. PMID 17296529.
- ^ Ansari AR, Patel N, Sanderson J, et al. (2010). "Low dose azathioprine or 6-mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease.". Aliment Pharmacol Ther 31 (6): 640–647. PMID 20015102.
- ^ Ansari AR, Duley JA. (March 2012). "Azathioprine co-therapy with allopurinol for inflammatory bowel disease: trials and tribulations.". Rev Assoc Med Bras 58 (Suppl.1): S28–33.
- ^ Goicoechea, M.; De Vinuesa, S. G.; Verdalles, U.; Ruiz-Caro, C.; Ampuero, J.; Rincon, A.; Arroyo, D.; Luno, J. (2010). "Effect of Allopurinol in Chronic Kidney Disease Progression and Cardiovascular Risk". Clinical Journal of the American Society of Nephrology 5 (8): 1388–93. doi:10.2215/CJN.01580210. PMC 2924417. PMID 20538833. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2924417/..
- ^ George, J; Carr, E; Davies, J; Belch, JJ; Struthers, A (2006). "High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid". Circulation 114 (23): 2508–16. doi:10.1161/CIRCULATIONAHA.106.651117. PMID 17130343.
- ^ Gout drug 'can prevent angina pain of heart disease', BBC News.
- ^ Drug-Resistant Epilepsy N Engl J Med 2011; 365:2238-2240December 8, 2011
- ^ Feig, D. I.; Soletsky, B.; Johnson, R. J. (2008). "Effect of Allopurinol on Blood Pressure of Adolescents with Newly Diagnosed Essential Hypertension: A Randomized Trial". JAMA: the Journal of the American Medical Association 300 (8): 924–32. doi:10.1001/jama.300.8.924. Lay summary – Journal Watch (September 3, 2008).
- ^ Reiter S, Simmonds HA, Zöllner N, et al. (1990). "Demonstration of a combined deficiency of xanthine oxidase and aldehyde oxidase in xanthinuric patients not forming oxipurinol.". Clin Chim Acta 187 (3): 221–234. PMID 2323062.
- ^ Day RO, Graham GG, Hicks M, et al. (2007). "Clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol.". Clin Pharmacokinet. 46 (8): 623–644. PMID 17655371.
- ^ Dalbeth, Nicola; Stamp, Lisa (2007). "Allopurinol Dosing in Renal Impairment: Walking the Tightrope Between Adequate Urate Lowering and Adverse Events". Seminars in Dialysis 20 (5): 391–5. doi:10.1111/j.1525-139X.2007.00270.x. PMID 17897242.
- ^ a b Tsai TF, Yeh TY. (2010). "Allopurinol in dermatology.". Am J Clin Dermatol. 11 (4): 225–232. PMID 20509717.
- ^ Roujeau JC, Kelly JP, Naldi L, Rzany B, Stern RS, Anderson T et al. (1995). "Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis". N Engl J Med 333 (24): 1600–7. doi:10.1056/NEJM199512143332404. PMID 7477195.
- ^ Hung, SI; Chung, WH; Liou, LB; Chu, CC; Lin, M; Huang, HP; Lin, YL; Lan, JL et al. (2005). "HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol". Proceedings of the National Academy of Sciences of the United States of America 102 (11): 4134–9. doi:10.1073/pnas.0409500102. PMC 554812. PMID 15743917. //www.ncbi.nlm.nih.gov/pmc/articles/PMC554812/.
- ^ Marc E. De Broe, William M. Bennett, George A. Porter (2003). Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals. Springer Science+Business Media. ISBN 9781402012778. http://books.google.com/?id=sLM8F-IBgNcC&pg=PA317&dq=interstitial+nephritis+allopurinol#v=onepage&q=interstitial%20nephritis%20allopurinol&f=false. "Acute interstitial nephritis has also been reported associated with by the administration of allopurinol."
- ^ Kozenko, Mariya; Grynspan, David; Oluyomi-Obi, Titi; Sitar, Daniel; Elliott, Alison M.; Chodirker, Bernard N. (2011). "Potential teratogenic effects of allopurinol: A case report". American Journal of Medical Genetics Part A 155 (9): 2247–52. doi:10.1002/ajmg.a.34139. PMID 21815259.
- ^ http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm
- ^ http://dailymed.nlm.nih.gov/dailymed/search.cfm?startswith=Allopurinol&x=0&y=0
Further reading
- Zahran AM, Azab KS, Abbady MI (2006). "Modulatory role of allopurinol on xanthine oxidoreductase system and antioxidant status in irradiated rats". Egyptian Journal of Radiation Sciences and Applications 19 (2): 373–388. ISSN 1110-0303.
- Hung, Shuen-Iu; Chung, Wen-Hung; Liou, Lieh-Bang; Chu, Chen-Chung; Lin, Marie; Huang, Hsien-Ping; Lin, Yen-Ling; Lan, Joung-Liang et al. (2005). "HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol". Proceedings of the National Academy of Sciences 102 (11): 4134–9. doi:10.1073/pnas.0409500102. PMC 554812. PMID 15743917. //www.ncbi.nlm.nih.gov/pmc/articles/PMC554812/.
- The Third International Thiopurine Symposium 2010, published in RAMB, for information on Allopurinol co-therapy: [1]
External links
- Zyloprim (patient information)
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Antigout preparations (M04)
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| Uricosurics |
- primary: Probenecid
- Sulfinpyrazone
- Benzbromarone
- Isobromindione
- secondary: Amlodipine
- Atorvastatin
- Fenofibrate
- Guaifenesin
- Losartan
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| Xanthine oxidase inhibitors |
- purine analogues: Allopurinol#
- Oxypurinol
- Tisopurine
other: Febuxostat
- Inositols (Phytic acid
- Myo-inositol)
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| Mitotic inhibitors |
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| Other |
- Cinchophen
- NSAIDs except aspirin
- Sevelamer
- Urate oxidase (Rasburicase
- Pegloticase)
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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noco (arth/defr/back/soft)/cong, sysi/epon, injr
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