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1. 小児における浮腫の評価およびマネージメントevaluation and management of edema in children [show details]
… have hypertension. Edema, anorexia, and growth impairment can be seen in a child with chronic kidney disease. Family history of angioedema favors a diagnosis of hereditary angioedema. A newborn …
2. 特発性全身性毛細血管漏出症候群idiopathic systemic capillary leak syndrome [show details]
… overload and pulmonary edema during this period (even those patients with normal renal function). A small number of reports describe chronic forms of systemic capillary… Hereditary angioedema should also be considered since ISCLS occasionally presents with acute cutaneous edema without hypotension.…
3. 血管浮腫の概要：臨床的特徴、診断、およびマネージメントan overview of angioedema clinical features diagnosis and management [show details]
… Urticaria/angioedema is considered chronic when it has been present on most days of the week for a period of six weeks or more. The evaluation of chronic urticaria/angioedema… Idiopathic edema – Idiopathic edema (as opposed to idiopathic angioedema) is a syndrome of persistent and recurrent fluid retention,… on ACE inhibitors and frequently in those with hereditary or acquired C1 inhibitor deficiency: ACE inhibitors should…
4. 軟部および骨肉腫の病原因子pathogenetic factors in soft tissue and bone sarcomas [show details]
… These include a genetic predisposition, gene mutations, radiation therapy (RT), chemotherapy, chemical carcinogens, chronic irritation,… anthracyclines and alkylating agents) and in those who are treated for a primary sarcoma. Chronic edema has been linked to soft tissue sarcomas, particularly lymphangiosarcoma. Viral infections are …
5. 末梢性リンパ浮腫の臨床的特徴および診断clinical features and diagnosis of peripheral lymphedema [show details]
… and the sequelae of severe chronic venous insufficiency. Risk factors for lymphedema include certain hereditary syndromes and other genetic mutations,… of the lymphatic system is chronic (eg, recurrent infection, thermal burns, chronic venous insufficiency), a mixed form of edema/lymphedema can develop.…

「ミルロイ病」

　　[★]

英: Milroy's disease、Milroy disease
同: 慢性遺伝性下腿浮腫遺伝性下腿浮腫 hereditary trophoedema、先天性遺伝性リンパ浮腫 congenital hereditary lymphedema、ノンネ・ミルロイ・メージュ症候ノンネ-ミルロイ-メージュ病 Nonne-Milroy-Meige disease、メージュ病 Meige's disease
関: リンパ浮腫、Milroy病

「浮腫」

　　[★]

英: edema
関: 水腫、angioedema、全身性浮腫

分類

	圧痕性浮腫		非圧痕性浮腫
	pitting edema		nonpitting edema
病態	水のみが間質に貯留圧痕を残す		水分＋血漿由来物質の蓄積(ムコ多糖、蛋白質）・炎症細胞の浸潤圧痕を残さない
疾患	fast edema	slow edema	甲状腺機能低下症局所性炎症(蜂窩織炎、虫さされ) 強皮症
	低アルブミン血症	心不全腎不全

低アルブミン血症はfast edema　と覚えておく

浮腫の原因

IMD.518

全身性

心性浮腫

うっ血性心不全

腎性浮腫

肝性浮腫

内分泌性浮腫
栄養失調性浮腫・栄養障害性浮腫
薬剤性浮腫
起立性浮腫
特発性浮腫

局所性

内科診断リファレンス p.4

循環血漿量の増加：心不全、腎疾患(急性腎炎、腎不全)、薬剤(ミノキシジル、NSAID、ピオグリタゾン、フルドロコルチゾン、エストロゲン、甘草)、refeeding edema
低アルブミン血症：ネフローゼ症候群、蛋白漏出性胃腸症、肝疾患、低栄養
血管透過性亢進：熱傷、外傷、炎症・敗血症、アレルギー反応(血管性浮腫など)、好酸球増多、糖尿病、IL-2治療、ビタミンB1欠乏。血管内増殖因子(systemic capillary leak syndrome, POEMS症候群, Castleman病などの血管疾患、卵巣過剰刺激症候群)
リンパ管閉塞：リンパ節切除、癌のリンパ管浸潤
間質膠質浸透圧増加：甲状腺機能低下症
静脈還流不全：深部静脈血栓症、IVC閉塞、SVC症候群、静脈弁不全
その他：カルシウム拮抗薬(細動脈抵抗の低下)、特発性浮腫(血管透過性亢進＋循環血漿量増加)