WordNet

an impairment of health or a condition of abnormal functioning
caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological

PrepTutorEJDIC

(体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
女性の話術芸人 =diseur
病気にかかった / 病的な,不健全な(morbid)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/03 23:24:20」(JST)

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Milroy's disease is a familial disease characterized by lymphedema, commonly in the legs, caused by congenital abnormalities in the lymphatic system. Disruption of the normal drainage of lymph leads to fluid accumulation and hypertrophy of soft tissues.^[1]^[2] It is also known as Milroy disease, Nonne-Milroy-Meige syndrome and hereditary lymphedema.^[3]

It was named by Sir William Osler for William Milroy, an American physician, who described a case in 1892, though it was first described by Rudolf Virchow in 1863.^[4]^[5]

Description

The most common presentation of Milroy Disease is bilateral lower extremity lymphedema, and may also be accompanied by hydrocele.^[6]

This disease is more common in women and an association with the gene FLT4 has been described.^[7] FLT4 codes for VEGFR-3, which is implicated in development of the lymphatic system.

References

^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. p. 849. ISBN 0-7216-2921-0.
^ David Lowell Strayer; Raphael Rubin (2007). Rubin's Pathology: Clinicopathologic Foundations of Medicine 5th Edition. Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-9516-8.
^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
^ synd/1326 at Who Named It?
^ W. F. Milroy. An undescribed variety of herditary edema. New York Medical Journal, 1892, 56: 505-508.
^ "Milroy Disease". United States Library of Medicine. Retrieved March 2014.
^ Spiegel R, Ghalamkarpour A, Daniel-Spiegel E, Vikkula M, Shalev SA (2006). "Wide clinical spectrum in a family with hereditary lymphedema type I due to a novel missense mutation in VEGFR3". Journal of Human Genetics 51 (10): 846–50. doi:10.1007/s10038-006-0031-3. PMID 16924388.

External links

GeneReview/NIH/UW entry on Milroy Disease

UpToDate Contents

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1. 小児における浮腫の病態生理および病因 pathophysiology and etiology of edema in children
2. リンパ浮腫の予防および治療 prevention and treatment of lymphedema
3. 外陰部病変：形態に基づく鑑別診断 vulvar lesions differential diagnosis based on morphology
4. 乳癌治療後の患者へのアプローチ approach to the patient following treatment for breast cancer

English Journal

Morbidity of sentinel node biopsy: relationship between number of excised lymph nodes and patient perceptions of lymphedema.

Goldberg JI, Riedel ER, Morrow M, Van Zee KJ.SourceBreast Service, Department of Surgery, Evelyn H. Lauder Breast Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Annals of surgical oncology.Ann Surg Oncol.2011 Oct;18(10):2866-72. Epub 2011 Apr 5.
BACKGROUND: Sentinel lymph node biopsy (SLNB) is associated with reduced morbidity, although lymphedema remains a significant complication. Previously, we found no association between number of excised lymph nodes (LNs) and measured lymphedema in SLNB patients. In this analysis, we examined the rela
PMID 21465310

Japanese Journal

Molecular characterization of two novel VEGFR3 mutations in Japanese families with Milroy's disease

FUTATANI Takeshi,NII Eiji,OBATA Makoto,ICHIDA Fukiko,OKABE Yoshie,KANEGANE Hirokazu,MIYAWAKI Toshio
Pediatrics international : official journal of the Japan Pediatric Society 50(1), 116-118, 2008-02-01
NAID 10024152911

Related Pictures

★リンクテーブル★

リンク元	「ミルロイ病」「Milroy's disease」
関連記事	「disease」

「ミルロイ病」

Milroy's disease
Classification and external resources
ICD-10	Q82.0
ICD-9	757.0
OMIM	153100
DiseasesDB	8228
eMedicine	med/1482
MeSH	D008209
GeneReviews	Milroy Disease;