serotonin syndrome



  1. a pattern of symptoms indicative of some disease
  2. a complex of concurrent things; "every word has a syndrome of meanings"
  3. a neurotransmitter involved in e.g. sleep and depression and memory (同)5-hydroxytryptamine


  1. (疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態

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English Journal

  • Treatment of sleep-related eating disorder.
  • Chiaro G1, Caletti MT, Provini F.
  • Current treatment options in neurology.Curr Treat Options Neurol.2015 Aug;17(8):361. doi: 10.1007/s11940-015-0361-6.
  • OPINION STATEMENT: Sleep-related eating disorder (SRED) is classified as an NREM-related parasomnia characterized by recurrent episodes of dysfunctional eating that occur after an arousal from the main sleep period with partial or complete amnesia for the event, resulting in weight gain from eating
  • PMID 26037737
  • Protective effect of eugenol against restraint stress-induced gastrointestinal dysfunction: Potential use in irritable bowel syndrome.
  • Garabadu D1, Shah A, Singh S, Krishnamurthy S.
  • Pharmaceutical biology.Pharm Biol.2015 Jul;53(7):968-74. doi: 10.3109/13880209.2014.950674. Epub 2014 Dec 4.
  • CONTEXT: Eugenol, an essential constituent found in plants such as Eugenia caryophyllata Thunb. (Myrtaceae) is reported to possess neuroprotective and anti-stress activities. These activities can potentially be useful in the treatment of stress-induced irritable bowel syndrome (IBS).OBJECTIVE: The p
  • PMID 25473818
  • Serotonin Syndrome: Analysis of Cases Registered in the French Pharmacovigilance Database.
  • Abadie D1, Rousseau V, Logerot S, Cottin J, Montastruc JL, Montastruc F.
  • Journal of clinical psychopharmacology.J Clin Psychopharmacol.2015 Jun 16. [Epub ahead of print]
  • BACKGROUND: More information would be required for a better understanding of the actual circumstances of serotonin syndrome (SS) occurrence in routine clinical practice.AIM: The objective of the study was to analyze characteristics of SS French pharmacovigilance reports, especially involved drugs an
  • PMID 26082973

Japanese Journal

  • Linezolidとescitalopram併用によるセロトニン症候群が疑われた1例
  • 抗うつ薬による副作用とその対処 (特集 痛み治療における合併症・副作用の予防と対策)
  • Serotonin 5-HT7 Receptor in the Ventral Hippocampus Modulates the Retrieval of Fear Memory and Stress-Induced Defecation
  • International journal of neuropsychopharmacology 19(6), pyv131, 2016-06-01
  • NAID 120005866845

Related Links

The most widely recognized example of serotonin syndrome was the death of Libby Zion in 1984. [59] Zion was a freshman at Bennington College at her death on March 5, 1984, at age 18. She died within 8 hours of her emergency ...
People with serotonin syndrome should stay in the hospital for at least 24 hours for close observation. Treatment may include: Benzodiazepines such as diazepam (Valium) or lorazepam (Ativan) to decrease agitation ...




serotonin syndrome


  • 抗うつ薬(特に SSRI と呼ばれる選択的セロトニン再取り込み阻害薬。≒セロトニン受容体作動薬)などのセロトニン系の薬物を服用中に出現する副作用
  • 精神症状(不安、混乱する、いらいらする、興奮する、動き回るなど)
  • 錐体外路症状(手足が勝手に動く、震える、体が固くなるなど)
  • 自律神経症状(汗をかく、発熱、下痢、脈が速くなるなど)
  • 服薬開始数時間以内に症状が表れることが多い
  • 服薬を中止すれば24時間以内に症状は消失
  • 「不安」、「混乱する」、「いらいらする」に加えて以下の症状がみられる場合に医療機関受診を推奨している(参考1)
  • 「興奮する」、「動き回る」、「手足が勝手に動く」、「眼が勝手に動く」、「震える」、「体が固くなる」、「汗をかく」、「発熱」、「下痢」、「脈が速くなる」




QJM. 2003 Sep;96(9):635-42

Hunter criteria

感度84%, 特異度97%


  • 1. 重篤副作用疾患別対応マニュアル



selective serotonin reuptake inhibitor, SSRI


  • TCAと違いcaridiotoxicityがない。また、ムスカリン受容体、ヒスタミン受容体、アドレナリン受容体、ドパミン受容体に結合しない。



  • some degree of sexual dysfunction
  • GI distress
  • serotonin syndrome: rare but dangeraous elevation of 5HT: can occur when both an SSRI and a monoamine oxidase inhibitor are administered simultaneously.
  • hyperthermia, muscle rigidity, myoclonus, and rapid fluctuations in mental status and vital signs.


  [★] セロトニン 5-HT 5HT  



  • n.