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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/09/01 03:04:47」(JST)

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English Journal

  • Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline.
  • Utoh M, Murayama N, Uno Y, Onose Y, Hosaka S, Fujino H, Shimizu M, Iwasaki K, Yamazaki H.SourceShin Nippon Biomedical Laboratories, Ltd., Pharmacokinetics and Bioanalysis Center , Kainan , Japan .
  • Xenobiotica; the fate of foreign compounds in biological systems.Xenobiotica.2013 Dec;43(12):1037-42. doi: 10.3109/00498254.2013.793874. Epub 2013 May 16.
  • Abstract 1. Caffeine (1,3,7-trimethylxanthine) is a phenotyping substrate for human cytochrome P450 1A2. 3-N-Demethylation of caffeine is the main human metabolic pathway, whereas monkeys extensively mediate the 7-N-demethylation of caffeine to form pharmacological active theophylline. 2. Roles of m
  • PMID 23679834
  • Transungual delivery of ketoconazole using novel lacquer formulation.
  • Hafeez F, Hui X, Chiang A, Hornby S, Maibach H.SourceDermatology Department, University of California, San Francisco, 90 Medical Center Way, Surge Building, Room 110, San Francisco, CA 94143-0989, USA. Electronic address:
  • International journal of pharmaceutics.Int J Pharm.2013 Nov 18;456(2):357-61. doi: 10.1016/j.ijpharm.2013.08.082. Epub 2013 Sep 9.
  • Onychomycosis, a common fungal infection of the nail, can have a substantial impact on quality of life. The success of topical therapy for onychomycosis depends on effective penetration, which can be enhanced using an appropriate delivery method. This study evaluated the effectiveness of a novel top
  • PMID 24029171
  • Experiments for a systematic comparison between stable-isotope-(deuterium) labeling and radio-((14)C) labeling for the elucidation of the in vitro metabolic pattern of pharmaceutical drugs.
  • Grunwald H, Hargreaves P, Gebhardt K, Klauer D, Serafyn A, Schmitt-Hoffmann A, Schleimer M, Schlotterbeck G, Wind M.SourceBasilea Pharmaceutica International AG, Basel, Switzerland.
  • Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2013 Nov;85:138-44. doi: 10.1016/j.jpba.2013.07.004. Epub 2013 Jul 19.
  • A systematic comparison between two labeling approaches for the investigation of the in vitro metabolic pattern of pharmaceutical drugs was performed by examining the use of (i) radiolabeled drugs analyzed with LC-MS-offline radiodetection and (ii) stable-isotope labeled drugs, used in a defined mix
  • PMID 23933567

Japanese Journal

  • In Vitro Susceptibility of Malassezia pachydermatis Isolates from Canine Skin with Atopic Dermatitis to Ketoconazole and Itraconazole in East Asia
  • WATANABE Shion,KOIKE Anna,KANO Rui,NAGATA Masahiko,CHEN Charles,HWANG Cheol-Yong,HASEGAWA Atsuhiko,KAMATA Hiroshi
  • Journal of Veterinary Medical Science, 2013
  • … pachydermatis isolates to ketoconazole (KTZ) and itraconazole (ITZ) obtained from AD lesions of canines in Japan, Korea and Taiwan. …
  • NAID 130003382408
  • Metabolism of (+)-Terpinen-4-ol by Cytochrome P450 Enzymes in Human Liver Microsomes
  • Haigou Risa,Miyazawa Mitsuo
  • Journal of Oleo Science 61(1), 35-43, 2012
  • … Second, oxidation of (+)-terpinen-4-ol was inhibited by (+)-menthofuran and ketoconazole, inhibitors known to be specific for these enzymes. …
  • NAID 130001882204
  • In Vitro Activities of Antifungal Agents against Clinical Isolates of Dermatophytes from Animals
  • ITOI Sayuri,KANO Rui,HASEGAWA Atsuhiko [他],KAMATA Hiroshi
  • Journal of Veterinary Medical Science 74(8), 1067-1069, 2012
  • … The in vitro susceptibility of 54 clinical isolates from animal dermatophytoses to ketoconazole (KTZ), itaconazole (ITZ) and terbinafine (TFN) was measured using microdilution assay (CLSI M38-A2 test) and by the E-test (KTZ and ITZ). …
  • NAID 130001879810

Related Links

High doses of ketoconazole are sometimes used to treat Cushing syndrome (a condition that occurs when there is too much corticosteroid hormone in the body) and advanced prostate cancer (cancer of a male ...
※この商品に関係するニュース記事へのリンクがページ最下部にあります。 「有効成分」 ケトコナゾール(Ketoconazole) 「同一成分含有商品」 ニズラル(ニゾラール) 200mg (10錠) 1520 円 Nizral (Ketoconazole) - 200mg (10 Tablets) ...




drug entries


  • 生物系と化学物質の選択的な相互作用を研究する学問 (SPC.2)


  • 薬の生物系に対する相互作用:薬理作用 <-化学の視点
  • 生物系の薬に対する相互作用:薬物動態 <-生物の視点


  • 薬物学 materia medica
  • 生薬学
  • 実験薬理学
  • 臨床薬理学
  • 動物薬理学
  • 人体薬理学
  • 比較薬理学
  • 薬理作用学(薬力学)
  • 薬物動態学
  • 中毒学、毒科学
  • 薬物治療学
  • 処方学


Ending of the drug name Category Example
~afil Erectile dysfunction sildenafil
~ane Inhalatinal general anesthetic halothane
~azepam Benzodiaizepine diazepam
~azine Phenothiazine (neuroleptic, antiemetic) chlorpromazine
~azole Ailtifungal ketoconazole
~barbital Barbiturate phenobarbital
~caine Local anesthetic lidocaine
~cillin Penicillin methicillin
~cycline Antibiotic, protein syntlesis inhibitor tetracycline
~ipramine TCA iimipramine
~navir Protease inhibitor saquinavir
~olol β-antagonist propranolol
~operidol Butyrophenone ( neuroleptic ) haloperidol
~oxin Cardiac glycoside ( inotropic agent ) digoxin
~phylline Methylxanthine theophylline
~pril ACE inhibitor captopril
~terol β2 agonist albuterol
~tidine H2 antagonist cimtidine
~triptyline TCA amitriptyline
~tropine Pituitary hormone somatotropine
~zosin a1 antagonist prazosin

















  • 痛風発作予防薬
  • 尿酸排泄促進薬
  • 尿酸生成抑制薬