出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/29 20:00:44」(JST)
Systematic (IUPAC) name | |
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trimethyl-(10-trimethylammoniodecyl)ammonium
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Identifiers | |
CAS Registry Number | 156-74-1 |
ATC code | None |
PubChem | CID: 10921 |
DrugBank | DB01245 Y |
ChemSpider | 10459 Y |
UNII | C1CG1S3T2W Y |
ChEBI | CHEBI:41934 Y |
ChEMBL | CHEMBL1134 Y |
Chemical data | |
Formula | C16H38N2 |
Molecular mass | 258.486 g/mol |
SMILES
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InChI
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Y (what is this?) (verify) |
Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent,[1] and is used in anesthesia to induce paralysis.
Decamethonium, which has a short action time, is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate - but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.
Decamethonium does not produce unconsciousness or anesthesia, and its effects may cause considerable psychological distress while simultaneously making it impossible for a patient to communicate. For these reasons, administration of the drug to a conscious patient is strongly advised against, except in necessary emergency situations.
Decamethonium was used clinically in the UK for many years, but it is now available only for research purposes.
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This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it.
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リンク元 | 「薬理学」「神経筋接合部」「脱分極性筋弛緩薬」「脱分極性遮断薬」「C10」 |
拡張検索 | 「decamethonium compound」 |
Ending of the drug name | Category | Example |
~afil | Erectile dysfunction | sildenafil |
~ane | Inhalatinal general anesthetic | halothane |
~azepam | Benzodiaizepine | diazepam |
~azine | Phenothiazine (neuroleptic, antiemetic) | chlorpromazine |
~azole | Ailtifungal | ketoconazole |
~barbital | Barbiturate | phenobarbital |
~caine | Local anesthetic | lidocaine |
~cillin | Penicillin | methicillin |
~cycline | Antibiotic, protein syntlesis inhibitor | tetracycline |
~ipramine | TCA | iimipramine |
~navir | Protease inhibitor | saquinavir |
~olol | β-antagonist | propranolol |
~operidol | Butyrophenone ( neuroleptic ) | haloperidol |
~oxin | Cardiac glycoside ( inotropic agent ) | digoxin |
~phylline | Methylxanthine | theophylline |
~pril | ACE inhibitor | captopril |
~terol | β2 agonist | albuterol |
~tidine | H2 antagonist | cimtidine |
~triptyline | TCA | amitriptyline |
~tropine | Pituitary hormone | somatotropine |
~zosin | a1 antagonist | prazosin |
+ | - | |
神経活動電位発生 | tetrodotoxin | |
batrachotoxin | ||
アセチルコリン放出 | excess of Ca2+ | hemicholinium |
botulinus toxin | ||
procaine | ||
Mg2+ | ||
4-aminopyridine | ||
lack of Ca2+ | ||
終板電位発生 | succinylcholine(suxamethonium) | curare alkaloids |
decamethonium | α-toxins | |
アセチルコリン加水分解 | cholinesterase inhibitors | |
筋活動電位発生 | veratridine | quinine |
tetrodotoxin | ||
筋収縮 | procaine | |
dantrolene |
.