selective serotonin reuptake inhibitor

選択的セロトニン再取り込み阻害薬 SSRI

WordNet

  1. an antidepressant drug that acts by blocking the reuptake of serotonin so that more serotonin is available to act on receptors in the brain (同)SSRI
  2. limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
  3. control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
  4. limit the range or extent of; "Contact between the young was inhibited by strict social customs"
  5. tending to select; characterized by careful choice; "an exceptionally quick and selective reader"- John Mason Brown
  6. characterized by very careful or fastidious selection; "the school was very selective in its admissions"
  7. a substance that retards or stops an activity
  8. a process of using up or consuming again; "psychopharmacologists discovered that amine reuptake is a process that inactivates monoamine neurotransmitters" (同)re-uptake
  9. a neurotransmitter involved in e.g. sleep and depression and memory (同)5-hydroxytryptamine

PrepTutorEJDIC

  1. 〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》
  2. 選択の,染択する / 注意して選ばれた / 淘汰(とうた)の / (無線が)選択度の高い
  3. 抑制する人(物) / 化学反応抑制剤

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/07/24 18:39:18」(JST)

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English Journal

  • Pregnancy Outcome Following Maternal Exposure to Mirtazapine: A Multicenter, Prospective Study.
  • Winterfeld U1, Klinger G, Panchaud A, Stephens S, Arnon J, Malm H, Te Winkel B, Clementi M, Pistelli A, Maňáková E, Eleftheriou G, Merlob P, Kaplan YC, Buclin T, Rothuizen LE.
  • Journal of clinical psychopharmacology.J Clin Psychopharmacol.2015 Jun;35(3):250-259.
  • This multicenter, observational prospective cohort study addresses the risk associated with exposure to mirtazapine during pregnancy. Pregnancy outcomes after exposure to mirtazapine were compared with 2 matched control groups: (1) exposure to any selective serotonin reuptake inhibitor (SSRI, contro
  • PMID 25830592
  • Long-Term, Open-Label, Safety Study of Edivoxetine 12 to 18 mg Once Daily as Adjunctive Treatment for Patients With Major Depressive Disorder Who Are Partial Responders to Selective Serotonin Reuptake Inhibitor Treatment.
  • Ball SG1, Atkinson S, Sparks J, Bangs M, Goldberger C, Dubé S.
  • Journal of clinical psychopharmacology.J Clin Psychopharmacol.2015 Jun;35(3):266-272.
  • Long-term safety, tolerability, and efficacy of adjunctive edivoxetine hydrochloride (hereafter edivoxetine), a highly selective and potent norepinephrine reuptake inhibitor, was assessed in patients with major depressive disorder (MDD) experiencing partial response to selective serotonin reuptake i
  • PMID 25815754
  • Studies of the biogenic amine transporters 15. Identification of novel allosteric dopamine transporter ligands with nanomolar potency.
  • Rothman RB1, Ananthan S2, Partilla JS2, Saini SK2, Moukha-Chafiq O2, Pathak V2, Baumann MH2.
  • The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2015 Jun;353(3):529-38. doi: 10.1124/jpet.114.222299. Epub 2015 Mar 18.
  • Novel allosteric modulators of the dopamine transporter (DAT) have been identified. We have shown previously that SRI-9804 [N-(diphenylmethyl)-2-phenyl-4-quinazolinamine], SRI-20040 [N-(2,2-diphenylethyl)-2-phenyl-4-quinazolinamine], and SRI-20041 [N-(3,3-diphenylpropyl)-2-phenyl-4-quinazolinamine]
  • PMID 25788711

Japanese Journal

  • 症例研究 SSRIと認知行動療法の併用療法が奏効した強迫性障害を主たる病態とした特定不能の摂食障害の1例
  • 柴山 修,堀江 武,樋口 裕二 [他]
  • 心身医学 55(5), 432-438, 2015
  • NAID 40020439513
  • パロキセチン大量服用によるtorsades de pointesの一例
  • 上田 剛士
  • 日本集中治療医学会雑誌 22(2), 113-116, 2015
  • … パロキセチンはselective serotonin reuptake inhibitor(SSRI)の中でも安全性は高いとされるが,高用量を服用すると代謝酵素CYP2D6の働きを阻害することで血中濃度が非線形的に上昇した結果TdPを起こしたと推測した。 …
  • NAID 130004846933
  • 嗅球摘出マウスの認知障害に対するフルボキサミンの改善作用
  • 中川西 修,吉田 文,高橋 浩平,根本 亙,八百板 富紀枝,只野 武,丹野 孝一
  • 東北薬科大学研究誌 61, 41-46, 2014-12
  • … This study was undertaken to examine the effect of the selective serotonin reuptake inhibitor(ssRi)fluvoxamine on cognitive dysfunctions in olfactory bulbectomized(OBX)mice. …
  • NAID 110009901312

Related Links

Medical uses [edit] The main indication for SSRIs is major depressive disorder (also called "major depression", "clinical depression" and often simply "depression"). SSRIs are fre
Selective serotonin re-uptake inhibitors or serotonin-specific reuptake inhibitor [1] (SSRIs) are a class of compounds typically used as antidepressants in the treatment of depression, anxiety disorders, and some personality disorders. ...



★リンクテーブル★
リンク元抗うつ薬」「選択的セロトニン再取り込み阻害薬」「選択的セロトニン再取り込み阻害剤
拡張検索selective serotonin reuptake inhibitors
関連記事inhibit」「selective」「inhibitor」「serotonin

抗うつ薬」

  [★]

antidepressant, antidepressants
薬理学、そううつ病、精神疾患

作用機序

三環系抗うつ薬 tricyclic antidepressant

  • 2つの説がある。
  • 1. (急性作用)シナプス前膜におけるノルアドレナリン、セロトニンの再取り込み↓→シナプス間隙における薬剤濃度↑
  • 2. (慢性作用)(2週間後)シナプス後膜における受容体の数↓
  • 慢性作用はシナプス間隙のノルアドレナリン、セロトニン濃度が上昇した結果、シナプス後膜の受容体が減少したために出現すると考えられる。

抗うつ薬

  • 三環系
  • 四環系
ミルナシプラン milnacipran
  • 非定型抗うつ薬 atypical agent

選択的セロトニン再取り込み阻害薬」

  [★]

selective serotonin reuptake inhibitor, SSRI
薬理学向精神薬


特徴

  • TCAと違いcaridiotoxicityがない。また、ムスカリン受容体、ヒスタミン受容体、アドレナリン受容体、ドパミン受容体に結合しない。

適応

副作用

  • some degree of sexual dysfunction
  • GI distress
sertraline:diarrhea
paroxetine:comstipation
  • serotonin syndrome: rare but dangeraous elevation of 5HT: can occur when both an SSRI and a monoamine oxidase inhibitor are administered simultaneously.
  • hyperthermia, muscle rigidity, myoclonus, and rapid fluctuations in mental status and vital signs.

選択的セロトニン再取り込み阻害剤」

  [★]

selective serotonin reuptake inhibitor
選択的セロトニン再取り込み阻害薬

selective serotonin reuptake inhibitors」

  [★]

SSRIs
SSRIs
SSRIs
SSRIs

inhibit」

  [★]

  • v.
  • 抑制する、阻害する、阻止する
abrogateblockdepressdepressiondeterinhibitioninterdictpreventpreventionrepressrepressionrestrainrestraintsuppresssuppression

       

selective」

  [★]

  • adj.
  • 選択的な、選択性の、選択の
choicechooseelectiveoptoptionoptionalselectselectionselectivelyselectivity

     

inhibitor」

  [★]

  • n.
blockerdepressantsuppressant

   

serotonin」

  [★] セロトニン 5-HT 5HT