概念

マクロファージの活性化がおこらない

病因

work occasionally; "As a student I jobbed during the semester breaks"
a specific piece of work required to be done as a duty or for a specific fee; "estimates of the citys loss on that job ranged as high as a million dollars"; "the job of repairing the engine took several hours"; "the endless task of classifying the samples"; "the farmers morning chores" (同)task, chore
a damaging piece of work; "dry rot did the job of destroying the barn"; "the barber did a real job on my hair"
a workplace; as in the expression "on the job";
an object worked on; a result produced by working; "he held the job in his left hand and worked on it with his right"
the performance of a piece of work; "she did an outstanding job as Ophelia"; "he gave it up as a bad job"
the responsibility to do something; "it is their job to print the truth"
(computer science) a program application that may consist of several steps but is a single logical unit
profit privately from public office and official business
a Jewish hero in the Old Testament who maintained his faith in God in spite of afflictions that tested him
a book in the Old Testament containing Jobs pleas to God about his afflictions and Gods reply (同)Book of Job
any long-suffering person who withstands affliction without despairing
the 10th letter of the Roman alphabet (同)j

『職』,勤め口;(職としての)仕事 / (しなければならない)『仕事』;職務 / 難しい(骨の折れる)仕事 / 手間(賃)仕事をする / (株の)仲買をする / (公職を利用して)私腹を肥やす / 〈商品〉‘を'卸売りする;〈株〉‘を'仲買する / (…に)…‘を'下請けに出す《+『out』+『名』+『to』+『名』》
ヨブ(旧約聖書で苦難に耐える人の典型とされる) / ヨブ記(旧約聖書の一書)
(連続するものの)10番目,第10番のもの

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PP-341 高lgE症候群(Job症候群)に伴ったフルニエ壊疽の1例(感染症/尿道、前立腺、性器2/膀胱・腎,一般演題ポスター,第96回日本泌尿器科学会総会)

リンク元	「免疫不全症候群」「ヨブ症候群」
関連記事	「症候群」「群」「J」「症候」「job」

英: immunodeficiency syndrome, immunodeficiency
同: 免疫不全症、免疫不全 immune deficiency、immunodeficiency disease immunodeficiency disorder ID
関: 先天性免疫不全症、原発性免疫不全症、免疫不全患者

重症複合免疫不全症 severe combined immunodeficiency SCID：重篤で主なものはX連鎖劣性遺伝。T細胞-でB細胞とNK細胞は病型ごとに欠損

抗体欠乏を主徴とする免疫不全症：B細胞の内因性欠陥またはT－B細胞相互間の異常により，抗体産生が障害された疾患群で，最も頻度が高い(原発性免疫不全症の約45%)

1. Wiskott-Aldrich症候群 WAS：血小板減少、免疫低下、湿疹。X連鎖劣性遺伝。WASpをコードする遺伝子の変異による。T細胞における免疫シナプス形成不全が本態。IgG,IgMは正常～低下、IgE, IgAは増加。リンパ球数は漸減。
2. DNA修復の欠陥

毛細血管拡張性運動失調症 ataxia telangiectasia AT：毛細血管拡張、小脳失調症、。常染色体劣性遺伝。ATM蛋白は細胞周期制御、DNA調節に関与していると考えられ、遺伝子異常により(in vitroで？)放射線高感受性、細胞周期の異常、染色体脆弱性が認められる。T細胞減少、IgA,IgE減少。IgG2,IgG4も減少。